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	题名	作者	年代	出处	被引量
1	Glucocorticosteroid therapy in inflammatory bowel diseases: From clinical practice to molecular biology显示文摘Inflammatory bowel diseases(IBDs),such as ulcerative colitis and Crohn's disease,are chronic pathologies associated with a deregulated immune response in the intestinal mucosa,and they are triggered by environmental factors in genetically susceptible individuals.Exogenous glucocorticoids(GCs)are widely used as anti-inflammatory therapy in IBDs.In the past,patients with moderate or severe states of inflammation received GCs as a first line therapy with an important effectiveness in terms of reduction of the disease activity and the induction of remission.However,this treatment often results in detrimental side effects.This downside drove the development of second generation GCs and more precise(non-systemic)drugdelivery methods.Recent clinical trials show that most of these new treatments have similar effectiveness to first generation GCs with fewer adverse effects.The remaining challenge in successful treatment of IBDs concerns the refractoriness and dependency that some patients encounter during GCs treatment.A deeper understanding of the molecular mechanisms underlying GC response is key to personalizing drug choice for IBDs patients to optimize their response to treatment.In this review,we examine the clinical characteristics of treatment with GCs,followed by an in depth analysis of the proposed molecular mechanisms involved in its resistance and dependence associated with IBDs.This thorough analysis of current clinical and biomedical literature may help guide physicians in determining a course of treatment for IBDs patients and identifies important areas needing further study.	Karen Dubois-Camacho Payton A Ottum Daniel Franco-Munoz Marjorie De la Fuente Alejandro Torres-Riquelme David Díaz-Jiménez Mauricio Olivares-Morales Gonzalo Astudillo Rodrigo Quera Marcela A Hermoso	2017	World Journal of Gastroenterology2017，23，36：	6
2	Long-term atmospheric corrosion of mild steel显示文摘	D. de la Fuente I. Díaz J. Simancas B. Chico M. Morcillo	2010	Corrosion Science2010，，2：	2
3	Effect of β-casomorphins and analogs on insulin release in dogs显示文摘	SCHUSDZIARRA V SCHICK A D de la FUENTE A	1983	Endocrinology1983，112，3：	1
4	Rituximab therapy in refractory neuropsychiatric lupus: current clinical evidence显示文摘	NARVAEZ J RIOS-RODRIGUEZ V DE LA FUENTE D	2011	Semin Arthritis Rheum2011，41，3：	1
5	DDT induces apoptosis in human mononuclear cells in vitro and is associated with increased apoptosis in exposed children 显示文摘	Pérez-Maldonado IN D??az-Barriga F de la Fuente H González-Amaro R Calderón J Yá?ez L	2004	Environ Res2004，94，1：	1
6	Studies of longterm weathering of aluminium in the atmosphere 显示文摘	Fuente D de la Otero-Huerta E Morcillo M	2007	Corrosion Science2007，49，7：	1
7	The origin of cor- relations in metabolomics data显示文摘	Camacho D De La Fuente A Mendes P	2005	Metabolomics2005，1，1：	1
8	Effects of arsenic, cadmium and lead on the induction of apoptosis of normal human mononuctear cells显示文摘	De la Fuente H Portales-Perez D Barsnda L	2002	Clin Exp Immunol2002，129，1：	1
9	An study on accelerated corrosion testing of weathering steel显示文摘	P. Montoya I. Díaz N. Granizo D. de la Fuente M. Morcillo	2013	Materials Chemistry and Physics2013，，：	1
10	IL-15 and IL-15R in leucocytes from patients with systemic lupus erythematosus显示文摘	Baranda L de la Fuente H Layseca-Espinosa E Portales-Pérez D Nio-Moreno P Valencia-Pacheco G	2005	Rheumatology (Oxford)2005，44，12：	1
11	Morphological study of 16-year patinas formed on copper in a wide range of atmospheric exposures显示文摘	D de la Fuente J Simancas M Moreillo	2008	Corrosion Science2008，50，：	1
12	Vertical subperiosteal mid-face lift for treatment of malar festoons显示文摘	Hoenig JF Knutti D de la Fuente A	2011	Aesth Plast Surg2011，35，4：	1
13	Standard and intensive lipid-lowering therapy with statins for the primary prevention of vascular diseases:a population-based study显示文摘	Mac í as Saint-Gerons D De la Fuente Honrubia C Montero Corominas D		0，，：	1
14	Per-formance of propofol target -controlled infusion models in the obese: pharmacokinetic and pharmavodynamic analysis 显示文摘	CORTINEZ L I DE LA FUENTE N ELEVELD D J el M	2014	Anesth Analg2014，119，2：	1
15	Long-Term Atmospheric Corrosion of Mild Sleel 显示文摘	Fuente de la D Diaz I Simancas J	2011	Corrosion Science2011，，53：	1
16	Studies of long-term weathering of aluminium in the atmosphere显示文摘	Fuente D de la Otero-Huerta E Morcillo M	2007	Corrosion Science2007，49，：	1
17	Effect ofVariable Amounts of Rust at the Steel/Paint Interface on the Behavior of Anticorrosive Paint Systems 显示文摘	FUENTE D de la SIMANCAS J MORCILLO M	2003	Progress in Or- ganic Coating2003，46，4：	1
18	Mapping air pollutioneffects on atmospheric degradation of cultural heritage显示文摘	de la Fuente D Vega J M Viejo F		Journalof Cultural Heritage0，14，2：	1
19	Interac-tion of copper and NO2 : Effect of joint presence ofSO2,relative humidity and temperature显示文摘	Mariaca L Fuente D de la Feliu Jr S	2008	Journal ofPhysics and Chemistry of Solids2008，69，：	1
20	Studies of long-term weathering of aluminium in the atmosphere 显示文摘	Fuente D de la Otero-Huerta E Morcillo M	2007	Corrosion Science2007，49，7：	1

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