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| 1 | Aminoguanidine impedes human pancreatic tumor growth and metastasis development in nude mice显示文摘AIM:To study the action of aminoguanidine on pancreatic cancer xenografts in relation to cell proliferation,apoptosis,redox status and vascularization.METHODS:Xenografts of PANC-1 cells were developed in nude mice. The animals were separated into two groups:control and aminoguanidine treated. Tumor growth,survival and appearance of metastases were determined in vivo in both groups. Tumors were excised and ex vivo histochemical studies were performed. Cell growth was assessed by Ki-67 expression. Apoptosis was studied by intratumoral expression of B cell lymphoma-2 protein (Bcl-2) family proteins and Terminal deoxynucleotidyl transferase biotin-dUTP Nick End Labeling (Tunel). Redox status was evaluated by the expression of endothelial nitric oxide synthase (eNOS),catalase,copper-zinc superoxide dismutase (CuZnSOD),manganese superoxide dismutase (MnSOD) and glutathione peroxidase (GPx). Finally,vascularization was determined by Massons trichromic staining,and by VEGF and CD34 expression.RESULTS:Tumor volumes after 32 d of treatment by aminoguanidine (AG) were significantly lower than in control mice (P < 0.01). Median survival of AG mice was significantly greater than control animals (P < 0.01). The appearance of both homolateral and contralateral palpable metastases was significantly delayed in AG group. Apoptotic cells,intratumoral vascularization (trichromic stain) and the expression of Ki-67,Bax,eNOS,CD34,VEGF,catalase,CuZnSOD and MnSOD were diminished in AG treated mice (P < 0.01),while the expression of Bcl-2 and GPx did not change.CONCLUSION:The antitumoral action of aminoguanidine is associated with decreased cell proliferation,reduced angiogenesis,and reduced expression of antioxidant enzymes. | Nora A Mohamad Graciela P Cricco Lorena A Sambuco Máximo Croci Vanina A Medina Alicia S Gutiérrez Rosa M Bergoc Elena S Rivera Gabriela A Martín | 2009 | World Journal of Gastroenterology2009，15，9： | 3 |
| 2 | Pattern of cerebral edema and hemorrhage in a mice model of diffuse brain injury显示文摘 | HELLAL F BONNEFONT ROUSSELOT D CROCI N | 2004 | Neurosci Lett2004，357，1： | 1 |
| 3 | Pattern of cerebral edema and hemorrhage in amaice model of diffuse braininjury显示文摘 | Hellal F Bonnefont - Roussselot D Croci N | 2004 | Neurosci Lett2004，357，1： | 1 |
| 4 | Silencing surviving gene expression promotes apoptosis of human breast cancer cells through a caspase-independent pathway 显示文摘 | Croci D O Cogno I S Vittar N B | 2008 | J Cell Bio- chem2008，105，2： | 1 |
| 5 | L-NAME reduces infarction,neurological deficit and blood-brain barrier disruption following cerebral ischemia in mice显示文摘 | Ding-Zhou L Marchand-Verrecchia C Croci N | 2002 | Eur J Pharmacol2002，457，23： | 1 |
| 6 | Mass volume measurement in severe head injury: accuracy and feasibility of two pragmatic methods显示文摘 | Stocchetti N Croci M Spagnoli D | 2000 | J Neurol Neurosurg Psychiatry2000，680，： | 1 |
| 7 | Minocycline effects on cere- bral edema:relations with inflammatory and oxidative stress mark- ers following traumatic brain injury in mice显示文摘 | Homsi S Federico F Croci N | 2009 | Brain Research2009，1291，： | 1 |
| 8 | L - NAME reduces infarction,neurological deficit and blood- brain barrier disruption following cerebral ischemia in mice 显示文摘 | Ding - Zhou L Marchand - Verrecchia C Croci N | 2002 | Eur J Pharmacol2002，457，23： | 1 |
| 9 | Morphol, ogical changes induced by different doses of gamma irradiation in garlic sprouts显示文摘 | Pellegrini C N Croci C A Orio|i G A | 2000 | Radiation Physics and Chernistry2000，57，： | 1 |
| 10 | L-NAME reduces infarction, neurological deficit and blood- brain barrier disruption following cerebral ischemia in mice 显示文摘 | DING-ZHOU L MARCHAND-VERRECCHIA C CROCI N | 2002 | Eur J Pharmacol2002，457，23： | 1 |
| 11 | Minocycline effects on cerebral edema: relations with inflammatory and oxidative stress markers following traumatic brain injury in mice显示文摘 | HOMSI S FEDERICO F CROCI N | 2009 | Brain Res2009，1291，： | 1 |
| 12 | Pattern of cerebral ede- maand hemorrhage in a mice model of diffuse brain injury显示文摘 | Hellal F Bonnefont RD Croci N | 2004 | Neurosei Lett2004，357，1： | 1 |
| 13 | L-NAME Reduces Infarction,Neurological Deficit and Blood-brain Barrier Disruption Following Cerebral Ischemia in Mice显示文摘 | DING-ZHOU L MARCHAND-VERRECCHIA C CROCI N | 2002 | Eur J Pharmacol(S0014-2999)2002，457，23： | 1 |
| 14 | Deleterious poly( ADP-ri- bose) polymerase-1 pathway activation in traumatic brain injury in rat显示文摘 | Besson VC Croci N Boulu RG | 2003 | Brain Res2003，989，1： | 1 |
| 15 | Silencing survivin gene expression promotes apoptosis of human breast cancer cells through a caspase-independent pathway显示文摘 | Croci D O Cogno I S Vittar N B Salvatierra E Trajtenberg F Podhajcer O L | 2008 | J Cell Biochem2008，105，： | 1 |
| 16 | Pattern of cerebral edema and hemorrhage in amaiee model of diffuse braininjury显示文摘 | Hellal F Bonnefont-Roussselot D Croci N | 2004 | Neurosci Lett2004，357，1： | 1 |
| 17 | Mass volume measurement in severe head injury:accuracy and feasibility of two pragmatic methods显示文摘 | STOCCHETTI N CROCI M SPAGNOLI D | 2000 | J Neural Neurosurg Psychiatry2000，68，1： | 1 |
| 18 | Disrupting galectin-I in- teractions with N-glycans suppresses hypoxia-driven angiogenesis and tumorigenesis in Kaposi's sarcoma 显示文摘 | Croci DO Salatino M Rubinstein N | 2012 | J Exp Mcd2012，209，11： | 1 |
| 19 | Pattern of cerebral edema and hemorrhage in a mice model of diffuse brain injury显示文摘 | Hellal F Bonnefont RD Croci N | | 0，，： | 1 |
| 20 | Characterization of a rat model to study acute neuroinflammation on histopathological,biochemical and functional outcomes显示文摘 | Ambrosini A Louin G Croci N | 2005 | J Neurosci Methods2005，144，2： | 1 |
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