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| 1 | Mi R-122 in hepatitis B virus and hepatitis C virus dual infection显示文摘Hepatitis B virus(HBV) and hepatitis C virus(HCV) infections are the most common causes of chronic liver diseases and hepatocelluar carcinomas. Over the past few years, the liver-enriched micro RNA-122(mi R-122) has been shown to differentially regulate viral replication of HBV and HCV. It is notable that thelevel of mi R-122 is positively and negatively regulated by HCV and HBV, respectively. Consistent with the welldocumented phenomenon that mi R-122 promotes HCV accumulation, inhibition of mi R-122 has been shown as an effective therapy for the treatment of HCV infection in both chimpanzees and humans. On the other hand, mi R-122 is also known to block HBV replication, and HBV has recently been shown to inhibit mi R-122 expression; such a reciprocal inhibition between mi R-122 and HBV suggests an intriguing possibility that mi R-122 replacement may represent a potential therapy for treatment of HBV infection. As HBV and HCV have shared transmission routes, dual infection is not an uncommon scenario, which is associated with more advanced liver disease than either HBV or HCV mono-infection. Thus, there is a clear need to further understand the interaction between HBV and HCV and to delineate the role of mi R-122 in HBV/HCV dual infection in order to devise effective therapy. This review summarizes the current understanding of HBV/HCV dual infection, focusing on the pathobiological role and therapeutic potential of mi R-122. | Kyoungsub Song Chang Han Srikanta Dash Luis A Balart Tong Wu | 2015 | World Journal of Hepatology2015，7，3： | 6 |
| 2 | Hepatocellular carcinoma xenograft supports HCV replication:A mouse model for evaluating antivirals显示文摘AIM: To develop a hepatocellular carcinoma (HCC) xenograft model for studying hepatitis C virus (HCV) replication in a mice, and antiviral treatment.METHODS: We developed a stable S3-green fluorescence protein (GFP) cell line that replicated the GFP-tagged HCV sub-genomic RNA derived from a highly efficient JFH1 virus. S3-GFP replicon cell line was injected subcutaneously into γ-irradiated SCID mice. We showed that the S3-GFP replicon cell line formed human HCC xenografts in SCID mice. Cells were isolated from subcutaneous tumors and then serially passaged multiple times in SCID mice by culturing in growth medium supplemented with G-418. The mouse-adapted S3-GFP replicon cells were implanted subcutaneously and also into the liver of SCID mice via intrasplenic infusion to study the replication of HCV in the HCC xenografts. The tumor model was validated for antiviral testing after intraperitoneal injection of interferon-α (IFN-α). RESULTS: A highly tumorigenic S3-GFP replicon cell line was developed that formed subcutaneous tumors within 2 wk and diffuse liver metastasis within 4 wk in SCID mice. Replication of HCV in the subcutaneous and liver tumors was confirmed by cell colony assay, detection of the viral RNA by ribonuclease protection assay and real-time quantitative reverse transcription polymerase chain reaction. High-level replication of HCV sub-genomic RNA in the tumor could be visualized by GFP expression using fluorescence microscopy. IFN-α cleared HCV RNA replication in the subcutaneous tumors within 2 wk and 4 wk in the liver tumor model. CONCLUSION: A non-infectious mouse model allows us to study replication of HCV in subcutaneous and metastatic liver tumors. Clearance of HCV by IFN-α supports use of this model to test other anti-HCV drugs. | Sidhartha Hazari Henry J Hefler Partha K Chandra Bret Poat Feyza Gunduz Tara Ooms Tong Wu Luis A Balart Srikanta Dash | 2011 | World Journal of Gastroenterology2011，17，3： | 2 |
| 3 | Fuzzy multi - objective programming for supplier selection and risk modeling: A possibility ap- proach 显示文摘 | DESHENG DASH WU YIDONG ZHANG | 2010 | European Journal of Operational Research2010，200，： | 1 |
| 4 | Modeling technological innovation risks of an entre- preneurial team usingsystem dynamics: An agent - based perspective 显示文摘 | DESHENG DASH WU XIE KEFAN LIU HUA ZHAO SHI DA- VID L OLSON | 2010 | Technological Forecasting & Social Change2010，，： | 1 |
| 5 | Fuzzy multi-objective Programming for supplier selection and risk modeling:A possibility approach显示文摘 | Desheng Dash Wu Yidong Zhang Dexiang Wu David L Olson | 2010 | European Journal of Operational Research2010，200，3： | 1 |
| 6 | Entrepreneurial team's risk - based decision - making: A dynamic game analysis Original Research Article 显示文摘 | Xie Kefan Chen Gang Desheng Dash Wu | 2011 | International Journal of Production Economics2011，134，1： | 1 |
| 7 | Online banking performance evaluation using data envelopment analysis and principal component analysis显示文摘 | BRUCE H DASH C WU D SH | 2009 | Computers and Operations Research2009，36，6： | 1 |
| 8 | Business intelligence in risk management:Some recent progresses 显示文摘 | Desheng Dash Wu Shu-Heng Chert David L Olson | 2014 | In- formation Sciences2014，256，： | 1 |
| 9 | Mod- eling technological innovation risks of an entrepre- neurial team using system dynamics: An agent- based perspective 显示文摘 | Desheng Dash Wu Xie Kefan Liu Hua | 2010 | Technological Forecasting and Social Change2010，77，6： | 1 |
| 10 | Network Environment and Financial Risk Using Machine Learning and Sentiment Analysis显示文摘 | Nan Li Xun Liang Xinli Li Chao Wang Desheng Dash Wu | 2009 | Human and Ecological Risk Assessment: An International Journal2009，，2： | 1 |
| 11 | Using text mining and sen- timent analysis for online forums hotspot detection显示文摘 | Nan Li Desheng Dash Wu | 2010 | Decision Support Systems2010，，48： | 1 |
| 12 | Supplier selection in a fuzzy group setting: A method using grey related analysis and Dempster–Shafer theory显示文摘 | Desheng (Dash) Wu | 2008 | Expert Systems With Applications2008，，5： | 1 |
| 13 | Efficient Estimating of Large Portfolio Probabilities in Copula Models 显示文摘 | DESHENG DASH WU | 2010 | Operational Research2010，，29： | 1 |
| 14 | Early warning of enterprise decline in a life cycle using neural networks and rough set theory显示文摘 | Cao Yu Chen Xiao-hong Wu Desheng Dash Mo Miao | 2011 | Expert Systems with Applications2011，38，6： | 1 |
| 15 | Using DEA-neural network approach to evaluate branch efficiency of a large Canadian bank显示文摘 | Desheng(Dash) Wu Zijiang Yang Liang Liang | | 0，，01： | 1 |
| 16 | Learning Mech- anism of Entrepreneurial Team' s Risk Decision Making: A Dynamic Game Analysis 显示文摘 | Xie Kefan Chen Gang Dash Wu Wu Qian | 2011 | International Journal of Produc- tion Economics2011，134，1： | 1 |
| 17 | Online banking performance evaluation using data envelopment analysis and principal component analysis 显示文摘 | Chien-Ta Bruce Ho Desheng Dash Wu | 2009 | Computers & Operations Research2009，，36： | 1 |
| 18 | Modeling technological innovation risks of an entrepreneurial team using system dynamics: An agent-based perspective显示文摘 | Desheng Dash Wu Xie Kefan Liu Hua Zhao Shi David L. Olson | 2010 | Technological Forecasting & Social Change2010，，6： | 1 |
| 19 | Using Text Mining and Sentiment Analysis for Online Forums Hotspot Detection and Forecast 显示文摘 | Nan Li Desheng Dash Wu | 2010 | Decision Support Systems2010，，48： | 1 |
| 20 | Early warning of enterprise decline in a life cycle using neural networks and rough set theory 显示文摘 | Cao Yu Chen Xiaohong Wu Desheng Dash | 2011 | Expert Systems with Application2011，38，6： | 1 |
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