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| 1 | Sintilimab versus docetaxel as second-line treatment in advanced or metastatic squamous non-small-cell lung cancer:an open-label,randomized controlled phase 3 trial(ORIENT-3)显示文摘Background:Treatment options for Chinese patients with locally advanced or metastatic squamous-cell non-small-cell lung cancer(sqNSCLC)after failure of first-line chemotherapy are limited.This study(ORIENT-3)aimed to evaluate the efficacy and safety of sintilimab versus docetaxel as second-line treatment in patients with locally advanced or metastatic sqNSCLC.Methods:ORIENT-3 was an open-label,multicenter,randomized controlled phase 3 trial that recruited patients with stage IIIB/IIIC/IV sqNSCLC after failure with first-line platinum-based chemotherapy.Patients were randomized in a 1:1 ratio to receive either 200 mg of sintilimab or 75 mg/m^(2) of docetaxel intravenously every 3 weeks,stratified by the Eastern Cooperative Oncology Group performance status.The primary endpoint was overall survival(OS)in the full analysis set(FAS).Secondary endpoints included progression-free survival(PFS),objective response rate(ORR),disease control rate(DCR),duration of response(DoR)and safety.Results:Between August 25,2017,and November 7,2018,290 patients were randomized.For FAS,10 patients fromthe docetaxel armwere excluded.Themedian OS was 11.79(n=145;95%confidence interval[CI],10.28-15.57)months with sintilimab versus 8.25(n=135;95%CI,6.47-9.82)months with docetaxel(hazard ratio[HR]:0.74;95%CI,0.56-0.96;P=0.025).Sintilimab treatment significantly prolonged PFS(median 4.30 vs.2.79 months;HR:0.52;95%CI,0.39-0.68;P<0.001)and showed higher ORR(25.50%vs.2.20%,P<0.001)and DCR(65.50%vs.37.80%,P<0.001)than the docetaxel arm.The median DoRwas 12.45(95%CI,4.86-25.33)months in the sintilimab arm and 4.14(95%CI,1.41-7.23)months in the docetaxel arm(P=0.045).Treatment-related adverse events of grade≥3were reported in 26(18.1%)patients in the sintilimab arm and 47(36.2%)patients in the docetaxel arm.Exploratory biomarker analysis showed potential predictive values of expression levels of two transcription factors,including OVOL2(HR:0.35;P<0.001)and CTCF(HR:3.50;P<0.001),for sintilimab treatment.Conclusions:Compared with docetaxel,sintilimab significantly improved the OS,PFS,and ORR of Chinese patients with previously treated locally advanced or metastatic sqNSCLC. | Yuankai Shi Lin Wu Xinmin Yu Puyuan Xing Yan Wang Jianying Zhou Airong Wang Jianhua Shi Yi Hu Ziping Wang Guangyu An Yong Fang Sanyuan Sun Caicun Zhou Changli Wang Feng Ye Xingya Li Junye Wang Mengzhao Wang Yunpeng Liu Yanqiu Zhao Ying Yuan Jifeng Feng Zhendong Chen Jindong Shi Tao Sun Gang Wu Yongqian Shu Qisen Guo Yi Zhang Yong Song Shucai Zhang Yuan Chen Wei Li Hongrui Niu Wenwei Hu Lijun Wang Jianan Huang Yang Zhang Ying Cheng Zhengdong Wu Bo Peng Jiya Sun Christoph Mancao Yanqi Wang Luyao Sun | 2022 | Cancer Communications2022，42，12： | 8 |
| 2 | Inositol Pyrophosphate lnsP8 Acts as an Intracellular Phosphate Signal in Arabidopsis显示文摘The maintenance of cellular phosphate(Pi)homeostasis is of great importance in living organisms.The SPX domain-containing protein 1(SPX1)proteins from both Arabidopsis and rice have been proposed to act as sensors of Pi status.The molecular signal indicating the cellular Pi status and regulating Pi homeostasis in plants,however,remains to be identified,as Pi itself does not bind to the SPX domain.Here,we report the identification of the inositol pyrophosphate lnsP8 as a signaling molecule that regulates Pi homeostasis in Arabidopsis.Polyacrylamide gel electrophoresis profiling of InsPs revealed that lnsP8 level positively correlates with cellular Pi concentration.We demonstrated that the homologs of diphosphoinositol pentaki-sphosphate kinase(PPIP5K),VIH1 and VIH2,function redundantly to synthesize lnsP8,and that the vih1 vih2 double mutant overaccumulates Pi.SPX1 directly interacts with PHR1,the central regulator of Pi starvation responses,to inhibit its function under Pi-replete conditions.However,this interaction is compromised in the vih1 vih2 double mutant,resulting in the constitutive induction of Pi starvation-induced genes,indicating that plant cells cannot sense cellular Pi status without lnsP8.Furthermore,we showed that lnsP8 could directly bind to the SPX domain of SPX1 and is essential for the interaction between SPX1 and PHR1.Collectively,our study suggests that lnsP8 is the intracellular Pi signaling molecule serving as the ligand of SPX1 for controlling Pi homeostasis in plants. | Jinsong Dong Guojie Ma Liqian Sui Mengwei Wei Viswanathan Satheesh Ruyue Zhang Shenghong Ge Jinkai Li Tong-En Zhang Christopher Wittwer Henning JJessen Huiming Zhang Guo-Yong An Dai-Yin Chao Dong Liu Mingguang Lei | 2019 | Molecular Plant2019，12，11： | 8 |
| 3 | Better to be alone than in bad company:The antagonistic effect of cisplatin and crizotinib combination therapy in non-small cell lung cancer显示文摘AIM To investigate the potential benefit of combining the cMET inhibitor crizotinib and cisplatin we performed in vitro combination studies.METHODS We tested three different treatment schemes in four non-small cell lung cancer(NSCLC) cell lines with a different cMET/epidermal growth factor receptor genetic background by means of the sulforhodamine B assay and performed analysis with Calcusyn.RESULTS All treatment schemes showed an antagonistic effect in all cell lines,independent of the cMET status.Despite their different genetic backgrounds,all cell lines(EBC-1,HCC827,H1975 and LUDLU-1) showed antagonistic combination indexes ranging from 1.3-2.7.These results were independent of the treatment schedule.CONCLUSION These results discourage further efforts to combine cMET inhibition with cisplatin chemotherapy in NSCLC. | Nele Van Der Steen Christophe Deben Vanessa Deschoolmeester An Wouters Filip Lardon Christian Rolfo Paul Germonpré Elisa Giovannetti Godefridus J Peters Patrick Pauwels | 2016 | World Journal of Clinical Oncology2016，7，6： | 2 |
| 4 | A Branched-Chain Amino Acid-Related Metabolic Signature that Differentiates Obese and Lean Humans and Contributes to Insulin Resistance显示文摘 | Christopher B. Newgard Jie An James R. Bain Michael J. Muehlbauer Robert D. Stevens Lillian F. Lien Andrea M. Haqq Svati H. Shah Michelle Arlotto Cris A. Slentz James Rochon Dianne Gallup Olga Ilkayeva Brett R. Wenner William S. Yancy Howard Eisenson Gera | 2009 | Cell Metabolism2009，，4： | 2 |
| 5 | Intramural hematoma in acute aortic syndrome:more than one variant of dissection?显示文摘 | Christoph AN Hans HS | 2002 | Circulation2002，106，3： | 1 |
| 6 | Aortic Dissection: New Frontiers in Diagnosis and Management 显示文摘 | Christoph AN Kim A Eagle | 2003 | Circulation2003，108，： | 1 |
| 7 | Linear all-optical signal processing using silicon micro-ring resonators显示文摘硅微戒指的共鸣器(MRR ) 是谁的紧缩、万用的设备周期的频率反应能为大量应用被利用。在这份报纸,我们用硅 MRR 同样被动的过滤器在线性所有光的信号处理应用上考察我们的最近的工作。我们集中于象调整格式变换那样的应用,调音的微分阶段移动(DPSK ) 解调,直接调制的激光(数据管理语言) 的调整速度改进,和独轮脚踏车搏动产生。实现极化差异电路的可能性,减少标准硅 MRR 的极化依赖,在 DPSK 解调的特别例子上被说明。 | Yunhong DING Haiyan OU Jing XU Meng XIONG Yi AN Hao HU Michael GALILI Abel Lorences RIESGO Jorge SEOANE Kresten YVIND Leif Katsuo OXENLOWE Xinliang ZHANG Dexiu HUANG Christophe PEUCHERET | 2016 | Frontiers of Optoelectronics2016，9，3： | 1 |
| 8 | Intramural hemorrhage of the thoracic aortic:diagnostic and therapeutic implication显示文摘 | Christoph AN Yskert VK Ben P | 1995 | Circulation1995，92，1： | 1 |
| 9 | Endovascular stent-graft placement in aortic dissection: a meta-analysis 显示文摘 | Holger E Christoph AN Markus NR | 2006 | J Eur Hear2006，27，4： | 1 |
| 10 | Reduced-particle size wheat bran and endoxylanase supplementation in broiler feed affect arabinoxylan hydrolysis and fermentation with broiler age differently显示文摘Since the caecal microbiota of young broilers are not yet able to ferment the dietary fibre(DF)fraction of the feed to a large extent,increasing the accessibility of DF substrates along the gastrointestinal tract is crucial to benefit from the health stimulating metabolic end-products(e.g.butyric acid)generated upon microbial DF fermentation.Therefore,the present study aimed to evaluate the potential of reduced-particle size wheat bran(RPS-WB)and endoxylanases as feed additives to stimulate arabinoxylan(AX)hydrolysis and fermentation along the hindgut of young broilers.To this end,RPS-WB and endoxylanase supplementation were evaluated in a 2×2 factorial design using a total of 256 male 1-d-old chicks(Ross 308).Broilers were assigned to 4 dietary treatments:a basal wheat-based diet with(1)no feed additives(control,CTRL),(2)an endoxylanase(XYL;Econase XT 25 at 0.10 g/kg diet),(3)1%wheat bran with an average reduced particle size of 297μm(RPS-WB)and(4)an endoxylanase and 1%RPS-WB(RPS-WB+XYL).Each dietary treatment was replicated 8 times and on d 10 and 28,respectively,24 and 16 broilers per treatment group were euthanised to analyse AX degradation,short-chain fatty acid production and digesta viscosity in the ileum and caecum.Broilers receiving XYL in their diet showed increased AX solubilisation and fermentation at both d 10 and 28 compared to the CTRL group(P<0.05).Adding RPS-WB to the diet stimulated wheat AX utilisation by the primary AX degraders in the caecum at 10 d of age compared to the CTRL group,as observed by the high AX digestibility coefficient for the RPS-WB supplemented group at this young age(P<0.05).At 28 d,RPS-WB supplementation lowered body-weight gains but increased butyric acid concentrations compared to the XYL and CTRL group(P<0.05).Although no synergistic effect for RPS-WB+XYL broilers was observed for AX hydrolysis and fermentation,these findings suggest that both additives can raise a dual benefit to the broiler as a butyrogenic effect and improved AX fermentation along the ileum and caecum were observed throughout the broiler's life. | An Bautil Michael R.Bedford Johan Buyse Christophe M.Courtin | 2023 | Animal Nutrition2023，，1： | 1 |
| 11 | Contact allergy to common ingredients in hair dyes显示文摘 | Heidi S?sted Thomas Rustemeyer Margarida Gon?alo Magnus Bruze An Goossens Ana M. Giménez‐Arnau Christophe J. Le Coz Ian R. White Thomas L. Diepgen Klaus E. Andersen Tove Agner Howard Maibach Torkil Menné Jeanne D. Johansen | 2013 | Contact Dermatitis2013，，1： | 1 |
| 12 | Does two-segment image reconstruction at 64-section CT coronary angiography improve image quality and diagnostic accuracy?显示文摘 | Christopher H Shaun AN | 2007 | Radiology2007，25，： | 1 |
| 13 | Management of patients with aortic dissection 显示文摘 | Ernst W Christoph AN Tim CR | 2008 | Dtsch arztebl2008，105，38： | 1 |
| 14 | A Frequent Toll‐Like Receptor 1 Gene Polymorphism Affects NK ‐ and T‐cell IFN ‐γ Production and is Associated with Helicobacter pylori ‐induced Gastric Disease显示文摘 | Chin‐An Yang Carmen Scheibenbogen Sandra Bauer Christoph Kleinle Thomas Wex Jan Bornschein Peter Malfertheiner Stephan Hellmig Ralf R. Schumann Lutz Hamann | 2012 | Helicobacter2012，，1： | 1 |
| 15 | Endovascular stent-graft placement in aortic dissection: a meta-analysis显示文摘 | Holger E Christoph AN Markus NR | 2006 | J Eur Heart2006，27，： | 1 |
| 16 | Management of congenital nonpigmented iris cyst显示文摘 | Christopher CS Peter AN Matthew WW | 2006 | Ophthalmology2006，113，： | 1 |
| 17 | Management of acute aortic syn- dromes 显示文摘 | Huseyin I Christoph AN | 2007 | Rev Esp Cardio12007，，5： | 1 |
| 18 | Management of acute aortic syndromes显示文摘 | Hüseyin I Christoph AN | 2007 | Rev Esp Cardiol2007，60，： | 1 |
| 19 | Pediatric cardiovascular CT angiography: radiation dose reduction using automatic anatomic tube current modulation 显示文摘 | Christopher H Denise MM Shaun AN | 2008 | AIR2008，190，5： | 1 |
| 20 | Partial thrombosis of the false lumen in patients with acute type B aortic dissection显示文摘 | Thomas TT Arturo E Christoph AN | 2007 | N Engl J Med2007，357，4： | 1 |
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