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| 1 | Computed tomography-guided percutaneous core needle biopsy in pancreatic tumor diagnosis显示文摘AIM: To evaluate the techniques, results, and complications related to computed tomography(CT)-guided percutaneous core needle biopsies of solid pancreatic lesions.METHODS: CT-guided percutaneous biopsies of solid pancreatic lesions performed at a cancer reference center between January 2012 and September 2013 were retrospectively analyzed. Biopsy material was collected with a 16-20 G Tru-Core needle(10-15 cm; Angiotech, Vancouver, CA) using a coaxial system and automatic biopsy gun. When direct access to the lesion was not possible, indirect(transgastric or transhepatic) access or hydrodissection and/or pneumodissection maneuvers were used. Characteristics of the patients, lesions, procedures, and histologic results were recorded using a standardized form. RESULTS: A total of 103 procedures included in the study were performed on patients with a mean age of 64.8 year(range: 39-94 year). The mean size of the pancreatic lesions was 45.5 mm(range: 15-195 mm). Most(75/103, 72.8%) procedures were performed via direct access, though hydrodissection and/or pneumodissection were used in 22.2%(23/103) of cases and indirect transhepatic or transgastric access was used in 4.8%(5/103) of cases. Histologic analysis was performed on all biopsies, and diagnoses were conclusive in 98.1%(101/103) of cases, confirming3.9%(4/103) of tumors were benign and 94.2%(97/103) were malignant; results were atypical in 1.9%(2/103) of cases, requiring a repeat biopsy to diagnose a neuroendocrine tumor, and surgical resection to confirm a primary adenocarcinoma. Only mild/moderate complications were observed in 9/103 patients(8.7%),and they were more commonly associated with biopsies of lesions located in the head/uncinate process(n =8), than of those located in the body/tail(n = 1) of the pancreas, but this difference was not significant.CONCLUSION: CT-guided biopsy of a pancreatic lesion is a safe procedure with a high success rate, and is an excellent option for minimally invasive diagnosis. | Chiang J Tyng Maria Fernanda A Almeida Paula NV Barbosa Almir GV Bitencourt José Augusto AG Berg Macello S Maciel Felipe JF Coimbra Luiz Henrique O Schiavon Maria Dirlei Begnami Marcos D Guimares Charles E Zurstrassen Rubens Chojniak | 2015 | World Journal of Gastroenterology2015，21，12： | 14 |
| 2 | Hepatic abscess induced by foreign body:Case report and literature review显示文摘Hepatic abscess due to perforation of the gastrointestinal tract caused by ingested foreign bodies is uncommon. Pre-operative diagnosis is difficult as patients are often unaware of the foreign body ingestion and symptoms and imagiology are usually non-specific. The authors report a case of 62-year-old woman who was admitted with fever and abdominal pain. Further investigation revealed hepatic abscess, without resolution despite antibiotic therapy. A liver abscess resulting from perforation and intra-hepatic migration of a bone coming from the pilorum was diagnosed by surgery. The literature concerning foreign body-induced perforation of the gastrointestinal tract complicated by liver abscess is reviewed. | Sofia A Santos Sara CF Alberto Elsa Cruz Eduardo Pires Tomás Figueira lia Coimbra José Estevez Mário Oliveira Luís Novais Joo R Deus | 2007 | World Journal of Gastroenterology2007，13，9： | 10 |
| 3 | Carcinoid tumor of the appendix: A consecutive series from 1237 appendectomies显示文摘AIM: To report the experience of the CHU Sart Tilman, University of Liège, Belgium, in the management of appendiceal carinoid tumor. METHODS: A retrospective review of 1237 appendecto- mies performed in one single centre from January 2000 to May 2004, was undertaken. Analysis of demographic data, clinical presentation, histopathology, operative re- ports and outcome was presented. RESULTS: Among the 1237 appendectomies, 5 appen- diceal carcinoid tumors were identified (0.4%) in 4 male and 1 female patients, with a mean age of 29.2 years (range: 6-82 years). Acute appendicitis was the clinical presentation for all patients. Four patients underwent open appendectomy and one a laparoscopic procedure. One patient was reoperated to complete the excision of mesoappendix. All tumors were located at the tip of the appendix with a mean diameter of 0.6 cm (range: 0.3-1.0 cm). No adjuvant therapy was performed. All patients were alive and disease-free during a mean follow-up of 33 mo. CONCLUSION: Appendiceal carcinoid tumor most of- ten presents as appendicitis. In most cases, it is found incidentally during appendectomies and its diagnosis is rarely suspected before histological examination. Appen- diceal carcinoid tumor can be managed by simple appen- dectomy and resection of the mesoappendix, if its size is ≤ 1 cm. | Vincent Tchana-Sato Olivier Detry Marc Polus Albert Thiry Bernard Detroz Sylvie Maweja Etienne Hamoir Thierry Defechereux Carla Coimbra Arnaud De Roover Michel Meurisse Pierre Honoré | 2006 | World Journal of Gastroenterology2006，12，41： | 8 |
| 4 | Targeting α-7 Nicotinic Acetylcholine Receptor in the Enteric Nervous System显示文摘 | Todd W. Costantini Michael Krzyzaniak Gerald A. Cheadle James G. Putnam Ann-Marie Hageny Nicole Lopez Brian P. Eliceiri Vishal Bansal Raul Coimbra | 2012 | The American Journal of Pathology2012，，2： | 2 |
| 5 | Efferent Vagal Nerve Stimulation Attenuates Gut Barrier Injury After Burn: Modulation of Intestinal Occludin Expression显示文摘 | Todd W. Costantini Vishal Bansal Carrie Y. Peterson William H. Loomis James G. Putnam Fermin Rankin Paul Wolf Brian P. Eliceiri Andrew Baird Raul Coimbra | 2010 | The Journal of Trauma: Injury Infection and Critical Care2010，，6： | 1 |
| 6 | Soil Structure evaluated by gamma-ray attenuation显示文摘 | Oliveira J C M Appoloni C R Coimbra M M | 1998 | Soil & Tillage Research1998，48，： | 1 |
| 7 | 3 - D numerical model for predicting NOx emissions from and industrial pulverized coal combustor显示文摘 | Coimbra C F M Azevedo J L T Carralho M G | 1994 | Fuel1994，73，： | 1 |
| 8 | Early events leading to renal injury in obese zucker(fatty) rats with type Ⅱ diabetes显示文摘 | Coimbra TM Janssen U Grone HJ | 2000 | Kidney Int2000，57，1： | 1 |
| 9 | Thermoeffector neuronal pathways in fever:a study in rats showing a new role of the locus coeruleus显示文摘 | Almeida MC Steiner AA Coimbra NC | 2004 | Journal of Physiology2004，558，： | 1 |
| 10 | Anxiogenic effect of median raphe nucleus lesion in stressed rats显示文摘 | Netto SM Silveira R Coimbra NC | 2002 | Prog Neuropsychopharmacol Biol Psychiatry2002，26，： | 1 |
| 11 | The roles of cells and cytokines in the pathogenesis of psoriasis 显示文摘 | Coimbra S Figueiredo A Castro E | 2012 | Int J Dermatol2012，51，4： | 1 |
| 12 | Patientcontrolled sedation using propofol for dressing changes in burn patients: a dose-finding study显示文摘 | Coimbra C Choinie M Thomas M | 2003 | Anesth-Analg2003，97，3： | 1 |
| 13 | Effects of phosphodiesterase inhibition on the inflammatory response following shock:role of pentoxifylline显示文摘 | Coimbra R Melbostad H Hoyt D B | 2004 | J Trauma2004，56，2： | 1 |
| 14 | Resveratrol attenuates cisplatin-induced nephrotoxicity in rats显示文摘 | do AMARAL C L FRANCESCATO H D C COIMBRA T M | 2008 | Archives of Toxicology2008，82，6： | 1 |
| 15 | Intra-hour DNI forecasting based on cloud tracking image analysis显示文摘 | Marquez R Coimbra C F M | 2013 | Solar Energy2013，91，： | 1 |
| 16 | Arabinosyl and glucosyl residues as structural features of acetylated galactomannans from green and roasted coffee infusions 显示文摘 | Nunes F M Domingues M R Coimbra M A | 2005 | Carbohydrate Research2005，，10： | 1 |
| 17 | Protective effect of quercetin on the evolution of cisplatin-induced acute tubular necrosis显示文摘 | FRANCESCATO H D C COIMBRA T M COSTA R S | 2004 | Kidney and Blood Pressure Research2004，27，3： | 1 |
| 18 | A genetic linkage map of the Japanese flounder, Paralichthys olivaceus 显示文摘 | Coimbra M R M Kobayashi K Koret sugu S | 2003 | Aquaculture2003，220，： | 1 |
| 19 | Role of hypertonic saline and pentoxifylline(HSPTX) on neutrophil activation and TNF-α synthesis:a novel resuscitation stratgy显示文摘 | Coimbra R Loomis W Melbostad H | 2005 | J Trauma2005，59，2： | 1 |
| 20 | The roles of cells and cytokines in the pathogenesis of psoriasis 显示文摘 | Coimbra S Figueiredo A Castro E | 2012 | Int J Der- matol2012，51，4： | 1 |
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