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| 1 | RTOG 0211:a phase 1/2 study of radiation therapy with concurrent gefitinib for newly diagnosed glioblastoma patients显示文摘PURPOSE: To determine the safety and efficacy of gefitinib,an epidermal growth factor receptor(EGFR) tyrosine kinase inhibitor,in combination with radiation for newly diagnosed glioblastoma(GBM) patients.METHODS AND MATERIALS: Between March 21,2002,and May 3,2004,Radiation Therapy Oncology Group(RTOG) 0211 enrolled 31 and 147GBM patients in the phase 1 and 2 arms,respectively.Treatment consisted of daily oral gefinitnib started at the time of conventional cranial radiation therapy(RT) and continued post RT for 18 months or until progression.Tissue microarrays from 68 cases were analyzed for EGFR expression.RESULTS: The maximum tolerated dose(MTD) of gefitinib was determined to be 500 mg in patients on non-enzyme-inducing anticonvulsant drugs(non-EIAEDs).All patients in the phase 2 component were treated at a gefitinib dose of 500 mg;patients receiving EIADSs could be escalated to 750 mg.The most common side effects of gefitinib in combination with radiation were dermatologic and gastrointestinal.Median survival was 11.5 months for patients treated per protocol.There was no overall survival benefit for patients treated with gefitinib + RT when compared with a historical cohort of patients treated with RT alone,matched by RTOG recursive partitioning analysis(RPA) class distribution.Younger age was significantly associated with better outcome.Per protocol stratification,EGFR expression was not found to be of prognostic value for gefitinib + RT-treated patients.CONCLUSIONS: The addition of gefitinib to RT is well tolerated.Median survival of RTOG 0211 patients treated with RT with concurrent and adjuvant gefitinib was similar to that in a historical control cohort treated with radiation alone. | Chakravarti A Wang M Robins HI Lautenschlaeger T Curran WJ Brachman DG Schultz CJ Choucair A Dolled-Filhart M Christiansen J Gustavson M Molinaro A Mischel P Dicker AP Bredel M Mehta M | 2013 | 中国神经肿瘤杂志2013，11，1： | 8 |
| 2 | Implantation of artificial sphincter for anal incontinence显示文摘 | Christiansen J Lorentzen M | 1987 | Lancet1987，2，8553： | 1 |
| 3 | Effects of prenatal steroids in the development of necrotizing enterocolitis in Wistar rat neonates 显示文摘 | Bortolin L Boer M Christiansen S | 2011 | Arch Argent Pediatr2011，109，1： | 1 |
| 4 | Do blood concentrations of neurone specific enolase and S-100 beta protein reflect cognitive dysfunction after abdominal surgery显示文摘 | Rasrnussen LS Christiansen M Rasmussen H | 2000 | Br J Anaesth2000，84，2： | 1 |
| 5 | A report on librarian-faculty relations from a sociological perspective 显示文摘 | CHRISTIANSEN L STOMBLER M THAXTON L | 2004 | The Journal of Academic Librarianship2004，30，2： | 1 |
| 6 | Effects of stocking density on foodintake, growth performance andoxygen consumption in Artic charr (Salvelinus alpinus)显示文摘 | Jorgensen E H Christiansen J S Jobling M | 1993 | Aquaculture1993，110，： | 1 |
| 7 | Low-dose perinatal exposure to di(2-ethylhexyl)phthalate induces anti-androgenic effects in male rats显示文摘 | Christiansen S Boberg J Axelstad M | | 0，，02： | 1 |
| 8 | Tuning RED for web traffic 显示文摘 | Christiansen M Jeffay K Ott D | 2000 | IEEE/ACM Transactions on Networking2000，9，3： | 1 |
| 9 | Individual differences in tonic immobility may reflect behavioural strategies 显示文摘 | ERHARD H W MENDL M CHRISTIANSEN S B | 1999 | Applied Animal Behaviour Science1999，64，： | 1 |
| 10 | Messenger ribonucleic acid level of pregnancy-associated plasma protein- A and the proform of eosinophil major basic protein: expression in human reproductive and nonproductive fissure显示文摘 | Overgaard MT Oxvig C Christiansen M | 1999 | Biol Reprod1999，61，4： | 1 |
| 11 | Seroprevalence of measles, rubella, and varieella in refugees 显示文摘 | Barnett E Christiansen D Figueira M | 2002 | Clin Infect Dis2002，35，4： | 1 |
| 12 | Modelling of macro- pore flow and transport processes at catchment scale 显示文摘 | Christiansen J S Thorsen M Clausen T | 2004 | Journal of hydrology2004，299，： | 1 |
| 13 | Nitric-oxide synthase inhibition in migraine 显示文摘 | Lassen L H Ashina M Christiansen I | 1997 | Lancet1997，349，9049： | 1 |
| 14 | Hydrochemi- cal characteristics of bulk meltwater from an entire ablation sea- son, Longyearbreen, Svalbard 显示文摘 | Yde J C Riger-Kusk M Christiansen H H | 2008 | Journal of Glaciology2008，54，185： | 1 |
| 15 | Do blood levels of neuron specific enolase and s-100 protein reflect cognitive dys- function after coronary artery bypass 显示文摘 | Rasmussen LS Christiansen M Hansen PB | 1999 | Acta Anaesthesiol Scand1999，43，5： | 1 |
| 16 | Low-dose perinatal exposure to di ( 2-ethylhexyl ) phthalate induces anti-androgenic effects in male rats显示文摘 | Christiansen S Boberg J Axelstad M | 2010 | Reprod Toxieol2010，30，2： | 1 |
| 17 | Pregnancy-associated plasma protein-A and its endogenous inhibitor,the proform of eosinophil major basic protein(proMBP),are related to complex stenosis morphology in patients with stable angina pectoris显示文摘 | Cosin-Sales J Christiansen M Kaminski P | 2004 | Circulation2004，109，14： | 1 |
| 18 | Messenger ribonucleic acid levels of pregnancy-associated plasma protein-A and the proform of eosinophil major basic protein:expression in human reproductive and nonreproductive tissues显示文摘 | Overgaard MT Oxvig C Christiansen M | 1999 | Biol Reprod1999，61，4： | 1 |
| 19 | Mutations in the HERG K+-Ion Channel:A Novel Link Between Long QT Syndrome and Sudden Infant Death Syndrome显示文摘 | Christiansen M Tonder N Larsen LA | 2005 | Am J Cardiol2005，95，3： | 1 |
| 20 | Inhibition of linolenic acid synthesis and modification of chilling resistance in cotton seeding显示文摘 | JOHN J B CHRISTIANSEN M N | 1976 | Plant Physiol1976，57，7： | 1 |
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