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| 1 | Meta-analyses on prevalence of selected Parkinson’s nonmotor symptoms before and after diagnosis显示文摘Background:Nonmotor symptoms are common among patients with Parkinson’s disease(PD)and some may precede disease diagnosis.Methods:We conducted a meta-analysis on the prevalence of selected nonmotor symptoms before and after PD diagnosis,using random-effect models.We searched PubMed(1965 through October/November 2012)for the following symptoms:hyposmia,constipation,rapid eye movement sleep behavior disorder,excessive daytime sleepiness,depression,and anxiety.Eligible studies were publications in English with original data on one or more of these symptoms.Results:The search generated 2,373 non-duplicated publications and 332 met the inclusion criteria,mostly(n=320)on symptoms after PD diagnosis.For all symptoms,the prevalence was substantially higher in PD cases than in controls,each affecting over a third of the patients.Hyposmia was the most prevalent(75.5%in cases vs.19.1%in controls),followed by constipation(50%vs.17.7%),anxiety(39.9%vs.19.1%),rapid eye movement sleep behavior disorder(37.0%vs.7.0%),depression(36.6%vs.14.9%),and excessive daytime sleepiness(33.9%vs.10.5%).We observed substantial heterogeneities across studies and meta-regression analyses suggested that several factors might have contributed to this.However,the prevalence estimates were fairly robust in several sensitivity analyses.Only 20 studies had data on any symptoms prior to PD diagnosis,but still the analyses revealed higher prevalence in future PD cases than in controls.Conclusion:These symptoms are common among PD patients both before and after diagnosis.Further studies are needed to understand the natural history of nonmotor symptoms in PD and their etiological and clinical implications. | Honglei Chen Edward J Zhao Wen Zhang Yi Lu Rui Liu Xuemei Huang Anna J Ciesielski-Jones Michele A Justice Deborah S Cousins Shyamal Peddada | 2015 | Translational Neurodegeneration2015，4，1： | 18 |
| 2 | P53 and RPA are sequestered in viral replication centers in the nuclei of cells infected with human cytomegalovirus 显示文摘 | Elizabech A F Deborah H S | 1998 | J Virol1998，72，3： | 1 |
| 3 | Therapeutic outcome according to histologic subtype in 121 patients with malignant pleural mesothelioma显示文摘 | Giovanni Luca Ceresoli Laura Deborah Locati Andrés José Mar??a Ferreri Cesare Cozzarini Paolo Passoni Giulio Melloni Piero Zannini Angelo Bolognesi Eugenio Villa | 2001 | Lung Cancer2001，，2： | 1 |
| 4 | Safety and tolerability of intraputaminal delivery of CERE-120 (adeno-associated virus serotype 2–neurturin) to patients with idiopathic Parkinson’s disease: an open-label, phase I trial显示文摘 | William J Marks Jill L Ostrem Leonard Verhagen Philip A Starr Paul S Larson Roy AE Bakay Robin Taylor Deborah A Cahn-Weiner A Jon Stoessl C Warren Olanow Raymond T Bartus | 2008 | Lancet Neurology2008，，5： | 1 |
| 5 | Bioeompatibility of methyleellulose-based constructs designed for intracerebral gelation following experimental traumatic brain injury 显示文摘 | Matthew C T Deborah A S Stuart W H | 2001 | Biomaterials2001，22，： | 1 |
| 6 | An offaxis hydrothermal vent field near the Mid-Atlantic Ridge at 30°N显示文摘 | Deborah S K Jeffrey A K Donna K B | 2001 | Nature2001，412，6843： | 1 |
| 7 | Polymerizations of multifunctional anhydride monomers to form highly crosslinked degradable networks显示文摘 | Kristi S A Deborah J Q | 2001 | Macromal Rapid Commun2001，22，： | 1 |
| 8 | Biological control of fungi causing alfalfa seedling damping-off with a disease-suppressive strain of Streptomyces 显示文摘 | Cecilia R J Deborah A S | 1996 | Biological Controlment1996，7，： | 1 |
| 9 | Intraocular lens implantation in the absence of capsular support显示文摘 | Michael D Wagoner Terry A Cox Reginald George Ariyasu Deborah S Jacobs Carol L Karp | 2003 | Ophthalmology2003，，4： | 1 |
| 10 | A model for battery lifetime analysis for organizing applications on a pocket computer显示文摘 | RAKHMATOV D VRUDHL1LA S DEBORAH A | 2003 | IEEE Transactions on very large scale integration sys- tems2003，11，： | 1 |
| 11 | The involvement of the apoptosis-modulating proteins ERK1/2,Bcl-xL and Bax in the resolution of acute in- flammation in vivo显示文摘 | Deborah A S Derek A W Paul R Colville-Nash | 2006 | Am J Pathol2006，168，1： | 1 |
| 12 | Electronic structure studies of tetrazolium-based ionic liquids 显示文摘 | Deborah D Z Jerry A B Mark S G | 2006 | Phys Chem B2006，110，11： | 1 |
| 13 | Electronic structure studies of tetrazolium-based ionic liquids显示文摘 | Deborah D Z Jerry A B Mark S G | 2006 | Phys Chem2006，10，11： | 1 |
| 14 | The use of microsatellite variation to infer population structure and demographic history in a natural model system显示文摘 | DAVID B G GARY W R DEBORAH A S | 1999 | Genetics1999，151，： | 1 |
| 15 | Suppression of the root-lesion (Pratylenchuspenetrans) in alfalfa (Medicago sativa) by Streptomyces pp 显示文摘 | Deborah A S Linda L K | 2001 | Journal of Plant and Soil2001，235，： | 1 |
| 16 | Electronic structure studies of tetrazolium-based ionic liquids显示文摘 | Deborah D Z Jerry A B Mark S G | 2006 | Phys Chem2006，110，11： | 1 |
| 17 | A compendium of strategies to prevent healthcare -associated infections in acute care hospitals显示文摘 | Deborah S Yokoe Leonard A Mermel Deverick J Anderson | 2008 | Infection control and hospital epidemiology2008，29，1： | 1 |
| 18 | Electronic structure studies of tetrazolium based ionic liquids显示文摘 | Deborah D Z Jerry A B Mark S G | 2006 | J Phys Chem2006，110，11： | 1 |
| 19 | Modification ofBrassicaseed oil by antisense expression of a stearoy-l acyl carrier protein desaturase gene显示文摘 | Knutzon Deborah S Thompson Gregory A Radke Sharon E | 1992 | Proc Natl Acad Sci1992，89，7： | 1 |
| 20 | The Role of MITF Phosphorylation Sites During Coat Color and Eye Development in Mice Analyzed by Bacterial Artificial Chromosome Transgene Rescue显示文摘 | Bauer Georg L Praetorius Christian Bergsteinsdóttir Kristín Hallsson Jón H Gísladóttir Bryndís K Schepsky Alexander Swing Deborah A O’Sullivan T Norene Arnheiter Heinz Bismuth Keren Debbache Julien Fletcher Colin Warming S?ren Copeland Neal | 2009 | Genetics2009，，2： | 1 |
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