|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Medically unexplained dyspnea:psychophysiological characteristics and role of breathing therapy显示文摘Background Medically unexplained dyspnea occurs commonly in medical settings and remains poorly understood. This study was conducted to investigate the psychophysiological characteristics of medically unexplained dyspnea and the efficacy of breathing retraining for these patients. Methods A group of patients with medically unexplained dyspnea were compared to patients with a variety of organic lung diseases and healthy subjects. In another group of patients,the influence of breathing therapy on complaints,anxiety, and breath-holding was evaluated for an average of 1.5 years. Results Patients with medically unexplained dyspnea reported more intense dyspnea than patients with a variety of organic lung diseases. Additionally,they were anxious and presented a broad range of symptoms in daily life and under challenge,for instance voluntary hyperventilation. More than one third of them qualified for panic disorder. They had shorter breath-holding time at rest,less increase in breath-holding time and higher chances of showing a “paradoxical” decrease of breath-holding time after hyperventilation. A combination of PaO2,forced expiratory volume in one second (FEV1),and anxiety measures distinguished them from organic dyspnea. Breathing retraining profoundly improved their symptoms and decreased the level of state and trait anxiety. Moreover,they better tolerated the voluntary hyperventilation and the symptoms induced were also markedly decreased after therapy. Breath-holding time was prolonged and PetCO2 in a representative group of patients increased. Conclusions Patients with medically unexplained dyspnea appear to have the feature of a “psychosomatic” patient: an anxious patient with a wide variety of symptoms of different organ systems that do not have an organic basis. They can be distinguished from organic dyspnea using a small set of physiological and psychological measures. Breathing retraining turns out to be an effective therapy for those “difficult to treat patients”. | 韩江娜 朱元珏 李舜伟 雒冬梅 胡征 Van Diest I De Peuter S Van de Woestijne KP Van den Bergh O | 2004 | Chinese Medical Journal2004，，1： | 10 |
| 2 | Dietary and metabolomic determinants of relapse in ulcerative colitis patients: A pilot prospective cohort study显示文摘AIM To identify demographic, clinical, metabolomic, and lifestyle related predictors of relapse in adult ulcerative colitis(UC) patients.METHODS In this prospective pilot study, UC patients in clinical remission were recruited and followed-up at 12 mo to assess a clinical relapse, or not. At baseline information on demographic and clinical parameters was collected. Serum and urine samples were collected for analysis of metabolomic assays using a combined direct infusion/liquid chromatography tandem mass spectrometry and nuclear magnetic resolution spectroscopy. Stool samples were also collected to measure fecal calprotectin(FCP). Dietary assessment was performed using a validated self-administered food frequency questionnaire. RESULTS Twenty patients were included(mean age: 42.7 ± 14.8 years, females: 55%). Seven patients(35%) experienced a clinical relapse during the follow-up period. While 6 patients(66.7%) with normal body weight developed a clinical relapse, 1 UC patient(9.1%) who was overweight/obese relapsed during the follow-up(P = 0.02). At baseline, poultry intake was significantly higher in patients who were still in remission during follow-up(0.9 oz vs 0.2 oz, P = 0.002). Five patients(71.4%) with FCP > 150 μg/g and 2 patients(15.4%) with normal FCP(≤ 150 μg/g) at baseline relapsed during the follow-up(P = 0.02). Interestingly, baseline urinary and serum metabolomic profiling of UC patients with or without clinical relapse within 12 mo showed a significant difference. The most important metabolites that were responsible for this discrimination were trans-aconitate, cystine and acetamide in urine, and 3-hydroxybutyrate, acetoacetate and acetone in serum. CONCLUSION A combination of baseline dietary intake, fecal calprotectin, and metabolomic factors are associated with risk of UC clinical relapse within 12 mo. | Ammar Hassanzadeh Keshtel iFloris F van den Brand Karen L Madsen Rupasri Mandal Rosica ValchevaKaren I Kroeker Beomsoo Han Rhonda C Bell Janis Cole Thomas Hoevers David S Wishart Richard N Fedorak Levinus A Dieleman | 2017 | World Journal of Gastroenterology2017，23，21： | 9 |
| 3 | Meeting report:a hard look at the state of enamel research显示文摘The Encouraging Novel Amelogenesis Models and Ex vivo cell Lines(ENAMEL) Development workshop was held on 23 June 2017 at the Bethesda headquarters of the National Institute of Dental and Craniofacial Research(NIDCR). Discussion topics included model organisms, stem cells/cell lines, and tissues/3 D cell culture/organoids. Scientists from a number of disciplines,representing institutions from across the United States, gathered to discuss advances in our understanding of enamel, as well as future directions for the field. | ophir d klein olivier duverger wendy shaw rodrigo s lacruz derk joester janet moradian-oldak megan k pugach j timothy wright sarah e millar ashok b kulkarni john d bartlett thomas gh diekwisch pamela den besten james p simmer | 2017 | International Journal of Oral Science2017，9，4： | 3 |
| 4 | Regulatory macrophages induced by infliximab are involved in healing in vivo and in vitro显示文摘 | Anne Christine W.Vos Manon E.Wildenberg IngridArijs MarjolijnDuijvestein Auke P.Verhaar Gertde Hertogh SéverineVermeire PaulRutgeerts Gijs R.van den Brink Daniel W.Hommes | 2012 | Inflamm Bowel Dis2012，，3： | 2 |
| 5 | MiR-125b, miR-100 and miR-99a co-regulate vincristine resistance in childhood acute lymphoblastic leukemia显示文摘 | F. Akbari Moqadam E.A.M. Lange-Turenhout Ingrid M. Ari?s R. Pieters M.L. den Boer | 2013 | Leukemia Research2013，，： | 2 |
| 6 | Caspase activation and disruption of mitochondrial membrane potential during UV radiation-induced apoptosis of human kemtinocytes requires activation of protein kinase C显示文摘 | Denning MF Wang Y Tibudan S | 2002 | Cell Death Differ2002，9，1： | 1 |
| 7 | Focused crawling: a new approach to topic-specific Web resource discovery显示文摘 | CHARKRABARTI S BERG M van den DOM B | 1999 | Computer Networks1999，31，1116： | 1 |
| 8 | Early prediction of endocrine therapy effect in advanced breast cancer patients using ^99mTc-depreotide scintigraphy 显示文摘 | VAN DEN BOSSCHE B VAN BELLE S DE WINTER F | 2006 | J Nucl Med2006，47，11： | 1 |
| 9 | Development of a combined new mechanical and enzymatic method for the isolation of intact preantral follicles from fetal calf and adult bovine ovaries 显示文摘 | FIGUEIREDO J R HULSHOF S C J VAN DEN HURK R | 1993 | Theriogenology1993，40，： | 1 |
| 10 | Experimental evidence for water weakening of quartzite by microcracldng plus solution-precipitation creep显示文摘 | Den Brok S W J Spiers C J | 1991 | Journal of Geologlcal Society1991，148，3： | 1 |
| 11 | GC-MS analysis of breath odor compounds in liver patients显示文摘 | Van den Velde S Nevens F Van Hee P | 2008 | J Chromatogr B Analyt Technol Biomed Life Sci2008，875，2： | 1 |
| 12 | Re cent sedimentation and sediment accumulation rates of the Ba Lat prodelta(Red River, Vietnam) 显示文摘 | van den Bergh G D Boer W Schaapveld M A S | 2007 | Journal of Asian Earth Sciences2007，，29： | 1 |
| 13 | Gibberellins are in- volved in nodulation of Sesbania rostrata 显示文摘 | Lievens S Goormachtig S Den Herder J | 2005 | Plant Physiology2005，139，3： | 1 |
| 14 | Standard mutation no- menclature in molecular diagnostics: practical and educational chal- lenges显示文摘 | Ogino S Gulley ML den Dunnen JT | 2007 | J Mol Diagn2007，9，1： | 1 |
| 15 | The osteogenic effect of electrosprayed nanoscale collagen/ calcium phosphate coatings on titanium显示文摘 | de Jonge L T Leeuwenburgh S C G van den Beucken J J J P | 2010 | Bioma?terials2010，31，9： | 1 |
| 16 | Comparing conventional gauze therapy to vacuum-assisted closure wound therapy:aprospective randomized trial显示文摘 | Mous CM van den Bemd GJ Heule F | 2007 | J Plast Reconstr Aesthet Surg2007，60，6： | 1 |
| 17 | Carotid artery plaque burden, stiffness, and mortality risk in elderly men: a prospective, population-based cohort study显示文摘 | Stork S van den Beld AW von Schacky C | 2004 | Circulation2004，110，3： | 1 |
| 18 | Epidemiolo- gy of work related neck and upper limb problems: psychoso- cial and personal risk factors (part I) and effective interven- tions from a bio behavioural perspective (part I1)显示文摘 | Bongers PM Ijmker S Van den Heuvel S | 2006 | J Occup Rehabil2006，16，： | 1 |
| 19 | The Neuropro- tective Properties of the Amyloid Precursor Protein Following Traumatic Brain Injury显示文摘 | Plummer S Van den Heuvel C Thornton E | 2016 | Aging Dis2016，7，2： | 1 |
| 20 | Optimization and validation of a micellar electrokinetic chromatographic method for the analysis of florfenicol显示文摘 | HILLAERT S van den BOSSCHE W | 2004 | Journal of Pharmaceutical and Biomedical Analysis2004，36，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员