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| 1 | Improved Land Use and Leaf Area Index Enhances WRF-3DVAR Satellite Radiance Assimilation: A Case Study Focusing on Rainfall Simulation in the Shule River Basin during July 2013显示文摘The application of satellite radiance assimilation can improve the simulation of precipitation by numerical weather prediction models. However, substantial quantities of satellite data, especially those derived from low-level(surface-sensitive)channels, are rejected for use because of the difficulty in realistically modeling land surface emissivity and energy budgets.Here, we used an improved land use and leaf area index(LAI) dataset in the WRF-3 DVAR assimilation system to explore the benefit of using improved quality of land surface information to improve rainfall simulation for the Shule River Basin in the northeastern Tibetan Plateau as a case study. The results for July 2013 show that, for low-level channels(e.g., channel 3),the underestimation of brightness temperature in the original simulation was largely removed by more realistic land surface information. In addition, more satellite data could be utilized in the assimilation because the realistic land use and LAI data allowed more satellite radiance data to pass the deviation test and get used by the assimilation, which resulted in improved initial driving fields and better simulation in terms of temperature, relative humidity, vertical convection, and cumulative precipitation. | Junhua YANG Zhenming JI Deliang CHEN Shichang KANG Congshen FU Keqin DUAN Miaogen SHEN | 2018 | Advances in Atmospheric Sciences2018，35，6： | 2 |
| 2 | Light-triggered NO-releasing nanoparticles for treating mice with liver fibrosis显示文摘Liver fibrosis, resulting from chronic liver damage and characterized by the accumulation of extracellular matrix (ECM) proteins, is a characteristic of most types of chronic liver diseases. The activation of hepatic stellate cells (HSC) is considered an essential pathological hallmark in liver fibrosis. Although nitric oxide (NO) can effectively induce HSC apoptosis, the systemic administration of NO is ineffective and may cause severe complications such as hypotension. To overcome this limitation, nanoparticles were designed to target HSCs and release NO locally under the exposure of near infrared light (NIR). To achieve this, upconversion nanoparticle (UCNP) cores were enveloped in mesoporous silica shells (UCNP@mSiO2), which were modified with hyaluronic acid (HA-UCNP@mSiO2) and Roussin’s black salt (RBS). HA molecules recognize and bind to CD44 proteins, which are overexpressed on activated HSCs. Under exposure to a 980-nm NIR laser, the UCNP cores convert the 980-nm wavelength into ultraviolet (UV) light, which then energizes the RBS (NO donors), resulting in an efficient release of NO inside of the HSCs. Once released, NO triggers HSC apoptosis and reverses the liver fibrosis. This targeted and controlled release method provides the theoretical and experimental basis for novel therapeutic approaches to treat hepatic fibrosis. | Hongxia Liang Zhenhua Li Zhigang Ren Qiaodi Jia Linna Guo Shasha Li Hongyu Zhang Shiqi Hu Dashuai Zhu Deliang Shen Zujiang Yu Ke Cheng | 2020 | Nano Research2020，13，8： | 1 |
| 3 | Electron-ion collider in China显示文摘Lepton scattering is an established ideal tool for studying inner structure of small particles such as nucleons as well as nuclei.As a future high energy nuclear physics project,an Electron-ion collider in China(EicC)has been proposed.It will be constructed based on an upgraded heavy-ion accelerator,High Intensity heavy-ion Accelerator Facility(HIAF)which is currently under construction,together with a new electron ring.The proposed collider will provide highly polarized electrons(with a po-larization of 80%)and protons(with a polarization of 70%)with variable center of mass energies from 15 to 20 GeV and the luminosity of(2–3)×1033 cm^(−2)·s^(−1).Polarized deuterons and Helium-3,as well as unpolarized ion beams from Carbon to Uranium,will be also available at the EicC.The main foci of the EicC will be precision measurements of the structure of the nucleon in the sea quark region,including 3D tomography of nucleon;the partonic structure of nuclei and the parton interaction with the nuclear environment;the exotic states,especially those with heavy flavor quark contents.In addition,issues fundamental to understanding the origin of mass could be addressed by measurements of heavy quarkonia near-threshold production at the EicC.In order to achieve the above-mentioned physics goals,a hermetical detector system will be constructed with cutting-edge technologies.This document is the result of collective contributions and valuable inputs from experts across the globe.The EicC physics program complements the ongoing scientific programs at the Jefferson Laboratory and the future EIC project in the United States.The success of this project will also advance both nuclear and particle physics as well as accelerator and detector technology in China. | Daniele PAnderle Valerio Bertone Xu Cao Lei Chang Ningbo Chang Gu Chen Xurong Chen Zhuojun Chen Zhufang Cui Lingyun Dai Weitian Deng Minghui Ding Xu Feng Chang Gong Longcheng Gui Feng-Kun Guo Chengdong Han Jun He Tie-Jiun Hou Hongxia Huang Yin Huang KrešImir KumeričKi LPKaptari Demin Li Hengne Li Minxiang Li Xueqian Li Yutie Liang Zuotang Liang Chen Liu Chuan Liu Guoming Liu Jie Liu Liuming Liu Xiang Liu Tianbo Liu Xiaofeng Luo Zhun Lyu Boqiang Ma Fu Ma Jianping Ma Yugang Ma Lijun Mao Cédric Mezrag HervéMoutarde Jialun Ping Sixue Qin Hang Ren Craig DRoberts Juan Rojo Guodong Shen Chao Shi Qintao Song Hao Sun PawełSznajder Enke Wang Fan Wang Qian Wang Rong Wang Ruiru Wang Taofeng Wang Wei Wang Xiaoyu Wang Xiaoyun Wang Jiajun Wu Xinggang Wu Lei Xia Bowen Xiao Guoqing Xiao Ju-Jun Xie Yaping Xie Hongxi Xing Hushan Xu Nu Xu Shusheng Xu Mengshi Yan Wenbiao Yan Wencheng Yan Xinhu Yan Jiancheng Yang Yi-Bo Yang Zhi Yang Deliang Yao Zhihong Ye Peilin Yin C-PYuan Wenlong Zhan Jianhui Zhang Jinlong Zhang Pengming Zhang Yifei Zhang Chao-Hsi Chang Zhenyu Zhang Hongwei Zhao Kuang-Ta Chao Qiang Zhao Yuxiang Zhao Zhengguo Zhao Liang Zheng Jian Zhou Xiang Zhou Xiaorong Zhou Bingsong Zou Liping Zou | 2021 | Frontiers of physics2021，16，6： | 1 |
| 4 | Thiol-disulfide exchanges modulate aldo–keto reductase family 1 member B10 activity and sensitivity to inhibitors显示文摘 | Yi Shen Linlin Zhong Stephen Markwell Deliang Cao | 2010 | Biochimie2010，，5： | 1 |
| 5 | A MODIFIED NONLINEAR DIFFUSION MODEL AND ITS APPLICATION TO IMAGE SMOOTHING AND EDGE DETECTION显示文摘A modified version of the Cotte, Lions, Morel and Coil theory for image selective smoothing and edge detection is proposed. Comparing with their model, the most important advantage of this modification is that the convolution with Gaussian processes in the filtering process is replaced by solving an initial-boundary value problem for the heat equation, which simplifies the numerical scheme to some extent. Numerical experiments on natural images are presented for this model. | Xu Deliang Wang Yaguang Zhou Chuqin Shen Haiping(Department of Applied Mathematics, Jiaotong University, Shanghai 200240) | 2001 | Journal of Electronics(China)2001，18，1： | 0 |
| 6 | Effects of Northern Hemisphere Annular Mode on terrestrial near-surface wind speed over eastern China from 1979 to 2017显示文摘Large-scale ocean‒atmosphere circulations(LOACs)have a pronounced effect on the near-surface wind speed(NSWS).In this study,we discussed the contributions of zonal and meridional flows to NSWS changes and identify the possible association between the Northern Hemisphere Annular Mode(NAM)and the NSWS changes over eastern China from 1979 to 2017.Results show that the reduction in NSWS over eastern China was mainly dominated by the weakening of the zonal wind component.NAM has a considerable effect on the NSWS over eastern China.When the NAM exhibits positive phases,the zonal-mean westerly weakens at low-to-mid-latitudes(10°-40°N).Meanwhile,descending flows prevail near 40°N,and ascending flows persist near 65°N in the troposphere.In the lower troposphere,there are northerly anomalies at low-to-mid-latitudes and southerly anomalies at mid-to-high latitudes(40°-70°N).The anomalous meridional flows transport heat from low to high latitudes and weaken the north‒south air temperature gradient.The decreased air temperature gradient over East Asia reduces the pressure gradient near the surface,decreasing NSWS in eastern China.NAM variations could dominate(32.0±15.8)%of the changes in the annual mean NSWS.Nevertheless,the contribution of NAM to the interannual changes of the zonal component in NSWS could reach(45.0±12.9)%. | Jin-Lin ZHA Cheng SHEN Jian WU De-Ming ZHAO Wen-Xuan FAN Hui-Ping JIANG Cesar AZORIN-MOLINA Deliang CHEN | 2022 | Advances in Climate Change Research2022，13，6： | 0 |
| 7 | 3-5 An Experiment Setup for Synergetic Effect of Irradiation and LBE in IMP显示文摘Due to its unique properties, such as favorable neutronic characteristic, low melting point(~125 ?C) and highboiling point (> 1 600 ?C), good natural circulation and chemical inertness with water and air (unlike sodium), etc,lead bismuth eutectic (LBE) has been considered as perspective coolant and spallation target for accelerator drivensystems (ADS)[1;2]. The spallation structural materials of ADS will be long-term irradiated with fast neutrons whilesimultaneous being contact with LBE coolant. In the past few decades, irradiation or LBE corrosion behaviors invarious of materials have been massively investigated for the purpose of developing ADS. However, there are onlya few experiment data on the combined effect of irradiation and LBE corrosion on structural materials due to lackof related experimental setups[3;4]. Such tests are not only essential for ensuring the safety and reliability of ADS,but also necessary for building a database for licensing any materials for use in LBE cooled nuclear systems. | Yao Cunfeng Wang Zhiguang Zhang Hongpeng Sheng Yanbin Chang Hailong Sun Jianrong Wei Kongfang Li Bingsheng Shen Tielong Pang Lilong Zhu Yabin Wang Dong Du Yangyang Wang Ji Cui Minhuan Zhu Huiping Liu Chao Yang Yongwei Fan Deliang | 2014 | IMP & HIRFL Annual Report2014，，1： | 0 |
| 8 | Neutrophil membrane-camouflaged nanoparticles alleviate inflammation and promote angiogenesis in ischemic myocardial injury显示文摘Acute myocardial infarction(AMI)induces a sterile inflammatory response,leading to cardiomyocyte damage and adverse cardiac remodeling.Interleukin-5(IL-5)plays an essential role in developing eosinophils(EOS),which are beneficial for the resolution of inflammation.Furthermore,the proangiogenic properties of IL-5 also contribute to tissue healing following injury.Therefore,targeted delivery of IL-5 is an innovative therapeutic approach for treating AMI.It has been shown that conventional IL-5 delivery can result in undesirable adverse effects and potential drug overdose.In this study,we successfully synthesized a biomimetic IL-5 nanoparticle by camouflaging the IL-5 nanoparticle in a neutrophilic membrane.The administration of neutrophil membrane-camouflaged nanoparticles(NM-NPIL-5)in the in vivo model showed that these nanoparticles promoted EOS accumulation and angiogenesis in the infarcted myocardium,thereby limiting adverse cardiac remodeling after AMI.Our results also demonstrated that the NM-NPIL-5 could serve as neutrophil“decoys”to adsorb and neutralize the elevated neutrophil-related cytokines in the injured heart by inheriting multiple receptors from their“parent”neutrophils.Finally,the targeted delivery of NM-NPIL-5 protected the cardiomyocytes from excessive inflammatory-induced apoptosis and maintained cardiac function.Our findings provided a promising cardiac detoxification agent for acute cardiac injury. | Dongjian Han Fuhang Wang Zhentao Qiao Bo Wang Yi Zhang Qingjiao Jiang Miaomiao Liu Yuansong Zhuang Quanxu An Yan Bai Jiahong Shangguan Jinying Zhang Gaofeng Liang Deliang Shen | 2023 | Bioactive Materials2023，，5： | 0 |
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