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| 1 | Fondaparinux预防老年急性内科患者发生静脉血栓形成的效果与安全性:随机安慰剂对照研究显示文摘目的:观察 Fondaparinux 对具有中高度静脉血栓发生危险的老年急性内科住院患者的抗凝效果与安全性。设计:双盲随机安慰剂对照研究。背景:8个国家的35个中心。参与者:849例≥60岁内科患者,住院原因分别为充血性心力衰竭、慢性肺病合并急性呼吸系统疾患、急性炎症性或感染性疾病,预期至少住院4天以上。干预:2.5 mg Fondaparinux 或安慰剂,每天1次皮下注射,持续6~14天。观察指标:主要指标为静脉血栓形成(治疗后15天内采用双侧静脉造影检查)及有症状的静脉血栓;次要指标为死亡与出血。患者随访时间为1个月。结果:Fondaparinux 治疗组425例患者和安慰剂组414例患者接受了安全性分析(10例未治疗)。644例患者(75.9%)可接受主要指标分析。静脉血栓检出率在 Fondaparinux 治疗组为5.6%(18/321),安慰剂组为10.5%(34/323),相对危险减少46.7%(95% CI 7.7%~69.3%)。安慰剂组5例患者发生有症状的静脉血栓,Fondaparinux治疗组无患者发生有症状的静脉血栓(P=0.029)。两组均有1例(0.2%)患者发生严重出血。随访结束时,安慰剂组、Fondaparinux 治疗组分别死亡25(6.0%)、14(3.3%)例患者。结论:Fondaparinux 可有效预防急性内科老年患者无症状性及有症状的静脉血栓。严重出血几率两组相似。 | Alexander T Cohen Bruce L Davidson Alexander S Gallus Michael R Lassen Martin H Prins Witold Tomkowski Alexander G G Turpie Jan F M Egberts Anthonie W A Lensing 石汉平(译) 王深明(校) | 2006 | 英国医学杂志中文版2006，9，5： | 3 |
| 2 | Diffusion and chemical activity of Zr-Sn and Zr-Ti systems 显示文摘 | ZEE R H WATTERS J F DAVIDSON R D | 1986 | Physical Review B1986，34，10： | 1 |
| 3 | Effects of atracurium on intraocuiar pressure, eye position, and blood pressure in eucapnic and phyocapnic isoflurane-anes- thetized dogs 显示文摘 | Mcmurphy R M Davidson H J Hodgson D S | 2004 | Am J Vet Res2004，65，5： | 1 |
| 4 | Asymmetric frontal brain activity, cortisol, and behavior associated with fearful temperament in rhesus monkeys显示文摘 | Kalin N H Larson C Shelton S E Davidson R J | 1998 | Behavioral Neuroscience1998，112，2： | 1 |
| 5 | Imaging findings of cochlear nerve de ficiency显示文摘 | CHRISTINE M DAVIDSON H C HARNSBERG ER H R | 2002 | AJNR Am J Neuroradiol2002，4，： | 1 |
| 6 | 显示文摘 | Halvorson R H Erickson R L Davidson C L | 2003 | Dental Materials2003，19，： | 1 |
| 7 | Flow patterns in the square cross-section riser of a circulating fluidized bed and the effect of riser exit design显示文摘 | E H van der Meer Thorpe R B Davidson J F | 2000 | Chemical Engineering Science2000，55，19： | 1 |
| 8 | Consumption of diacylglycerol oil as part of a reduced-energy diet enhances loss of body weight and fat in comparison with consumption of a triacylglycerol control oil显示文摘 | Maki K C Davidson M H Tsushima R | 2002 | The American Journal of Clinical Nutrition2002，76，6： | 1 |
| 9 | Gene regulation for higher cells:a theory显示文摘 | Britten R J Davidson E H | 1969 | Science1969，165，891： | 1 |
| 10 | Nutri tional status of elective gastrointestinal surgery patients pre and post-operatively显示文摘 | Fettes S B Davidson H I Richardson R A | 2002 | Clin Nutr2002，21，3： | 1 |
| 11 | Training effects in mice after long-term voluntary exercise显示文摘 | DAVIDSON S R BURNETT M LAURIE H G | 2006 | Med Sci Sports Exe2006，38，2： | 1 |
| 12 | Effects of solidification rate and ageing on the microstructure and mechanical properties of AZ91 alloy显示文摘 | Cáceres C H Davidson C J Griffiths J R | | 0，，： | 1 |
| 13 | Cholangiocarcinoma 显示文摘 | KHAN S A THOMAS H C DAVIDSON B R | 2005 | Lancet2005，366，： | 1 |
| 14 | The angiotensin Ⅰ converting enzyme gene and predisposition to high blood pressure显示文摘 | HARRAP S B DAVIDSON H R CONNOR J M | 1993 | Hypertension1993，21，4： | 1 |
| 15 | Effects of solidification rate and ageing on the microstructure and mechanical properties of AZ91 alloy 显示文摘 | Cáceres C H Davidson C J Griffiths J R | 2002 | Materials Science and Engineering A2002，325，： | 1 |
| 16 | Effects of solidification rate and ageing on the microstructure and mechanical properties of AZ91 alloy显示文摘 | Cacercs C H Davidson C J Griffiths J R | 2002 | Materials Science and Engineering2002，325，12： | 1 |
| 17 | Diocotron instability for intense relativistic non-neutral electron flow in planar diode geometry显示文摘 | Davidson R C Tsang K T Uhm H S | 1988 | Phys Fluids1988，31，6： | 1 |
| 18 | Relations bewween PET- derved measures of thalamic glucose metabolism and EEG alpha power 显示文摘 | Larson C L Davidson R J Abercmmbie H C | 1998 | Psychophysioloty1998，35，2： | 1 |
| 19 | Computer control Ⅱ :Mathematics of control 显示文摘 | KUEHN D R DAVIDSON H | 1961 | Chem Engng Prog1961，57，6： | 1 |
| 20 | Effects of solidification rate and ageing on the microstructure and mechanical properties of AZ91alloy显示文摘 | Cceres C H Davidson C J Griffiths J R | 2002 | Materials Science and Engineering2002，，5： | 1 |
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