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| 1 | Diabetic retinopathy and age-related macular degeneration: a survey of pharmacoutilization and cost in Calabria, Italy显示文摘The aged population is constantly growing, thus fostering an increase in age-dependent diseases. Among these, diabetic retinopathy (DR) along with age-related macular degeneration entails progressive vision loss. Since such conditions are associated with the proliferation of novel vessels, their pharmacotherapeutic management consists of the intravitreal injection of anti-vascular endothelial growth factor drugs, able to hinder the driving of vascular proliferation prompted by vascular endothelial growth factor. The humanized anti-vascular endothelial growth factor monoclonal antibody ranibizumab provided evidence for efficacy in several trials, hence earning approval by the US Food and Drug Administration for therapeutic use in all the stages of DR. Due to the lack of epidemiologic and pharmacoeconomic evaluation in the local Calabria Region context, the present retrospective observational study focused on prevalence of DR and age-related macular degeneration, treatment and cost of therapy with ranibizumab in 870 patients arriving to clinical observation at the 'Mater Domini” University Hospital in Calabria, Italy from January 2014 to June 2017. Data were extracted from the database of ophthalmology ward and subjected to statistical analysis. The results suggest that the most frequent retinal diseases are age-related macular degeneration and DR and that the use of ranibizumab has been decreasing over the 4-year study period together with the associated cost per patient which was similar for both disorders. Therefore, appropriateness of treatment with drugs other than ranibizumab needs to be assessed in this setting and deep monitoring of pharmacologic treatment for retinal diseases is necessary to prevent or delay visual acuity decrease and complete vision loss. Study procedures were performed in accordance with the 'Mater Domini” University Hospital ethical standards of the responsible committee on human experimentation. | Damiana Scuteri Ada Vero Mariacristina Zito Maria Diana Naturale Giacinto Bagetta Carlo Nucci Paolo Tonin Maria Tiziana Corasaniti | 2019 | Neural Regeneration Research2019，14，8： | 3 |
| 2 | Compression through embedded multiwavelet transform coding 显示文摘 | Mariantonia Cotronei Damiana Lazzaro Laura B Montefusco | 2000 | IEEE Trans on IP2000，9，2： | 2 |
| 3 | Neurodegenerative diseases as proteinopathies-driven immune disorders显示文摘In the pathophysiology of neurodegenerative disorders,the role of misfolded protein deposition leading to neurodegeneration has been primarily discussed.In the last decade,however,it has been proposed a parallel involvement of innate immune activation,chronic inflammation and adaptive immunity in the neurodegeneration mechanisms triggered by proteinopathies.New insights in the neurodegenerative field strongly suggest a role for the immune system in the pathophysiology of neurodegenerative disorders.Therefore,the hypothesis underlining the modulation of the innate and the adaptive immune system in the events linked to brain deposition of misfolded proteins could open new perspectives in the setting of specific immunotherapeutic strategies for the treatment of neurodegenerative diseases.Therefore,we have reviewed the pathogenic hypothesis in neurodegenerative pathologies,underling the links between the deposition of misfolded protein mechanisms and the immune activation. | Fausta Ciccocioppo Giuseppina Bologna Eva Ercolino Laura Pierdomenico Pasquale Simeone Paola Lanuti Damiana Pieragostino Piero Del Boccio Marco Marchisio Sebastiano Miscia | 2020 | Neural Regeneration Research2020，15，5： | 2 |
| 4 | The Antioxidant Activity of Coumarins and Flavonoids显示文摘 | Guilherme Borges Bubols Damiana da Rocha Vianna Alexander Medina-Remon Gilsane von Poser Rosa Maria Lamuela-Raventos Vera Lucia Eifler-Lima Solange Cristina Garcia | 2013 | Mini-Reviews in Medicinal Chemistry2013，，3： | 1 |
| 5 | Image compression through Embedded Multiwavelet Transform Coding显示文摘 | Damiana L Montefusco L B | 2000 | IEEE Trans on Image Processing2000，，2： | 1 |
| 6 | Antioxidant capacity,ascorbic acid, total phenols and carotenoids changes during harvest and after storage ofH hayward kiwifruit显示文摘 | Silvia Tavarini Elena Degl Damiana Amorini | 2008 | Food Chemistry2008，107，： | 1 |
| 7 | Radial basis functions for the multivariate interpolation of large scattered data sets 显示文摘 | Damiana L Laura B M | 2002 | Journal of Computational and Applied Mathematics2002，140，： | 1 |
| 8 | Image compression through embedded muhiwavelet transform coding 显示文摘 | Mariantonia Cotronei Damiana Lazzaro | 2000 | IEEE Transactions on Image Processing2000，9，2： | 1 |
| 9 | Bone Morphogenetic Protein-4 Inhibits Corticotroph Tumor Cells:Involvement in the Retinoic Acid Inhibitory Action显示文摘 | Damiana Giacomini Marcelo Paez-Pereda Marily Theodoropoulou | 2006 | Endocrinology2006，147，1： | 1 |
| 10 | Retinoic acid as a novel medical therapy for cushing' s disease in dogs 显示文摘 | VICTOR C DAMIANA G MARCELO P P | 2006 | Endocri- nology2006，147，9： | 1 |
| 11 | Silicone oil removal from a silicone intraocular lens with perfluorohexyloctane显示文摘 | Damiana Z Norbert S Bernd K | 2000 | J Cataract Refract Surg2000，26，： | 1 |
| 12 | Inability to detect hepatitis B surface antigen (HBsAg) in the duodenum of HBsAg-positive persons显示文摘 | Dr. S. Victor Feinman MD Barnet Berris MD Jonathan C. Sinclair MD Strathearn Wilson PhD Damiana Wrobel MD | 1981 | Digestive Diseases and Sciences1981，，4： | 1 |
| 13 | Radial basis functions for the multivariate interpolation of large scattered data sets显示文摘 | Damiana Lazzaro Laura B. Montefusco | 2002 | Journal of Computational and Applied Mathematics2002，，1： | 1 |
| 14 | Optimal size and layout planning for district heating and cooling networks with distributed genera- tion options 显示文摘 | Damiana Chinese | 2008 | International Journal of Energy sector Management2008，2，3： | 1 |
| 15 | Dopamine facilitates dendritic spine formation by cultured striatal medium spiny neurons through both D1 and D2 dopamine receptors显示文摘 | Caroline Fasano Marie-Josée Bourque Gabriel Lapointe Damiana Leo Dominic Thibault Michael Haber Christian Kortleven Luc DesGroseillers Keith K. Murai Louis-éric Trudeau | 2013 | Neuropharmacology2013，，： | 1 |
| 16 | A new computational method for hepatic fat microvesicles counting in histological study in rats显示文摘 | Céphora Maria Sabarense Keller Sullivan Oliveira Rocha Damiana Diniz Rosa José Helvecio Martins Marina Maria Lelis da Silva Pereira Fabyano Fonseca Silva Brian Lynn Steward | 2012 | Biochemical and Biophysical Research Communications2012，，2： | 1 |
| 17 | Anticancer drug screening of natural products:In vitro cytotoxicity assays,techniques,and challenges显示文摘Natural products include several diverse compounds that have been found to be effective against cancer.Discovering anticancer compounds in nature is a multistep and complex process that requires pre-clinical and clinical studies.Only a few of the available natural products are used to treat cancer since most of them have very high complexity and low bioavailability.Therefore,the process of anticancer drug discovery requires a straightforward and effective method to assess anticancer activity using in vitro assays.This review summarizes various cell-based assays and techniques used to measure cell viability,migration,and apoptosis,focusing in particular on the principles,mechanisms,advantages,and disadvantages of each assay to provide a preliminary platform for cancer drug discovery. | Agustina Setiawati Damiana Sapta Candrasari F.D.Erika Setyajati Vincentia Krisnina Prasetyo Dewi Setyaningsih Yustina Sri Hartini | 2022 | Asian Pacific Journal of Tropical Biomedicine2022，12，7： | 1 |
| 18 | The Antioxidant activity of coumarins andflavonoids显示文摘 | Guilherme Borges Bubols Damiana da Rocha Vianna AlexanderMedina -Rem6n | 2013 | Mini Reviews in Medicinal Chemisrty2013，13，3： | 1 |
| 19 | Image Compression t-hrough Embedded Multi-Wavelet Transform Coding显示文摘 | Damiana C Montefusco L | 2000 | IEEE Trans on Image Processing2000，9，2： | 1 |
| 20 | Diffused introduction of Organic Rankine Cycle for biomass-based power generation in an industrial district:a systems analysis显示文摘 | DAMIANA CHINESE ANTONELLA ME-NEGHETTI GIOACCHINO NARDIN | 2004 | Int J Energy Res2004，28，11： | 1 |
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