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| 1 | Resveratrol attenuates metabolic,sperm,and testicular changes in adult Wistar rats fed a diet rich in lipids and simple carbohydrates显示文摘High-fat diets affect male reproduction and sexual function.Therefore,we evaluated the effects of prolonged resveratrol administration on the metabolic,sperm,and testicular parameters of rats fed a cafeteria diet.Male Wistar rats were divided at weaning into control(Cv n=20)and cafeteria(CAF,n=16)groups.At 3 months,half of them were given daily supplementations of resveratrol(C-R,n=10;CAF-R,n=8)at a dosage of 30 mg kg-1 body mass for 2 months.Animals were killed at 5 months of age,and blood,spermatozoa,and testes were collected for further analysis.Data were analyzed by one-way ANOVA,and P<0.05 was considered statistically significant.The CAF diet promoted hyperglycemia(P<0.0001),and treatment with resveratrol reversed this condition(P<0.0001).The CAF diet reduced sperm viability and motility,while resveratrol improved these parameters(F<0.05).Regarding testicular morphology,the height of the seminiferous epithelium was reduced in the CAF group compared with that of the C group(P=0.0007).Spermatogenic cell proliferation was also reduced in the CAF group compared with that of the C group.However,the CAF-R showed an increase in cell proliferation rate compared with that of the untreated CAF group(P=0.0024).Although it did not modify body mass,the consumption of a CAF diet promoted hyperglycemia,adverse testicular morphology remodeling,and abnormal sperm,which were attenuated by treatment with resveratrol,thus suggesting a protective effect of this antioxidant on spermatogenesis. | Fabiana A de Oliveira Waldemar S Costa Francisco J B Sampaio Bianca M Gregorio | 2019 | Asian Journal of Andrology2019，21，2： | 2 |
| 2 | Development of hepatorenal syndrome in bile duct ligated rats显示文摘AIM: To evaluate in bile duct ligated rats whether there were progressive alterations of renal function without changes in histopathology. METHODS: Male Wistar rats were submitted to sham-surgery or bile duct ligation (BDL) and divided according to the post-procedure time (2, 4 and 6-wk). To determine renal function parameters, rats wereplaced in metabolic cages and, at the end of the experiment, blood and urine samples were obtained. Histology and hydroxyproline content were analyzed in liver and renal tissue. RESULTS: Rats with 2 wk of BDL increased free water clearance (P = 0.02), reduced urinary osmolality (P = 0.03) and serum creatinine (P = 0.01) in comparison to the sham group. In contrast, rats at 6 wk of BDL showed features of HRS, including signif icant increase in serum creatinine and reductions in creatinine clearance, water excretion and urinary sodium concentration. Rats with 4 wk of BDL exhibited an intermediate stage of renal dysfunction. Progressive hepatic f ibrosis according to post-procedure time was confirmed by histology. The increased levels of liver hydroxyproline contrasted with the absence of structural changes in the kidney, as assessed by histology and unchanged hydroxyproline content in renal tissue. CONCLUSION: Our data show that BDL produced progressive renal dysfunction without structural changes in the kidney, characterizing HRS. The present model will be useful to understand the pathophysiology of HRS. | Regina M Pereira Robson AS dos Santos Eduardo A Oliveira Virgínia HR Leite Filipi LC Dias Alysson S Rezende Lincoln P Costa Lucíola S Barcelos Mauro M Teixeira Ana Cristina Sim■es e Silva | 2008 | World Journal of Gastroenterology2008，14，28： | 2 |
| 3 | Case-control study on infant mortality in southern Brazil 显示文摘 | Karina G M Maria T A O Costa J S D | 2006 | Revista de saude publica2006，40，2： | 1 |
| 4 | Study of catalyst deactivation and reaction mechanism of steam reforming,partial oxidation,and oxidative steam reforming of ethanol over Co/CeO2 catalyst显示文摘 | de Lima S M da Silva A M da Costa L O O | 2009 | J Catal2009，268，2： | 1 |
| 5 | Can the integration\sof multiple biomarkers and sediment geochemistry aidsolving the complexity of sediment risk assessment?Acase study with a benthic fish显示文摘 | Costa P M Caeiro S Vale C | 2012 | Environmental Pollution2012，161，0： | 1 |
| 6 | Trends in the analytical methods for the determinationof trans fatty acids content in foods显示文摘 | ALBUQUERQUE T G COSTA H S CASTILHO M C | 2011 | Trends in Food Scienceand Technology2011，22，11： | 1 |
| 7 | Characterization in vitro and in vivo of the putative multigene 4-coumarate:Co A ligase network in Arabidopsis;syringyl lignin and sinapate/sinapyl alcohol derivative formation显示文摘 | COSTA M A BEDGAR D L MOINUDDIN S G | 2005 | Phytochemistry2005，66，17： | 1 |
| 8 | Ampicillin/sulbactam compared with polymyxins for the treatment of infections caused by carbapenem-resistant Acinetobacter spp显示文摘 | Oliveira M S Prado G V Costa S F | 2008 | J Antimicrob Chemother2008，61，： | 1 |
| 9 | FTIR and DSC studies of mechanically deformed β-PVDF films 显示文摘 | Lanceros-Mendez S Mano J F Costa A M | 2001 | J Macromol Sci Phys2001，1340，34： | 1 |
| 10 | DNA vaccines against dengue virus based on the nsl gene: the influence of different signal sequences on the protein expression and its correlation to the immune response elicited in mice显示文摘 | Costa S M Azevedo A S Paes M V | 2007 | Virology2007，358，： | 1 |
| 11 | Transcription and temporal cascade in Chilo iridescent virus infected cells 显示文摘 | D'Costa S M Yao H Bilimoria S L | 2001 | Arch Viro2001，146，11： | 1 |
| 12 | Bactericidal synergism through bacteriocins and high pressure in a meat model system duringstorage显示文摘 | Garriga M Aymerich M T Costa S | 2002 | Food microbiology2002，19，5： | 1 |
| 13 | Transcription and temporal cascade in Chilo iridescent virus infected ceils 显示文摘 | D'COSTA S M YAO H BILIMORIA S L | 2001 | Archives of Virology2001，146，11： | 1 |
| 14 | Brown pigment of the nanopowder spinel ferrite prepared by combustion reaction显示文摘 | COSTA A C F M LEITE A M D FERREIRA H S | | 0，，： | 1 |
| 15 | Experimental and computational study alifted,lion-premixed turbulent free jet flame显示文摘 | T Mahmud S K Sangha M Costa eta 1 | | 0，，： | 1 |
| 16 | Chi- tosan/carrageenan nanopartictes: Effect of cross-link- ing with tripolyphosphate and charge ratios 显示文摘 | RODRIGUES S COSTA A M GRENHAA A | 2012 | Car- bohydrate Polymers2012，89，： | 1 |
| 17 | A new and fast tech- nique to generate offspring after germ ceils transplantation in adult fish:the Nile tilapia (Oreochromis niloticus) model显示文摘 | Lacerda S M Batlouni S R Costa G M | 2010 | PLoS One2010，5，10： | 1 |
| 18 | DNA vaccine against the non-structural 1 protein ( NS1 ) of dengue 2 virus显示文摘 | Costa S M Freire M S Alves A M | 2006 | Vaccine2006，24，： | 1 |
| 19 | Registered and enrolled nurses'experiences of ethical issue in nursing practice显示文摘 | Johnston M J Costa CD Turale S | 2004 | Australian Journal of Advanced Nursing2004，22，1： | 1 |
| 20 | Correlation between the surface properties and deNOx activity of ceria-zirconia catalysts显示文摘 | ADAMOWSKA M MULLER S COSTA P D KRZTON A BURG P | 2007 | Applied Catalysis B: Environmental2007，74，34： | 1 |
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