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| 1 | One Stone Four Birds:A Novel Liposomal Delivery System Multi-functionalized with Ginsenoside Rh2 for Tumor Targeting Therapy显示文摘Liposomes hold great potential in anti-cancer drug delivery and the targeting treatment of tumors.However,the clinical therapeutic efficacy of liposomes is still limited by the complexity of tumor microenvironment(TME)and the insufficient accumulation in tumor sites.Meanwhile,the application of cholesterol and polyethylene glycol(PEG),which are usually used to prolong the blood circulation and stabilize the structure of liposomes respectively,has been questioned due to various disadvantages.Herein,we developed a ginsenoside Rh2-based multifunctional liposome system(Rh2-lipo)to effectively address these challenges once for all.Different with the conventional’wooden’liposomes,Rh2-lipo is a much more brilliant carrier with multiple functions.In Rh2-lipo,both cholesterol and PEG were substituted by Rh2,which works as membrane stabilizer,long-circulating stealther,active targeting ligand,and chemotherapy adjuvant at the same time.Firstly,Rh2 could keep the stability of liposomes and avoid the shortcomings caused by cholesterol.Secondly,Rh2-lipo showed a specifically prolonged circulation behavior in the blood.Thirdly,the accumulation of the liposomes in the tumor was significantly enhanced by the interaction of glucose transporter of tumor cells with Rh2.Fourth,Rh2-lipo could remodel the structure and reverse the immunosuppressive environment in TME.When tested in a 4T1 breast carcinoma xenograft model,the paclitaxel-loaded Rh2-lipo realized high efficient tumor growth suppression.Therefore,Rh2-lipo not only innovatively challenges the position of cholesterol as a liposome component,but also provides another innovative potential system with multiple functions for anti-cancer drug delivery. | Chao Hong Jianming Liang Jiaxuan Xia Ying Zhu Yizhen Guo Anni Wang Chunyi Lu Hongwei Ren Chen Chen Shiyi Li Dan Wang Huaxing Zhan Jianxin Wang | 2020 | Nano-Micro Letters2020，12，10： | 8 |
| 2 | The Arabidopsis MutS homolog AtMSH5 is required for normal meiosis显示文摘MSH5,傻瓜相当或相同的事物脱氧核糖核酸失配修理蛋白质家庭的一个成员,被显示了在象老鼠,开始发育的酵母和 Caenorhabditis elegans 那样的多样的有机体为合适的同源染色体再结合被要求。在这篇论文,我们证明带通常认为的破坏 AtMSH5 基因的变异的 Arabidopsis 植物在 meiotic 期间展出缺点,生产不能生存的花粉粒和反常胚囊的一个比例,并且从而导致在富饶的减少。AtMSH5 表示被限制到 meiotic 花发芽,它在成熟分裂期间与一个可能的角色一致。男成熟分裂的 Cytological 分析从 diplotene 揭示了众多的 univalents 的存在到中期我,它在交叉频率与大减小被联系。在异种的剩余 chiasmata 的平均数字每性母细胞被归结为 2.54,它在野生型占约 25% 数量。这里,量的细胞遗传学的分析表明在 Atmsh5 异种的剩余 chiasmata 在 meiocytes 之中是随机分布式的,建议 AtMSH5 有在干扰敏感的交叉形成期间的一个必要角色。总起来说,证据显示 AtMSH5 通过在前期期间便于交叉形成支持相应再结合我在 Arabidopsis。 | Xiaoduo Lu Xiaolin Liu Lizhe An Wei Zhang Jian Sun Huijuan Pei Hongyan Meng Yunliu Fan Chunyi Zhang | 2008 | Cell Research2008，18，5： | 6 |
| 3 | Advanced multiple response surface method of sensitivity analysis for turbine blisk reliability with multi-physics coupling显示文摘To reasonably implement the reliability analysis and describe the significance of influencing parameters for the multi-failure modes of turbine blisk, advanced multiple response surface method(AMRSM) was proposed for multi-failure mode sensitivity analysis for reliability. The mathematical model of AMRSM was established and the basic principle of multi-failure mode sensitivity analysis for reliability with AMRSM was given. The important parameters of turbine blisk failures are obtained by the multi-failure mode sensitivity analysis of turbine blisk. Through the reliability sensitivity analyses of multiple failure modes(deformation, stress and strain) with the proposed method considering fluid–thermal–solid interaction, it is shown that the comprehensive reliability of turbine blisk is 0.9931 when the allowable deformation, stress and strain are3.7*10^(-3)m, 1.0023*10~9 Pa and 1.05*10^(-2)m/m, respectively; the main impact factors of turbine blisk failure are gas velocity, gas temperature and rotational speed. As demonstrated in the comparison of methods(Monte Carlo(MC) method, traditional response surface method(RSM), multiple response surface method(MRSM) and AMRSM), the proposed AMRSM improves computational efficiency with acceptable computational accuracy. The efforts of this study provide the AMRSM with high precision and efficiency for multi-failure mode reliability analysis, and offer a useful insight for the reliability optimization design of multi-failure mode structure. | Zhang Chunyi Song Lukai Fei Chengwei Lu Cheng Xie Yongmei | 2016 | Chinese Journal of Aeronautics2016，29，4： | 4 |
| 4 | Gene-lndexed Mutations in Maize显示文摘 | Xiaoduo Lu Jisheng Liu Wen Ren Qun Yang Zhenguang Chai Rumei Chen Lei Wang Jun Zhao Zhihong Lang Haiyang Wang Yunliu Fan Jiuran Zhao Chunyi Zhang | 2018 | Molecular Plant2018，11，3： | 4 |
| 5 | Chinese expert consensus on conversion therapy for hepatocellular carcinoma(2021 edition)显示文摘Recent advances in systemic and locoregional treatments for patients with unresectable or advanced hepatocellular carcinoma(HCC)have resulted in improved response rates.This has provided an opportunity for selected patients with initially unresectable HCC to achieve adequate tumor downstaging to undergo surgical resection,a‘conversion therapy’strategy.However,conversion therapy is a new approach to the treatment of HCC and its practice and treatment protocols are still being developed.Review the evidence for conversion therapy in HCC and develop consensus statements to guide clinical practice.Evidence review:Many research centers in China have accumulated significant experience implementing HCC conversion therapy.Preliminary findings and data have shown that conversion therapy represents an important strategy to maximize the survival of selected patients with intermediate stage to advanced HCC;however,there are still many urgent clinical and scientific challenges for this therapeutic strategy and its related fields.In order to summarize and learn from past experience and review current challenges,the Chinese Expert Consensus on Conversion Therapy for Hepatocellular Carcinoma(2021 Edition)was developed based on a review of preliminary experience and clinical data from Chinese and non-Chinese studies in this field and combined with recommendations for clinical practice.Sixteen consensus statements on the implementation of conversion therapy for HCC were developed.The statements generated in this review are based on a review of clinical evidence and real clinical experience and will help guide future progress in conversion therapy for patients with HCC. | Hui-Chuan Sun Jian Zhou Zheng Wang Xiufeng Liu Qing Xie Weidong Jia Ming Zhao Xinyu Bi Gong Li Xueli Bai Yuan Ji Li Xu Xiao-Dong Zhu Dousheng Bai Yajin Chen Yongjun Chen Chaoliu Dai Rongping Guo Wenzhi Guo Chunyi Hao Tao Huang Zhiyong Huang Deyu Li Gang Li Tao Li Xiangcheng Li Guangming Li Xiao Liang Jingfeng Liu Fubao Liu Shichun Lu Zheng Lu Weifu Lv Yilei Mao Guoliang Shao Yinghong Shi Tianqiang Song Guang Tan Yunqiang Tang Kaishan Tao Chidan Wan Guangyi Wang Lu Wang Shunxiang Wang Tianfu Wen Baocai Xing Bangde Xiang Sheng Yan Dinghua Yang Guowen Yin Tao Yin Zhenyu Yin Zhengping Yu Bixiang Zhang Jialin Zhang Shuijun Zhang Ti Zhang Yamin Zhang Yubao Zhang Aibin Zhang Haitao Zhao Ledu Zhou Wu Zhang Zhenyu Zhu Shukui Qin Feng Shen Xiujun Cai Gaojun Teng Jianqiang Cai Minshan Chen Qiang Li Lianxin Liu Weilin Wang Tingbo Liang Jiahong Dong Xiaoping Chen Xuehao Wang Shusen Zheng Jia Fan 无 | 2022 | Hepatobiliary Surgery and Nutrition2022，11，2： | 4 |
| 6 | Effects of Cs-substitution and partial reduction on catalytic performance of Keggin-type phosphomolybdic polyoxometalates for selective oxidation of isobutane显示文摘The catalytic performance of Cs-substituted phosphomolybdic salts was studied for selective oxidation of isobutane. The results of activity tests revealed that 360 °C was the optimal reaction temperature. It was demonstrated that oxidizing sites not only took dominating part in the activation of isobutane, but also influenced the product distribution. Besides, appropriate Cs addition led to moderate acidity of catalysts, favoring the selectivity to desired products. Furthermore, to obtain partially reduced catalysts, different calcination atmospheres were investigated and certain proportion of Mo^(5+) produced during calcination was crucial for the redox reaction. The catalyst calcined in N_2 showed the highest yield of MAA(7.0%). Fe-substitution enhanced the activity of catalysts by rapid reoxidation of Mo^(5+). | Shizhe Liu Lu Chen Guowei Wang Jianwei Liu Yanan Gao Chunyi Li Honghong Shan | 2016 | Journal of Energy Chemistry2016，25，1： | 4 |
| 7 | Radial Non-uniformity Index Research on High-density,High-flux CFB Riser with Stratified Injection显示文摘A high-density, high-flux circulating fluidized bed (CFB) riser (100 mm in ID and 10.614 m in height) was applied in a wide range of operating conditions (with solid fluxes up to 400 kg/m2s and superficial gas velocities up to 12 m/s) to examine its radial non-uniformity dynamics. The solids holdup was determined through the use of a fiber-optic probe at 11 axial levels. The results indicated that under all operating conditions, the high superficial gas velocity and low solid fluxes maintained a low radial non-uniformity index (RNI). The high-density/flux CFB riser had several unique characteristics, so that the peak of the radial solids holdup profile occurred at a position with r/R=0.8. The RNI and solids holdup at the cross-sectional position had a good logarithmic relationship at the low-density condition (with a mean solids holdup of <0.2), and the RNI decreased when the mean solids holdup exceeded 0.2. Investigation of the dynamics of stratified injection revealed that the feed ratio had an important effect on Gs and on solids holdup distribution. A novel '<' shaped axial solids holdup profile was found. Gs decreased sharply when the up-flow feed ratio exceeded 0.5, and RNI was lowest when the up-flow feed ratio was 1. | Geng Qiang Wang Lu Li Zhichao Li Chunyi Liu Yibin You Xinghua | 2012 | China Petroleum Processing & Petrochemical Technology2012，14，4： | 3 |
| 8 | Integration of high-throughput phenotyping,GWAS,and predictive models reveals the genetic architecture of plant height in maize显示文摘Plant height(PH)is an essential trait in maize(Zea mays)that is tightly associated with planting density,biomass,lodging resistance,and grain yield in the field.Dissecting the dynamics of maize plant architecture will be beneficial for ideotype-based maize breeding and prediction,as the genetic basis controlling PH in maize remains largely unknown.In this study,we developed an automated high-throughput phenotyping platform(HTP)to systematically and noninvasively quantify 77 image-based traits(i-traits)and 20 field traits(f-traits)for 228 maize inbred lines across all developmental stages.Time-resolved i-traits with novel digital phenotypes and complex correlations with agronomic traits were characterized to reveal the dynamics of maize growth.An i-trait-based genome-wide association study identified 4945 traitassociated SNPs,2603 genetic loci,and 1974 corresponding candidate genes.We found that rapid growth of maize plants occurs mainly at two developmental stages,stage 2(S2)to S3 and S5 to S6,accounting for the final PH indicators.By integrating the PH-association network with the transcriptome profiles of specific internodes,we revealed 13 hub genes that may play vital roles during rapid growth.The candidate genes and novel i-traits identified at multiple growth stages may be used as potential indicators for final PH in maize.One candidate gene,ZmVATE,was functionally validated and shown to regulate PH-related traits in maize using genetic mutation.Furthermore,machine learning was used to build predictive models for final PH based on i-traits,and their performancewas assessed across developmental stages.Moderate,strong,and very strong correlations between predictions and experimental datasets were achieved from the early S4(tenth-leaf)stage.Colletively,our study provides a valuable tool for dissecting the spatiotemporal formation of specific internodes and the genetic architecture of PH,as well as resources and predictive models that are useful for molecular design breeding and predicting maize varieties with ideal plant architectures. | Weixuan Wang Weijun Guo Liang Le Jia Yu Yue Wu Dongwei Li Yifan Wang Huan Wang Xiaoduo Lu Hong Qiao Xiaofeng Gu Jian Tian Chunyi Zhang Li Pu | 2023 | Molecular Plant2023，16，2： | 1 |
| 9 | Feature ranking in rough sets显示文摘 | Hu Keyun Lu Yuchang Shi Chunyi | 2003 | AI communications2003，16，： | 1 |
| 10 | Feature Ranking in Rough Sets显示文摘 | Hu Keyun Lu Yuchang Shi Chunyi | 2003 | AI Communications2003，16，： | 1 |
| 11 | Feature Ranking in Rough Sets显示文摘 | Hu Keyun Lu Yuchang Shi Chunyi | 2003 | AI Communications2003，，16： | 1 |
| 12 | Feature Ranking in Rough Sets 显示文摘 | HU Keyun LU Yunchang SHI Chunyi | 2003 | AI Communications2003，16，： | 1 |
| 13 | Feture Ranking in Rough Sets显示文摘 | Hu Keyun Lu Yuchang Shi Chunyi | 2003 | AI Communications2003，16，： | 1 |
| 14 | Feature ranking in rough sets显示文摘 | Hu Keyun Lu Yuchang Shi Chunyi | 2003 | AI communications2003，，16： | 1 |
| 15 | Feature Ranking in Rough Sets显示文摘 | Hu Keyun Lu Yuchang Shi Chunyi | 2003 | AI Communications2003，16，1： | 1 |
| 16 | Design and performance evaluation of mobile Web services in libraries: A case study of the Oriental Institute of Technology Library显示文摘 | Wang Chunyi Ke Haoren Lu Wenchen | 2012 | Electronic Library2012，30，1： | 1 |
| 17 | Design and per- formance evaluation of mobile web services in libraries : a case study of the Oriental Institute of Technology Library 显示文摘 | WANG Chunyi KE Haoren LU Wenchen | 2012 | Elec- tronic Library2012，，： | 1 |
| 18 | Feature ranking in rough set显示文摘 | ~u Keyun Lu Yuehang Shi Chunyi | 2003 | kI Communications2003，16，1： | 1 |
| 19 | Mycoplasma pneumoniae encephalitis in childhood显示文摘 | Lin Wenchuan Lee Pinglng Lu Chunyi | 2002 | Microbiology Immunology Infection2002，35，： | 1 |
| 20 | Roadmap for rechargeable batteries:present and beyond显示文摘Rechargeable batteries currently hold the largest share of the electrochemical energy storage market,and they play a major role in the sustainable energy transition and industrial decarbonization to respond to global climate change.Due to the increased popularity of consumer electronics and electric vehicles,lithium-ion batteries have quickly become the most successful rechargeable batteries in the past three decades,yet growing demands in diversified application scenarios call for new types of rechargeable batteries.Tremendous efforts are made to developing the next-generation post-Li-ion rechargeable batteries,which include,but are not limited to solid-state batteries,lithium–sulfur batteries,sodium-/potassium-ion batteries,organic batteries,magnesium-/zinc-ion batteries,aqueous batteries and flow batteries.Despite the great achievements,challenges persist in precise understandings about the electrochemical reaction and charge transfer process,and optimal design of key materials and interfaces in a battery.This roadmap tends to provide an overview about the current research progress,key challenges and future prospects of various types of rechargeable batteries.New computational methods for materials development,and characterization techniques will also be discussed as they play an important role in battery research. | Sen Xin Xu Zhang Lin Wang Haijun Yu Xin Chang Yu-Ming Zhao Qinghai Meng Pan Xu Chen-Zi Zhao Jiahang Chen Huichao Lu Xirui Kong Jiulin Wang Kai Chen Gang Huang Xinbo Zhang Yu Su Yao Xiao Shu-Lei Chou Shilin Zhang Zaiping Guo Aobing Du Guanglei Cui Gaojing Yang Qing Zhao Liubing Dong Dong Zhou Feiyu Kang Hu Hong Chunyi Zhi Zhizhang Yuan Xianfeng Li Yifei Mo Yizhou Zhu Dongfang Yu Xincheng Lei Jianxiong Zhao Jiayi Wang Dong Su Yu-Guo Guo Qiang Zhang Jun Chen Li-Jun Wan | 2024 | Science China Chemistry2024，67，1： | 0 |
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