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| 1 | Therapeutic alternatives for the treatment of type 1 hepatorenal syndrome: A Delphi technique-based consensus显示文摘AIM To propose several alternatives treatment of type 1 hepatorenal syndrome(HRS-1) what is the most severe expression of circulatory dysfunction on patients with portal hypertension.METHODS A group of eleven gastroenterologists and nephrologists performed a structured analysis of available literature.Each expert was designated to review and answer a question.They generated draft statements for evaluation by all the experts.Additional input was obtained from medical community.In order to reach consensus,a modified three-round Delphi technique method was used.According to United States Preventive Services Task Force criteria,the quality of the evidence and level of recommendation supporting each statement was graded.RESULTS Nine questions were formulated.The available evidence was evaluated considering its quality,number of patients included in the studies and the consistency of its results.The generated questions were answered by the expert panel with a high level of agreement.Thus,a therapeutic algorithm was generated.The role of terlipressin and norepinephrine was confirmed as the pharmacologic treatment of choice.On the other hand the use of the combination of octreotide,midodrine and albumin without vasoconstrictors was discouraged.The role of several other options was also evaluated and the available evidence was explored and discussed.Liver transplantation is considered the definitive treatment for HRS-1.The present consensus is an important effort that intends to organize the available strategies based on the available evidence in the literature,the quality of the evidence and the benefits,adverse effects and availability of the therapeutic tools described.CONCLUSION Based on the available evidence the expert panel was able to discriminate the most appropriate therapeutic alternatives for the treatment of HRS-1. | Juan P Arab Juan C Claro Juan P Arancibia Jorge Contreras Fernando Gomez Cristian Munoz Leyla Nazal Eric Roessler Rodrigo Wolff Marco Arrese Carlos Benítez | 2016 | World Journal of Hepatology2016，8，25： | 3 |
| 2 | Hepatocellular carcinoma in non-alcoholic steatohepatitis without cirrhosis显示文摘Cirrhosis is an emerging major cause of the development of hepatocellular carcinoma(HCC),but in non-alcoholic fatty liver disease(NAFLD),up to 50%of patients with HCC had no clinical or histological evidence of cirrhosis.It is currently challenging to propose general recommendations for screening patients with NAFLD without cirrhosis,and each patient should be evaluated on a caseby-case basis based on the profile of specific risk factors identified.For HCC screening in NAFLD,a valid precision-based screening is needed.Currently,when evaluating this population of patients,the use of non-invasive methods can guide the selection of those who should undergo a screening and surveillance program.Hence,the objective of the present study is to review the epidemiology,the pathophysiology,the histopathological aspects,the current recommendations,and novel perspectives in the surveillance of non-cirrhotic NAFLD-related HCC. | Cristiane Valle Tovo Angelo Zambam de Mattos Gabriela Perdomo Coral Giovana D P Sartori Livia Villela Nogueira Gustavo Tovo Both Cristiane A Villela-Nogueira Angelo A de Mattos | 2023 | World Journal of Gastroenterology2023，29，2： | 1 |
| 3 | Interaction of human neutrophils with endothelial cells regulates the expression of endogenous proteins annexin 1, galectin - 1 and galectin - 3 显示文摘 | Cristiane D Mylinh L Mauro P | 2006 | Cel/ Biology Inter- national2006，30，4： | 1 |
| 4 | Supported metallocene on mesoporous materials显示文摘 | Fernando S Cristiane F P Dirce P | 2007 | Applied catalysis A: General2007，333，1： | 1 |
| 5 | 限饲和再投喂对不同日龄鸡消化酶促反应的影响显示文摘试验旨在评价限饲和再投喂对两个不同日龄(7和35d)鸡酶活性和胃肠道器官重量的影响,在每种日龄下,鸡被限饲70%(30%自由采食)7d,然后自由采食3d。对照组自由采食10d。对胰腺中糜蛋白酶、胰蛋白酶、淀粉酶、脂肪酶活性和小肠中蔗糖酶、麦芽糖酶的活性进行分析,并且测量了腺胃、肌胃、小肠和大肠的重量。在14d,与对照组相比,限饲组的胰蛋白酶、淀粉酶活性均降低,但在42d,与对照组相比,限饲组蔗糖酶活性降低,表明限饲对酶活性的影响与日龄有关。限饲可以降低完成期(42d)各器官的重量。日龄35~42d的鸡,在再投喂后,器官重量增加,并且达到与对照组一致。在起始期(14d),腺胃和肌胃受限饲的影响很小,在完成期,肌胃也是受影响最小的器官,而小肠时受影响最严重。限饲的所有影响在恢复饲喂3d后被逆转,表明这种改变时快速且可逆的,并且限饲和再投喂与年龄有关。 | Cristiane R A Duarte Maria L M Vicentini P Pinheiro D F | 2014 | 饲料博览2014，0，10： | 1 |
| 6 | Ankyrin Repeatcontaining Proteins in Arabidopsis: Characterization of a Novel and Abundant Group of Genes Coding Ankyrin-transmembrane Proteins 显示文摘 | CRISTIAN B TORBEN J PERE P | 2004 | Gene2004，340，： | 1 |
| 7 | Environmental and anthropogenic risk factors for highly pathogenic avian influenza subtype HSN1 outbreaks in Romania: 2005-2006 显示文摘 | Michael P Ward Daniel Maftei Cristian Apostu | 2008 | Veterinary ResearchCommunications2008，32，： | 1 |
| 8 | Dehydrated halloysite intercalated mechanochemically with urea: thermal behavior and structural aspects 显示文摘 | Keller P N Cristiane R B F Fernando W | 2009 | Journal of Colloid and Interface Science2009，338，： | 1 |
| 9 | Damage contlol:extremities显示文摘 | Giannoudis P Cristian K | 2004 | Injury2004，35，7： | 1 |
| 10 | Peroxide bleaching agent effects on enamel surface microhardness,roughness and morphology显示文摘 | Cristiane F P de Oliveira R Vanessa C | 2004 | Braz Oral Res2004，18，4： | 1 |
| 11 | Color and COD retention by nanofiltration membranes显示文摘 | CRISTIANE N L JOSE C C P HUMBERTO G R | 2005 | Desalination2005，172，： | 1 |
| 12 | Surface complexation modeling of phosphate adsorption by water treatment residual显示文摘 | Michael A B Domenico G Cristian P | 1998 | Journal of Environmental Quality1998，27，： | 1 |
| 13 | Enhancing Titanium Stability in Fusayama Saliva Using Electrochemical Elaboration of TiO2 Nanotubes显示文摘 | Isabela M Cristian P Dcmetrescu I | 2008 | Rev Chim2008，59，6： | 1 |
| 14 | TNT detection using a voltammetrie electronic tongue based on neural networks 显示文摘 | Eduardo G B Cristian O P Rafael M P | 2013 | Sensors and Actuators A2013，192，： | 1 |
| 15 | Melanocortin 1 receptor is expressed by uveal malignant melanoma and can be considered a new target for diagnosis and immunotherapy 显示文摘 | MERCEDES N L CRISTIAN P MARCOS R | 2007 | Invest Ophthalmol- VisSci2007，48，3： | 1 |
| 16 | Effect of di-(2-ethylhexyl) phthalate on N-cadherin and catenin protein expression in rat testis 显示文摘 | Cristian M S Livia L Roberto P | 2006 | Reproductive Toxicology2006，22，1： | 1 |
| 17 | Effect of differentcooking methods on the oxidation,proximate and fatty acid composi-tion of silver catfish fillets显示文摘 | JUCIELI W VIVIAN C B CRISTIANE P R | 2008 | Food Chemistry2008，106，1： | 1 |
| 18 | Synthesis of Nanometric Zirconia Powders by Hydrothermal Reactions of Zr(IV) Peroxide Precuesors显示文摘 | Radu R P Cristian B Tudor S | 2000 | Int J Mater Product Tech2000，15，35： | 1 |
| 19 | Mechanical and thermal properties of multiwalled carbon nanotube- polypropylene composites using itaconic acid as compatibilizer and coupling agent显示文摘 | Mehrdad Y P Cristian M Patricio T | 2013 | Macromolecular Research2013，21，2： | 1 |
| 20 | Measles virus V protein inhibits p53 family member p73显示文摘 | Cristian D C Palosaari H Parisien J P | 2008 | Virology2008，80，11： | 1 |
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