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| 1 | 血糖控制良好的2型糖尿病患者血清VEGF-A及其受体VEGFR1和VEGFR2含量检测(英文)显示文摘研究目的:探讨血糖控制良好的2型糖尿病患者血管内皮生长因子-A(VEGF-A)及其受体VEGFR1和VEGFR2含量及其临床意义。研究方法:本文以31例血糖得到良好控制且没有明显大血管或微血管病变的2型糖尿病患者作为研究对象(实验组),30位健康志愿者为对照组,同期检测患者及健康志愿者的空腹血糖、血脂、糖化血红蛋白水平,及血清VEGF-A、VEGFR1和VEGFR2含量,并加以比较和统计学分析。重要结论:研究结果表明,血糖控制良好的2型糖尿病患者血清中的VEGF-A及其受体VEGFR1和VEGFR2的含量和健康志愿者基本一致,两者无统计学意义,这可能显示血糖水平的合理控制能延缓血管并发症的产生。同时,2型糖尿病患者的血清VEGFR2含量和高密度脂蛋白胆固醇水平之间存在负相关,而血清VEGF-A、VEGFR2含量和甘油三脂水平之间存在正相关,这也表明糖尿病患者的血脂紊乱可能参与了血管生成的调节。 | Barbara RUSZKOWSKA-CIASTEK Alina SOKUP Maciej W. SOCHA Zofia RUPRECHT Lidia HALAS Barbara GóRALCZYK Krzysztof GóRALCZYK Grazyna GADOMSKA Danuta ROSC | 2014 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2014，15，6： | 2 |
| 2 | Sorption of Bile Acids and Cholesterol by Dietary Fiber of Carrots,Cabbage and Apples显示文摘 | Danuta G Jozef K | 2002 | Food Science and Technology2002，5，： | 1 |
| 3 | A preliminary evaluation of VEGF-A, VEGFR1 and VEGFR2 in patients with well-controlled type 2 diabetes mellitus显示文摘 | Barbara Ruszkowska-Ciastek Alina Sokup Maciej W. Socha Zofia Ruprecht Lidia Ha?as Barbara Góralczyk Krzysztof Góralczyk Gra?yna Gadomska Danuta Ro?? | 2014 | Journal of Zhejiang University SCIENCE B2014，，6： | 1 |
| 4 | Myco- phenolic acid inhibits the autocrine PDGF-B synthesis and PDGF-BB-induced mRNA expression of Egr-1 in rat mesangial cells 显示文摘 | DANUTA S BERND G CHRISTINA S | 2009 | Nephrol Dial Transplant2009，24，1： | 1 |
| 5 | Inverse analysis for identification of rheological and friction models in metal forming显示文摘 | Danuta S Jerzy G Maciej P | 2006 | Computer Methods in Applied Mechanics and Engineering2006，195，48： | 1 |
| 6 | White grape pomace as a source of dietary fibre and polyphenols and its effect on physical and nutraceutical characteristics of wheat biscuits显示文摘 | Sylwia Mildner‐Szkudlarz Joanna Bajerska Renata Zawirska‐Wojtasiak Danuta Górecka | 2012 | Food Agric2012，，2： | 1 |
| 7 | Role of gastric acid secretion in progression of acute gastric erosions induced by ischemia–reperfusion into gastric ulcers显示文摘 | Tomasz Brzozowski Peter Ch Konturek Stanislaw J Konturek Danuta Drozdowicz Slawomir Kwiecie? Robert Pajdo Wladyslaw Bielanski Eckhart G Hahn | 2000 | European Journal of Pharmacology2000，，1： | 1 |
| 8 | Isolation and characteriza- tion of a novel strain of Stenotrophomonas maltophilia possessing various dioxygenases for monocyclic hydrocarbon degradation 显示文摘 | Urszula G Izabela G Danuta W | 2009 | Brazilian Journal of Microbiology2009，，2： | 1 |
| 9 | Mycophenolic acid inhibits the autocrine PDGF-B synthesis and PDGF-BB-induced mRNA expression of Egr-1 in rat mesangial cells显示文摘 | Danuta S Bernd G Christina S | | 0，，01： | 1 |
| 10 | Selection of topoisomerase mutations and overexpression of adeB mRNA transcripts during an outbreak of Acinetobater baumannii 显示文摘 | HIGGINS P G HILMAR WISPLINGHOFF DANUTA STEFANIK | 2004 | J Antimicrob Chemother2004，54，4： | 1 |
| 11 | In vitro activities of the beta-lactamase inhibitors clavulanic acid, sulbactam, and tazobactam alone or in combination with-lactams against epidemiologically characterized multidmg-resistant Acinetobacter bau- mannii strains显示文摘 | PAUL G HILMAR W DANUTA S | 2004 | Antimicrobial Agents and Chemotherapy2004，48，5： | 1 |
| 12 | Inverse analysis for identification of rheological and friction models in metal forming 显示文摘 | Danuta S Jerzy G Maciej P | 2006 | Computer Methods in Applied Mechanics and Engineering2006，195，4849： | 1 |
| 13 | HPLC-atmospheric pressure chemical ionization mass spectro- metric method for enantioselective determination of R, S-propranolol and R, S-hyoscyamine in human plasma 显示文摘 | DANUTA S DONALD E M NAOMI G | 2007 | J Chromatogr B2007，859，： | 1 |
| 14 | In vitro activities of the β-Lactamase inhibitors clavulanic acid,sulbactam,and tazobactam alone or in combination with β-Lactams against epidemiologically characterized multidrug-resistant acinetobacter baumannii strains显示文摘 | Paul G Higgins Hilmar Wisplinghoff Danuta Stefanik | 2004 | Antimicrobial Agents and chemotherapy2004，48，5： | 1 |
| 15 | Plasminogen activators(tPA and u- PA )and plasminogen activators inhibitors (PAI- 1 and PAI-2) in some myeloproliferative syndromes 显示文摘 | Danuta R Elzbieta K N Grazyna G | 2000 | Med Sci Monit2000，6，4： | 1 |
| 16 | Selection of topoisomerase mutations and overexpression of adeB mRNA transcripts during an outbreak of Acinetobacter baumannii显示文摘 | Paul G Hilmar W Danuta S | 2004 | J Antimicrob Chemther2004，54，： | 1 |
| 17 | Grapefruit-seed extract attenuates ethanol-and stress-induced gastric lesions via activation of prostaglandin, nitric oxide and sensory nerve pathways显示文摘AIM: Grapefruit-seed extract (GSE) containing flavonoids, possesses antibacterial and antioxidative properties but whether it influences the gastric defense mechanism and gastroprotection against ethanol- and stress-induced gastric lesions remains unknown. METHODS: We compared the effects of GSE on gastric mucosal lesions induced in rats by topical application of 100% ethanol or 3.5 h of water immersion and restraint stress (WRS) with or without (A) inhibition of cyclooxygenase (COX)-1 activity by indomethacin and rofecoxib, the selective COX-2 inhibitor, (B) suppression of NO-synthase with L-NNA (20 mg/kg ip), and (C) inactivation by capsaicin (125 mg/kg sc) of sensory nerves with or without intragastric (ig) pretreatment with GSE applied 30 min prior to ethanol or WRS. One hour after ethanol and 3.5 h after the end of WRS, the number and area of gastric lesions were measured by planimetry, the gastric blood flow (GBF) was assessed by H2-gas clearance technique and plasma gastrin levels and the gastric mucosal generation of PGE2, superoxide dismutase (SOD) activity and malonyldialdehyde (MDA) concentration, as an index of lipid peroxidation were determined. RESULTS: Ethanol and WRS caused gastric lesions accompanied by the significant fall in the GBF and SOD activity and the rise in the mucosal MDA content. Pretreatment with GSE (8-64 mg/kg i g) dose-dependently attenuated gastric lesions induced by 100% ethanol and WRS; the dose reducing these lesions by 50% (ID50) was 25 and 36 mg/kg, respectively, and this protective effect was similar to that obtained with methyl PGE2 analog (5 μg/kg i g). GSE significantly raised the GBF, mucosal generation of PGE2, SOD activity and plasma gastrin levels while attenuating MDA content. Inhibition of PGE2 generation with indomethacin or rofecoxib and suppression of NO synthase by L-NNA or capsaicin denervation reversed the GSE-induced protection and the accompanying hyperemia. Co-treatment of exogenous calcitonine gene-related peptide (CGRP) with GSE restored the protection and accompanying hyperemic effects of GSE in rats with capsaicin denervation. CONCLUSION: GSE exerts a potent gastroprotective activity against ethanol and WRS-induced gastric lesions via an increase in endogenous PG generation, suppression of lipid peroxidation and hyperemia possibly mediated by NO and CGRP released from sensory nerves. | Tomasz Brzozowski Peter C Konturek Danuta Drozdowicz Stanislaw J Konturek Oxana Zayachivska Robert Pajdo Slawomir Kwiecien Wieslaw W Pawlik Eckhart G Hahn | 2005 | World Journal of Gastroenterology2005，11，41： | 1 |
| 18 | Isolation and characterization of a novel strain of Stenotrophomonas maltophilia possessing various dioxygenases for monocyclic hydrocarbon degradation显示文摘 | Urszula G Izabela G Danuta W | 2009 | Braz J Microbiol2009，40，2： | 1 |
| 19 | Assessment of ghrelin and leptin receptor levels in postmenopausal women who received oral or transdermal menopausal hormonal therapy显示文摘Objective:In postmenopausal women,an increased leptin concentration and reduced levels of ghrelin and adiponectin were observed.The aim of this study was to evaluate the concentrations of the active form of ghrelin,total ghrelin,leptin receptor,lipoprotein(a)(Lp(a)),and plasminogen activator inhibitor type 1(PAI-1) in postmenopausal women who received oral or transdermal menopausal hormonal therapy(MHT).Methods:The study involved 76 healthy women:46 women aged from 44 to 58 years who received oral(26) or transdermal(20) MHT;the control group consisted of 30 women aged from 44 to 54 years who did not receive MHT.The plasma concentrations of total ghrelin,the active form of ghrelin,Lp(a),and PAI-1:Ag were measured by enzyme-linked immunosorbent assay(ELISA).The concentration of the leptin receptor was measured by enzyme immunometric assay(EIA).Results:We observed a significantly higher concentration of total ghrelin and the active form of ghrelin in women who received transdermal MHT in comparison with those who took oral MHT.We also found a significantly lower concentration of total ghrelin in women who received oral MHT compared with the control group.A higher concentration of PAI-1:Ag was found in the group of women who took transdermal MHT in comparison with those who took oral MHT and with the control group.The differences were statistically significant.Additionally,we found a significant negative correlation between the concentrations of total ghrelin and PAI-1:Ag and a positive correlation between the concentrations of total ghrelin and leptin receptor in women who received transdermal MHT.Conclusions:The study showed that women who used transdermal MHT had higher levels of total ghrelin than women who took oral MHT.This indicates a beneficial effect of the transdermal route of MHT.However,transdermal therapy was associated with adverse effects with regard to the observed higher levels of PAI-1:Ag,which in turn,can lead to a reduction in fibrinolytic activity. | Barbara RUSZKOWSKA Alina SOKUP Arleta KULWAS Maciej W.SOCHA Krzysztof GóRALCZYK Barbara GóRALCZYK Danuta ROS | 2012 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2012，13，1： | 0 |
| 20 | 未受控制的高血糖对2型糖尿病患者粘附分子的影响(英文)显示文摘目的:评估可溶性血管细胞间黏附分子(s VCAM-1)、可溶性细胞间黏附分子(s ICAM-1)、可溶性选择素E和可溶性血栓调节蛋白在血糖控制良好和不受控制的2型糖尿病患者中的水平。创新点:对2型糖尿病患者的血管内皮炎症标记物进行评估。方法:62例糖尿病患者分成两组:第一组包括35个血糖控制良好的糖尿病患者,第二组包括27个未控制血糖并伴有微蛋白尿的糖尿病患者。对照组由25名健康志愿者组成。测定血浆中s VCAM-1、s ICAM-1、可溶性选择素E和可溶性血栓调节蛋白的浓度,同时测定血清肌酐及血浆中空腹血糖和糖化血红蛋白(Hb A1c)的浓度。结论:与血糖控制良好的糖尿病组相比,未控制血糖组具有相对低的ICAM-1水平和更高的VCAM-1水平。未控制血糖组中患者的糖化血红蛋白和ICAM-1之间呈正相关,肾小球滤过率和可溶性选择素E之间呈正相关,而肌酐和ICAM-1之间呈负相关。研究证实2型糖尿病的发病机理中炎症过程的出现与血管内皮功能受损有关。未受控制的高血糖对粘附分子的反向作用表明,在糖尿病的并发症中VCAM-1和ICAM-1具有不同功能。 | Barbara RUSZKOWSKA-CIASTEK Alina SOKUP Tomasz WERNIK Zofia RUPRECHT Barbara GóRALCZYK Krzysztof GóRALCZYK Grazyna GADOMSKA Danuta RO | 2015 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2015，16，5： | 0 |
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