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| 1 | Procedural complexity independent of P2Y12 reaction unit(PRU)values is associated with acute in situ thrombosis in Pipeline flow diversion of cerebral aneurysms显示文摘background Acute in situ thrombosis is an ischaemic phenomenon during Pipeline embolisation device(PED)procedures with potentially high morbidity and mortality.There is controversy regarding the role of platelet function testing with P2Y12 assay as a predictor of intraprocedural thromboembolic events.There is limited knowledge on whether procedural complexity influences these events.Methods Data were collected retrospectively on 742 consecutive PED cases at a single institution.Patients with intraprocedural acute thrombosis were compared with patients without these events.results A cohort of 37 PED cases with acute in situ thrombosis(mean age 53.8 years,mean aneurysm size 8.4 mm)was matched with a cohort of 705 PED cases without intraprocedural thromboembolic events(mean age 56.4 years,mean aneurysm size 6.9 mm).All patients with in situ thrombosis received intra-arterial and/or intravenous abciximab.The two groups were evenly matched in patient demographics,previous treatment/subarachnoid hemorrhage(SAH)and aneurysm location.There was no statistical difference in postprocedural P2Y12 reaction unit(PRU)values between the two groups,with a mean of 156 in the in situ thrombosis group vs 148 in the control group(p=0.5894).Presence of cervical carotid tortuosity,high cavernous internal carotid artery grade,need for multiple PED and vasospasm were not significantly different between the two groups.The in situ thrombosis group had statistically significant longer fluoroscopy time(60.4 vs 38.4 min,p<0.0001),higher radiation exposure(3476 vs 2160 mGy,p<0.0001),higher rates of adjunctive coiling(24.3% vs 8.37%,p=0.0010)and higher utilisation of balloon angioplasty(37.8% vs 12.2%,p<0.0001).Clinically,the in situ thrombosis cohort had higher incidence of major and minor stroke,intracerebral haemorrhage and length of stay.Conclusions Predictors of procedural complexity(higher radiation exposure,longer fluoroscopy time,adjunctive coiling and need for balloon angioplasty)are associated with acute thrombotic events during PED placement,independent of PRU values. | Bowen Jiang Matthew T Bender Erick M Westbroek Jessica K Campos Li-Mei Lin Risheng Xu Rafael J Tamargo Judy Huang Geoffrey P Colby Alexander L Coon | 2018 | Stroke & Vascular Neurology2018，3，3： | 2 |
| 2 | A high- density whole-genome association study reveals that APOE is the major susceptibility gene for sporadic late-onset Alzheimer's disease 显示文摘 | Coon K D Myers A J Craig D W | 2007 | J Clin Psychiatry2007，68，4： | 1 |
| 3 | Optimal training sequences for channel estimation in cyclic-prefix-based single-carrier systems with transmit diversity显示文摘 | Coon J Beach M McGeehan J | 2004 | IEEE Signal Processing Letters2004，11，9： | 1 |
| 4 | Evidence for linkage on chromosome 3q25-27 in a large autism extended pedigree 显示文摘 | Coon H Matsunami N Stevens J | 2005 | Hum Hered2005，60，4： | 1 |
| 5 | Analysis of chromosome 22markers in nine schizophrenia pedigrees 显示文摘 | Coon H Holik J Hoff M | 1994 | Am J Med Genet1994，54，1： | 1 |
| 6 | Prognostic implications of loss of heterozygosity at 8p21 and9p2l in head and neck squamous cell carcinoma 显示文摘 | Coon SW Savera AT Zarbo R J | 2004 | Int J Cancer2004，111，： | 1 |
| 7 | A microstructure investigation of the origin of brittle behavior in the transverse direction in Mo-based alloy bars 显示文摘 | Wadsworth J Packer C M Chewey P M Coons W C | 1984 | Metallurgical Transactions A1984，15，9： | 1 |
| 8 | Assessing the work environment for creativity 显示文摘 | Amabile T M Conti R Coon H Lazenby J Herron M | 1996 | Academy of Management Journal1996，39，5： | 1 |
| 9 | The use of varying levels of pepsin for pepsin digestion studies with animal protein显示文摘 | Johnson J Coon C N | 1979 | Poultry Science1979，58，： | 1 |
| 10 | Risks to the superior gluteal neurovascular bundle during percutaneous iliosacral screw insertion: an anatomical cadaver study显示文摘 | Collinge C Coons D Aschenbrenner J | 2005 | J Orthop Trauma2005，19，2： | 1 |
| 11 | Cytochrome P450 显示文摘 | Porter T D Coon M J | 2004 | J Biol Chem2004，266，13： | 1 |
| 12 | Effect of oligosaccharide additions on nitrogen-corrected true metabolizable energy of soy protein concentrate显示文摘 | Leske K L Jevne C J Coon C N | 1993 | Pouh Sci1993，72，2： | 1 |
| 13 | A high- density whole-genome association study reveals that APOE is the major Susceptibility gene for sporadic late-onset Alzheimer's disease 显示文摘 | Coon K D Myers A J Craig D W | 2007 | J Clin Psychiatry2007，68，4： | 1 |
| 14 | A Bayesian analysis of the compression set and stress-strain behavior in a thermally aged silicone foam 显示文摘 | Coons J E McKay M D Hamada M S | 2006 | Polymer Degradation and Stability2006，91，： | 1 |
| 15 | A comparison of four methods for determining available lysine in animal protein meals显示文摘 | Nordheim J P Coon C N | 1984 | Poult Sci1984，63，： | 1 |
| 16 | Adaptive frequency-domain equalization for single-carrier multipleinput multiple-output wireless transmissions 显示文摘 | Coon J Armour S Beach M and Geehan J M | 2005 | IEEE Transactions on Signal Processing2005，53，8： | 1 |
| 17 | Assessing the Work Environment for Creativity 显示文摘 | Amabile TM Conti R Coon H Lazenby J Herron M | 1996 | Academy of Management Journal1996，139，5： | 1 |
| 18 | Peptide and protein sequence analysis by electron transfer dissociation mass spectrometry显示文摘 | SYKA J E COON J J SCHROEDER M J | 2004 | Proc Natl Acad Sci U S A2004，101，26： | 1 |
| 19 | Assessing the Work Environment for Creativity 显示文摘 | Amabile T Conti R Coon H Lazenby J Herron M | 1996 | The Academy of Management Journal1996，39，5： | 1 |
| 20 | Estimate octane numbers using an enhanced method显示文摘 | TWU C H COON J E | 1997 | Hydrocarbon Processing1997，3，： | 1 |
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