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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Conservation of an alpha 2 domain within the telenseanworld, MHC class I from therainbow trout Oncorhynchus mykiss 显示文摘 | Hansen J D Strassburger P D Pasquier L | 1996 | Dev Comp lmmunol1996，20，： | 1 |
| 3 | Poststrok dementia:incidence and relationship to prestroke cognitive decline显示文摘 | Enon H Duvieu l Guerouaou D Lebert F Pasquier F1eys D | 2001 | Nem''ology2001，57，： | 1 |
| 4 | On the wigins of the adaptive immune system: novel insights from invertebrates and cold - blooded vertebrates显示文摘 | Kasahara M Suzuid T Pasquier L D | 2004 | Trends Immunol2004，，25： | 1 |
| 5 | Epidemiology of vascular dementia:a meta-an alysis显示文摘 | Leys D Pasquier F Parnetti L | 1998 | Haemostasis1998，28，： | 1 |
| 6 | The Mayer-Rokitansky- Kuster-Hauser syndrome (congenital absence of uterus and vagina)- phenotypic manifestations and genetic approaches 显示文摘 | Guerrier D Mouchel T Pasquier L | 2006 | J Neg Res Bio2006，5，1： | 1 |
| 7 | Bpidemiology of vascular dementia a meta-analysis显示文摘 | Leys D Pasquier L | 1998 | Haemostasis1998，，28： | 1 |
| 8 | Epidemiology of vascular dementia: a meta-analysis 显示文摘 | Leys D Pasquier F Parnetti L | 1998 | Haemostasis1998，28，： | 1 |
| 9 | The Mayer-Rokitansky-Küster-Hauser syndrome (congenital absence of uterus and vagina)--phenotypic manifestations and genetic approaches显示文摘 | Guerrier D Mouchel T Pasquier L | | 0，，： | 1 |
| 10 | Chemical fingerprinting of unevaporated automotive gasoline samples显示文摘 | SANDERCOCK P M L PASQUIER E D | 2003 | Forensic Science International2003，134，24： | 1 |
| 11 | Chemical fingerprinting of gasoline(Part 3) :Comparison of unevaporated automotive gasoline samples from Australia and New Zealand 显示文摘 | SANDERCOCK P M L PASQUIER E D | 2004 | Forensic Science International2004，140，10： | 1 |
| 12 | Chemical fingerprinting of gasoline(Part 2) :Comparison of unevaporated and evaporated automotive gasoline samples显示文摘 | SANDERCOCK P M L PASQUIER E D | 2004 | Forensic Science International2004，140，10： | 1 |
| 13 | Conservation of an alpha 2 domain within the teleostean world, MHC class Ⅰ from the rainbow trout Oncorhynchus mykiss 显示文摘 | Hansen J D Strassburger P du Pasquier L | 1996 | Dev Comp Immunol1996，20，6： | 1 |
| 14 | Conservation of an alpha zdomain within the teleostean world,MHC class I from the rainbow trout Oncorhychus mykiss显示文摘 | HANSEN J D STASSBURGER P DU PASQUIER L | 1996 | Developmental & comparative immunology1996，20，6： | 1 |
| 15 | Evolution of the MHC: Isolation of class Ⅱ β-chain cDNA clones from the amphibian Xenopus laevis 显示文摘 | KEISUKE S FLAJNIK M F PASQUIER L D | 1993 | J Immunology1993，150，： | 1 |
| 16 | The Mayer-Rokitansky K- uster-Hauser syndrome(congenital absence of uterus and vagina) - phenotypic manifestations and genetic appmaches 显示文摘 | Guerrier D Mouchel T Pasquier L el al | 2006 | J Ncg Res- Bio2006，5，1： | 1 |
| 17 | Epidemiology of vascular dementia:A metaanalysis显示文摘 | Leys D Pasquier L | 1998 | Haemostasis1998，28，： | 1 |
| 18 | Conservation of an alpha-domain within the teleostean world,MHC class Ⅰ from the rainbowl trout Oncorhynchus mykiss显示文摘 | Hansen J D Strassburger P Du Pasquier L | 1996 | Dev Comp Immunol1996，20，： | 1 |
| 19 | The Mayer-Rokitansky- Kuster-Hauser syndrome (congenital absence of uterus and vagina) -phenotypic manifestations and genetic approaches 显示文摘 | Guerrier D Mouchel T Pasquier L | 2006 | J Negat Results Biomed2006，5，： | 1 |
| 20 | Costimulatory recep- tors in jawed vertebrates: conserved CD28, odd CTLA4 and multiple BTLAs显示文摘 | Bernard D Hansen JD Du Pasquier L | 2007 | Bey Comp Immunol2007，31，3： | 1 |
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