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| 1 | Synthesis, Antitumor Activity and Preliminary Structure-activity Relationship of 2-Aminothiazole Derivatives显示文摘In this paper, we described the synthesis of 2-aminoflfiazole sublibrary containing methyl, bromo, phenylor butylidene at 4- or/and 5-position of its core. All target compounds were evaluated tbr their antitumor activitiesagainst human lung cancer cell line H1299 and human glioma cell line SHG-44. Among the compotmds screened,4,5,6,7-tetrahydrobenzo[d]thiazole(26b) exhibited the most potent antittunor activities with IC50 values of 4.89 and4.03 μmol/L against the two tested cell lines, respectively. Preliminary structure-activity relationship(SAR) studies ofthese compound were subsequently investigated. | LI Hongshuang WANG Xinran DUAN Guiyun XIA Chengcai XIAO Yuliang LI Furong GE Yanqing YOU Guirong HAN Junfen FU Xiaopan | 2016 | Chemical Research in Chinese Universities2016，32，6： | 3 |
| 2 | Basic fibroblast growth factor protects against influenza A virus-induced acute lung injury by recruiting neutrophils显示文摘Influenza virus (IAV)infection is a major cause of severe respiratory illness that affects almost every country in the world.IAV infections result in respiratory illness and even acute lung injury and death,but the underlying mechanisms responsible for IAV pathogenesis have not yet been fully elucidated.In this study,the basic fibroblast growth factor 2 (FGF2)level was markedly increased in H1N1 virus-infected humans and mice.FGF2,which is predominately derived from epithelial cells,recruits and activates neutrophils via the FGFR2-PI3K-AKT-NFKB signaling pathway.FGF2 depletion or knockout exacerbated influenzaassociated disease by impairing neutrophil recruitment and activation.More importantly,administration of the recombinant FGF2 protein significantly aUeviated the severity of IAV-induced lung injury and promoted the survival of IAV-infected mice.Based on the results from experiments in which neutrophils were depleted and adoptively transferred,FGF2 protected mice against IAV , infection by recruiting neutrophils.Thus,FGF2 plays a critical role in preventing IAV-induced lung injury,and FGF2 is a promising potential therapeutic target during IAV infection. | Keyu Wang Chengcai Lai Tieling Li Cheng Wang Wei Wang Bing Ni Changqing Bai Shaogeng Zhang Lina Han Hongjing Gu Zhongpeng Zhao Yueqiang Duan Xiaolan Yang Li Xing Lingna Zhao Shanshan Zhou Min Xia Chengyu Jiang Xiliang Wang Penghui Yang | 2018 | Journal of Molecular Cell Biology2018，10，6： | 3 |
| 3 | Remote sensing precipitable water with GPS显示文摘The principle and method of remote sensing precipitable water (PW) by the Global Positioning System (GPS) are introduced. A series of tropospheric delay have been obtained from the dual frequency receiver’s data of global tracking stations in East Asia and precise satellite ephemeris of IGS from July 31 to August 20, 1997. The continuous PW at the interval of 30 min have been estimated at Shanghai and Wuhan GPS sites. The results are compared with PW from conventional radiosonde during the same period, and the RMS is about 0.50 cm. | Chengcai Li Jietai Mao Jianguo Li Qing Xia | 1999 | Chinese Science Bulletin1999，44，11： | 3 |
| 4 | Chromosomal-level genome of macadamia(Macadamia integrifolia)显示文摘Macadamia from the family Proteaceae is a plant native to Australia and has long been favoured by people for its crispy and high nutritional and medicinal value.Here,the genome of GUIRE 1(GR1),a highly heterozygous superior cultivar of macadamia nut,was sequenced and assembled using nanopore sequencing,and a 807-Mb genome(contig N50,1.9 Mb;scaffold N50,54.70 Mb)and 14 chromosomes were obtained.A total of 453 Mb(about 55.95%)repetitive sequences and 37,657 protein-coding genes were obtained by gene annotation and homologous protein comparison.Proteaceae diverged from Nelumbonaceae nearly 115.37 million years ago and from Rubiaceae about 140 million years ago.A genome-wide duplication(WGD)event occurred in macadamia 41 million years ago based on the WGD analysis.The functional enrichment analysis of M.integrifolia-specific gene families revealed their roles in signal transduction,protein phosphorylation,protein binding,and defense response.Here,a highly heterozygous genome of M.integrifolia was unlocked to provide a database for breeding and molecular mechanism research. | Chengcai Xia Sirong Jiang Qiujin Tan Wenquan Wang Long Zhao Chenji Zhang Yuting Bao Qi Liu Jianjia Xiao Ke Deng Miaohua He Pengliang An Wenlin Wang Meiling Zou Zhiqiang Xia | 2022 | Tropical Plants2022，1，1： | 3 |
| 5 | Retrieval of column-averaged volume mixing ratio of CO_2 with ground-based high spectral resolution solar absorption显示文摘The total column-averaged volume mixing ratio of atmospheric carbon dioxide(XCO2)has been retrieved with high spectral resolution solar absorption data obtained from ground-based Fourier transform spectrometer(FTS)measurements at Xichong,a coastal site in the district of Shenzhen in southern China.Based on differential optical absorption spectroscopy(DOAS)theory,the XCO2was retrieved by finding the best match of observed high spectral resolution solar absorption data and monochromatic radiation transfer model calculations.The averaged XCO2in the whole observation period was about 394.9 ppm.The uncertainty of the retrieval was estimated to be 2.0 ppm(0.51%)by comparing retrievals at two bands.The preliminary results show that XCO2retrieved by this method can be used to validate satellite remote sensing of XCO2: | Jian Li Chengcai Li Jietai Mao Dongwei Yang Dong Wang Lin Mei Guangming Shi Yefang Wang Xia Mao | 2014 | Chinese Science Bulletin2014，59，14： | 1 |
| 6 | Cascade reaction to 1H-pyrazoles from hydrazones via sodium Ni-trite promoted dual C-C/C-N formation,annulation and aromatization with 1,2-dichloroethane显示文摘A novel route for tandem C-C/C-N formation,annulation and aromatization of hydrazones with 1,2-dichloroethane to synthesize 1 H-pyrazoles has been developed.Furthermore,the 1,2-dichloroethane serves as alkylation reagent in good to excellent yields.This methodology features mild reaction conditions and good functional group tolerance,providing a direct approach for the preparation of 1 Hpvrazoles. | Liqiang Hao Hongyan Liu Zheng Zhang Fuqiang Wen Chengcai Xia Zengfen Pang | 2021 | Chinese Chemical Letters2021，32，7： | 0 |
| 7 | Synthesis and Biological Evaluation ofPyrano[2,3-f]chromene-4,8-dione Derivatives as Potential Anticancer Agents显示文摘Based on the hit 5-hydroxy-2-methyl-10-propyl-2,3-dihydro-4H,8H-pyrano[2,3-j]chromene-4,8-dione(1), a series of pyrano[2,3-f]chromene-4,8-dione derivatives was designed and synthesized using pb_loroghicinol as startingmaterial. Meanwhile, a regioselective synthetic route was developed for 5-methoxy-2,3-dihydro-4H,8H-pyrano-[2,3-f]chromene-4,8-dione products(11a-11f), and their structures were further confirmed by nuclear Overhausereffect(NOE). The evaluation of anticancer activities of these compounds against four human cancer cell lines,including human glioma cell line (SHG-44), human lung cancer cell line(H1299), breast cancer cell line(/vICF7) andhuman colon carcinoma cell line(HCT-116) in vitro shows that 5-methoxy-2,2-dimethyl-9-chloro-10-trifluormethyl-2,3-dihydro-4H,8H-pyrano[2,3-f]chromene-4,8-dione(lle) possesses the best anticancer activities with IC50 values of6.68, 7.90, 5.16 and 4.82 gmol/L, respectively. Finally, the preliminary structure-activity relationships(SARs) weresttmmarized, which could pave the way for generating more potent anticancer agents with drug-like properties. | LI Hongshuang WU Xiaming ZHANG Ruize HAO Liqiang DUAN Guiyun XIAO Yuliang XIA Chengcai LI Furong YOU Guirong HAN Junfen | 2017 | Chemical Research in Chinese Universities2017，33，2： | 0 |
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