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| 1 | Redox modulation of protein kinase/phosphatase balance in melanoma cells: the role of endogenous and gamma - glutamyltransferase - dependent H202 production显示文摘 | PIERI L DOMINICI S DEL BELLO B | 2003 | Biochim Biophys Acta2003，1621，1： | 1 |
| 2 | Hydrogen peroxide produced during gamna-glutamyltranspeptidase activity is involved in prevention of apop-tosis and maintainance of proliferation in U937 cells 显示文摘 | Paolicchi A Comporti M | 1999 | FASEB-J1999，13，1： | 1 |
| 3 | Cross-talk between calpain and caspase-3/-7 in cisplatin-induced apoptosis of melanoma cells: a major role of calpain inhibition in cell death protection and p53 status 显示文摘 | Del Bello B Moretti D Gamberucci A | 2007 | Oneogene2007，26，19： | 1 |
| 4 | Role of caspase 3 and-7 in Apaf-1 proteolytic cleavage and degradation events during cisplatin-induced apoptosis in melanoma cells显示文摘 | Del Bello B Valentini M A Mangiavacchi P | 2004 | Exp Cell Re2004，293，2： | 1 |
| 5 | Cisplatin-induced apoptosis inhibits autophagy, which acts as a pro-survival mechanism in human melanoma cells 显示文摘 | Del Bello B Toscano M Moretti D | 2013 | PLoS One2013，8，57： | 1 |
| 6 | Cleavage of Bcl-2 in oxidant-and cisplatin-induced apoptosis of human melanoma cells显示文摘 | Del Bello B Valentini MA Zunino F | 2001 | Oncogene2001，20，33： | 1 |
| 7 | Novel variants of musclecalpain 3 identified in human melanoma cells: cisplatin-inducedchanges in vitro and differential expression in melanocytic lesions显示文摘 | Moretti D Del Bello B Cosci E | 2009 | Carcinogenesis2009，30，： | 1 |
| 8 | Real-world cure rates for hepatitis C virus treatments that include simeprevir and/or sofosbuvir are comparable to clinical trial results显示文摘AIM To assess the real-world effectiveness and cost of simeprevir(SMV), and/or sofosbuvir(SOF)-based therapy for chronic hepatitis C virus(HCV) infection.METHODS The real-world performance of patients treated with SMV/SOF ± ribavirin(RBV), SOF/RBV, and SOF/RBV with pegylated-interferon(PEG) were analyzed in a consecutive series of 508 patients with chronic HCV infection treated at a single academic medical center. Patients with genotypes 1 through 4 were included. Rates of sustained virological response-the absence of a detectable serum HCV RNA 12 wk after the end of treatment [sustained virological response(SVR) 12]-were calculated on an intention-to-treat basis. Costs were calculated from the payer's perspective using Medicare/Medicaid fees and Redbook Wholesale Acquisition Costs. Patient-related factors associated with SVR12 were identified using multivariable logistic regression.RESULTS SVR 12 rates were as follows: 86%(95%CI: 80%-91%)among 178 patients on SMV/SOF ± RBV; 62%(95%CI: 55%-68%) among 234 patients on SOF/RBV; and 78%(95%CI: 68%-86%) among 96 patients on SOF/PEG/RBV. Mean costs-per-SVR 12 were $174442(standard deviation: ± $18588) for SMV/SOF ± RBV; $223003(± $77946) for SOF/RBV; and $126496(± $31052) for SOF/PEG/RBV. Among patients on SMV/SOF ± RBV, SVR12 was less likely in patients previously treated with a protease inhibitor [odds ratio(OR): 0.20, 95%CI: 0.06-0.56]. Higher bilirubin(OR: 0.47, 95%CI: 0.30-0.69) reduced the likelihood of SVR12 among patients on SOF/RBV, while FIB-4 score ≥ 3.25 reduced the likelihood of SVR 12(OR: 0.18, 95%CI: 0.05-0.59) among those on SOF/PEG/RBV. CONCLUSION SVR 12 rates for SMV and/or SOF-based regimens in a diverse real-world population are comparable to those in clinical trials. Treatment failure accounts for 27% of costs. | Kian Bichoupan Neeta Tandon James F Crismale Joshua Hartman David Del Bello Neal Patel Sweta Chekuri Alyson Harty Michel Ng Keith M Sigel Meena B Bansal Priya Grewal Charissa Y Chang Jennifer Leong Gene Y Im Lawrence U Liu Joseph A Odin Nancy Bach Scott L Friedman Thomas D Schiano Ponni V Perumalswami Douglas T Dieterich Andrea D Branch | 2017 | World Journal of Virology2017，6，4： | 1 |
| 9 | Redox modulation of protein kinase/phosphatase balance in melanoma cells: the role of endogenous and γ-glutamyl transpeptidase depent H2O2 production显示文摘 | Pieri L Dominici S Del Bello B | 2003 | Biochi Biophy Acta2003，1621，： | 1 |
| 10 | Novel variants of muscle ealpain 3 identified in human melanoma cells: cisplatin induced changes in vitro and differential expression in melanocytic lesions 显示文摘 | MORETT1 D DEL BELLO B COSCI E | 2009 | Carcinogenesis2009，30，6： | 1 |
| 11 | Calpain-3 impairs cell proliferation and stimulates oxidative stress-mediated cell death in melanoma cell显示文摘 | MORETTI D DEL BELLO B ALLAVENA G | 2015 | PLoS One2015，10，01： | 1 |
| 12 | Membrance gammaglutamyl transpeptidase activity of melanoma cells : effects on cellular H2O2 production, cell surface protein thiol oxidation an NF-кB action status显示文摘 | Maellaro E Dominici S Del Bello B | 2000 | J Cell Sci2000，113，： | 1 |
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