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| 1 | Tenofovir rescue therapy for chronic hepatitis B patients after multiple treatment failures显示文摘AIM:To evaluate the efficacy and safety of tenofovir disoproxil fumarate(TDF) for chronic hepatitis B(CHB) patients after multiple failures.METHODS:A total of 29 CHB patients who had a suboptimal response or developed resistance to two or more previous nucleoside/nucleotide analogue(NA) treatments were included.Study subjects were treated with TDF alone(n = 13) or in combination with lamivudine(LAM,n = 12) or entecavir(ETV,n = 4) for ≥ 6 mo.Complete virologic response(CVR) was defined as an achievement of serum hepatitis B virus(HBV) DNA level ≤ 60 IU/mL by real-time polymerase chain reaction method during treatment.Safety assessment was based on serum creatinine and phosphorus level.Eleven patients had histories of LAM and adefovir dipivoxil(ADV) treatment and 18 patients were exposed to LAM,ADV,and ETV.Twenty-seven patients(93.1%) were hepatitis B e antigen(HBeAg) positive and the mean value of the baseline serum HBV DNA level was 5.5 log IU/mL ± 1.7 log IU/mL.The median treatment duration was 16 mo(range 7 to 29 mo).RESULTS:All the patients had been treated with LAM and developed genotypic and phenotypic resistance to it.Resistance to ADV was present in 7 patients and 10 subjects had a resistance to ETV.One patient had a resistance to both ADV and ETV.The cumulative probabilities of CVR at 12 and 24 mo of TDF containing treatment regimen calculated by the Kaplan Meier method were 86.2% and 96.6%,respectively.Although one patient failed to achieve CVR,serum HBV DNA level decreased by 3.9 log IU/mL from the baseline and the last serum HBV DNA level during treatment was 85 IU/mL,achieving near CVR.No patients in this study showed viral breakthrough or primary non-response during the follow-up period.The cumulative probability of HBeAg clearance in the 27 HBeAg positive patients was 7.4%,12%,and 27% at 6,12,and 18 mo of treatment,respectively.Treatment efficacy of TDF containing regimen was not statistically different according to the presence of specific HBV mutations.History of prior exposure to specific antiviral agents did not make a difference to treatment outcome.Treatment efficacy of TDF was not affected by combination therapy with LAM or ETV.No patient developed renal toxicity and no cases of hypophosphatemia associated with TDF therapy were observed.There were no other adverse events related to TDF therapy observed in the study subjects.CONCLUSION:TDF can be an effective and safe rescue therapy in CHB patients after multiple NA therapy failures. | Yu Jin Kim Dong Hyun Sinn Geum-Youn Gwak Moon Seok Choi Kwang Cheol Koh Seung Woon Paik Byung Chul Yoo Joon Hyeok Lee | 2012 | World Journal of Gastroenterology2012，18，47： | 16 |
| 2 | Toothpick impaction with sigmoid colon pseudodiverticulum formation successfully treated with colonoscopy显示文摘Foreign bodies in the colon are encountered with increasing frequency, but only sporadic reports concerning their management have appeared in the literature. While most ingested foreign bodies usually pass through the gastrointestinal tract uneventfully, sharp foreign bodies such as toothpicks infrequently cause intestinal perforation and may even result in death. We report our experience with a patient with a sigmoid colon pseudodiverticulum formation, a complication of accidental ingestion of a toothpick that was diagnosed and successfully managed colonoscopically. | Youn Son Chung Yong Woo Chung Sun You Moon Su Mi Yoon Min-Jeong Kim Kyoung Oh Kim Cheol Hee Park Taeho Hahn Kyo-Sang Yoo Sang Hoon Park Jong Hyeok Kim Choong Kee Park | 2008 | World Journal of Gastroenterology2008，14，6： | 10 |
| 3 | MRI of gastric carcinoma:Results of T and N-staging in an in vitro study显示文摘AIM:To determine the accuracy of 1.5-T magnetic resonance imaging (MRI) in the evaluation of gastric wall invasion and perigastric lymph node metastasis in gastric adenocarcinoma.METHODS: Twenty resected gastric specimens containing 20 tumors were studied with a 1.5-T MR system using a commercial head surface coil. MR scanning was performed with a T1 weighted image (TR/TE = 500/20), and a T2 weighted image (TR/TE=2500/90). MR findings were compared with pathologic findings.RESULTS: A T1-weighted image demonstrated three layers in the normal gastric wall. All of the gastric tumors were well demonstrated by lesions and location. In a MRI findings of gastric wall invasion, there was 1 case of T1, 7 of T2, 11 of T3. Pathologic results of resected specimens included 3 cases of pT1, 4 of pT2, and 12 of pT3. The accuracy of T staging with MRI was 74% (14 of 19). MRI findings of lymph node me-tastasis included 6 cases of N0, 13 cases of N1. The accuracy of the N staging with MRI was 47% (9 of 19).CONCLUSION: MRI has a high diagnostic accuracy in the evaluation of the T staging of gastric cancer in vitro and thus potentially enables preoperative histo-pathologic staging. | Il Young Kim Sang Won Kim Hyeong Cheol Shin Moon Soo Lee Dong Jun Jeong Chang Jin Kim Young Tong Kim | 2009 | World Journal of Gastroenterology2009，15，32： | 9 |
| 4 | Effect of electrical stimulation on neural regeneration via the p38-RhoA and ERK1/2-Bcl-2 pathways in spinal cord-injured rats显示文摘Although electrical stimulation is therapeutically applied for neural regeneration in patients, it remains unclear how electrical stimulation exerts its effects at the molecular level on spinal cord injury(SCI). To identify the signaling pathway involved in electrical stimulation improving the function of injured spinal cord, 21 female Sprague-Dawley rats were randomly assigned to three groups: control(no surgical intervention, n = 6), SCI(SCI only, n = 5), and electrical simulation(ES; SCI induction followed by ES treatment, n = 10). A complete spinal cord transection was performed at the 10^(th) thoracic level. Electrical stimulation of the injured spinal cord region was applied for 4 hours per day for 7 days. On days 2 and 7 post SCI, the Touch-Test Sensory Evaluators and the Basso-Beattie-Bresnahan locomotor scale were used to evaluate rat sensory and motor function. Somatosensory-evoked potentials of the tibial nerve of a hind paw of the rat were measured to evaluate the electrophysiological function of injured spinal cord. Western blot analysis was performed to measure p38-RhoA and ERK1/2-Bcl-2 pathways related protein levels in the injured spinal cord. Rat sensory and motor functions were similar between SCI and ES groups. Compared with the SCI group, in the ES group, the latencies of the somatosensory-evoked potential of the tibial nerve of rats were significantly shortened, the amplitudes were significantly increased, RhoA protein level was significantly decreased, protein gene product 9.5 expression, ERK1/2, p38, and Bcl-2 protein levels in the spinal cord were significantly increased. These data suggest that ES can promote the recovery of electrophysiological function of the injured spinal cord through regulating p38-RhoA and ERK1/2-Bcl-2 pathway-related protein levels in the injured spinal cord. | Min Cheol Joo Chul Hwan Jang Jong Tae Park Seung Won Choi Seungil Ro Min Seob Kim Moon Young Lee | 2018 | Neural Regeneration Research2018，13，2： | 6 |
| 5 | Virological response to adefovir monotherapy and the risk of adefovir resistance显示文摘AIM:To evaluate virological response to adefovir(ADV) monotherapy and emergence of ADV-resistant mutations in lamivudine(LAM)-resistant chronic hepatitis B patients.METHODS:Seventy-seven patients with documented LAM resistance who were treated with 10 mg/d ADV for>96 wk were analyzed for ADV resistance.RESULTS:At week 48 and 96,eight(10%)and 14(18%)of 77 LAM-resistant patients developed the ADV-resistant strain(rtA181V/T and/or rtN236T mutations),respectively.Hepatitis B virus(HBV)DNA levels during therapy were significantly higher in patients who developed ADV resistance than in those who did not.Incidence of ADV resistance at week 96 was 11%,8%and 6%among patients with complete virological response(HBV DNA level<60 IU/mL);0%,5%and 19%among patients with partial virological response(HBV DNA level≥60 to 2000 IU/mL);and 32%,34% and 33%among patients with inadequate virological response(HBV DNA levels>2000 IU/mL)at week 12,week 24 and week 48,respectively.HBV DNA levels >2000 IU/mL at week 24 showed best performance characteristics in predicting ADV resistance.CONCLUSION:Development of ADV resistance mutations was associated with HBV DNA levels,which could identify patients with LAM resistance who are likely to respond to ADV monotherapy. | Dong Hyun Sinn Geum-Youn Gwak Moon Seok Choi Kwang Cheol Koh Seung Woon Paik Byung Chul Yoo Joon Hyeok Lee Hyang Ie Lee | 2011 | World Journal of Gastroenterology2011，17，30： | 5 |
| 6 | Prevalence of premature ejaculation in young and middle-aged men in Korea: a multicenter intemet-based survey from the Korean Andrological Society显示文摘 | Hyun Jun Park Jong Kwan Park Kwangsung Park Sung Won Lee Sae-Woong Kim Dae Yul Yang DU Geon Moon Kweon-Sik Min Ki-Hak Moon Sang-Kuk Yang Jae Seog Hyun Nam Cheol Park | 2010 | Asian Journal of Andrology2010，12，6： | 5 |
| 7 | The feasibility of combined transcatheter arterial chemoembolization and radiotherapy for advanced hepatocellular carcinoma显示文摘 | Ju‐Yeon Cho Yong‐Han Paik Hee Chul Park Jeong Il Yu Won Sohn Geum‐Youn Gwak Moon Seok Choi Joon Hyeok Lee Kwang Cheol Koh Seung Woon Paik Byung Chul Yoo | 2014 | Liver Int2014，，5： | 5 |
| 8 | Nose-to-brain delivery of macromolecules mediated by cell-penetrating peptides显示文摘Brain delivery of macromolecular therapeutics(e.g., proteins) remains an unsolved problem because of the formidable blood–brain barrier(BBB). Although a direct pathway of nose-to-brain transfer provides an answer to circumventing the BBB and has already been intensively investigated for brain delivery of small drugs,new challenges arise for intranasal delivery of proteins because of their larger size and hydrophilicity. In order to overcome the barriers and take advantage of available pathways(e.g., epithelial tight junctions, uptake by olfactory neurons, transport into brain tissues, and intra-brain diffusion), a low molecular weight protamine(LMWP) cell-penetrating peptide was utilized to facilitate nose-to-brain transport. Cell-penetrating peptides(CPP)have been widely used to mediate macromolecular delivery through many kinds of biobarriers. Our results show that conjugates of LMWP–proteins are able to effectively penetrate into the brain after intranasal administration.The CPP-based intranasal method highlights a promising solution for protein therapy of brain diseases. | Tingting Lin Ergang Liu Huining He Meong Cheol Shin Cheol Moon Victor C.Yang Yongzhuo Huang | 2016 | Acta Pharmaceutica Sinica B2016，6，4： | 4 |
| 9 | β-Sitosterol sensitizes MDA-MB-231 cells to TRAIL-induced apoptosis显示文摘目的:与TNF相关的 导致apoptosis ligand (小道)结合了调查是否代替 P-sitosterol ( SITO )的有毒的集中在小道抵抗的 MDA-MB-231 乳癌 cells.Methods 导致 apoptosis :细胞生存能力和生长被3-( 4,5-dimethyl-2-thiazolyl )估计 -2,5-diphnyl-2H-tetrazolim 溴化物试金,染色质冷凝作用,lactate 脱氢酶( LDH )的版本,并且 Annexin V^+cells.The apoptosis相关的蛋白质被西方的 blotting.Results 检测:有在与 SITO 的有毒的集中敏化的潜水艇一起的联合的小道的治疗到调停小道的 apoptosis.The 协同的治疗的 MDA-MB-231 乳癌细胞导致了染色质冷凝作用, DNA 破碎, LDH 的版本,并且 apoptosis 的 Annexin V^+cells.The 指示物被相关到活动,它显著地导致细胞毒素的效果和 apoptotic 特征由协同的治疗导致了的 polymerase.Both 是的多形核白细胞(自动数据处理核糖)的劈开由一个 pan-caspase 禁止者禁止了的 caspase 的正式就职 z-VAD-fmk ,证明 caspases.These 结果的重要角色显示 caspases 是 apoptosis 的关键管理者在 MDA-MB-231 cells.Conclusion 由 SITO 和小道的联合治疗导致了: SITO 和小道的协同的治疗导致 apoptosis ,它能用作一项潜在的预防措施和治疗学的代理人。 | Cheol PARK Dong-oh MOON Chung-ho RYU Byung tae CHOI Won ho LEE Gi-young KIM Yung hyun CHOI | 2008 | Acta Pharmacologica Sinica2008，29，3： | 4 |
| 10 | Milan criteria are useful predictors for favorable outcomes in hepatocellular carcinoma patients undergoing liver transplantation after transarterial chemoembolization显示文摘AIM: To evaluate whether the Milan criteria are useful in patients with hepatocellular carcinoma (HCC) who received transarterial chemoembolization (TACE) before liver transplantation (LT). METHODS: Thirty-six HCC patients who fulfilled the Milan criteria after having received TACE and subsequently underwent LT were included (TACE + LT group) in the study. As controls, 21 patients who also met the Milan criteria and underwent LT without prior treatment were selected (LT group). Post-LT clinical outcomes, such as HCC recurrence, survival rate, and histologic features of explanted livers, were compared between the two groups. RESULTS: Baseline characteristics were not different between the two groups. Pre-LT maximal tumor diameter in TACE + LT group was similar to that of LT group (2.0 ± 0.6 cm vs 2.3 ± 0.9 cm; P = 0.10). Post-LT histologic findings also revealed similar maximal tumor diameter in the two groups (2.4 ± 1.4 cm vs 2.3 ± 0.9 cm; P = 0.70). Explanted livers showed similar incidence of unfavorable pathologic features. The morality within 60 d after transplantation was not different between the two groups (8.3% vs 9.5%; P = 0.99). Post-LT 5-year survival rate (57% vs 74%; P = 0.70) and cumulative recurrence rate (8.3% vs 4.8%; P = 0.90) were not significantly different between the two groups. CONCLUSION: The Milan criteria are still a useful selec- tion criteria showing favorable outcomes in HCC patientsreceiving TACE before LT. | Do Young Kim Moon Seok Choi Joon Hyoek Lee Kwang Cheol Koh Seung Woon Paik Byung Chul Yoo Sung Wook Shin Sung Wook Choo Young Soo Do Jong Chul Rhee | 2006 | World Journal of Gastroenterology2006，12，43： | 4 |
| 11 | High-risk esophageal varices in patients treated with locoregional therapy for hepatocellular carcinoma:Assessment with liver computed tomography显示文摘AIM:To assess the diagnostic performance of followup liver computed tomography(CT) for the detection of high-risk esophageal varices in patients treated with locoregional therapy for hepatocellular carcinoma(HCC).METHODS:We prospectively enrolled 100 patients with cirrhosis who underwent transcatheter arterial chemoembolization,radiofrequency ablation or both procedures for HCCs.All patients underwent upper endoscopy and subsequently liver CT.Three radiologists independently evaluated the presence of high-risk esophageal varices with transverse images alone and with three orthogonal multiplanar reformation(MPR) images,respectively.With endoscopic grading as the reference standard,diagnostic performance was assessed by using receiver operating characteristic(ROC) curve analysis.RESULTS:The diagnostic performances(areas under the ROC curve) of three observers with transverse images alone were 0.947 ± 0.031,0.969 ± 0.024,and 0.916 ± 0.038,respectively.The mean sensitivity,specificity,positive predicative value(PPV),and negative predicative value(NPV) with transverse images alone were 90.1%,86.39%,70.9%,and 95.9%,respectively.The diagnostic performances,mean sensitivity,specificity,PPV,and NPV with three orthogonal MPR images(0.965 ± 0.025,0.959 ± 0.027,0.938 ± 0.033,91.4%,89.5%,76.3%,and 96.6%,respectively) were not superior to corresponding values with transverse images alone(P > 0.05),except for the mean specificity(P = 0.039).CONCLUSION:Our results showed excellent diagnostic performance,sensitivity and NPV to detect high-risk esophageal varices on follow-up liver CT after locoregional therapy for HCC. | Hyojin Kim Dongil Choi Joon Hyeok Lee Soon Jin Lee Hangi Jo Geum-Youn Gwak Kwang Cheol Koh Moon Seok Choi Seonwoo Kim | 2012 | World Journal of Gastroenterology2012，18，35： | 4 |
| 12 | Gallbladder lymphangioma:A case report and review of the literature显示文摘Lymphangiomas are rare, benign tumors of the lymphatic system, usually present in children aged 5 years and younger. Because they are asymptomatic until the mass enlarges to cause symptoms, most lymphangiomas are diagnosed at adulthood incidentally. We experienced a case of a 60-year-old man diagnosed with a cystic lymphangioma of the gallbladder, which was successfully resected without any complication. Magnetic resonance imaging and magnetic resonance cholangiopancreatography were very helpful for the diagnosis of the cystic lesion around the gallbladder as were ultrasonography and computed tomography scan. These showed a multi-lobulated cystic mass with intact cystic duct and bile duct in the gallbladder fossa. The patient underwent an open cholecystectomy and the histological findings were consistent with a cystic lymphangioma of the gallbladder. We here report the case of cystic lymphangioma of the gallbladder with a review of the literature. | Jwa-Kyung Kim Kyo-Sang Yoo Joon Ho Moon Kwang Hyuk Park Yong Woo Chung Kyoung Oh Kim Cheol Hee Park Taeho Hahn Sang Hoon Park Jong Hyeok Kim Jang Yeong Jeon Min Jung Kim Kwang Seon Min Department of Pathology Hallym University College of Medicine Anyang Korea Choong Kee Park | 2007 | World Journal of Gastroenterology2007，13，2： | 3 |
| 13 | Serum prostate-specific antigen value adjusted for non-cancerous prostate tissue volume in patients undergoing radical prostatectomy: a new predictor of biochemical recurrence in localized or locally advanced prostate cancer显示文摘这研究的目的是调查为全部的肿瘤体积(PSA/tumor 体积) 调整的前列腺特定的抗原(PSA ) 价值和浆液 PSA 价值在激进的前列腺切除术以后作为病理学的调查结果和临床的结果的一个预言者为非癌的前列腺织物体积(NCPV )(PSA/NCPV ) 调整了的浆液的意义。407 个病人的临床、病理学的数据(中部的年龄:66.5 年;变化:41.8 鈥 ? 5.7 年) 回顾地被考察。中部的后续时期是 18.1 个月(范围:1.0 鈥 ? 07.8 个月) 。生物化学的复发被定义为可检测的 PSA 层次(比 0.2 ng ml 大 ? 1 ) 并且生物化学的复发的倍被花是第一次 PSA 变得可检测。在 multivariate 模型, PSA/NCPV 是囊外的扩展和积极外科的边缘的一个独立预言者(P < 0.05 ) ,但是 PSA/tumor 体积不。Kaplan 鈥揗e ier 曲线表明 PSA/NCPV 与生物化学的没有复发的幸存相关(P < 0.001;木头等级测试) 但是 PSA/tumor 体积(P=0.275;木头等级测试) 。PSA/NCPV 也是为 multivariate 考克斯上的生物化学的没有复发的幸存的一个重要独立预示的因素比例的危险分析(P=0.004,相对 risk=2.42 ) 。我们的调查结果建议 PSA/NCPV 与囊外的扩展和外科的边缘地位独立地被联系并且可以是在激进的前列腺切除术以后的 PSA 复发的一个独立预示的变量。 | Ja Hyeon Ku Kyung Chul Moon Sung Yong Cho Cheol Kwak Hyeon Hoe Kim | 2011 | Asian Journal of Andrology2011，13，2： | 3 |
| 14 | Genome-Wide Identification and Validation of a Novel Methylation Biomarker, SDC2 , for Blood-Based Detection of Colorectal Cancer显示文摘 | TaeJeong Oh Nayoung Kim Youngho Moon Myung Soon Kim Benjamin D. Hoehn Chan Hee Park Tae Soo Kim Nam Kyu Kim Hyun Cheol Chung Sungwhan An | 2013 | The Journal of Molecular Diagnostics2013，，4： | 2 |
| 15 | An experimental research on the fluidity and mechanical properties of high-strength lightweight self-compacting concrete显示文摘 | Yun Wang Choi Yong Jic Kim Hwa Cheol Shin Han Young Moon | 2004 | Cement and Concrete Research2004，，9： | 2 |
| 16 | Overtube-balloon–assisted direct peroral cholangioscopy by using an ultra-slim upper endoscope (with videos)显示文摘 | Hyun Jong Choi Jong Ho Moon Bong Min Ko Su Jin Hong Hyun Cheol Koo Young Koog Cheon Young Deok Cho Joon Seong Lee Moon Sung Lee Chan Sup Shim | 2009 | Gastrointestinal Endoscopy2009，，4： | 2 |
| 17 | Effect of tamsulosin on ejaculatory function in BPH/LUTS显示文摘这研究被承担在 tamsulosin 的射精的功能上决定影响(0.2 mg ) 给日报(OD ) 一次 12 个星期并且到在经历这治疗的病人为射精的机能障碍识别风险因素。有国际 Prostatic 症状分数(IPSS )≥ 的男性; 8 在这研究被注册。所有参加者完成了问询表,包括 IPSS 和男性健康问询表(MSHQ ) ,和浆液有虚空以后的剩余的前列腺特定的抗原, transrectal 超声和 uroflowmetry 被测量。在开始 0.2 以后; mg OD tamsulosin,病人们在药的第四和第 12 个星期被重新估计。摆平 chi 的测试,独立 t 测试和单程的 ANOVA 被用来比较工具。二进制逻辑回归分析被用来为所有风险因素计算机会比率。177 个人的一个总数组成了学习队。没有重要差别为可勃起的函数,射精的函数,满足,性活动和愿望域在基线和后续之间被观察(EFD, EjFD, SDA 并且增加) 或为可勃起或射精的麻烦平均数分数。在 12 个星期以后,射精的机能障碍(EjD ) 的全面发生是 13.4 %。EjD (在射精的减少的频率,延期,干,减少的力量 / 力量,减少的体积,减少的快乐和疼痛) 的七种不同类型的发生是 2.4 %, 3.1 %, 3.9 %, 3.9 %, 6.3 %, 7.1 %并且 3.1 %分别地。基线 EjFD 分数比为非应答者为 IPSS 应答者是更高的(26.09 对 24.06, P=0.03 ) 。EjFD 分数减小在 IPSS 应答者是更经常的。EjD 的发生小,然而并非可以忽略并且在有不太更低的尿道症状,更小的前列腺,更高的基线 MSHQ 总数和更高的 EjFD 分数的病人是更经常的。 | Sang Hoon Song Hwancheol Son Kwang Taek Kim Sae Woong Kim Du Geon Moon Ki Hak Moon Kwangsung Park Jong Kwan Park Sung-Won Lee Jae Seog Hyun Nam Cheol Park | 2011 | Asian Journal of Andrology2011，13，6： | 2 |
| 18 | Pre-S Mutation Is a Significant Risk Factor for Hepatocellular Carcinoma Development: A Long-Term Retrospective Cohort Study显示文摘 | Dong Hyun Sinn Moon Seok Choi Geum-Youn Gwak Yong-Han Paik Joon Hyeok Lee Kwang Cheol Koh Seung Woon Paik Byung Chul Yoo | 2013 | Digestive Diseases and Sciences2013，，3： | 2 |
| 19 | Effects of bamboo charcoal and bamboo vinegar as antibiotic alternatives on growth performance, immune responses and fecal microflora population in fattening pigs显示文摘 | Gyo Moon CHU Cheol Kyu JUNG Hoi Yun KIM Ji Hee HA Jong Hyun KIM Min Seob JUNG Shin Ja LEE Yuno SONG Rashid Ismael Hag IBRAHIM Jae Hyeon CHO Sung Sill LEE Young Min SONG | 2012 | Animal Science Journal2012，，2： | 2 |
| 20 | Clinicopathologic features and prognosis of combined hepatocellular cholangiocarcinoma显示文摘 | Kwang Cheol Koh Hyuk Lee Moon Seok Choi Joon Hyoek Lee Seung Woon Paik Byung Chul Yoo Jong Chul Rhee Jae Won Cho Cheol Keun Park Hong Joo Kim | 2005 | The American Journal of Surgery2005，，1： | 2 |
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