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| 1 | Immunological roulette: Luck or something more? Considering the connections between host and environment in TB显示文摘Accurate prediction of which patient will progress from a sub-clinical Mycobacterium tuberculosis infection to active tuberculosis represents an elusive,yet critical,clinical research objective.From the individual perspective,progression can be considered to be the product of a series of unfortunate events or even a run of bad luck.Here,we identify the subtle physiological relationships that can influence the odds of progression to active TB and how this progression may reflect directed dysbiosis in a number of interrelated systems.Most infected individuals who progress to disease have apparently good immune responses,but these responses are,at times,compromised by either local or systemic environmental factors.Obvious disease promoting processes,such as tissue-damaging granulomata,usually manifest in the lung,but illness is systemic.This apparent dichotomy between local and systemic reflects a clear need to define the factors that promote progression to active disease within the context of the body as a physiological whole.We discuss aspects of the host environment that can impact expression of immunity,including the microbiome,glucocorticoid-mediated regulation,catecholamines and interaction between the gut,liver and lung.We suggest the importance of integrating precision medicine into our analyses of experimental outcomes such that apparently conflicting results are not contentious,but rather reflect the impact of these subtle relationships with our environment and microbiota. | John E Pearl Mrinal Das Andrea M Cooper | 2018 | Cellular & Molecular Immunology2018，15，3： | 3 |
| 2 | Inflammation and Alzheimer’s disease显示文摘 | Haruhiko Akiyama Steven Barger Scott Barnum Bonnie Bradt Joachim Bauer Greg M Cole Neil R Cooper Piet Eikelenboom Mark Emmerling Berndt L Fiebich Caleb E Finch Sally Frautschy W.S.T Griffin Harald Hampel Michael Hull Gary Landreth Lih–Fen Lue Robert Mrak | 2000 | Neurobiology of Aging2000，，3： | 2 |
| 3 | Use of genetic mouse models in the study of diabetic nephropathy显示文摘 | Allen T J Cooper M E Lan H Y | 2004 | Curr Diab Rep2004，4，6： | 1 |
| 4 | Copolymeriza tion of CO2 and 1, 2-Cyclohexene Oxide Using a CO2- soluble Chromium Porphyrin Catalyst 显示文摘 | Mang S Cooper A I Colelough M E | 2000 | Macromolecules2000，33，2： | 1 |
| 5 | Improving drought tolerance in maize: a view from industry显示文摘 | Campes H Cooper M Habben J E | 2004 | Field Crop Research2004，90，： | 1 |
| 6 | Denitrification in arable soils in relation to their physico-chemical properties and fertilization practice显示文摘 | SIMEK M COOPER J E Picek T | 2000 | Soil Biology & Biochemistry2000，32，： | 1 |
| 7 | A parametric study of droplet deformation through a microfluidic contraction: Low viscosity Newtonian droplets 显示文摘 | HARVIE D J E DAVIDSON M R COOPER WHITE J J | 2006 | Chemical Engineering Science2006，61，51： | 1 |
| 8 | DEA and its Uses in Different Countries 显示文摘 | Cooper W W Seiford L M Thanassoulis E | 2004 | European Journal of Operational Research2004，154，2： | 1 |
| 9 | Population-based study of survival after osteoporotic fractures显示文摘 | Cooper C Atkinson E J O'Fallon W M | 1993 | Am J Epidemiol1993，137，： | 1 |
| 10 | Chelate-assisted Phytoextraction of Lead from Contaminated Soils显示文摘 | Cooper E M Sims J T Cumningham S D | 1999 | Environ Qual1999，28，： | 1 |
| 11 | Bulk power system restoration training teniques显示文摘 | COOPER M E ADIBI M M | 1993 | IEEE Trans on Power Systems1993，8，1： | 1 |
| 12 | Environmenntal endoctrine disruption:An effects assessment and analysis 显示文摘 | Crisp T M Clegg E D Cooper R L | 1998 | Environ Health perspec1998，106，： | 1 |
| 13 | Use of Bar-tonella antigens for serologic diagnosis of cat-scratchdisease at a national referral center 显示文摘 | Dalton M J Robinson L E Cooper J | 1995 | Arch InternMed1995，155，15： | 1 |
| 14 | Advanced glycation end-products induce vascular dysfunction via resistance to nitric oxide and suppression of endothelial nitric oxide synthase显示文摘 | Aino Soro-Paavonen Wei-Zeng Zhang Kylie Venardos Melinda T Coughlan Emma Harris David CK Tong Daniella Brasacchio Karri Paavonen Jaye Chin-Dusting Mark E Cooper David Kaye Merlin C Thomas Josephine M Forbes | 2010 | Journal of Hypertension2010，，4： | 1 |
| 15 | Ponicidin and oridonin are responsible for the antiangiogenic activity of Rabdosia rubescens, a constituent of the herbal supplement PC SPES显示文摘 | Meade Tollin L C Wijeratne E M Cooper D | 2004 | J Nat Prod2004，67，1： | 1 |
| 16 | Neural systems underlying the suppression of unwanted memories 显示文摘 | Anderson M C Ochsner K N Kuhl B Cooper J Robertson E Gabrieli S W Glover G H Gabrieli J | 2004 | Sci- ence2004，303，： | 1 |
| 17 | The Happy Personality: A Meta-- Analysis of 137 Personality and W ell--being显示文摘 | DeNeve E M Cooper H | 1998 | Psychology Bulletin1998，124，2： | 1 |
| 18 | Renal microvascu- lar injury in diabetes:RAGE and redox signaling 显示文摘 | COUGHLAN M T COOPER M E FORBES J M | 2007 | Antioxid Red- ox Signal2007，9，3： | 1 |
| 19 | Clinical review:the role of advanced glycation end products in progression and complications of diabetes显示文摘 | GOH S Y COOPER M E | 2008 | J Clin Endocrinol Metab2008，93，： | 1 |
| 20 | An analytical model for the impulse of a single-cycle pulse detonation engine 显示文摘 | Witenberger E Austin J Cooper M | 2003 | Journal of Propulsion and Power2003，19，1： | 1 |
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