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| 1 | Using iron fertilizer to control Cd accumulation in rice plants: A new promising technology显示文摘Effects of two kinds of iron fertilizer, FeSO4 and EDTA·Na2Fe were studied on cadmium accumulation in rice plants with two rice genotypes, Zhongzao 22 and Zhongjiazao 02, with soil culture systems. The results showed that application of iron fertilizers could hardly make adverse effects on plant growth and rice grain yield. Soil application of EDTA·Na2Fe significantly reduced the Cd accumulation in rice roots, shoots and rice grain. Cd concentration in white rice of both rice genotypes in the treatment of soil application of EDTA·Na2Fe was much lower than 0.2 mg/kg, the maximal Cd permission concentra- tion in cereal crop foods in State standard. However, soil application of FeSO4 or foliar application of FeSO4 or EDTA·Na2Fe resulted in the significant increase of Cd accumulation in rice plants including rice grain compared with the control. The results also showed iron fertilizers increased the concentra- tion of iron, copper and manganese element in rice grain and also affected zinc concentration in plants. It may be a new promising way to regulate Cd accumulation in rice grain in rice production through soil application of EDTA·Na2Fe fertilizers to maintain higher content of available iron and ferrous iron in soils. | SHAO GuoSheng, CHEN MingXue, WANG DanYing, XU ChunMei, MOU RenXiang, CAO ZhaoYun & ZHANG XiuFu China National Rice Research Institute, Hangzhou 31006, China | 2008 | Science China(Life Sciences)2008，51，3： | 28 |
| 2 | Effect of various crop rotations on rice yield and nitrogen use efficiency in paddy–upland systems in southeastern China显示文摘To evaluate the effects of various rotation systems on rice grain yield and N use efficiency, a paddy–upland cropping experiment(2013–2016) was conducted in southeastern China. The experiment was designed using six different rice––winter crop rotations: rice–fallow(RF),rice–wheat(RW), rice–potato with rice straw mulch(RP), rice–green manure(Chinese milk vetch; RC–G), rice–oilseed rape(RO), and rice–green manure crop(oilseed rape with fresh straw incorporated into soil at flowering; RO–G) and three N rates, N0(0 kg N ha-1), N1(142.5 kg N ha-1), and N2(202.5 kg N ha-1). Average rice yields in the RF(5.93 t ha-1) rotation were significantly lower than those in the rotations with winter crops(7.20–7.48 t ha-1)under the N0 treatment, suggesting that incorporation of straw might be more effective for increasing soil N than winter fallow. The rice yield differences among the rotations varied by year with the N input. In general, the grain yields in the RP and RO–G rotations –were respectively 11.6–28.5% and 14.80–37.19% higher than those in the RF in plots with N applied. Increasing the N rate may have tended to minimize the average yield gap between the RF and the other rotations; the yield gaps were 18.55%, 4.14%, and 0.23% in N0, N1, and N2, respectively. However, the N recovery efficiency in the RF was significantly lower than that in other rotations, except for 2015 under both N1 and N2 rates, a finding that implies a large amount of chemical N loss. No significant differences in nitrogen agronomic efficiency(NAE) and physiological efficiency(NPE) were found between the rotations with legume(RC–G) and non–legume(RO and RW) winter crops, a result that may be due partly to straw incorporation. For this reason, we concluded that the return of straw could reduce differences in N use efficiency between rotations with and without legume crops. The degree of synchrony between the crop N demand and the N supply was evaluated by comparison of nitrogen balance degree(NBD) values. The NBD values in the RP and RW were significantly lower than those in the other rotations under both N1 and N2 rates. Thus,in view of the higher grain yield in the RP compared to the RW under the N1 rate, the RP rotation might be a promising practice with comparable grain yield and greater N use efficiency under reduced N input relative to the other rotations. The primary yield components of the RF and RP were identified as number of panicles m-2 and numbers of kernels panicle-1, respectively. The NAE and NPE were positively correlated with harvest index, possibly providing a useful indicator for evaluating N use efficiency. | Song Chen Shaowen Liu Xi Zheng Min Yin Guang Chu Chunmei Xu Jinxiang Yan Liping Chen Danying Wang Xiufu Zhang | 2018 | The Crop Journal2018，6，6： | 13 |
| 3 | Epidemiological Data of Work-Related Musculoskeletal Disorders—China,2018–2020显示文摘Summary What is already known about this topic?In recent decades,work-related musculoskeletal disorders(WMSDs)have become increasingly prominent and have become an important issue that is of universal concern and an urgent need to be solved in all countries of the world.What is added by this report?The top three industries or occupational groups with the highest standardized prevalence rate of WMSDs were flight attendants,medical staff,and vegetable greenhouses in that order.Women workers were 1.5 times more likely to suffer from WMSDs than men workers. | Ning Jia Huadong Zhang Ruijie Ling Yimin Liu Gang Li Zaoliang Ren Yan Yin Hua Shao Hengdong Zhang Bing Qiu Meibian Zhang Dayu Wang Qiang Zeng Rugang Wang Jianchao Chen Danying Zhang Liangying Mei Yongquan Liu Jixiang Liu Chengyun Zhang Tianlai Li Qing Xu Ying Qu Xueyan Zhang Xin Sun Zhongxu Wang | 2021 | China CDC weekly2021，3，18： | 13 |
| 4 | Investigation on Work-Related Musculoskeletal Disorders--China, 2018−2019显示文摘What is already known about this topic?Work-related musculoskeletal disorders(WMSDs)have a high prevalence and seriously harmful,which has attracted extensive attention in various countries in the world.Currently,the occurrence and rules of WMSDs in key industries are not known in China.What is added by this report?The prevalence of WMSDs is relatively high among professional populations in key industries in China,with the most commonly affected body parts concentrated in neck,shoulders,and low back and increasing with age and working years.What are the implications for public health practice?This study determined the prevalence and distribution characteristics of WMSDs in key industries in China and provided scientific evidence to recommend for inclusion of WMSDs in the new revision of the list of occupational diseases in China. | Ning Jia Huadong Zhang Ruijie Ling Yimin Liu Gang Li Zaoliang Ren Yan Yin Hua Shao Hengdong Zhang Bing Qiu Meibian Zhang Dayu Wang Qiang Zeng Rugang Wang Jianchao Chen Danying Zhang Liangying Mei Yongquan Liu Jixiang Liu Chengyun Zhang Tianlai Li Qing Xu Ying Qu Xueyan Zhang Xin Sun Zhongxu Wang | 2020 | China CDC weekly2020，2，18： | 11 |
| 5 | Agronomic performance of drought-resistance rice cultivars grown under alternate wetting and drying irrigation management in southeast China显示文摘Compared to drought-susceptible rice cultivars(DSRs),drought-resistance rice cultivars(DRRs)could drastically reduce the amount of irrigation water input and simultaneously result in higher grain yield under water-saving irrigation conditions.However,the mechanisms underlying these properties are unclear.We investigated how improved agronomic traits contribute to higher yield and higher water use efficiency(WUE)in DRRs than in DSRs under alternate wetting and drying(AWD).Two DRRs and two DSRs were field-grown in 2015 and 2016 using two different irrigation regimes:continuous flooding(CF)and AWD.Under CF,no statistical differences in grain yield and WUE were observed between DRRs and DSRs.Irrigation water under the AWD regime was 275–349 mm,an amount 49.8%–56.2% of that(552–620 mm)applied under the CF regime.Compared to CF,AWD significantly decreased grain yield in both DRRs and DSRs,with a more significant reduction in DSRs,and WUE was increased in DRRs,but not in DSRs,by 9.9%–23.0% under AWD.Under AWD,DRRs showed a 20.2%–26.2% increase in grain yield and an 18.6%–24.5% increase in WUE compared to DSRs.Compared to DSRs,DRRs showed less redundant vegetative growth,greater sink capacity,higher grain filling efficiency,larger root biomass,and deeper root distribution under AWD.We conclude that these improved agronomic traits exert positive influences on WUE in DRRs under AWD. | Guang Chu Tingting Chen Song Chen Chunmei Xu Danying Wang Xiufu Zhang | 2018 | The Crop Journal2018，6，5： | 8 |
| 6 | Rhizosphere Aeration Improves Nitrogen Transformation in Soil, and Nitrogen Absorption and Accumulation in Rice Plants显示文摘Two rice cultivars(Xiushui 09 and Chunyou 84)were used to evaluate the effects of various soil oxygen(O2)conditions on soil nitrogen(N)transformation,absorption and accumulation in rice plants.The treatments were continuous flooding(CF),continuous flooding and aeration(CFA),and alternate wetting and drying(AWD).The results showed that the AWD and CFA treatments improved soil N transformation,rice growth,and N absorption and accumulation.Soil NO3–content,nitrification activity and ammonia-oxidising bacteria abundance,leaf area,nitrate reductase activity,and N absorption and accumulation in rice all increased in both cultivars.However,soil microbial biomass carbon and pH did not significantly change during the whole period of rice growth.Correlation analysis revealed a significant positive correlation between the nitrification activity and ammonia-oxidising bacteria abundance,and both of them significantly increased as the total N accumulation in rice increased.Our results indicated that improved soil O2 conditions led to changing soil N cycling and contributed to increases in N absorption and accumulation by rice in paddy fields. | XU Chunmei CHEN Liping CHEN Song CHU Guang WANG Danying ZHANG Xiufu | 2020 | Rice science2020，27，2： | 6 |
| 7 | Nicotinic mechanisms influencing synaptic plasticity in the hippocampus显示文摘烟碱的醋胆素受体(nAChRs ) 在整个马头鱼尾的怪兽被表示,并且烟碱的发信号在 neuronal 功能起一个重要作用。在学习和相关行为与海马趾的功能联系了的存储器的上下文, nAChR 活动的一个潜在地重要的特征是它在 synaptic 粘性上有的影响。在海马趾的神经原的 Synaptic 粘性长被认为作出贡献细胞学习和记忆的机制。细胞的机制的这些一样的类型是在烟碱嗜好的发展的一个因素。烟碱的发信号被表明了由在 vitro,经由多重步在海马趾的神经原影响 synaptic 粘性的研究,并且发信号也被显示了在 vivo 唤起 synaptic 粘性。这评论集中于贡献海马趾的 synaptic 粘性在的 nAChRs 子类型细胞并且电路水平。它也在可以贡献嗜好的马头鱼尾的怪兽在长期的变化上考虑烟碱的影响。 | Andon Nicholas PLACZEK Tao A ZHANG John Anthony DANI | 2009 | Acta Pharmacologica Sinica2009，30，6： | 4 |
| 8 | Soil Nitrogen Distribution and Plant Nitrogen Utilization in Direct-Seeded Rice in Response to Deep Placement of Basal Fertilizer-Nitrogen显示文摘Deep placement of controlled-release fertilizer increases nitrogen (N) use efficiency in rice planting but is expensive. Few studies on direct-seeded rice have examined the effects of deep placement of conventional fertilizer. With prilled urea serving as N fertilizer, a two-year field experiment with two N rates (120 and 195 kg/hm2) and four basal N application treatments (B50, all fertilizer was broadcast with 50% as basal N;D50, D70 and D100 corresponded to 50%, 70% and 100% of N deeply placed as basal N, respectively) were conducted in direct-seeded rice in 2013 and 2014. Soil N distribution and plant N uptake were analyzed. The results showed that deep placement of basal N significantly increased total N concentrations in soil. Significantly greater soil N concentrations were observed in D100 compared with B50 at 0, 6 and 12 cm (lateral distance) from the fertilizer application point both at mid-tillering and heading stages. D100 presented the highest values of dry matter and N accumulation from seeding to mid-tillering stages, but it presented the lowest values from heading to maturity stages and the lowest grain yield for no sufficient N supply at the reproductive stage. The grain yield of D50 was the highest, however, no significant difference was observed in grain yield, N agronomic efficiency or N recovery efficiency between D70 and D50, or between D70 and B50, while D70 was more labor saving than D50 for only one topdressing was applied in D70 compared with twice in other treatments. The above results indicated that 70% of fertilizer-N deeply placed as a basal fertilizer and 30% of fertilizer-N topdressed as a panicle fertilizer constituted an ideal approach for direct-seeded rice. This recommendation was further verified through on-farm demonstration experiments in 2015, in which D70 produced in similar grain yields as B50 did. | WANG Danying YE Chang XU Chunmei WANG Zaiman CHEN Song CHU Guang ZHANG Xiufu | 2019 | Rice science2019，26，6： | 3 |
| 9 | Effects of increasing panicle-stage N on yield and N use efficiency of indica rice and its relationship with soil fertility显示文摘Because of the higher nitrogen(N)recovery efficiency(NRE)of panicle-stage fertilization compared with basal and tillering fertilization,increasing the proportion of N topdressing at the booting stage(panicleN)is recommended and commonly practiced in parts of China.To investigate the effects of increasing panicle-N on grain yield and N use efficiency(NUE)and the relationships of the increase and the rice cultivar and soil fertility status,we increased the percentage of panicle-N from 20%to 40%by correspondingly reducing the N amount applied only at the tillering stage in both high-and low-fertility blue clayey paddy fields in 2018 and 2019.Four indica cultivars with diverse panicle types were used,and their grain yield,dry matter accumulation,and NUE were compared.In high-fertility soil,increasing topdressing panicle-N from 20%to 40%reduced tillering ability and reduced the effective panicle numbers of the multi-and medium-panicle cultivars Huanghuazhan(HHZ),C Liangyouhuazhan(CHZ),and Tianyouhuazhan(THZ).These cultivars gave the greatest yield when 30%of N was supplied as panicle fertilizer,whereas the yield,NRE,N agronomic efficiency(NAE),and nitrogen physiological efficiency(NPE)of the heavy-panicle inbred cultivar Yangdao 6(YD6)continued to increase,resulting in improved dry matter accumulation and grain filling in the late growth stage.The yield,NAE,NRE,and NPE of YD6 peaked when the panicle-N constituted 40%.While in low-fertility soil,the multipanicle cultivar HHZ showed the greatest yield when 30%of fertilizer-N was applied once at the panicle initiation(PI)stage,while the medium-panicle cultivar CHZ showed the greatest yield when the panicle-N percentage was 40%.Our results suggest that the percentage of panicle-N fertilizer should not exceed 30%for multipanicle cultivars,while can be appropriately increased to 40%for heavy-panicle indica cultivars.The effect of increasing topdressing panicle-N on the yield of medium-panicle cultivars was related to soil fertility.The optimum panicle-N percentage was 30%in the high-fertility soil and 40%in the low-fertility soil. | Chang Ye Hengyu Ma Xiu Huang Chunmei Xu Song Chen Guang Chu Xiufu Zhang Danying Wang | 2022 | The Crop Journal2022，10，6： | 3 |
| 10 | Nicotine Decreases Ethanol-Induced Dopamine Signaling and Increases Self-Administration via Stress Hormones显示文摘 | William M. Doyon Yu Dong Alexey Ostroumov Alyse M. Thomas Tao A. Zhang John A. Dani | 2013 | Neuron2013，，： | 1 |
| 11 | Nominal and robust stability regions of optimization-based PID controllers显示文摘 | Ou Linlin Zhang Weidong Gu Danying | 2006 | ISA Transactions2006，45，3： | 1 |
| 12 | Incidence and Risk Factors of the Upper-Limb Musculoskeletal Disorders Among Occupational Groups in Key Industries—China,2018–2021显示文摘What is already known about this topic?The burden of illness and economic losses due to upper-limb work-related musculoskeletal disorders(UL-WMSDs)is high;thus,they have become a major global public health problem.At present,the epidemiological characteristics of UL-WMSDs in China's occupational population are still unknown.What is added by this report?The incidence of UL-WMSDs among key occupational groups in China is 22.5%,with distinct occupational characteristics.What are the implications for public health practice?This study has primarily determined the occurrence and potential risk factors of UL-WMSDs in key industries in China and provided data support for recommending prevention and control of the occurrence of such diseases in key industries in China,and in facilitating the addition into the China’s List of Legal Occupational Diseases. | Ning Jia Meibian Zhang Huadong Zhang Ruijie Ling Yimin Liu Gang Li Yan Yin Hua Shao Hengdong Zhang Bing Qiu Dongxia Li Dayu Wang Qiang Zeng Rugang Wang Jianchao Chen Danying Zhang Liangying Mei Xinglin Fang Yongquan Liu Jixiang Liu Chengyun Zhang Tianlai Li Jun Qi Qing Xu Ying Qu Xueyan Zhang Xin Sun Zhongxu Wang | 2022 | China CDC weekly2022，4，50： | 1 |
| 13 | Rapid determination of serological cytokine biomarkers for hepatitis B virus-related hepatocellular carcinoma using antibody microarrays显示文摘Hepatocellular 癌(HCC ) 是与增加的发生世界范围的最经常的肿瘤之一。为 HCC 的 biomarkers 的探索是为改进诊断和处理的功效的主要目的之一。microarray 技术为诊所为 biomarkers 的平行探索提供一个高产量的平台。在这研究,我们使用了抗体 microarrays 屏蔽肝炎 B 病毒(HBV ) 的新奇 cytokine biomarkers 相关 HCC。在 sera 的秘密 Cytokine 模式包括 43 个 HBV 相关的 HCC 病人, 33 个长期的肝炎 B 病人,和 33 正常从 109 个盒子被决定由 RayBio 的控制吗?Biotin 基于标签的人的抗体数组。关联分析与常规临床的诊断 biomarkers 被执行,包括浆液丙氨酸 aminotransferase, alpha-fetoprotein (法新社) 和肝炎 B 表面抗原。我们的结果在 HBV 相关的 HCC 组显示出那,它有法新社的最高的百分比积极(> 20 ng/ml ) 比率,六 cytokines 被发现差别在 HCC 病人表示了(P < 0.05 ) ,与正常控制或长期的肝炎 B 相比组。二巨噬细胞相关的 cytokines,导出巨噬细胞的 chemokine (MDC ) 和刺激巨噬细胞的蛋白质(MSP ) ,在 HCC 组的显示的重要差别。而且,为预言的一个 HCC 诊断模型被构造,由哪个和法新社的 MDC 和 MSP 的联合从 60% 改进了诊断敏感(法新社独自一个) 到 73.2% 与类似的特性。我们的结果建议了抗体 microarrays 屏蔽的那 MDC 和 MSP 可能为 HBV 相关的 HCC 的潜在的辅助诊断用作新奇 cytokines biomarkers。 | Taotao Liu Ruyi Xue Ling Dong Hao Wu Danying Zhang Xizhong Shen | 2011 | Acta Biochimica et Biophysica Sinica2011，43，1： | 1 |
| 14 | Self-assembled supramolecular materials for photocatalytic H_(2)production and CO_(2)reduction显示文摘Photosynthetic organisms harness solar radiation to produce energy-rich compounds from water and atmospheric CO_(2)via exquisite supramolecular assemblies,which offers a design principle for highly efficient artificial photocatalytic systems.As an emerging research field,significant effort has been devoted to self-assembled supramolecular materials for photocatalytic H_(2)production and CO_(2)reduction.In this review,we introduce the basic concepts of supramolecular photocatalytic materials.After that,we will discuss recent advances in the preparation of supramolecular photocatalytic materials from zero-dimension to three-dimension which include molecular assemblies,micelles,hybrid nanoparticles,nanofibers,nanosheets,microcrystals,lipid bilayers,supramolecular organic frameworks,supramolecular metal-organic frameworks,gels,and host-guest metal-organic frameworks,etc.Furthermore,we show the recent progress in the photocatalytic properties of supramolecular photocatalytic materials,i.e.photocatalytic proton reduction,water splitting,CO_(2)to HCOOH,CO_(2)to CO,CO_(2)to CH4 conversions,etc.Finally,we provide our perspective for the future research,with a focus on the development of new structures and highly efficient photocatalysis. | Jia Tian Junlai Yu Qingxuan Tang Jiangshan Zhang Danying Ma Yifei Leiand Zhan-Ting Li | 2022 | Materials Futures2022，1，4： | 1 |
| 15 | Role of JNK Activation and Mitochondrial Bax Translocation in Allicin-Induced Apoptosis in Human Ovarian Cancer SKOV3 Cells显示文摘 | Ling Xu Jin Yu Dongxia Zhai Danying Zhang Wei Shen Lingling Bai Zailong Cai Chaoqin Yu Leo M. Lee | 2014 | Evidence-Based Complementary and Alternative Medicine2014，，： | 1 |
| 16 | COVID-19 reinfection in the presence of neutralizing antibodies显示文摘Due to the high transmissibility of the SARS-CoV-2 virus,it continues to infect over 300000 people worldwide per day(WHO statistics,December 2020),even almost one year after the first COVID-19 cases were confirmed[1,2].One of the most important public health discussions being undertaken currently concerns the protective nature of the immune response and the possibility of reinfection in recovered individuals. | Ju Zhang Nan Ding Lili Ren Rui Song Danying Chen Xuesen Zhao Budong Chen Junyan Han Jiarui Li Yangzi Song Lin Di Kai Han Fengting Yu Ruming Xie Zhihai Chen Wen Xie Jingyuan Liu Shan Cen Yuhai Bi Angela R.Wu Fujie Zhang Chen Chen Hui Zeng | 2021 | National Science Review2021，8，4： | 1 |
| 17 | Nondegradative Role of Atg5-Atg12/ Atg16L1 Autophagy Protein Complex in Antiviral Activity of Interferon Gamma显示文摘 | Seungmin Hwang Nicole S. Maloney Monique W. Bruinsma Gautam Goel Erning Duan Lei Zhang Bimmi Shrestha Michael S. Diamond Adish Dani Stanislav V. Sosnovtsev Kim Y. Green Carlos Lopez-Otin Ramnik J. Xavier Larissa B. Thackray Herbert W. Virgin | 2012 | Cell Host & Microbe2012，，4： | 1 |
| 18 | Proteomic profiling of hepatitis B virus-related hepatocellular carcinoma with magnetic bead-based matrix-assisted laser desorption/ionization time-of-flight mass spectrometry显示文摘Proteomic 技术在 hepatocellular 癌(HCC ) 的监视正在答应策略。这研究试图调查与磁性的祷告(MB ) 和帮助矩阵的激光解吸附作用 / 电离 time-of-flight (MALDI-TOF ) 质量介绍的浆液 spectrometry (MS ) 并且进一步为 HCC 识别 biomarkers。从 80 个长期的肝炎 B (CHB ) 病人,与 HBV 病人一起的 94 HCC 伴随物和 24 个健康题目的浆液样品被 MALDI-TOF MS 在 MB 上在肽丰富以后检验。基于基因算法,为 HCC 的诊断模型在 30 个 HCC 病人和 24 个健康 subjects/30 CHB 病人之间被建立。确认用完了留下的案例。在模型的标记通过液体被识别层析(LC )/MSMS。三个组很好与对方被分开,二个辨别模型为 HCC 被建立。这二个模型的全面识别能力分别地是 96.25% 和 93.33% 。确认证明为 HCC 的错误诊断比率分别地是 1.6% 和 23.4% 。为 HCC 的识别 biomarkers 包括了凝血素先锋(碎片) ,钙依赖者分泌物使活跃之物 1, apoptosis 的 Baculoviral 禁止者包含重复的蛋白质 6,等等。基于 MB 的 MALDI-TOF MS 在识别浆液 biomarkers 是适用的并且能在感染 HBV 的病人之中在 HCC 的监视被使用。 | Taotao Liu Ruyi Xue Xiaowu Huang Danying Zhang Ling Dong Hao Wu Xizhong Shen | 2011 | Acta Biochimica et Biophysica Sinica2011，43，7： | 1 |
| 19 | Analytical de-sign of two-degree-of-freedom control scheme for open-loop unstable processes with time delay显示文摘 | Liu Tao Zhang Weidong Gu Danying | 2005 | Journal ofProcess Control2005，15，5： | 1 |
| 20 | The first steps in the evaluation of a'black-box'decision support tool:a protocol and feasibility study for the evaluation of Watson for Oncology显示文摘Background and aim:Medical specialists aim to provide evidence-based care based on the most recent scientific insights,but with the ongoing expansion of medical literature it seems unfeasible to remain updated.”Black-box”decision support tools such as Watson for Oncology(Watson)are gaining attention as they offer a promising opportunity to conquer this challenging issue,but it is not known if the advice given is congruent with guidelines or clinically valid in other settings.We present a protocol for the content evaluation of black-box decision support tools and a feasibility study to test the content and usability of Watson using this protocol.Methods:The protocol consists of developing synthetic patient cases based on Dutch guidelines and expert opinion,entering the synthetic cases into Watson and Oncoguide,noting the response of each system and evaluating the result using a cross-tabulation scoring system resulting in a score range of??12 to+12.Treatment options that were not recommended according to the Dutch guideline were labeled with a”red flag”if Watson recommended it,and an”orange flag”if Watson suggested it for consideration.To test the feasibility of applying the protocol,we developed synthetic patient cases for the adjuvant treatment of stage I to stage III colon cancer based on relevant patient,clinical and tumor characteristics and followed our protocol.Additionally,for the feasibility study we also compared the recommendations from the NCCN guideline with Watson’s advice,and evaluated usability by a cognitive walkthrough method.Results:In total,we developed 190 synthetic patient cases(stage I:n=8;stage II:n=110;and stage III:n=72).Overall concordance scores per case for Watson versus Oncoguide ranged from a minimum score of-4(n=6)to a maximum score of+12(n=17)and from??4(n=9)to+12(n=24)for Watson versus the NCCN guidelines).In total,69 cases(36%)were labeled with red flags,96 cases(51%)with orange flags and 25 cases(13%)without flags.For the comparison of Watson with the NCCN guidelines,no red or orange flags were identified.Conclusions:We developed a research protocol for the evaluation of a black-box decision support tool,which proved useful and usable in testing the content and usability of Watson.Overall concordance scores ranged considerably between synthetic cases for both comparisons between Watson versus Oncoguide and Watson versus NCCN.Non-concordance is partially attributable to guideline differences between the United States and The Netherlands.This implies that further adjustments and localization are required before implementation of Watson outside the United States.Relevance for patients:This study describes the first steps of content evaluation of a decision support tool before implementation in daily oncological patient care.The ultimate goal of the incorporation of decision support tools in daily practice is to improve personalized medicine and quality of care. | Lotte Keikes Stephanie Medlock Daniěl J.van de Berg Shuxin Zhang Onno R.Guicherit Cornelis J.A.Punt Martijn G.H.van Oijen | 2018 | Journal of Clinical & Translational Research2018，4，3： | 1 |
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