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| 1 | Diallyl disulfide-induced G2/M arrest of human gastric cancer MGC803 cells involves activation of p38 MAP kinase pathways显示文摘AIM: To determine the role of p38 MAP kinase signal transduction pathways in diallyl disulfide (DADS)-induced G2/M arrest in human gastric cancer MGC803 cells.METHODS: MGC803 cell growth inhibition was measured by MTT assay. Phase distribution of cell cyde was analyzed by flow cytometry. Expression of Cdc25C, p38, phosphorylation of p38 (pp38) were determined by Western blotting.RESULTS: MT1- assay showed that SB203580, a specific p38 MAPK inhibitor blocked DADS-induced growth inhibition.Flow cytometry analysis revealed that treatment of MGC803 cells with 30 mg/L DADS increased the percentage of cells in the G2/M phase from 9.3% to 39.4% (P<0.05), whereas inhibition of p38 activity by SB203580 abolished induction of G2/M arrest by DADS. Western blotting showed that phosphorylation of p38 was increased 3.52-fold following treatment of MGC803 cells with 30 mg/L DADS for 20 min(P<0.05), whereas Cdc25C was decreased 68% following treatment of MGCS03 cells with 30 mg/L DADS for 24 h(P<0.05). Decreased Cdc25C protein expression by DADS was attenuated by SB203580 (P<0.05).CONCLUSION: DADS-induced G2/M arrest of MGC803 cells involves activation of p38 MAP kinase pathways.Decreased Cdc25C protein expression by p38 MAPK played a crucial role in G2/M arrest after treatment with DADS. | Jing-PingYuan Gui-HuaWang HuiLing QiSu Yue-HongYang YingSong Rong-JunTang YaoLiu ChenHuang | 2004 | World Journal of Gastroenterology2004，10，18： | 25 |
| 2 | Inhibition of the STAT3 signaling pathway is involved in the antitumor activity of cepharanthine in SaOS2 cells显示文摘瞄准: 调查位于 cepharanthine (CEP ) 的 antitumor 活动下面的分子的机制,从 Stephania cepharantha Hayata 提取的碱。 | ZanChen ChenHuang Yan-lingYang YiDing Han-qiangOu-Yang You-yiZhang MingXu | 2012 | Acta Pharmacologica Sinica2012，33，1： | 14 |
| 3 | On the k-error linear complexity of binary sequences derived from polynomial quotients显示文摘The k-error linear complexity is an important cryptographic measure of pseudorandom sequences in stream ciphers. In this paper, we investigate the k-error linear complexity of p2-periodic binary sequences defined from the polynomial quotients modulo p, which are the generalizations of the well-studied Fermat quotients.Indeed, first we determine exact values of the k-error linear complexity over the finite field F2 for these binary sequences under the assumption of 2 being a primitive root modulo p2, and then we determine their k-error linear complexity over the finite field Fp. Theoretical results obtained indicate that such sequences possess‘good' error linear complexity. | CHEN ZhiXiong NIU ZhiHua WU ChenHuang | 2015 | Science China(Information Sciences)2015，58，9： | 7 |
| 4 | Cryptanalysis and Improvement of a New Certificateless Signature Scheme in the Standard Model显示文摘Digital signature,as an important cryptographic primitive,has been widely used in many application scenarios,such as e-commerce,authentication,cloud computing,and so on.Certificateless Public Key Cryptography(PKC)can get rid of the certificate management problem in the traditional Public Key Infrastructure(PKI)and eliminate the key-escrow problem in the identity-based PKC.Lately,a new Certificateless Signature(CLS)scheme has been proposed by Kyung-Ah Shim(IEEE SYSTEMS JOURNAL,2018,13(2)),which claimed to achieve provable security in the standard model.Unfortunately,we present a concrete attack to demonstrate that the scheme cannot defend against the Type I adversary.In this type of attack,the adversary can replace the public key of the signer,and then he plays the role of the signer to forge a legal certificateless signature on any message.Furthermore,we give an improved CLS scheme to resist such an attack.In terms of the efficiency and the signature length,the improved CLS is preferable to the original scheme and some recently proposed CLS schemes in the case of precomputation. | Chenhuang Wu Hui Huang Kun Zhou Chunxiang Xu | 2021 | China Communications2021，18，1： | 1 |
| 5 | Effect of crosslink structures on dynamic mechanical properties of natural rubber vulcanizates under different aging conditions显示文摘 | RuliangFan YongZhang ChenHuang YinxiZhang YongzhongFan KangSun | 2001 | J Appl Polym Sci2001，，3： | 1 |
| 6 | Parotid tumors:a 10 year experience 显示文摘 | Ching ChiaLin Ming HsuiTsai Chiu ChenHuang | 2008 | AmericanJounalofOtolar- yngology Head and Neek Medicine and Surgery2008，29，： | 1 |
| 7 | Elliptic Curve Quaternary Sequences Constructed Using the Reverse Gray Mapping显示文摘Quaternary sequences are the most important sequences in view of many practical applications. Using the reverse Gray mapping, we propose a new construction of elliptic curve quaternary sequences with strong pseudorandom properties. We apply a result of Marzouk and Winterhof on the relation between the pseudorandom measures for binary sequences and the measures for quaternary sequences to analyze the well-distribution measure and correlation measure of order, which were introduced by Mauduit and S′arkzy, for the proposed sequences. | WU Chenhuang CHEN Zhixiong | 2014 | Chinese Journal of Electronics2014，23，3： | 1 |
| 8 | Basal repertoire of toxin-related transcripts in the zoanthid Protopalythoa variabilis(Cnidaria,Anthozoa)显示文摘OBJECTIVE To analyze the whole transcriptome of zoanthid Protopalythoa variabilis(P.variabilis),a cnidarian,and discover the potential toxic substances in P.variabilis.METHODS The P.variabilis RNA deep sequencing was performed using the HiSeq 2500 automatic sequencing platform.All the unigenes generated from the assembly process were functionally annotated based on the similarity with databases.The multiple alignments of translated toxin-related sequences were performed with Clustalw2,and amino acid identity and similarity highlighted by using BoxShade tool.Three different methods including ITASSER,PEP-FOLD and MODELLER were applied to predict tri-dimensional models of toxin-related polypeptides from translated transcript sequences of P.variabilis.The toxicity of one of the putative toxins,namely ShK/Aurelin-like peptide,was evaluated using zebrafish model.RESULTS A total of 67,549,914 pairs of quality-filtered,90-base-pair Illumina reads from an mRNA sample were obtained.The de novo assemblies yielded 276,526 contigs.The sequence comparison of 130,121 unigenes with entries in Toxin database showed that 1542 unigenes were potential peptide toxins at which 11 unigenes were related to Stichodactyla toxin(ShK)domain(Pfam ID:PF01549).ShK is a 35 residues peptide sequence that was firstly discovered from the sea anemone Stichodactyla helianthus.Here,we found out one ShK-like peptide that processed a relatively higher sequence similarity with known ShK(Uniprot ID:P29186)of Bunodosoma granuliferum(red warty sea anemone).The Protopalythoa Shk-like peptide was submitted to Probis server to detect probable binding site and found to match with a protein AURELIN(PDB id:2lg4,UniProt id:Q0MWV8)which possesses structural homology with previously identified antimicrobial peptides and K+-channel-blocking toxins.Our results showed that the ShK/Aurelin-like peptide was lethal to zebrafish embryos at concentrations above 30-μmol·L1,and could induce zebrafish locomotor deficit at 10μmol·L-1.CONCLUSION This study,for the first time,presented the whole transcriptome profile and a potential toxic peptide of P.variabilis. | ChenHUANG Jean-EtienneRLMORLIGHEM HefengZHOU EricaPatríciaLIMA PaulaBragaGOMES CarlosDanielPEREZ InchioLOU SimonMingYuenLEE GRadis-BAPTISTA | 2015 | 中国药理学与毒理学杂志2015，29，S1： | 0 |
| 9 | Construction of k-ary Pseudorandom Elliptic Curve Sequences显示文摘We present a method for constructing k-ary sequences over elliptic curves.Using the multiplicative character of order k of finite fields,we construct a family of k-ary pseudorandom elliptic curve sequences.The pseudorandom measures,such as the well-distribution measure,the correlation measure of order ■,and the linear complexity are estimated by using certain character sums.Such sequences share the same order of magnitude on the well-distribution measure,the correlation measure of order ■ as the 'truly' random sequences.The method indicates that it is possible to construct 'good' pseudorandom sequences over elliptic curves widely used in public key cryptography. | WU Chenhuang WENG Xin CHEN Zhixiong | 2011 | Wuhan University Journal of Natural Sciences2011，16，5： | 0 |
| 10 | On k-Error Linear Complexity of Some Explicit Nonlinear Pseudorandom Sequences显示文摘Combining with the research on the linear complexity of explicit nonlinear generators of pseudorandom sequences,we study the stability on linear complexity of two classes of explicit inversive generators and two classes of explicit nonlinear genera-tors. We present some lower bounds in theory on the k-error linear complexity of these explicit generators,which further improve the cryptographic properties of the corresponding number generators and provide very useful information when they are applied to cryptography. | CHEN Zhixiong WU Chenhuang | 2008 | Wuhan University Journal of Natural Sciences2008，13，5： | 0 |
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