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| 1 | Impact of Temperature on Mortality in Three Major Chinese Cities显示文摘Objective To study the relation between temperature and mortality by estimating the temperature-related mortality in Beijing,Shanghai,and Guangzhou.Methods Data of daily mortality,weather and air pollution in the three cities were collected.A distributed lag nonlinear model was established and used in analyzing the effects of temperature on mortality.Current and future net temperature-related mortality was estimated.Results The association between temperature and mortality was J-shaped,with an increased death risk of both hot and cold temperature in these cities.The effects of cold temperature on health lasted longer than those of hot temperature.The projected temperature-related mortality increased with the decreased cold-related mortality.The mortality was higher in Guangzhou than in Beijing and Shanghai.Conclusion The impact of temperature on health varies in the 3 cities of China,which may have implications for climate policy making in China. | ZHANG Jing LI Tian Tian TAN Jian Guo HUANG Cun Rui KAN Hai Dong | 2014 | Biomedical and Environmental Sciences2014，27，7： | 5 |
| 2 | Cytogenetic comparisons between A and G genomes in Oryza using genomic in situ hybridization显示文摘Oryza sativa (一个染色体) 和 O 的 genomic 结构。meyeriana (G 染色体) 比较地在 situ 杂交(GISH ) 用二色的 genomic 被学习。GISH 清楚地能在 O 的染色体之间区别。sativa 和 O。在没有堵住 DNA 的种间的 F1 混血儿的 meyeriana,和合作杂交几乎没被检测。O 的平均有丝分裂的染色体长度。meyeriana 被发现是乘 O 的的 1.69。sativa。染色的 4,6-diamidino-2-phenylindole 的比较出现了 O 的染色体。meyeriana 更广泛地被标记,建议 G 染色体与更重复的序列比被放大一个染色体。在分裂期间原子核, 9-12 多彩石印版中心通常被检测,将近,所有多彩石印版中心组成了 G 染色体特定的 DNA。中心由相应于 G 染色体的染色质压缩形成了的更多和更大的多彩石印版与它的父母相比在混血儿被检测。在 F1 混血儿的 pachytene 期间, A 和 G 的大多数染色体互相,除了 1-2,染色体在他们的手臂的结束配对的触处。在 meiotic 中期我, chromosomal 协会的三种类型,即 O。sativa-O。sativa (A-A ) , O。sativa-O。meyeriana (A-G ) 和 O。meyeriana-O。meyeriana (G-G ) ,在 F1 混血儿被观察。配对配置的 A-G 染色体包括了 bivalents 和 trivalents。结果向学习染色体组织和 O 的进化提供了一个基础。meyeriana。 | Zhi Yong Xiong Guang Xuan Tan Guang Yuan He Guang Cun He Yun Chun Song | 2006 | Cell Research2006，16，3： | 4 |
| 3 | Erratum to Simultaneous inhibition of PI3Kα and CDK4/6synergistically suppresses KRAS-mutated non-small cell lung cancer显示文摘In the published Figure 11,errors appeared in Figure 1B on page 69.In Figure 1B,bands for p-Akt S473,Akt,and Actin in H1355 cells were mistakenly placed.Here,we have updated Figure 1B to correct the mistake above.The errors do not impact the conclusions of this article.We apologize for the errors and for any confusion it may have caused. | Yuxiang Wang Xian Li Xueling Liu Yi Chen Chunhao Yang Cun Tan Bobo Wang Yiming Sun Xi Zhang Yinglei Gao Jian Ding Linghua Meng | 2019 | Cancer Biology & Medicine2019，16，4： | 1 |
| 4 | CARBONIUM CYCLIZATION—STUDIES ON LIGNANS CONTAINING THE DIBENZOCYCLOOCTADIENE SYSTEM.Ⅰ显示文摘Schisandrin(1)under the Ritter reaction conditions(conc.H2SO4/CH3CN)gave trace amounts of the expected acetamidoderivatives(2a,2b).The main product is 5a,from intramolecular car-bonium cyclization. | Rui TAN Qi Tai ZHENG Cun Heng HE Xiao Tian LIANG Institute of Materia Medica,Nan-wei Road,Beijing 100050 | 1990 | Chinese Chemical Letters1990，1，1： | 0 |
| 5 | Unbiased screening reveals that blocking exportin 1 overcomes resistance to PI3Kαinhibition in breast cancer显示文摘Dear Editor,Targeting PI3K is a promising approach for cancer therapy,and the PI3Kα-selective inhibitor alpelisib has been approved for breast cancer treatment.1,2,3 However,the development of acquired resistance poses a significant clinical challenge.Loss of PTEN and activation of mTOR,CDK4/6,or PIM have been reported to mediate acquired resistance to alpelisib.4,5,6,7 The mechanisms leading to resistance to PI3Kαinhibitors appear to be different under different circumstances,and the aforementioned strategies may be beneficial for a particular group of patients.New strategies to overcome acquired resistance in a broad spectrum of patients need to be discovered. | Xue-Ling Liu Bo-Bo Wang Yi Wang Yu-Xiang Wang Chun-hao Yang Cun Tan Xi Zhang Qiao-jun He Jian Ding Ling-Hua Meng | 2019 | Signal Transduction and Targeted Therapy2019，4，1： | 0 |
| 6 | Performance Evaluation of Three Parameterizations on Internal Tidal Mixing in the Northern Pacific显示文摘The accurate assessment of the energy dissipation of internal tides(ITs)is of great importance because ITs contribute significantly to abyssal mixing.Thus,in this study,the IT-driven dissipation and diapycnal diffusion in the northern Pacific are esti-mated using parameterizations proposed by St.Laurent et al.(2002),Koch-Larrouy et al.(2007),and de Lavergne et al.(2020)(hereaf-ter referred to as LSJ02,KL07,and dL20,respectively).The performances of the three parameterizations are evaluated by comparing the calculated results with fine structure observations.In particular,the dissipation estimated by LSJ02 parameterization shows a bottom-intensified characteristic,with the patterns showing good agreement with the observations near seamounts.Moreover,43%of the results calculated using the LSJ02 parameterization have errors lower than one order of magnitude in the generation sites of ITs.Meanwhile,the strongest dissipation estimated by the KL07 parameterization shifts to the thermocline,with the results showing the highest level of consistency with observations in the generation sites.The proportion of results with errors lower than one order of magnitude is 80.7%.Furthermore,the results calculated by dL20 parameterization agree well with the observations in the upper and middle layers,with the parameterization showing an accurate estimation of the remote dissipation.The percentages of the errors lower than one order of magnitude between the dL20 parameterization and observations account for 77.1%and 88.7%in the genera-tion sites and far-field regions,respectively. | TAN Jiao MENG Jing CHEN Xu JIA Cun DU Tao YANG Xiaoxin LIU Tianyang | 2023 | Journal of Ocean University of China2023，22，3： | 0 |
| 7 | Simultaneous inhibition of PI3Kα and CDK4/6 synergistically suppresses KRAS-mutated non-small cell lung cancer显示文摘Objective: Activating KRAS mutations are the most common drivers in the development of non-small cell lung cancer(NSCLC).However, unsuccess of treatment by direct inhibition of KRAS has been proven. Deregulation of PI3K signaling plays an important role in tumorigenesis and drug resistance in NSCLC. The activity of PI3Kα-selective inhibition against KRAS-mutated NSCLC remains largely unknown.Methods: Cell proliferation was detected by sulforhodamine B assay. Cell cycle distribution and apoptosis were measured by flow cytometry. Cell signaling was assessed by Western blot and immunohistochemistry. RNA interference was used to down-regulate the expression of cyclin D1. Human NSCLC xenografts were employed to detect therapeutic efficacy in vivo.Results: CYH33 possessed variable activity against a panel of KRAS-mutated NSCLC cell lines. Although CYH33 blocked AKT phosphorylation in all tested cells, Rb phosphorylation decreased in CYH33-sensitive, but not in CYH33-resistant cells, which was consistent with G1 phase arrest in sensitive cells. Combined treatment with the CDK4/6 inhibitor, PD0332991, and CYH33 displayed synergistic activity against the proliferation of both CYH33-sensitive and CYH33-resistant cells, which was accompanied by enhanced G1-phase arrest. Moreover, down-regulation of cyclin D1 sensitized NSCLC cells to CYH33. Reciprocally, CYH33 abrogated the PD0332991-induced up-regulation of cyclin D1 and phosphorylation of AKT in A549 cells. Co-treatment with these two drugs demonstrated synergistic activity against A549 and H23 xenografts, with enhanced inhibition of Rb phosphorylation.Conclusions: Simultaneous inhibition of PI3Kα and CDK4/6 displayed synergistic activity against KRAS-mutated NSCLC. These data provide a mechanistic rationale for the combination of a PI3Kα inhibitor and a CDK4/6 inhibitor for the treatment of KRASmutated NSCLC. | Yuxiang Wang Xian Li Xueling Liu Yi Chen Chunhao Yang Cun Tan Bobo Wang Yiming Sun Xi Zhang Yinglei Gao Jian Ding Linghua Meng | 2019 | Cancer Biology & Medicine2019，16，1： | 0 |
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