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| 1 | Immune response to an indigenously developed r-Hepatitis B vaccine in mixed population: Study of an accelerated vaccination schedule显示文摘AIM: To establish the safety and efficacy of an indigenously developed r-hepatitis B vaccine using an accelerated schedule and to highlight the social awareness and commitment in preventing the spreading of hepatitis B virus infection.METHODS: The study was a multicentric, double blind,randomized (3:1) study using three doses of vaccine immunization schedule (20 μg for those above 10 years old and 10 μg for those below 10 years old) on d 0, 30and 60. One hundred and sixty-six subjects were enrolled(87 males and 76 females aged 5-35 years). The main outcome measure was assessment of immunogenicity and safety.RESULTS: A 100% seroconversion response was observed on the 30th d after the 1st injection in both the experimental groups. The sero-protection data reported a 41.2-65.6% response on the 30th d after the 1st injection and reached 100% on the 60th d. Descriptive statical analysis showed a geometric mean titer value of 13.77 mIU/mL in the test (BEVAC) group and 10.95 mIU/mL in the commercial control (ENGERIX-B) group on the 30th d after the 1st injection. The response on the 60th d showed a geometric mean titre value (GMT) of 519.84 mIU/mL in the BEVAC group and 475.46 mIU/mL in the ENGERIX-B group. On the 90th d, the antibody titer response was observed to be 2627.58 mIU/mL in the BEVAC group and 2272.72 mIU/mL in the ENGERIX-B group. Two subjects in each group experienced pains at injection site after the first vaccination. A total of six subjects in both groups experienced a solicited adverse reaction, which included pains, swelling and redness at the injection site, three subjects in the group-B had a pain at the injection site after the third dose. No other serious adverse events occurred and no dose-related local or general symptoms were observed during the study.CONCLUSION: The vaccine is safe, efficacious and immunogenic in comparison with the well documented ENGERIX-B. | A Chowdhury A Santra CM Habibullah AA Khan J Karunakaramaiah TSA Kishore AVR Raju S Lahiri | 2005 | World Journal of Gastroenterology2005，11，7： | 12 |
| 2 | Targeting random mutations to hotspots in antibody variable domains for affinity improvement 显示文摘 | Chowdhury P S | 2002 | Methods in Molecular Biology2002，178，： | 2 |
| 3 | Genetic determinant s of diabetic nephropathy显示文摘 | Chowdhury T A Dyer P H Kumar S | | 0，，： | 2 |
| 4 | Current systematic reviews and meta-analyses of COVID-19显示文摘BACKGROUND Coronavirus disease 2019(COVID-19)has left a significant impact on the world's health,economic and political systems;as of November 20,2020,more than 57 million people have been infected worldwide,with over 1.3 million deaths.While the global spotlight is currently focused on combating this pandemic through means ranging from finding a treatment among existing therapeutic agents to inventing a vaccine that can aid in halting the further loss of life.AIM To collect all systematic reviews and meta-analyses published related to COVID-19 to better identify available evidence,highlight gaps in knowledge,and elucidate further meta-analyses and umbrella reviews that are yet to be performed.METHODS We explored studies based on systematic reviews and meta-analyses with the keyterms,including severe acute respiratory syndrome(SARS),SARS virus,coronavirus disease,COVID-19,and SARS coronavirus-2.The included studies were extracted from Embase,Medline,and Cochrane databases.The publication timeframe of included studies ranged between January 01,2020,to October 30,2020.Studies that were published in languages other than English were not considered for this systematic review.The finalized full-text articles are freely accessible in the public domain.RESULTS Searching Embase,Medline,and Cochrane databases resulted in 1906,669,and 19 results,respectively,that comprised 2594 studies.515 duplicates were subsequently removed,leaving 2079 studies.The inclusion criteria were systematic reviews or meta-analyses.860 results were excluded for being a review article,scope review,rapid review,panel review,or guideline that produced a total of 1219 studies.After screening articles were categorized,the included articles were put into main groups of clinical presentation,epi-demiology,screening and diagnosis,severity assessment,special populations,and treatment.Subsequently,there was a second subclassification into the following groups:gastrointestinal,cardiovascular,neurological,stroke,thrombosis,anosmia and dysgeusia,ocular manifestations,nephrology,cutaneous manifestations,D-dimer,lymphocyte,anticoagulation,antivirals,convalescent plasma,immunosuppressants,corticosteroids,hydroxychloroquine,renin-angiotensin-aldosterone system,technology,diabetes mellitus,obesity,pregnancy,children,mental health,smoking,cancer,and transplant.CONCLUSION Among the included articles,it is clear that further research is needed regarding treatment options and vaccines.With more studies,data will be less heterogeneous,and statistical analysis can be better applied to provide more robust clinical evidence.This study was not designed to give recommendations regarding the management of COVID-19. | Mahmoud Nassar Nso Nso Mostafa Alfishawy Anastasia Novikov Salim Yaghi Luis Medina Bahtiyar Toz Sofia Lakhdar Zarwa Idrees Yungmin Kim Dawa Ongyal Gurung Raheel S Siddiqui David Zheng Mariam Agladze Vikram Sumbly Jasmine Sandhu Francisco Cuevas Castillo Nadya Chowdhury Ravali Kondaveeti Sakil Bhuiyan Laura Guzman Perez Riki Ranat Carlos Gonzalez Harangad Bhangoo John Williams Alaa Eldin Osman Joyce Kong Jonathan Ariyaratnam Mahmoud Mohamed Ismail Omran Mariely Lopez Akwe Nyabera Ian Landry Saba Iqbal Anoosh Zafar Gondal Sameen Hassan Ahmed Daoud Bahaaeldin Baraka Theo Trandafirescu Vincent Rizzo | 2021 | World Journal of Virology2021，10，4： | 2 |
| 5 | Enhancement of leaching rate of uranium in presence of ultrasound 显示文摘 | BALASUBRAHMANYAM A ROY S B CHOWDHURY S | 2006 | Ind Eng Chem Res2006，45，22： | 1 |
| 6 | Finite element analysis of a TMJ im-plant显示文摘 | Kashi A Chowdhury A R Saha S | 2010 | J Dent Res2010，89，3： | 1 |
| 7 | Flurbiprofen, a unique on-ste- roidal anti-inflammatory drug with antimicrobial activity against Triehophyton, Microsporum and Epidermophyton species显示文摘 | Chowdhury B Adak M Bose S K | 2003 | Lett Appl Microbiol2003，37，2： | 1 |
| 8 | Possible link between glycolysis and apoptosis induced sodium fluoride显示文摘 | Otsuki S Morshed SR Chowdhury SA | 2005 | J Dent Res2005，84，10： | 1 |
| 9 | Weakly sol- vated PEG-functionalized silica nanoparticles with liquid-like be- havior显示文摘 | Bourlinos A B Chowdhury S R Jiang D D | 2005 | J Mater Sci2005，40，： | 1 |
| 10 | Effect of coherent to incoherent structural transition on magnetic anisotropy in Co/Pt muhilayers 显示文摘 | Chowdhury P Kulkkarni P D Krishnan M Barshilia H C Sagdeo A Rai S K Lodha G S Rao D V S | 2012 | Journal of Applied Physics2012，112，02： | 1 |
| 11 | Alteration of serum inflammatory cytokines in active pulmonary tuberculo- sis following anti-tuberculosis drug therapy显示文摘 | Chowdhury I H Ahmed A M Choudhuri S | 2014 | Mol Immunol2014，62，1： | 1 |
| 12 | Maternal genome-wide DNA methylation patterns and congenital heart defects 显示文摘 | CHOWDHURY S ERICKSON SW MACLEOD SL | 2011 | PLoSOne2011，6，16： | 1 |
| 13 | Electron affinities of benzo-, naphtho-, and anthraquinones determined from gas-phase equilibria measurements显示文摘 | Heinis T Chowdhury S Scott S L | 1988 | J Am Chem Soc1988，110，2： | 1 |
| 14 | A Reliability Test System for Education Purpose: Basic Data显示文摘 | BILLINTON R KUMAR S CHOWDHURY N | 1989 | IEEE Trans on IS1989，4，3： | 1 |
| 15 | On some broad-band microstip resonators显示文摘 | RPODAR D CHATTERJEE J S CHOWDHURY S K | 1983 | IEEE Trans on Antenna Propagate1983，31，5： | 1 |
| 16 | Impact of interleukin-6 promoter polymorphism and serum interleukin-6 level on the acute inflammation and neovascularization stages of patients with Eales' disease显示文摘 | SEN A PAINE S K CHOWDHURY I H | 2011 | Mol Vis2011，17，： | 1 |
| 17 | Journal as markers of intellectual space: Journal co-citation analysis of in- formation retrieval area 1987-1997显示文摘 | Ding Y Chowdhury G G Foo S | 2000 | Scientometrics2000，47，1： | 1 |
| 18 | Functional- ized nanostructures with liquid-like behavior: expanding the gal- lery of available nanostructures 显示文摘 | Boudinos A B Chowdhury S R Herrera R | 2005 | Adv Func Mater2005，15，： | 1 |
| 19 | Modeling of microwave-assisted extraction of natural dye from seeds of Bixa orellana (Atmatto) using respome surface methodology (R SM) and artificial neural Network (ANN)显示文摘 | SINHA K CHOWDHURY S SAHA P D | 2013 | Industrial Crops and Products2013，，41： | 1 |
| 20 | Impact of resonator geometry and its coupling with ground plane on ultrathin metamaterial perfect absorbers显示文摘 | Huang L Chowdhury D R Ramani S | 2012 | Applied Physics Letters2012，101，10： | 1 |
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