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| 1 | 澳大利亚临床共识指南:儿童卒中的诊断和急性期处理显示文摘卒中是导致儿童死亡的十大原因之一,幸存的致残患儿将面临几十年的残疾生活,给患儿及其家庭带来了巨大负担。由于安全性和有效性的证据有限,以及诊断的延误,目前卒中患儿无法接受再灌注治疗。儿童卒中诊断和急性期处理的澳大利亚临床共识指南,旨在最大限度地减少临床诊疗中的不确定性,并记录与成人卒中不同的危险因素、病因和假性卒中情况的最佳证据。临床问题的阐述来自于对2007年至2017年数据库的系统检索,但仅限于英语和儿科研究。该指南应用SIGN方法和国家健康与医学研究委员会系统对证据进行筛选和分类,通过推荐、评估、发展和评价系统(GRADE系统)对推荐进行强弱分级。该指南提供了60多项基于证据的推荐,以帮助参与院前和急症处理的临床医师快速识别儿童卒中,选择最合适的初步检查方案来确定诊断、明确病因,并选择最恰当的干预措施以挽救脑组织、预防复发。同时,指南也提供了颅内压和先天性心脏病管理方面的推荐。该指南的实施需要将院前和急诊系统重组,包括建立区域性卒中网络,建立儿科卒中疾病编码,快速MRI,以及对能够提供再灌注治疗的初级儿科卒中中心进行认证。该指南能够审核治疗的基准时间线,获得急性期的干预措施及预后判断。它还将促进澳大利亚儿童卒中登记的发展,并与国际登记处建立数据联系,以便准确收集卒中发病率、治疗和结果相关的数据。 | Medley TL Miteff C Andrews I Ware T Cheung M Monagle P Mandelstam S Wray A Pridmore C Troedson C Dale RC Fahey M Sinclair A Walsh P Stojanovski S Macka MT 徐佳丽(译) 吴川杰(译) 肖潇(译) 吕俊萱(译) 张博维(译) 吉训明(译) | 2019 | 中国脑血管病杂志2019，16，4： | 9 |
| 2 | Mammary gland growth and vascularity at parturition and during lactation in primiparous ewes fed differing levels of selenium and nutritional plane during gestation显示文摘Background: Objectives were to examine the effects of selenium(Se) supply and maternal nutritional plane during gestation on mammary gland growth, cellular proliferation, and vascularity at parturition and d 20 of lactation. Rambouillet primiparous ewes(n = 84) were allocated to treatments in a 2 x 3 factorial. Factors were dietary Se(adequate Se [ASe, 11.5 μg/kg BW] or high Se [HSe, 77.0 μg/kg BW]) and nutritional plane(60% [RES], 100% [CON], or 140% [EXC]). At parturition, lambs were removed and 42 ewes(7/treatment) were necropsied. Remaining ewes were fed a common diet meeting requirements for lactation and mechanically milked twice daily until necropsy on d 20. At both necropsy periods, mammary glands were dissected and tissues harvested. Samples were analyzed for RNA, DNA, and protein content, cell proliferation, and vascularity. Where interactions were present(P ≤ 0.05), least squares means from the highest-order interaction are presented. Results: Final body weight of ewes was least(P ≤ 0.002) in RES, intermediate for CON, and greatest for EXC, regardless of stage of the ewe at necropsy(parturition or d 20 of lactation). In ewes necropsied at parturition, mammary glands were heavier(P = 0.02) in EXC compared to RES, with CON intermediate. Concentration of RNA(mg/g) was decreased(P = 0.01) in EXC compared to CON at parturition. There was a tendency(P = 0.07) for a Se by nutrition interaction in percentage of cells proliferating where ASe-EXC ewes had greater(P ≤ 0.02) number of proliferating cells then all other treatments. Mammary vascular area tended(P = 0.08) to be affected by a Se by nutrition interaction where ASe-CON had less(P = 0.007) vascular area than HSe-CON ewes. In ewes necropsied at d 20 of lactation, the number of alveoli per area was decreased(P ≤ 0.05) in RES compared to CON and EXC-fed ewes. Conclusions: Results of this study indicate that proper maternal nutritional plane during gestation is important for mammary gland development, even out to d 20 of lactation. | Tammi L Neville Allison M Meyer Arshi Reyaz Pawel B Borowicz Dale A Redmer Lawrence P Reynolds Joel S Caton Kimberly A Vonnahme | 2013 | Journal of Animal Science and Biotechnology2013，4，4： | 3 |
| 3 | Reversible in- hibitor of β-glucosidase 显示文摘 | DALE M P ENSLEY H E KERN K | 1985 | Biochemistry1985，24，： | 1 |
| 4 | Application of high energy ignition systems to engines 显示文摘 | DALE J D CHECKCL M D SMY P R | 1997 | Progress in Energy and Combustion Science1997，23，5： | 1 |
| 5 | Spatial and temporal variability in seed dynamics of machair sand dune plant communities, the Outer Hebrides, Scotland显示文摘 | Owen N W Kent M Dale M P | 2001 | Journal of Biogeography2001，28，5： | 1 |
| 6 | Genetic influence on language delay in two year old children 显示文摘 | Dale P S Simonoff E Bishop D V M | 1998 | Nataze Neuzosci1998，1，： | 1 |
| 7 | Norwegian testing of emulsion properties at sea-The importance of oil type and release conditions显示文摘 | Daling P S Moldestad M O Johansen O | 2003 | Spill Science & Technology Bulletin2003，8，2： | 1 |
| 8 | Synthesis of silica-sodalite from non-aqueous systems显示文摘 | Bibby D M Dale M P | 1985 | Nature1985，317，： | 1 |
| 9 | The role of anxiety in pros-tate carcinoma:a structured review of the literature显示文摘 | Dale W Bilir P Han M | 2005 | Cancer2005，104，3： | 1 |
| 10 | 16 S ribosomal DNA amplification for phylogenetic study显示文摘 | Willian G W Susan M B Dale A P | 1991 | J Bacteriol1991，173，2： | 1 |
| 11 | 16S ribosomal DNAamplification for phylogenetic study显示文摘 | William G W Susan M B Dale A P | 1991 | Journal of Bacteriology1991，173，2： | 1 |
| 12 | Starch production and industrial use显示文摘 | Ellis R P Cochrane M P Dale M F B | 1998 | Journal of the Science of Food and Agriculture1998，77，3： | 1 |
| 13 | Starch Production and Industrial Use 显示文摘 | ELLIS R P COCHRANE M P Dale M F B | 1998 | J Sci Food Agric1998，77，： | 1 |
| 14 | Starch production and industrial use显示文摘 | Ellis R P Cochrane M P Dale M F B etal | 1998 | Journal of Science of Food and Agriculture1998，77，： | 1 |
| 15 | An objective method of weighting in similarity analysis 显示文摘 | Williams W T Dale M B Macnaughton-Smith P | 1964 | Nature1964，201，4917： | 1 |
| 16 | Spatial and temporalvariability in seed dynamics of machair sand dunecommunities, Outer Hebriges,Scottland 显示文摘 | Owen N W Kent M Dale M P | 2001 | Journalof Biogeograph2001，28，： | 1 |
| 17 | Sacred Land, Mineral Wealth and Biodiversity at Coronation Hill显示文摘 | Lane M B Ross H Dale A P Rickson R E | 2003 | Northern Australia: Indigenous Knowledge and Social Impact Analysis2003，，6： | 1 |
| 18 | Transgenic Pinus radiate from agro bacterium tumefactions mediated transformation of cotyledons 显示文摘 | Grant J E Cooper P A Dale T M | 2004 | Plant Cell Reports2004，22，： | 1 |
| 19 | 16S ribosomal DNA ampli- fication for phylogenetic study 显示文摘 | William G W Susan M B Dale A P | 1991 | Journal of Bacteriology1991，173，2： | 1 |
| 20 | 16S ribosomal DNA amplification for phylogenetic study显示文摘 | William G W Susan M B Dale A P | 1991 | Journal of Bacteriology1991，1，： | 1 |
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