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| 1 | Texture analysis on gadoxetic acid enhanced-MRI for predicting Ki-67 status in hepatocellular carcinoma: A prospective study显示文摘Objective: To investigate the value of whole-lesion texture analysis on preoperative gadoxetic acid enhanced magnetic resonance imaging(MRI) for predicting tumor Ki-67 status after curative resection in patients with hepatocellular carcinoma(HCC).Methods: This study consisted of 89 consecutive patients with surgically confirmed HCC. Texture features were extracted from multiparametric MRI based on whole-lesion regions of interest. The Ki-67 status was immunohistochemical determined and classified into low Ki-67(labeling index ≤15%) and high Ki-67(labeling index >15%) groups. Least absolute shrinkage and selection operator(LASSO) and multivariate logistic regression were applied for generating the texture signature, clinical nomogram and combined nomogram. The discrimination power, calibration and clinical usefulness of the three models were evaluated accordingly. Recurrence-free survival(RFS) rates after curative hepatectomy were also compared between groups.Results: A total of 13 texture features were selected to construct a texture signature for predicting Ki-67 status in HCC patients(C-index: 0.878, 95% confidence interval: 0.791-0.937). After incorporating texture signature to the clinical nomogram which included significant clinical variates(AFP, BCLC-stage, capsule integrity, tumor margin,enhancing capsule), the combined nomogram showed higher discrimination ability(C-index: 0.936 vs. 0.795,P<0.001), good calibration(P>0.05 in Hosmer-Lemeshow test) and higher clinical usefulness by decision curve analysis. RFS rate was significantly lower in the high Ki-67 group compared with the low Ki-67 group after curative surgery(63.27% vs. 85.00%, P<0.05).Conclusions: Texture analysis on gadoxetic acid enhanced MRI can serve as a noninvasive approach to preoperatively predict Ki-67 status of HCC after curative resection. The combination of texture signature and clinical factors demonstrated the potential to further improve the prediction performance. | Zheng Ye Hanyu Jiang Jie Chen Xijiao Liu Yi Wei Chunchao Xia Ting Duan Likun Cao Zhen Zhang Bin Song | 2019 | Chinese Journal of Cancer Research2019，31，5： | 11 |
| 2 | Genome-Wide Analysis of Histone Modifications: H3K4me2, H3K4me3, H3K9ac, and H3K27ac in Oryza sativa L. Japonica显示文摘当以前的研究证明了 histone 修正能由调整基因抄写影响工厂生长和开发时,在这些修正和基因表示之间的关系的知识仍然是有限的。这研究使用了高产量的定序跟随的染色质 immunoprecipitation (ChIP-Seq ) ,到调查四 histone 修正的染色体宽的分发:H3K4 (H3K4me2 和 H3K4me3 ) 和在 Oryza sativa L 的 H3K9 和 H3K27 (H3K9ac 和 H3K27ac ) 的 acylation 的 di 和 trimethylation。装饰用的梨树。由分析出版 DNase-Seq 数据,这研究探索了 DNase 过分敏感(DH ) 沿着米饭染色体的地点。histone 标记主要在通用区域出现了并且在基因的抄写开始地点(TSS ) 附近被充实。这分析证明四 histone 修正和 DH 地点都与活跃抄写被联系。而且,四 histone 修正与答应被用来在米饭基因注解预言失踪的基因的特征的抄本 regionsa 是高度并发的。预言被试验性地证实二的抄写预言了失踪的基因进一步验证。而且,顺序主题分析被构造以便识别 DH 地点和许多通常认为的抄写因素绑定地点。 | Zhou Du Hui Li Qiang Wei Xin Zhao Chunchao Wang Qilin Zhu Xin Yi Wenying Xua X. Shirley Liu Weiwei Jin Zhen Su | 2013 | Molecular Plant2013，6，5： | 8 |
| 3 | Multifunctional dextran micelles as drug delivery carriers and magnetic resonance imaging probes显示文摘Multifunctional nanoparticles combining diagnostic and therapeutic agents into a single platform make cancer theranostics possible and have attracted wide interests in the field. In this study, a multifunctional nanocomposite based on dextran and superparamagnetic iron oxide nanoparticles(SPIO) was prepared for drug delivery and magnetic resonance imaging(MRI). Amphiphilic dextran was synthesized by grafting stearyl acid onto the carbohydrate backbone, and micelle was formed by the resulted amphiphilic dextran with low critical micelle concentration at 1.8 mg L-1. Doxorubicin(DOX) and a cluster of the manganese-doped iron oxide nanoparticles(Mn-SPIO)nanocrystals were then coencapsulated successfully inside the core of dextran micelles, resulting in nanocomposites with diameter at about 100 nm. Cell culture experiments demonstrated the potential of these Mn-SPIO/DOX nanocomposites as an effective multifunctional nanoplatform for the delivery of anticancer drug DOX with a loading content(DLC) of 16 %. Confocal laser scanning microscopyreveals that the Mn-SPIO/DOX had excellent internalization ability against MCF-7/Adr cells after 2-h labeling compared with free DOXáHCl. Under a 3.0-T MRI scanner, Mn-SPIO/DOX nanocomposite-labeled cells in gelatin phantom show much darker images than the control. Their transverse relaxation(T2) rate is also significantly higher than that of the control cells(33.9 versus 2.3 s-1). Our result offers an effective strategy to treat MCF-7/Adr at optimized low dosages with imaging capability. | Bingbing Lin Hongying Su Rongrong Jin Danyang Li Changqiang Wu Xin Jiang Chunchao Xia Qiyong Gong Bin Song Hua Ai | 2015 | Science Bulletin2015，60，14： | 6 |
| 4 | Infl uence of structural parameters on dynamic characteristics and wind-induced buffeting responses of a super-long-span cable-stayed bridge显示文摘A 3D finite element(FE) model for the Sutong cable-stayed bridge(SCB) is established based on ANSYS. The dynamic characteristics of the bridge are analyzed using a subspace iteration method. Based on recorded wind data, the measured spectra expression is presented using the nonlinear least-squares regression method. Turbulent winds at the bridge site are simulated based on the spectral representation method and the FFT technique. The influence of some key structural parameters and measures on the dynamic characteristics of the bridge are investigated. These parameters include dead load intensity, as well as vertical, lateral and torsional stiffness of the steel box girder. In addition, the influence of elastic stiffness of the connection device employed between the towers and the girder on the vibration mode of the steel box girder is investigated. The analysis shows that all of the vertical, lateral and torsional buffeting displacement responses reduce gradually as the dead load intensity increases. The dynamic characteristics and the structural buffeting displacement response of the SCB are only slightly affected by the vertical and torsional stiffness of the steel box girder, and the lateral and torsional buffeting displacement responses reduce gradually as the lateral stiffness increases. These results provide a reference for dynamic analysis and design of super-long-span cable-stayed bridges. | Wang Hao Chen Chunchao Xing Chenxi Li Aiqun | 2014 | Earthquake Engineering and Engineering Vibration2014，13，3： | 5 |
| 5 | The landscape of gene-CDS-haplotype diversity in rice:Properties,population organization,footprints of domestication and breeding,and implications for genetic improvement显示文摘Polymorphisms within gene coding regions represent the most important part of the overall genetic diversity of rice.We characterized the gene-coding sequence-haplotype(gcHap)diversity of 45963 rice genes in 3010 rice accessions.With an average of 226±390 gcHaps per gene in rice populations,rice genes could be classified into three main categories:12865 conserved genes,10254 subspecific differentiating genes,and 22844 remaining genes.We found that 39218 rice genes carry>255179 major gcHaps of potential functional importance.Most(87.5%)of the detected gcHaps were specific to subspecies or populations.The inferred proto-ancestors of local landrace populations reconstructed from conserved predominant(ancient)gcHaps correlated strongly with wild rice accessions from the same geographic regions,supporting a multiorigin(domestication)model of Oryza sativa.Past breeding efforts generally increased the gcHap diversity of modern varieties and'caused significant frequency shifts in predominant gcHaps of 14266 genes due to independent selection in the two subspecies.Low frequencies of“favorable”gcHaps at most known genes related to rice yield in modern varieties suggest huge potential for rice improvement by mining and pyramiding of favorable gcHaps.The gcHap data were demonstrated to have greater power than SNPs for the detection of causal genes that affect complex traits.The rice gcHap diversity dataset generated in this study would facilitate rice basic research and improvement in the future. | Fan Zhang Chunchao Wang Min Li Yanru Cui Yingyao Shi Zhichao Wu Zhiqiang Hu Wensheng Wang Jianlong Xu Zhikang Li | 2021 | Molecular Plant2021，14，5： | 5 |
| 6 | Amphiphilic dextran/magnetite nanocomposites as magnetic resonance imaging probes显示文摘Superparamagnetic iron oxide (SPIO) nanoparticles are effective contrast agents for enhancement of magnetic resonance imaging at the tissue, cellular or even molecular levels. High quality SPIO nanoparticles can be synthesized in the organic phase but need to be transferred into water before any biomedical applications. In this study, amphiphilic poly(ε-caprolactone) grafted dextran (Dex-g-PCL) was used as carriers for particle encapsulation and stabilization in the aqueous phase. Multiple SPIO nanoparticles were self-assembled together with the help of Dex-g-PCL during phase transfer from chloroform to water, and diameters of Dex-g-PCL/SPIO nanocomposites were (64 ± 22) nm through dynamic light scattering measurement. These nanocomposites were superparamagnetic at 300 K with saturated magnetization of 88 emu/g Fe. In the magnetic field of 1.5 T, Dex-g-PCL/SPIO nanocomposites had a T2 relaxivity of 363 Fe mL·mol-1·s-1. This unique nanocomposite brought significant mouse liver contrast with signal intensity changes of -60% at 5 min after intravenous administration. However, uptake of Dex-g-PCL/SPIO nanocomposites in liver reticuloendothelial cells (Kupffer cells) did not immediately happen at shorter time points (<4 h) as verified by histology studies, and it was evident that more iron staining would be located in Kupffer cells 24 h after contrast agent administration. After 24 h and 10 d, the signal intensities (SI) gradually recovered, and SI changes were -44% and -31%, respectively. From our observation, the time window for enhanced-MRI could last at least 12 days and totally recovered after 16 days. This novel sensitive MRI contrast agent may find potential applications in discovering small liver lesions such as early tumor diagnosis. | WANG QiaoYing SU HongYing XIA ChunChao SUN JiaYu LIU Chen WANG ZhiYong GONG QiYong SONG Bin GAO FaBao AI Hua GU ZhongWei | 2009 | Chinese Science Bulletin2009，54，17： | 5 |
| 7 | Near-infrared fluorescent amphiphilic polycation wrapped magnetite nanoparticles as multimodality probes显示文摘Construction of multifunctional/multimodality nanoparticles for cancer diagnosis and therapy has become an attractive area of investigation. In this report, we designed a multimodality nanoprobe for cell labeling, and can be detectable by both magnetic resonance and near infrared (NIR) fluorescence imaging. Multiple hydrophobic superparamagnetic iron oxide (SPIO) nanocrystals are self-assembled into nanocomposites in water phase with the help of partially alkylated hyperbranched polycation, polyethylenimine (PEI), which already conjugated with the indocyanine dye Cy5.5 and can be used for cell imaging under NIR fluorescence imaging. The amphiphilic PEI/SPIO nanocomposites have a strong T 2 relaxivity. The iron uptake process in MCF-7/Adr displays a time dependent behavior. Confocal laser scanning microscopy reveals that the nanoprobes are internalized into the cytoplasm of MCF-7/Adr after 24 h labeling. Both MR and NIR fluorescence imaging showed strong image contrast against unlabeled cells. Under a clinical MRI scanner, labeled cells in gelatin phantom present much darker images than controlled ones. The T2 relaxation rate of the labeled cells is 98.2 s 1 , significantly higher than that of the control ones of 2.3 s 1 . This study provides an important alternative to label MCF-7/Adr at optimized low dosages with high efficiency, and may be useful to label other biologically important cells and track their behaviors in vivo. | WANG Dan SU HongYing LIU yanHong WU ChangQiang XIA ChunChao SUN JiaYu GAO FaBao GONG QiYong SONG Bin AI Hua | 2012 | Chinese Science Bulletin2012，57，31： | 4 |
| 8 | Comparative analysis of metabolite changes in two contrasting rice genotypes in response to low-nitrogen stress显示文摘Identification of metabolites responsible for tolerance to low nitrogen availability(low-N)will aid in the genetic improvement of rice yield under nitrogen deficiency.In this study,a backcross introgression line(G9)and its recurrent parent Shuhui 527(SH527),which show differential responses to low-N stress,were used to identify metabolites associated with lowN tolerance in rice.Differences in metabolite contents in the leaves of G9 and SH527 at three growth stages under low-N stress were assessed by gas chromatography–mass spectrometry.Many metabolites,including amino acids and derivatives,were highly enriched in G9 compared with SH527 under the control condition,suggesting that the two genotypes had basal metabolite differences.Low-N stress induced genotype-specific as well as growth stagedependent metabolite changes.Metabolites induced specifically in G9 that were involved in glycolysis and tricarboxylic acid metabolism were enriched at the tillering and grain filling stages,and metabolites involved in nitrogen and proline metabolism were enriched at the booting stage.Enrichment of pyroglutamate,glutamate,2-oxoglutarate,sorbose,glycerate-2-P,and phosphoenolpyruvic acid in G9 suggests that these metabolites could be involved in low-N stress tolerance.The results presented here provide valuable information for further elucidation of the molecular mechanisms of low-N tolerance in crops. | Xiuqin Zhao Wensheng Wang Ziyan Xie Yongming Gao Chunchao Wang Muhammed Mahbubur Rashid Mohammad Rafiqul Islam Binying Fu Zhikang Li | 2018 | The Crop Journal2018，6，5： | 2 |
| 9 | A soft actor-critic deep reinforcement learning method for multi-timescale coordinated operation of microgrids显示文摘This paper develops a multi-timescale coordinated operation method for microgrids based on modern deep rein-forcement learning.Considering the complementary characteristics of different storage devices,the proposed approach achieves multi-timescale coordination of battery and supercapacitor by introducing a hierarchical two-stage dispatch model.The first stage makes an initial decision irrespective of the uncertainties using the hourly predicted data to minimize the operational cost.For the second stage,it aims to generate corrective actions for the first-stage decisions to compensate for real-time renewable generation fluctuations.The first stage is formulated as a non-convex deterministic optimization problem,while the second stage is modeled as a Markov decision process solved by an entropy-regularized deep reinforcement learning method,i.e.,the Soft Actor-Critic.The Soft Actor-Critic method can efficiently address the exploration-exploitation dilemma and suppress variations.This improves the robustness of decisions.Simulation results demonstrate that different types of energy storage devices can be used at two stages to achieve the multi-timescale coordinated operation.This proves the effectiveness of the proposed method. | Chunchao Hu Zexiang Cai Yanxu Zhang Rudai Yan Yu Cai Bowei Cen | 2022 | Protection and Control of Modern Power Systems2022，7，1： | 2 |
| 10 | A NEW FIXED POINT THEOREM FOR CONE MAPS AND ITS APPLICATIONS显示文摘A new fixed point theorem for cone maps is established, which differs from thefixed point theorems of the type of cone-expansion and cone-compression. Thetheorem is used in nonlinear integral equations and nonlinear Sturm-Liouvilleboundary value problems and some new results are obtained.MR Subject Classification: 47H10, 45G15, | Huang Chunchao (Fuzhou University) | 1998 | Annals of Differential Equations1998，14，3： | 2 |
| 11 | Effect of the particle size of Al2O3 on the properties of filled heat-conductive silicone rubber显示文摘 | Zhou Wenying Qi Shuhua Tu Chunchao | 2007 | Journal of Applied Polymer Science2007，104，2： | 1 |
| 12 | Mechanical Properties of Silica Aerogels Prepared from a Mixture of TEOS and Organo-alkoxysilanes of Type R_1SiX_3显示文摘Silica aerogels were prepared from a mixture of tetraethylorthosilicate and organoalkoxysilanes. The effects of organo-alkoxysilanes on the mechanical properties of the silica aerogels were studied. The flexibility of silica aerogels was significantly improved by incorporation of organo-alkoxysilanes. When MTES and TEOS were combined as precursors of silica areogels, with the increased amount of MTES, the apparent elastic modulus and apparent compressive strength monotonously rose. At the same organoalkoxysilanes to TEOS ratio, the size of alkyl groups of the organo-alkoxysilanes had little effect on the mechanical properties. In series of MTES and TEOS, the lowest elastic modulus of silica skeleton and the highest compressive strength of silica skeleton were observed at MTES to TEOS ratio of around 50:50. At a certain organo-alkoxysilanes to TEOS ratio, the elastic modulus of silica skeleton increased and the compressive strength of silica skeleton decreased with the size increase of the alkyl groups. | 杨海龙 孔祥明 ZHANG Yanrong WU Chunchao CAO Enxiang | 2014 | Journal of Wuhan University of Technology(Materials Science)2014，29，1： | 1 |
| 13 | Transformation of high order linear differential-algebraic systems to first order显示文摘 | Volker Mebrmann Shi Chunchao | 2006 | Numerical Algorithms2006，42，34： | 1 |
| 14 | Transformation of high order linear differential-algebraic systems to first order显示文摘 | Volker Mehrmann Shi Chunchao | 2006 | Numerical Algorithms2006，42，34： | 1 |
| 15 | Identification of quantitative trait loci associated with resistance to Xanthomonas oryzae pv. oryzae pathotypes prevalent in South China显示文摘Bacterial blight(BB), which is caused by Xanthomonas oryzae pv. oryzae(Xoo), is an important rice disease responsible for significant yield losses. In the rice-growing regions of South China where BB outbreaks are common, the resistance of cultivars with BB resistance genes Xa4 and Xa21 has been lost because of rapid changes in the Xoo population structure and virulence. In this study, 421 diverse rice accessions were evaluated regarding their resistance to two Xoo strains, namely GD1358(C5) and IV, which are prevalent pathotypes in South China and overcame the resistance of Xa4 and Xa21, respectively. Using the 4.8 mio filtered SNP dataset, we conducted a genome-wide association study, which identified 13 loci associated with BB resistance, including eight new quantitative trait loci(QTL) and five QTL harboring known BB resistance genes: Xa3/Xa26, xa5, Xa35(t), Xa36(t), Xa40, Xa43(t), and xa44(t). Intriguingly, a steep peak was detected on chromosomes 5 and 11. Six QTL including three new ones, were distributed on chromosome 11, whereas a new QTL q BB5.1 and a known QTL were detected on chromosome 5. Haplotype analyses indicated that the LOC;s05 g01610(Os PRAF2) gene within the q BB5.1 region, which encodes a PRAF protein, is associated with BB resistance. Furthermore, Os PRAF2 knockout lines generated using the CRISPR-Cpf1 system were significantly more resistant to Xoo strains than the wild-type plants. Our results provide researchers and breeders with useful information regarding QTL and gene resources,which may be relevant for developing new BB-resistant rice cultivars. | Jialing Lu Quanlin Li Chunchao Wang Mingming Wang Dan Zeng Fan Zhang Wenxue Zhai Yongli Zhou | 2022 | The Crop Journal2022，10，2： | 1 |
| 16 | Novel heat conductive composite silicone rubber显示文摘 | Qi Shuhua Tu Chunchao | 2007 | J Appl Polym Sci2007，104，4： | 1 |
| 17 | Proteomic analysis of Deinococcus radiodurans recovering from γ-irradiation 显示文摘 | Zhang Chunchao Wei Jianfeng Zheng Zhiguo | 2005 | Proteomics2005，5，： | 1 |
| 18 | Metal oxide nanoparticles as an electron-transport layer in high-performance and stable inverted polymer solar cells 显示文摘 | You Jingbi Chen Chunchao Dou Letian | 2012 | Advanced Materials2012，24，38： | 1 |
| 19 | Available transfer capability enhancement using FACTS devices显示文摘 | Xiao Yang Song Yonghua Liu Chunchao | 2003 | IEEE Trans on Power Systems2003，18，1： | 1 |
| 20 | Revisit bayesian approaches for spam detection显示文摘 | Yeh Chunchao Chiang Sounjan | 2008 | The 9th International Conference for Young Computer Scientists2008，，： | 1 |
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