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| 1 | Physiopathology of ischemic stroke and its modulation using memantine:evidence from preclinical stroke显示文摘Ischemic stroke is the most common type of cerebrovascular disease and is caused by an interruption of blood flow in the brain.In this disease,two different damage areas are identifying:the lesion core,in which cells quickly die;and the penumbra(surrounding the lesion core),in which cells are functionally weakened but may recover and restore their functions.The currently approved treatments for ischemic stroke are the recombinant tissue plasminogen activator and endovascular thrombectomy,but they have a short therapeutic window(4.5 and 6 hours after stroke onset,respectively)and a low percentage of stroke patients actually receive these treatments.Memantine is an approved drug for the treatment of Alzheimer's disease.Memantine is a noncompetitive,low affinity and use-dependent antagonist of N-methyl-D-aspartate glutamate receptor.Memantine has several advantages over developing a new drug to treat focal ischemic stroke,but the most important is that it has sufficient safe probes in preclinical models and humans,and if the preclinical studies provide more evidence about pharmacological actions in tissue protection and repair,this could help to increase the number of clinical trials.The present review summarizes the physiopathology of isquemic stroke and the pharmacological actions in neuroprotection and neuroplasticity of memantine in the post stroke stage of preclinical stroke models,to illustrate their potential to improve functional recovery in human patients. | Hilda Martínez-Coria Isabel Arrieta-Cruz María-Esther Cruz Héctor E.López-Valdés | 2021 | Neural Regeneration Research2021，16，3： | 8 |
| 2 | Zine-induced changes in ionic currents of clonal rat pancreatic β-cells:activation of ATP-sensitive K+ channels 显示文摘 | Cens T Cruz H | 2000 | J physiol2000，529，3： | 1 |
| 3 | Purification of metallurgical grade silicon by acid leaching显示文摘 | SANTOS I C GONCALVES A P SANTOS C S ALMEIDA M AFONSO M H CRUZ M J | 1990 | Hydrometallurgy1990，23，： | 1 |
| 4 | Efficiency of chain codes to represent binary objects 显示文摘 | Sdnchez Cruz H Bribiesea E Rodriguez Diaz M A | 2007 | Pattern Recogni- tion2007，40，6： | 1 |
| 5 | Vasoconstrictive effect of bile acid on isolated human placental chorionic veins显示文摘 | Seplveda M H Gonzalez C Cruz M A | 1991 | EurJ Obstet Gynecol Reprod Biol1991，42，： | 1 |
| 6 | Determining Robust Impacts of Land-Use-Induced Land Cover Changes on Surface Climate over North America and Eurasia: Results from the First Set of LUCID Experiments显示文摘 | de Noblet-Ducoudré Nathalie Boisier Juan-Pablo Pitman Andy Bonan G B Brovkin V Cruz Faye Delire C Gayler V van den Hurk B J J M Lawrence P J van der Molen M K Müller C Reick C H Strengers B J Voldoire A | 2012 | EN2012，，9： | 1 |
| 7 | Diazonamide A and a synthetic structural analog:disruptive effects on mitosis and cellular microtubules and analysis of their interactions with tubulin显示文摘 | Cruz M Z Vervoot H C Bai R | 2003 | Mol Pharmocol2003，63，： | 1 |
| 8 | The role of ontologies in data in tegration显示文摘 | CRUZ I F XIAO H | 2005 | Engineering Intelligent Systems for Elec- trical Engineering and Communications2005，13，4： | 1 |
| 9 | Ultrasonically induced degradation of microcystin-LR and RR:identification of products,effect of pH,formation and destruction of peroxides显示文摘 | Song W H Armah A Cruz D L | | 0，，： | 1 |
| 10 | Direct observation of the femtosecond excited-state cis-trans isomerization in bacteriorhodopsin显示文摘 | MATHIES R A CRUZ C H B POLLARD W T | 1988 | Science1988，240，4853： | 1 |
| 11 | Characterisation of okadaic acid related toxins by liquid chromatography coupled with mass spectrometry显示文摘 | PAZ B H DARANAS A CRUZ P | 2007 | Toxicon2007，50，： | 1 |
| 12 | Adverse events following infusion of T cells for adoptive immunotherapy: A 10 year experience 显示文摘 | Cruz CR Hanley PJ Liu H | 2010 | Cytotherapy2010，12，6： | 1 |
| 13 | Domain control in muttiferroic BiFeO3 through substrate vicinality显示文摘 | Chu Y H Cruz M P Yang C H | 2007 | Adv Mater2007，19，： | 1 |
| 14 | Blending PSO and ANN for optimal design of FSS filters with Koch Island patch elements 显示文摘 | Da F Silva P H Cruz R M S D' Assuncao A G | 2010 | IEEE Trans on Magnetics2010，46，8： | 1 |
| 15 | Isolation and characterization of microsatellites in Pacific white shrimp Penaeus ( Litopenaeus ) vannamei显示文摘 | Cruz P Mejia-Ruiz C H Perez-Enriquez R | 2002 | Mol Eco Notes2002，2，： | 1 |
| 16 | Determining Robust Impacts of Land-Use-Induced Land Cover Changes on Surface Climate over North America and Eurasia: Results from the First Set of LUCID Experiments显示文摘 | de Noblet-Ducoudré Nathalie Boisier Juan-Pablo Pitman Andy Bonan G B Brovkin V Cruz Faye Delire C Gayler V van den Hurk B J J M Lawrence P J van der Molen M K Müller C Reick C H Strengers B J Voldoire A | 2012 | EN2012，，9： | 1 |
| 17 | Assessing canopy fuel stratum characteristics in crown fire prone fuel types of western North America 显示文摘 | Cruz M G Alexander M E Wakimoto R H | 2003 | International Journal of Wildland Fire2003，，： | 1 |
| 18 | Perceived vibration strength in mobile devices: The effect of weight and frequency 显示文摘 | YAO H Y GRANT D CRUZ M | 2010 | Haptics IEEE Transactions on2010，3，1： | 1 |
| 19 | The monitoring anti predic- tion of mining subsidence in the Amaga, Angelopolis, Venecia and Bolombolo Regions, Antioquia, Colombia 显示文摘 | Donnelly L J Dela Cruz H Asmar 1 | 2001 | Engineering Geolo- gy2001，59，： | 1 |
| 20 | Adverse events following infusion ofT cells for adoptive immunotherapy: A 10 year experience 显示文摘 | Cruz CR Hanley PJ Liu H | 2010 | Cy-totherapy2010，12，6： | 1 |
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