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    题名 作者 年代 出处 被引量
1Comparison of different diagnostic methods in infants with Cholestasis显示文摘AIM: To evaluate different methods in differentiating idiopathic neonatal hepatitis from biliary atresia. METHODS: Sixty-five infants with cholestatic jaundice and final diagnosis of idiopathic neonatal hepatitis and biliary atresia were studied prospectively from September 2003 to March 2006. A thorough history and physical examination were undertaken and the liver enzymes were examined. All cases underwent abdominal ultrasonography, hepatobiliary scintigraphy, and percutaneous liver biopsy. The accuracy, sensitivity, specificity and predictive values of these various methods were compared. RESULTS: There were 34 girls and 31 boys, among them 46 subjects had idiopathic neonatal hepatitis (age, 61 ± 17 d) and 19 had biliary atresia (age, 64 ± 18 d). The mean age at onset of jaundice was significantly lower in cases of biliary atresia when compared to idiopathic neonatal hepatitis cases (9 ± 13 d vs 20 ± 21 d; P = 0.032). The diagnostic accuracy of different methods was as follows: liver biopsy, 96.9%; clinical evaluation, 70.8%; ultrasonography, 69.2%; hepatobiliary scintigraphy, 58.5%; and liver enzymes, 50.8%.CONCLUSION: Our results indicate that clinical evaluation by an experienced pediatric hepatologist and a biopsy of the liver are considered as the most reliable methods to differentiate idiopathic neonatal hepatitis and biliary atresia.Seyed Mohsen Dehghani Mahmood Haghighat Mohammad Hadi Imanieh Bita Geramizadeh 2006World Journal of Gastroenterology2006,12,36:14
2Cyclic vomiting syndrome in children: Experience with 181 cases from southern Iran显示文摘AIM: To evaluate the clinical presentation, response to prophylactic therapy and outcome of children with cyclic vomiting syndrome (CVS) in Shiraz, Iran.METHODS: During a period of 11 years (March 1994 to March 2005), 181 consecutive children with a final diagnosis of CVS were evaluated, treated and followed in our center. Patients were randomized to receive either amitriptyline or propranolol as prophylactic treatments. RESULTS: There were 88 boys and 93 girls with mean age of onset of symptoms of 4.9 ± 3.3 years (range, neonatal period to 14 years), the mean age at final diagnosis was 6.9 years (range, 1.5 to 14), and the mean duration between the onset of the first attack and the final diagnosis of CVS was 2 ± 1.81 years (range, 1/6 to 8). The mean duration of each attack was 4.26 days (range, from few hours to 10 d) and the mean interval between the attacks was 1.8 mo (range, 1 wk to 12 mo). The time of onset of the attacks was midnight to early morning in about 70% of cases. Amitriptyline was effective in 46 out of 81 (56%) patients (P < 0.001). Propranolol appeared to have a superior action and was effective in 74 out of 83 (92%) patients (P < 0.0001).CONCLUSION: There is a significant lag time between the onset of clinical symptoms and the final diagnosis of CVS in our area. In patients with typical clinical presentations of CVS, who are examined by an experienced physician, invasive workup is not necessary. Propranolol appears more effective than amitriptyline for prophylactic use in children with CVS.Mahmood Haghighat Seyed Mohammad Rafie Seyed Mohsen Dehghani Gholam Hossein Fallahi Marzieh Nejabat 2007World Journal of Gastroenterology2007,13,12:11
3Engineering carbon quantum dots for photomediated theranostics显示文摘碳量点(CQD ) 由于许多作为古典基于金属的半导体量点(QD ) 的潜在的选择出现了他们的先锋,他们合成的容易,高 biocompatibility,低费用,并且特别地他们的强壮的 photoresponsiveness, tunability,和稳定性。光是能提供空间与时间的控制的万用的、悦耳的刺激。它和 CQD 的相互作用得到象波长依赖者那样的有趣的回答光排出物,费用 / 电子转移,和热产生,对 photomediated bioapplications 的一个范围合适的过程。CQD 的 carbogenic 核心和表面特征能通过万用的工程策略被调节资助特定的光、物理化学的性质,当有特定的一半的变化形式能启用指向的探针的设计时。调节 CQD 的回答到相片相互作用和 bionanoprobes 的设计的基本途径被介绍,它启用包含诊断和治疗学的生物医学的应用。这些策略为在新窗户中与没有金属、新兴的 2D materials.Open 图象的一个范围为 QD 探针的 nanomedicine。Mahbub Hassan Vincent G. Gomes Alireza Dehghani Sara M. Ardekani 2018Nano Research2018,11,1:9
4Influence of the roughness and shape of quartz particles on their flotation kinetics显示文摘Surface roughness and shape play an important role on the behavior of particles in various processes such as flotation. In this re-search, the influence of different grinding methods on the surface roughness and shape characteristics of quartz particles as well as the effect of these parameters on the flotation of the particles was investigated. The surface roughness of the particles was determined by measuring their specific surface area via the gas adsorption method. The shape characteristics of the particles were measured and calculated by images obtained by scanning electron microscopy via an image analysis system. The flotation kinetics was determined using a laboratory flotation cell. The results showed that the particles of rod mill products have higher roughness and elongation ratio and lower roundness than the parti-cles of ball mill products. The flotation kinetics constant of the particles increased with their surface roughness increasing. Particles with higher elongation and lower roundness indicated higher floatability. In addition, the influence of the surface roughness on the flotation kinet-ics was greater than that of shape parameters.Mehdi Rahimi Fahimeh Dehghani Bahram Rezai Mohammad Reza Aslani 2012International Journal of Minerals,Metallurgy and Materials2012,19,4:8
5Post-transplant lymphoproliferative disorder after liver transplantation: Incidence, long-term survival and impact of serum tacrolimus level显示文摘AIM To investigate incidence and survival of post-transplant lymphoproliferative disorder(PTLD) patients after liver transplantation. METHODS A cross-sectional survey was conducted among patients who underwent liver transplantation at Shiraz Transplant Center(Shiraz, Iran) between August 2004 and March 2015. Clinical and laboratory data of patients were collected using a data gathering form. RESULTS There were 40 cases of PTLD in the pediatric age group and 13 cases in the adult group. The incidence of PTLD was 6.25% in pediatric patients and 1.18% in adult liver transplant recipients. The post-PTLD survival of patients at 6 mo was 75.1% ± 6%, at 1 year was 68.9% ± 6.5% and at 5 years was 39.2% ± 14.2%. Higher serum tacrolimus level was associated with lower post-PTLD survival in pediatric patients(OR = 1.07, 95%CI: 1.006-1.15, P = 0.032). A serum tacrolimus level over 11.1 ng/mL was predictive of post PTLD survival(sensitivity = 90%, specificity = 52%, area under the curve = 0.738, P = 0.035). CONCLUSION Incidence of PTLD in our liver transplant patients is comparable to other centers. Transplant physicians may consider adjustment of tacrolimus dose to maintain its serum level below this cutoff point.Ahad Eshraghian Mohammad Hadi Imanieh Seyed Mohsen Dehghani Saman Nikeghbalian Alireza Shamsaeefar Frouzan Barshans Kourosh Kazemi Bita Geramizadeh Seyed Ali Malek-Hosseini 2017World Journal of Gastroenterology2017,23,7:7
6Graphene oxide based carbon composite as adsorbent for Hg removal:Preparation, characterization, kinetics and isotherm studies显示文摘The presence of Hg in the aqueous media is known to cause severe health issues in both humans and animals.Many technologies and especially adsorbents have been applied for its removal. In this study, a graphene oxide–carbon composite(GO–CC) as a new adsorbent was prepared by sol gel procedure and characterized using field emission scanning electron microscopy, BET and EDX. The effects of different variables including solution p H, contact time, adsorbent dose and GO ratio in adsorbent matrix on the removal capacity of Hg were studied. The isotherm data correlated well with the Langmuir isotherm model. Further analysis recommended that the Hg^(2+) adsorption process is governed by the intra-particle and external mass transfer, in which the film diffusion was the rate restrictive step. The presented composite has maximum absorption capacity, q_(max) of 68.8 mg·g^(-1), which is comparable with carbon based adsorbent reported in the previous publications.Tayebeh Esfandiyari Navid Nasirizadeh Mohammad Dehghani Mohammad Hassan Ehrampoosh 2017Chinese Journal of Chemical Engineering2017,25,9:5
7Optimized Fuzzy Controller for MPPT of Grid-connected PV Systems in Rapidly Changing Atmospheric Conditions显示文摘Due to nonlinear behavior of power production of photovoltaic(PV)systems,it is necessary to apply the maximum power point tracking(MPPT)techniques to generate the maximum power.The conventional MPPT methods do not function properly in rapidly changing atmospheric conditions.In this study,a fuzzy logic controller(FLC)optimized by a combination of particle swarm optimization(PSO)and genetic algorithm(GA)is proposed to obtain the maximum power point(MPP).The proposed FLC uses the ratio of power variations to voltage variations and the derivative of power variations to voltage variations as inputs and uses the duty cycle as the output.The range of changes in fuzzy membership functions and fuzzy rules are proposed as an optimization problem optimized by the PSO-GA.The proposed design is validated for MPPT of a PV system using MATLAB/Simulink software.The results indicate a better performance of the proposed FLC compared to the common methods.Majid Dehghani Mohammad Taghipour Gevork B.Gharehpetian Mehrdad Abedi 2021Journal of Modern Power Systems and Clean Energy2021,9,2:4
8Characterization of hot deformation behavior of 410 martensitic stainless steel using constitutive equations and processing maps显示文摘A. Momeni K. Dehghani 2010Materials Science & Engineering A2010,,21:4
9Organisms causing spontaneous bacterial peritonitis in children with liver disease and ascites in Southern Iran显示文摘AIM: To determine the causative agents of spontaneous bacterial peritonitis (SBP) in children with liver disease and ascites in our center.METHODS: During a 2.5 year period, from September 2003 to March 2006, 12 patients with 13 episodes of SBP were studied. In all cases at the time of admission serum albumin and glucose, urinalysis and urine culture was performed. Analysis [white blood cell (WBC) count with differential, albumin, glucose], gram stain, culture by BACTEC method and antibiogram was done on ascitic fluids. Abdominal paracentesis was repeated after 48 h of antibiotic therapy for bacteriologic assay. The patients were followed for at least three months in a gastroenterology clinic. RESULTS: There were 7 girls (58%) and 5 boys (42%) with a median age of 5.2 years (range, 6 mo to 16 years). All cases had positive ascitic fluid culture. Gram stain was positive in 5 (38.5%) of them. The isolated organisms were S. pneumoniae in 5 (38.5%), E. coli in 2 (15.3%), S. viridans in 2 (15.3%), and K. pneumoniae, H. influenza, Enterococci, and nontypable Streptococcus each in one (7.7%). All of them except Enterococci were sensitive to ciprofloxacin and ceftriaxone. All ascitic fluid cultures were negative after 48 h of antibiotic therapy. CONCLUSION: S. pneumoniae is the most common cause of SBP in the pediatric age group and we recom-mend a third generation cephalosporine (e.g., Ceftriax-ione or Cefotaxime) for empirical therapy in children with SBP.Mahmood Haghighat Seyed Mohsen Dehghani Abdolvahab Alborzi Mohammad Hadi Imanieh Bahman Pourabbas Mehdi Kalani 2006World Journal of Gastroenterology2006,12,36:4
10High Resolution and Wide Dynamic Range Pressure Sensor Based on Two-Dimensional Photonic Crystal显示文摘在场的作者高分辨率和宽动态范围 photonic 水晶压力传感器的一个新图案。这个传感器与坐飞机包围的硅杆的方形的数组基于二维的 photonic 水晶。传感器由被联合到 photonic 水晶 nanocavity 的 photonic 水晶波导组成。波导被移开一个排 Si 杆设置, nanocavity 被修改一 Si 杆的半径形成。传感器为 1300 nm1400 nm 波长被设计。模拟结果证明 nanocavity 的反响的波长被增加压力线性地转移到更大的波长。设计传感器有在 0.1 GPa 之间的线性行为到应用压力的 10 GPa 和压力敏感的 8 nm/GPa。Saeed OLYAEE Ali Asghar DEHGHANI 2012Photonic Sensors2012,2,1:3
11Expression analysis of BORIS during pluripotent, differentiated, cancerous, and non-cancerous cell states显示文摘BORIS/CTCFL 是 11 锌手指蛋白质,它是 CTCF,有多样的 rolesin 基因表示的无所不在地表示的蛋白质和染色质组织的 paralog。几研究证明了 BORIS 的表示被限制为 normaladult 睾丸, pluripotent 房间,和多样的癌症房间线。因此,它作为一个癌症睾丸(CT ) 被知道有 beenhypothesized 展出 oncogenic 性质并且涉及癌症房间增长的基因。相反,显示出的另外的 reportshave 它的表示是更普遍的并且能被检测在区分并且正常体的房间;因此, itmight 有角色一般来说细胞的功能。现在的学习被瞄准处于 pluripotent 的 differentcell 状态分析 BORIS 的表示,区分,癌、非癌。我们发现 pluripotencyand 区别的二个房间状态不伴有 BORIS 表示的重要变化。而且,鲍里斯抄本被检测在近似,在癌症和非癌症房间的一样的水平排队。这些调查结果建议与一些以前的报告相对照,老鼠 BORIS 的表示不限于仅仅癌的房间或 pluripotentcell 状态。Sara Soltanian 2014Acta Biochimica et Biophysica Sinica2014,46,8:3
12Genetic and Genotype × Environment Interaction Effects for Appearance Quality of Rice显示文摘This study was conducted to generate genetic information in rice varieties based on a complete diallel crosses over two years. The results indicated that genotype effect was significant for all traits. Genotype × environment interaction effects were significant only for cooked grain length (CGL) and cooked grain shape (CGSH). General combining ability (GCA) and specific combining ability (SCA) effects were significant for entire traits, which indicated the important roles of both additive and non-additive gene actions. GCA × environment interaction effects were significant for CGL, CGSH and grain elongation index (GEI). In the controlling of the inheritance of milled grain shape (GSH), milled grain width (MGW), GEI, milled grain length (MGL), CGSH and cooked grain width (CGW), the additive gene effects were more important than non-additive one. The average degree of dominance was within the range of partial dominance for all of the traits. The narrow-sense heritability was ranged from 0.65 (GSH) to 0.36 (CGL). GCA effects were significant for all of the parents in milled grain length and it was significant for some of the parents in other traits. The crosses of Deilmani × IRFAON-215 exhibited significant SCA for GEI. The positive mean of heterosis was observed for CGW. The highest maximum values of heterosis were revealed in GEI, flowed by GSH, MGW and CGW. GCA and MPV were significantly and positively correlated together for all traits.Sharifi Peyman Dehghani Hamid Mumeni Ali Moghaddam Mohammad 2009Agricultural Sciences in China2009,8,8:3
13Solitary rectal ulcer syndrome in children:A literature review显示文摘Solitary rectal ulcer syndrome(SRUS) is a benign and chronic disorder well known in young adults and less in children.It is often related to prolonged excessive straining or abnormal defecation and clinically presents as rectal bleeding,copious mucus discharge,feeling of incomplete defecation,and rarely rectal prolapse.SRUS is diagnosed based on clinical symptoms and endoscopic and histological findings.The current treatments are suboptimal,and despite correct diagnosis,outcomes can be unsatisfactory.Some treatment protocols for SRUS include conservative management such as family reassurance,regulation of toilet habits,avoidance of straining,encouragement of a high-fiber diet,topical treatments with salicylate,sulfasalazine,steroids and sucralfate,and surgery.In children,SRUS is relatively uncommon but troublesome and easily misdiagnosed with other common diseases,however,it is being reported more than in the past.This condition in children is benign;however,morbidity is an important problem as reflected by persistence of symptoms,especially rectal bleeding.In this review,we discuss current diagnosis and treatment for SRUS.Seyed Mohsen Dehghani Abdorrasoul Malekpour Mahmood Haghighat 2012World Journal of Gastroenterology2012,18,45:3
14Metformin alleviates cholestasis-associated nephropathy through regulating oxidative stress and mitochondrial function显示文摘Background and aim:Cholestasis-associated renal injury or cholemic nephropathy(CN)is a serious clinical problem.Previous studies mentioned that oxidative stress and mitochondrial impairment play a role in CN.There is no specific pharmacological intervention for CN.Metformin is an anti-diabetic drug administered for decades.On the other hand,novel pharmacological properties have emerged for this drug.The effect of metformin on oxidative stress parameters has been well-recognized in different experimental models.It has also been found that metformin positively affected mitochondrial function.The current study aimed to evaluate the effects of metformin in an animal model of CN.Methods:Rats underwent bile duct ligation(BDL)and were treated with metformin(250 and 500 mg/kg)for 14 consecutive days.Two weeks after the BDL operations,urine,serum,and kidney samples were collected and analyzed.Results:Markers of oxidative stress,including reactive oxygen species(ROS)formation,lipid peroxida-tion,protein carbonylation,depleted antioxidant capacity,and decreased glutathione(GSH)levels were detected in BDL animals.Moreover,mitochondrial indices,including adenosine triphosphate(ATP)level,dehydrogenase activity,mitochondrial membrane potential,and mitochondrial permeability,were impaired in the kidney of cholestatic rats.Renal histopathological alterations in cholestatic animals included tubular degeneration and interstitial inflammation,cast formation,and fibrosis.It was found that metformin significantly alleviated oxidative stress and improved mitochondrial indices in the kidney of cholestatic rats.Tissue histopathological alterations were also mitigated in metformin-treated groups.Conclusions:Metformin could be a candidate for managing CN.The nephroprotective role of metformin is primarily associated with its effects on oxidative stress parameters and mitochondrial function.Mohammad Mehdi Ommati Hamidreza Mohammadi Khadijeh Mousavi Negar Azarpira Omid Farshad Reyhaneh Dehghani Asma Najibi Sedigheh Kamran Hossein Niknahad Reza Heidari 2021Liver Research2021,5,3:3
15Hot Ductility of Severe Plastic Deformed AA6061 Aluminum Alloy显示文摘The hot ductility of 6061 aluminum alloy,which was subjected to two different severe plastic deformations(SPD),was studied at different temperatures and strain rates.The tensile tests were carried out at the temperature range of 300-500 ℃ and at the strain rates of 0.0005-0.01 s^(-1).The microstructure evolution was characterized using optical microscopy,transmission electron microscopy and X-ray diffraction technique.The influences of the microstructure after SPD,thermomechanical parameters(temperature and strain rate) and specimen size on the hot formability of this alloy were then analyzed.The results show that a decrease in grains/subgrains exhibited significant effect on the hot ductility of SPDed samples.The constitutive equations were then developed to model the hot formability of the studied alloy.The developed model can be represented by Zener-Hollomon parameter in a hyperbolic sinusoidal equation form.Both the changes of elongation to failure and Zener-Hollomon parameter indicate that the hot ductility of the alloy is more sensitive to the temperature rather than to the strain rate.The uniform elongation is independent of the specimen size,but the postnecking elongation increases dramatically as the ratio of l/A^(1/2) decreases.Ali Akbar Khamei Kamran Dehghani 2015Acta Metallurgica Sinica(English Letters)2015,28,3:2
16Climate change and potential distribution of zoonotic cutaneous leishmaniasis in Central Iran: Horizon 2030 and 2050显示文摘Objective: To investigate and predict the effects of climate change on the potential distribution of the main vector and reservoir hosts of the disease in Yazd province in the future.Methods: Distribution data for vector and reservoir hosts of zoonotic cutaneous leishmaniasis in Yazd province were obtained from earlier studies conducted in the area.MaxEnt ecological niche modeling was used to predict environmental suitability.BCC-CSM1-1(m) model and two climate change scenarios, RCP 4.5 and RCP 8.5 were used for horizons 2030 and 2050 climate projections.Future projections were based on data of a regional climate change model.Results: With both scenarios in 2030 and 2050, the results of jackknife test indicated that the mean temperature of wettest quarter and temperature annual range had the greatest effect on the model for the vector and the reservoir hosts, respectively.Conclusions: The climate conditions are the major determinants of zoonotic cutaneous leishmaniasis incidence rate in Yazd Province.These climate conditions provide favorable habitats for ease transmission of zoonotic cutaneous leishmaniasis in this endemic area.Habitats suitability for the vector and reservoir will be expanding in the coming years compared with the current conditions, such that, in horizon 2030 & 2050, the probability of the presence of the vector and reservoir within 38 580 and 37 949 km^2, respectively, from Yazd province is above 60%.Moreover, an increase is predicted in the presence of the vector in the western parts and the reservoir in the northern and central parts of the province in the future.Understanding the role of environmental and bioclimatic factors in zoonotic cutaneous leishmaniasis occurrence can provide a guide for policy-makers in the creation and implementation of more effective policies for prevention and control.Babak Shiravand Ahmad Ali Hanafi-Bojd Abbas Ali Dehghani Tafti Mohammad Reza Abai Ali Almodarresi Masoud Mirzaei 2019Asian Pacific Journal of Tropical Medicine2019,12,5:2
17Microstructural evolution and mechanical properties of nanostructured Cu-Al-Ni shape memory alloys显示文摘The melt spinning technique, with an applied cooling rate of about 106 K/s, was used to produce a nanostructured Cu+13.2Al+ 5.1Ni (in wt%) shape memory alloy. The properties of nanostructured ribbons were then compared with those of conventional coarse struc-ture. The microstructural evolution was characterized using scanning electron microscopy (SEM), atomic force microscopy (AFM) and X-ray diffraction (XRD) techniques. Microhardness measurements indicate a two-fold increase in hardness because of the produced nanos-tructure. Comparing to its coarse structure, the nanostructured Cu-Al-Ni shape memory alloy exhibited the enhanced mechanical properties including a ductility of 6.5% and a pronounced plateau in the stress-strain curve.M. Izadinia K. Dehghani 2012International Journal of Minerals,Metallurgy and Materials2012,19,4:2
18Spatial Variability of Soil Organic Carbon in Different Hillslope Positions in Toshan Area, Golestan Province, Iran: Geostatistical Approaches显示文摘Accessibility to organic carbon(OC) budget is required for sustainable agricultural development and ecosystem preservation and restoration. Using geostatistical models to describe and demonstrate the spatial variability of soil organic carbon(SOC) will lead to a greater understanding of this dynamics. The aim of this paper is to present the relationships between the spatial variability of SOC and the topographic features by using geostatistical methods on a loess mountain-slope in Toshan region, Golestan Province, northern Iran. Hence, 234 soil samples were collected in a regular grid that covered different parts of the slope. The results showed that such factors as silt, clay, saturated moisture content, mean weighted diameter(MWD) and bulk density were all correlated to the OC content in different slope positions, and the spatial variability of SOC more to slope positions and elevations. The coefficient of variation(CV) indicated that the variability of SOC was moderate in different slope positions and for the mountain-slope as a whole. However, the higher variability of SOC(CV = 45.6%) was shown in the back-slope positions. Also, the ordinary cokriging method for clay as covariant gave better results in evaluating SOC for the whole slope with the RMSE value 0.2552 in comparison with the kriging and the inverse distance weighted(IDW) methods. The interpolation map of OC for the slope under investigation showed lowering SOC concentrations versus increasing elevation and slope gradient. The spatial correlation ratio was different between various slope positions and related to the topographic texture.Abolfazl BAMERI Farhad KHORMALI Farshad KIANI Amir Ahmad DEHGHANI 2015Journal of Mountain Science2015,12,6:2
19Investigating a potential reservoir landslide and suggesting its treatment using limit-equilibrium and numerical methods显示文摘A reservoir landslide not only reduces the water storage capacity, but also causes extensive damages to the dam body, power/water transmission lines, roads, and other infrastructures. The Latian Dam, located 35 km north east of Tehran(Iran), is one of the cases which has encountered serious problems with instability of its rock abutments. This paper addresses the stability analysis of the right abutment of the Latian Dam using limit equilibrium and numerical methods. Geomechanical characteristics of the rock abutment were first estimated based on engineering classification of the rock mass. Different search methods were examined for locating the critical circular/non-circular slip surface in conjunction with the general limit equilibrium method. The effect of variability of rock mass properties, water table, and earthquake load on the factor of safety(FS) and probability of failure(PF) was studied. In the event of rapid drawdown in the reservoir, the limit equilibrium analysis calculated FS=1.067 and PF=21.1%, and the numerical analysis returned FS=1.01. The results of the analyses suggest that the right abutment of the Latian Dam is prone to slide and needs treatment. Investigations demonstrated that a slope reduction by 15? at the upper part of the abutment would meet stability conditions even in the worst-case scenario(FS=1.297 and PF=2.07%).Nima BABANOURI Hesam DEHGHANI 2017Journal of Mountain Science2017,14,3:2
20Effects of herbal extracts and compounds and pharmacological agents on pulmonary fibrosis in animal models:a review显示文摘Pulmonary fibrosis, a chronic inflammatory disease that occurs mainly in older adults, is a serious health threat with few effective treatment options. The etiological aspects of pulmonary fibrosis remain unknown, though some factors such as cigarette smoking, viral infections, surfactant protein polymorphisms, and chronic or high doses use of certain drugs are considered to be risk factors for the progression of pulmonary fibrosis. No standard treatments have been introduced in clinic yet. Although glucocorticoids and antioxidant drugs have been administered, the severe and broad-spectrum adverse effects of glucocorticoids limit their use. Efforts to identify novel therapeutic agents with improved safety profiles are therefore ongoing. In this review, the authors have described the effects of herbal extracts and compounds and certain pharmacological agents on pulmonary fibrosis in animal models. These effects indicate that herbs are a promising source of compounds that can play pivotal roles in the treatment of lung fibrosis.hoda mojiri-forushani ali asghar hemmati mohammad amin dehghani ali reza malayeri hossein hassan pour 2017Journal of Integrative Medicine2017,15,6:2
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