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| 1 | 重组脊髓灰质炎病毒用于治疗复发胶质母细胞瘤(英文)显示文摘Background The prognosis of patients with recurrent World Health Organization(WHO)grade IV malignant glioma is dismal,and there is currently no effective therapy.We conducted a dose-finding and toxicity study in this population of patients,evaluating convection-enhanced,intratumoral delivery of the recombinant nonpathogenic polio-rhinovirus chimera(PVSRIPO).PVSRIPO recognizes the poliovirus receptor CD155,which is widely expressed in neoplastic cells of solid tumors and in major components of the tumor microenvironment.Methods We enrolled consecutive adult patients who had recurrent supratentorial WHO grade IV malignant glioma,confirmed on histopathological testing,with measurable disease(contrast-enhancing tumor of≥1 cm and≤5.5 cm in the greatest dimension).The study evaluated seven doses,ranging between 107 and 1010 50%tissue-culture infectious doses(TCID50),first in a dose-escalation phase and then in a dose-expansion phase.Results From May 2012 through May 2017,a total of 61 patients were enrolled and received a dose of PVSRIPO.Dose level-1(5.0×107TCID50)was identified as the phase 2 dose.One dose-limiting toxic effect was observed;a patient in whom dose level 5(1010TCID50)was administered had a grade 4 intracranial hemorrhage immediately after the catheter was removed.To mitigate locoregional inflammation of the infused tumor with prolonged glucocorticoid use,dose level 5 was deescalated to reach the phase 2 dose.In the dose-expansion phase,19%of the patients had a PVSRIPO-related adverse event of grade 3 or higher.Overall survival among the patients who received PVSRIPO reached a plateau of 21%(95%confidence interval,11 to 33)at 24 months that was sustained at 36 months.Conclusions Intratumoral infusion of PVSRIPO in patients with recurrent WHO grade IV malignant glioma confirmed the absence of neurovirulent potential.The survival rate among patients who receivedPVSRIPO immunotherapy was higher at 24 and 36 months than the rate among historical controls. | Desjardins A Gromeier M Herndon JE 2nd Beaubier N Bolognesi DP Friedman AH Friedman HS McSherry F Muscat AM Nair S Peters KB Randazzo D Sampson JH Vlahovic G Harrison WT McLendon RE Ashley D Bigner DD | 2018 | 中华神经外科疾病研究杂志2018，17，4： | 2 |
| 2 | Efficient transmission calcula- tions for polydisperse water sprays using spectral scaling 显示文摘 | Godoy W F DesJardin P E | 2007 | Journal of Quantitative Spectroscopy & Radiative Transfer2007，108，： | 1 |
| 3 | Correlation of plasma coagulation parameters with thromboprophylaxis,patient characteristics,and outcome in the MEDENOX study显示文摘 | Desjardins L Bara L Boutitie F | | 0，，05： | 1 |
| 4 | United states department of agriculture-agricultural research service research on pre-harvest prevention of mycotoxins and mycotoxigenic fungi in US crops显示文摘 | CLEVELAND T E DOWD P F DESJARDINS A E | 2003 | Pest Manag Sci2003，59，67： | 1 |
| 5 | Rosuvastatin increases vascular endothelial PPAR (gamma) expression and corrects blood pressure variability in obese dyslipidae- mic mice显示文摘 | Desjardins F Sekkali B Verreth W | 2008 | Eur Heart J2008，29，1： | 1 |
| 6 | Vascular endothelial growth factor receptor-2 activates ADP-ribosylation factor 1 to promote endothelial nitric-oxide synthase activation and nitric oxide release from endothelial cells显示文摘 | Daher Z Boulay PL Desjardins F | | 0，，： | 1 |
| 7 | Effect of CO2Enrichment andHigh Photosynthetic Photon flux on the Development of Autotrophy and Growth of Tissue Cultured Strawberry Raspberry and Asparagus Plants显示文摘 | Desjardins Y Lafoxge F Lussier C | 1988 | Acta Hort1988，230，： | 1 |
| 8 | Effect of CO2 Enrichment andHigh Photosynthetic Photon flux on the Development of Autotrophy and Growth of Tissue Cultured Strawberry Raspberry and Asparagus Plants显示文摘 | Desjardins Y Lafoxge F Lussier C | 1988 | Acta Hort1988，230，： | 1 |
| 9 | Control of blood pres- sure variability in caveolin-l-deficient mice : role of nitric oxide i- dentified in vivo through spectral analysis 显示文摘 | Desjardins F Lobysheva I Pelat M | 2008 | Cardiovasc Res2008，79，3： | 1 |
| 10 | Effect of light intensity and CO2 enrichment during in vitro rooting on subsequent growth of plantlets of strawberry, raspberry and asparagus in acclimatization 显示文摘 | Laforge F Lussier C Desjardins Y | 1991 | SciHort1991，47，259： | 1 |
| 11 | Rosuvastatin increases vascular endothelial PPAR(gamma) expression and corrects blood pressure variability in obese dyslipidaemic mice显示文摘 | Desjardins F Sekkali B Verreth W | 2008 | Eur Heart J2008，29，1： | 1 |
| 12 | United states department of agriculture-agricultural research service research on pre-harvest prevention of mycotoxins and mycotoxigenic fungi in US crops显示文摘 | Cleveland T E Dowd P F Desjardin A E | 2003 | Pest Management Sci2003，59，： | 1 |
| 13 | Rosuvastatin in- creases Vascular endothelial PPAR -expression and corrects blood pressurevariability in obese dyslipidaemie mice显示文摘 | Desjardins F Sekkali B Verreth W | 2008 | Eur Heart J2008，29，1： | 1 |
| 14 | Efficient transmission cal- culations for polydisperse water sprays using spectral scaling显示文摘 | Godoy W F DesJardin P E | 2007 | Journal of Quantitative Spectroscopy and Radiative Transfer2007，108，3： | 1 |
| 15 | Organic carbon and 13C contents in soils and soil size fractions,and their changes due to deforestation and pasture installation in eastern Amazonia显示文摘 | Desjardins T Andreux F Volkoff B | 1994 | Geoderma1994，61，： | 1 |
| 16 | Rosuvastatin increases vascular endothelial PPARgamma expression and corrects blood pressure variability in obese dyslipidaemic mice 显示文摘 | Desjardins F Sekkali B Verreth W | 2008 | Eur Heart J2008，29，1： | 1 |
| 17 | Sleep cognitions associated with anxiety and depression in the elderly显示文摘 | Leblane M F Desjardins S Desgagne A | 2015 | Clin Interv Aging2015，10，1： | 1 |
| 18 | Rosuvastatin increases vascular endothelial PPARgamma expression and corrects blood pressure variability in obese dyslipidaemic mice显示文摘 | Desjardins F Sekkali B Verreth W | 2008 | Eur Heart J2008，29，1： | 1 |
| 19 | Nitric oxide dependent endothelial function and cardiovascular disease显示文摘 | Desjardins F Balligand JL | 2006 | Acta Clin Belg2006，61，： | 1 |
| 20 | Rosuvastatin increases vascular endothelial PPARgamma expression and corrects blood pressure variability in obese dyslipidaemic mice 显示文摘 | Desjardins F Sekkali B Verreth W et M | 2008 | Eur Heart J2008，29，1： | 1 |
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