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| 1 | Past,present,and future of biochar显示文摘After entering the twenty-first century,biochar has become a focal point of multidisciplinary research because of its special characteristics,broad application,and promising development prospects.Basic and applied research on the application of biochar in the areas of agriculture,environment,and energy have increased dramatically in the face of food security,environmental pollution,and energy shortage.Although there are some disputes about biochar research,many studies have demonstrated the importance of biochar research from the perspective of scientific advancement and practical application.This paper briefly recalls the history of biochar application;introduces research progress on the basic characteristics of biochar and its associated production technologies;summarizes the research status and existing problems of biochar application in the areas of agriculture,environment,and energy;and analyzes the potential problems and development trends of biochar research in the future. | Wenfu Chen Jun Meng Xiaori Han Yu Lan Weiming Zhang | 2019 | Biochar2019，1，1： | 66 |
| 2 | COL4A3 mutations cause focal segmenta glomerulosclerosis显示文摘 | Jingyuan Xie Xiaoxi Wu Hong Ren Weiming Wang Zhaohui Wang Xiaoxia Pan Xu Hao Jun Tong Jun Ma Zhibin Ye Guoyu Meng Yufei Zhu Krzysztof Kiryluk Xiangyin Kong Landian Hu Nan Chen | 2014 | Journal of Molecular Cell Biology2014，8，6： | 15 |
| 3 | Liquefaction macrophenomena in the great Wenchuan earthquake显示文摘On May 12,2008 at 14:28,a catastrophic magnitude Ms 8.0 earthquake struck the Sichuan Province of China.The epicenter was located at Wenchuan(31.00oN,103.40oE).Liquefaction macrophenomena and corresponding destruction was observed throughout a vast area of 500 km long and 200 km wide following the earthquake.This paper illustrates the geographic distribution of the liquefaction and the relationship between liquefaction behavior and seismic intensity,and summarizes the liquefaction macrophenomena,including sandboils and waterspouts,ground subsidence,ground fi ssures etc.,and relevant liquefaction features.A brief summary of the structural damage caused by liquefaction is presented and discussed.Based on comparisons with liquefaction phenomena observed in the 1976 Tangshan and 1975 Haicheng earthquakes,preliminary analyses were performed,which revealed some new features of liquefaction behavior and associated issues arising from this event.The site investigation indicated that the spatial non-uniformity of liquefaction distribution was obvious and most of the liquefi ed sites were located in regions of seismic intensity VIII.However,liquefaction phenomena at ten different sites in regions of seismic intensity VI were also observed for the fi rst time in China mainland.Sandboils and waterspouts ranged from centimeters to tens of meters,with most between 1 m to 3 m.Dramatically high water/sand ejections,e.g.,more than 10 m,were observed at four different sites.The sand ejections included silty sand,fi ne sand,medium sand,course sand and gravel,but the ejected sand amount was less than that in the 1976 Tangshan earthquake.Possible liquefaction of natural gravel soils was observed for the fi rst time in China mainland. | Chen Longwei Yuan Xiaoming Cao Zhenzhong Hou Longqing Sun Rui Dong Lin Wang Weiming Meng Fanchao Chen Hongjuan | 2009 | Earthquake Engineering and Engineering Vibration2009，8，2： | 14 |
| 4 | Policy and Management of Carbon Peaking and Carbon Neutrality:A Literature Review显示文摘The vision of reaching a carbon peak and achieving carbon neutrality is guiding the low-carbon transition of China’s socioeconomic system.Currently,a research gap remains in the existing literature in terms of studies that systematically identify opportunities to achieve carbon neutrality.To address this gap,this study comprehensively collates and investigates 1105 published research studies regarding carbon peaking and carbon neutrality.In doing so,the principles of development in this area are quantitively analyzed from a space–time perspective.At the same time,this study traces shifts and alterations in research hotspots.This systematic review summarizes the priorities and standpoints of key industries on carbon peaking and carbon neutrality.Furthermore,with an emphasis on five key management science topics,the scientific concerns and strategic demands for these two carbon emission-reduction goals are clarified.The paper ends with theoretical insights on and practical countermeasures for actions,priority tasks,and policy measures that will enable China to achieve a carbon-neutral future.This study provides a complete picture of the research status on carbon peaking and carbon neutrality,as well as the research directions worth investigating in this field,which are crucial to the formulation of carbon peak and carbon neutrality policies. | Yi-Ming Wei Kaiyuan Chen Jia-Ning Kang Weiming Chen Xiang-Yu Wang Xiaoye Zhang | 2022 | Engineering2022，8，7： | 14 |
| 5 | Stability analysis of the temperature cracks in Xiaowan arch dam显示文摘In the Xiaowan arch dam there are massive temperature cracks nearly parallel to the dam axis. Obviously, whether the cracks may spread or not during the water storage process is one of the crucial factors for the safety of a dam. In this paper, a new type of crack element, in which the contact component is implicitly included into the concrete component, is proposed to simulate the effects of the existing cracks. The crack element is proved by numerical example to share the merits of both conventional contact elements and joint elements. With a finite element model of the cracked arch dam together with its rock foundation established, the transient displacement and stress fields of the dam are obtained. The complicated rock foundation, the construction process of the arch dam, the massive cracks, the transient temperature field, as well as the water storage process have been taken into consideration in the simulation. In addition to the global model, several sub-models for typical crack tips are also generated with finer elements placed around the tips. Thus, more accurate displacement and stress distribution are obtained by simultaneous sub-model simulation. Based on the calculation of stress intensity factor for crack tips by extension method, the temperature cracks in the Xiaowan arch dam are finally proved to be stable. | WANG WeiMing DING JianXin WANG GuoJin ZOU LiChun CHEN ShengHong | 2011 | Science China(Technological Sciences)2011，54，3： | 12 |
| 6 | UNCONFINED SEEPAGE ANALYSIS OF DISCONTINUOUS ROCK SLOPE显示文摘The unconfined seepage field of arch dam abutment s lope was studied. This paper is composed of two parts. The first part concerns with the numerical methods used in the analysis, which i ncludes the identification of rock blocky system and the algorithm of the unconf ined seepage flow in the discontinuity network with the consideration of the gro uting curtain and drainage curtain. In the second part a complicated arch dam ab utment slope was studied, for which the seepage flow field characteristics was a nalyzed and the seepage control system was evaluated. | Chen, Shenghong Wang, Weiming She, Chengxue Xu, Mingxi | 2000 | Journal of Hydrodynamics2000，12，3： | 11 |
| 7 | Inhibition of lung cancer cell proliferation mediated by human mesenchymal stem cells显示文摘人的间充质的干细胞(hMSCs ) 主要为他们的潜在的临床的使用被学习。最近,癌症研究的领域里的许多注意对 hMSCs 被给予了。在这研究,我们由使用一个合作文化系统和调节 hMSCs 的媒介在 vitro 并且在 vivo 在肺癌症房间线 SK-MES-1 和 A549 的增长上调查了 hMSCs 的影响。我们的结果证明 hMSCs 能禁止 SK-MES-1 和 A549 房间的增长,并且经由一些可溶的因素在 vitro 导致肿瘤房间的 apoptosis。动物学习证明从 hMSCs 的这些可溶的因素能由 preliminarily 与调节 hMSCs 的媒介对待肿瘤细胞压制 tumorigenesis 和肿瘤 angiogenesis。在肿瘤房间的脉管的 endothelial 生长因素的 downregulated 表示可能是在肿瘤 angiogenesis 的干扰的机制,它被西方的污点分析和 immunohistochemistry 试金验证。一起拿,我们的结果建议 hMSCs 能由 secreting 一些禁止肿瘤细胞生长可溶的因素。 | Lin Li Hui Tian Zhitao Chen Weiming Yue Shuhai Li Wenjun Li | 2011 | Acta Biochimica et Biophysica Sinica2011，43，2： | 11 |
| 8 | Development of the straw biochar returning concept in China显示文摘Biochar produced from straw has been shown to improve soil physicochemical properties.This review introduces the fundamental concepts,the broad applications,and underlying theory of straw biochar returning.Current developments in biochar industry and the production practices prevalent among enterprises in China are critiques.This review analyzes current knowledge gaps,challenges,and opportunities in the industrial application of straw biochar returning.Biochar standards,the quantitative and qualitative analysis methods for biochar,and high-value-added products that are based on biochar are critically examined with goal of providing recommendations for future studies.We propose production and modification of biochar that is application oriented to enhance its fitness for purpose as well as long-term and large-space-scale field study to better understand its impact on soil properties and ecotoxicology.Finally,we make prospects for the future development of SBR,including constructing a standard system about straw biochar returning and promoting self-discipline of biochar industry and the establishment of a biochar-based agricultural production model. | Jun Meng Tianyi He Edmond Sanganyado Yu Lan Weiming Zhang Xiaori Han Wenfu Chen | 2019 | Biochar2019，1，2： | 9 |
| 9 | WheatOmics:A platform combining multiple omics data to accelerate functional genomics studies in wheat显示文摘Dear Editor,Mold-breaking progress in whole-genome sequencing and rapid accumulation of multi-omics data have revolutionized the research strategies of functional genomics in wheat(Wang et al.,2018).However,how to access these vast multi-omics data and to extract key information on genes of in-terest,is still challenging for most wet-lab or field wheat re-searchers who have little bioinformatic experiences and cannot access the expensive computational resources.Here,we pre-sent WheatOmics(http://gffzz513af15b15bc4712h6bq90uqow9cq6q0u.ffgz.tsg.suse.edu.cn/,previously designated as Triticeae Multi-omics Center,http://gffzz601e21d286504235h6bq90uqow9cq6q0u.ffgz.tsg.suse.edu.cn/),a free,web-accessible,and user-friendly platform.WheatOmics not only empowers the effective access to the visualized multi-omics data of user-interested genes but also offers several distinctive and practical toolkits that can ease almost every aspect of wheat functional genomics studies(Figure 1A). | Shengwei Ma Meng Wang Jianhui Wu Weilong Guo Yongming Chen Guangwei Li Yanpeng Wang Weiming Shi Guangmin Xia Daolin FU Zhensheng Kang Fei Ni | 2021 | Molecular Plant2021，14，12： | 9 |
| 10 | Comparative Analysis of Leaf Trichomes, Epidermal Wax And Defense Enzymes Activities in Response to Puccinia horiana in Chrysanthemum and Ajania Species显示文摘White rust caused by Puccinia horiana is a destructive disease of chrysanthemum plants.To better understand the resistance mechanisms of composite species to this disease,the leaf cuticular traits,antioxidant and defensive enzymes activities of immune(Chrysanthemum makinoi var.wakasaense)and highly susceptible(Ajania shiwogiku var.kinokuniense)species were compared.Trichome density of two species was markedly different,negatively associated with plant resistance to P.horiana.Total wax load in C.makinoi var.wakasaense was two times more than that in A.shiwogiku var.kinokuniense.The wax composition in immune one was abundant in esters and primary alcohols.Superoxide dismutase(SOD,EC 1.15.1.1),peroxidase(POD,EC 1.11.1.7),polyphenoloxidase(PPO,EC 1.14.18.1 or EC 1.10.3.2)and phenylalanine ammonia lyase(PAL,EC 4.3.1.5)activitieswere investigated.In C.makinoi var.wakasaense,the activity of SOD and POD increased rapidly after inoculation,whichmight be non-host induced reactive oxygen species(ROS)activated antioxidant enzymes,however SOD and POD remained a low and steady level in the highly susceptible one after inoculation.Quick increase in PPO activities after inoculation was observed in both species,however it remained higher in C.makinoi var.wakasaense at the late period of inoculation.PAL in C.makinoi var.wakasaense was induced after pathogen inoculation,but not in A.shiwogiku var.kinokuniense,suggesting that these two enzymes might contribute to the resistance to P.horiana. | Yinjie Wang Jun Zeng Xiaolong Xia Yang Xu Jing Sun Jing Gu Hainan Sun Haini Lei Fadi Chen Jiafu Jiang Weiming Fang Sumei Chen | 2020 | Horticultural Plant Journal2020，6，3： | 8 |
| 11 | Assessment of the immune responses to Treponema pallidum Gpd DNA vaccine adjuvanted with IL-2 and chitosan nanoparticles before and after Treponema pallidum challenge in rabbits显示文摘Syphilis is a multistage,sexually transmitted disease caused by the spirochete,Treponema pallidum(Tp).A significantly high incidence of syphilis has been reported in several countries,including China,and there is an urgent need for the development of efficacious vaccines against syphilis.DNA vaccines are a major breakthrough in the field of vaccination with several advantages over traditional vaccines.Animal model studies of Tp DNA vaccines have not been reported elsewhere but our previous reports describe the development of a single-gene Tp DNA vaccine and preclinical immunization study.In this study,chitosan(CS) nanoparticles were used as a vector and an interleukin-2 expression plasmid(pIL-2) as an adjuvant to enhance a TpGpd DNA vaccine candidate(pTpGpd) in a rabbit Tp skin challenge model.At week 8 after the first immunization,three rabbits from each group were used to determine cytokine measurements and spleen lymphocyte proliferation assay.pTpGpd in combination with pIL-2 wrapped with CS led to the greatest enhancement of anti-TpGpd antibodies and T-cell proliferation.During infection,levels of anti-TpGpd antibodies and T-cell proliferation were measured.Both the serum special IgG and IL-2,interferon-γ were significantly increased by the co-injection of the IL-2 plasmid compared with the injection of TpGpd DNA alone(P<0.05).Furthermore,IL-2 plasmid coinjection efficiently enhanced the antigen-specific lymphocyte proliferation response.Additionally,the ratios of positive skin lesions and ulcer lesions in groups immunized with pTpGpd were significantly lower than those of the pIL-2,CS or pIL-2 mixed with CS control groups(P<0.001).CS vectored and pIL-2 adjuvanted pTpGpd immunized animals exhibited the lowest rates of positive skin tests(8.33%) and ulcer lesions(4.17%) and the fastest recovery(42 d).These experiments indicate that co-injection of a pIL-2 plasmid with pTpGpd DNA vaccine wrapped with CS can significantly strengthen the long-term stability of immune response during infection,efficiently improve the protective effect against T.pallidum spirochetes infection and attenuate syphilitic lesion development. | ZHAO FeiJun ZHANG XiaoHong LIU ShuangQuan ZENG TieBing YU Jian GU WeiMing ZHANG YueJun CHEN Xi WU YiMou | 2013 | Science China(Life Sciences)2013，56，2： | 8 |
| 12 | Identification of the lower limit of high-quality source rocks and its relation to hydrocarbon accumulation——Taking the Beier Sag in the Hailaer Basin as an example显示文摘The theory of 'source rock control' has evolved from source-rock-control hydrocarbon accumulation, to effective source-rock-control hydrocarbon accumulation, and to high-quality source-rock-control hydrocarbon accumulation. However, there are problems, such as whether high-quality source rocks exist or not? What high-quality source rocks are, and how to identify them, are yet to be agreed upon. Aimed at this issue of concern to explorationists, and taking the Beier Sag in the Hailaer Basin as an example, this paper defines the high-quality source rocks and the lower limit for evaluation of high-quality source rocks, by using the inflection point on the relationship curve of hydrocarbon (oil) expulsion, which is calculated by the material balance principle, versus total organic carbon (TOC). The results show that when TOC is low, all source rocks have limited hydrocarbon expulsion and slow growth rate, thus they cannot be high-quality source rocks. However, when TOC rises to some threshold, hydrocarbon expulsion increases significantly with TOC. This inflection point should be the lower limit of high-quality source rocks: those with TOC greater than the inflection-point value are high-quality source rocks. In addition, the lower limit of high-quality source rocks is also related to the type and maturity of organic matters in the source rocks, as well as the mineral components of the source rocks affecting the residual hydrocarbons. Theoretically, the lower limit of high-quality source rocks depends on geological conditions rather than being a constant value. However, for the sake of simplicity and practicability, in this paper TOC=2.0% is regarded as the lower limit of high-quality source rocks. The examination of such standard in the work area indicates that the high-quality source rocks in members K 1 n 2 and K 1 n 1 of the Nantun formation contribute 76% and 82% to oil generation, and 96% and 91% to oil expulsion , respectively. The distribution of high-quality source rocks is also closely related to the distribution of hydrocarbon reservoirs in the region, demonstrating that high-quality source rocks control hydrocarbon accumulation. | Lu Shuangfang Chen Fangwen Li Jijun Wang Weiming Li Huiguang Cao Ruicheng Ma Yanling | 2012 | Petroleum Science2012，9，1： | 7 |
| 13 | Effects of Sini San used alone and in combination with fluoxetine on central and peripheral 5-HT levels in a rat model of depression显示文摘OBJECTIVE: To investigate the effects of Sini San and fluoxetine on the levels of central and peripheral 5-HT in a rat model of depression, and provide new insight into the treatment of depression with integrated Chinese-Western Medicine.METHODS: A rat model of depression was established by chronic mild stress(CMS). Model rats received either Sini San, fluoxetine, a combination of the two drugs, or no drug treatment. Healthy naive rats were used as controls. Open field and sucrose preference tests were used to assess depression-like behavior. ELISA and immunohistochemistry were used to determine central and peripheral levels of 5-HT.RESULTS: In the group with no drug treatment,central 5-HT expression decreased while peripheral5-HT concentrations increased as CMS continued.Four weeks after CMS, Sini San alone was less effective in reducing depression-like behavior than fluoxetine alone or in combination with Sini San,but combined use was more effective than fluoxetine alone. Eight weeks after CMS, Sini San alone or in combination with fluoxetine was more effective in reducing depression-like behavior than fluoxetine alone. Furthermore Sini San and fluoxetine used alone or in combination notably increased central 5-HT expression and decreased peripheral 5-HT levels in the rat model.CONCLUSION:The results of the present study indicate that there is a synergistic action between the two medicines in the treatment of depression. Sini San exhibited a relatively long lag before its effects were observed; however, by eight weeks the Traditional Chinese Medicine appeared at least as effective as fluoxetine. We suggest that Sini San can replace fluoxetine in the later stages of depression treatment to minimize side effects observed with long-term fluoxetine administration. | Yubo Li Yuxiu Sun Xueling Ma Xiaoxing Xue Wenting Zhang Zhiqian Wu Yulin Ouyang Jianxin Chen Weiming Wang Shuzhen Guo Wei Wang | 2013 | Journal of Traditional Chinese Medicine2013，33，5： | 6 |
| 14 | Diallyl trisulfide induces apoptosis and inhibits proliferation of A549 cells in vitro and in vivo显示文摘肺癌症是在整个世界的癌症相关的死亡的领先的原因。在最近的年里,肺的腺癌在频率超过了有鳞的房间癌并且是在许多国家的肺癌症的占优势的形式。流行病学的调查显示出在消费和死亡从许多癌症评估的大蒜(瞀或蒜之类 sativum ) 之间的一种反的关系。Diallyl trisulfide (DATS ) 是导出大蒜的混合物之一(是也知道:organosulfer 混合物,振荡) 。DATS 能导致 apoptosis 并且禁止许多癌症细胞线的生长。我们的学习证明 DATS 导致的 apoptotic 事件是通过导致了 Bax/Bcl-2 和 caspase-3, -8, 和 -9 的活动的比率的起来规定的 anti-apoptotic Bcl-2 的重要减少的线粒体依赖者 caspase 串联。最后, DATS 导致了 apoptosis 并且在一个集中依赖者和时间依赖者举止禁止了增长。由与 A549 异种皮移植建立女 BALB/c 裸体老鼠的一个动物模特儿,没有与控制组相比引起重量损失或任何另外的副作用,而且,我们在裸体老鼠发现 DATS 的那口头的 gavage A549 异种皮移植的显著地延迟的生长。在 vitro 并且在 vivo 的所有证据建议 DATS 能是理想的反癌症药。 | Wenjun Li Hui Tian Lin Li Shuhai Li Weiming Yue Zhitao Chen Lei Qi Wensi Hu Yingchao Zhu Bin Hao Cun Gao Libo Si Fei Gao | 2012 | Acta Biochimica et Biophysica Sinica2012，44，7： | 6 |
| 15 | Human fused NKG2D-IL-15 protein controls xenografted human gastric cancer through the recruitment and activation of NK cells显示文摘Interleukin (IL )-15 在生来的杀手(NK ) 和 CD8+T 房间增长和功能起一个重要作用并且是比为肿瘤免疫疗法的 IL-2 更有效的。由附近的房间的 IL-15 的 trans 演讲比它的可溶的 IL-15 为 NK 房间激活是更有效的。在这研究,熔化蛋白质 dsNKG2D-IL-15,由经由一个连接器联合到人的 IL-15 的人的 NKG2D 的二相同的细胞外的域组成了,在 Escherichia coli 被设计。DsNKG2D-IL-15 能高效地与二个 NKG2D 领域和 trans 礼品 IL-15 把人的肿瘤房间的链相关的蛋白质 A (云母) 绑在主要 histocompatibility 建筑群一级到 NK 或 CD8+ T 房间。我们移植了人的胃的癌症(SGC-7901 ) 房间进裸体老鼠和有进 C57BL/6 老鼠的云母(B16BL6 云母) 的宫外的表示的老鼠黑瘤房间。然后,我们学习了反肿瘤效果在二个 xenografted 肿瘤模特儿由 dsNKG2D-IL-15 调停了。人的 dsNKG2D-IL-15 在压制胃的癌症生长比 IL-15 展出了更高的效率。外长的人的 dsNKG2D-IL-15 集中地在老鼠肿瘤纸巾被散布基于在 vivo 实时成像。房间渗入了进跟随外部血 mononuclear 房间的注射进忍受人的胃的癌症的裸体老鼠的肿瘤纸巾的人的 CD56+ 的频率被人的 dsNKG2D-IL-15 治疗显著地增加。人的 dsNKG2D-IL-15 也由激活和招募的老鼠 NK 和 CD8+ T 房间推迟了移植黑瘤(B16BL6 云母) 的生长。在 C57BL/6 老鼠的人的 dsNKG2D-IL-15 的反黑瘤效果主要被减少由在里面老鼠 NK 房间的 vivo 弄空。这些数据热点为肿瘤的人的 dsNKG2D-IL-15 的潜在的使用治疗。 | Yan Chen Bei Chen Ti Yang Weiming Xiao Li Qian Yanbing Ding Mingchun Ji Xiaoqun Ge Weijuan Gong | 2017 | Cellular & Molecular Immunology2017，14，3： | 6 |
| 16 | Human mesenchymal stem cells with adenovirus-mediated TRAIL gene transduction have antitumor effects on esophageal cancer cell line Eca-109显示文摘apoptotic ligand TNF 相关的导致 apoptosis ligand (小道) 被相信是癌症 genetherapy 的一个有希望的候选人,然而,全身地处理这疾病的基因治疗策略被 thevector 的低效的交货经常损害到肿瘤组织。间充质的干细胞(MSC ) 被显示出到家到肿瘤地点并且能潜在地 actas 为 antitumor 基因治疗向量的盾和车辆。这里,我们使用了表示小道到 transduceMSCs 的 adenoviral 向量并且在食道的癌症房间 Eca-109 上学习了这些带小道的 MSC 的导致 apoptosis 活动。我们在 vitro,表示小道的 MSC 能禁止增长并且由 MTT 试金, co-cultureexperiments 和流动 cytometry 分析在 Eca-109 房间导致 apoptosis 的 resultsshowed。在 vivo,表示小道的 MSC 也显示了一个能力在一个 Eca-109 异种皮移植老鼠模型禁止肿瘤生长。一起, ourfindings 显示基于 MSCs 的小道基因交货的基因治疗策略为食道的癌症的 improvingthe 治疗有宽潜在的价值。 | Lin Li Fengling Li Hui Tian Weiming Yue Shuhai Li Guanqing Chen | 2014 | Acta Biochimica et Biophysica Sinica2014，46，6： | 5 |
| 17 | Preparation of polymer-supported hydrated ferric oxide based on Donnan membrane effect and its application for arsenic removal显示文摘In the present study a novel technique was proposed to prepare a polymer-supported hydrated ferric oxide (D201-HFO) based on Donnan membrane effect by using a strongly basic anion exchanger D201 as the host material and FeCl3-HCl-NaCl solution as the reaction environment. D201-HFO was found to exhibit higher capacity for arsenic removal than a commercial sorbent Purolite ArsenX. Furthermore, it presents favorable adsorption selectivity for arsenic removal from aqueous solution, as well as satis- factory kinetics. Fixed-bed column experiments showed that arsenic sorption on D201-HFO could re- sult in concentration of this toxic metalloid element below 10 μg/L, which was the new maximum con- centration limit set recently by the European Commission and imposed by the US EPA and China. Also, the spent D201-HFO is amenable to efficient regeneration by NaOH-NaCl solution. | ZHANG QingJian PAN BingCai CHEN XinQing ZHANG WeiMing PAN BingJun ZHANG QuanXing L.LV X.S.ZHAO | 2008 | Science China Chemistry2008，51，4： | 4 |
| 18 | Qiguiyishen decoction reduced the accumulation of extracellular matrix in the kidneys of rats with adriamycin-induced nephropathy显示文摘OBJECTIVE: To investigate the effect of Qiguiyishen decoction(QGYS) on the severity of nephropathy.METHODS: Twenty-four rats were randomly divided into four groups(Ⅰ, Ⅱ, Ⅲ, Ⅳ) according to the random number table. Group Ⅰ as control group did not establish nephropathy model. Groups Ⅱ,Ⅲ, and Ⅳ were intravenously administered Adriamycin(7.5 mg/kg) through the tail vein to establish nephropathy model. QGYS was prepared with the extracts of Huangqi(Radix Astragali Mongolici),Danggui(Radix Angelicae Sinensis),Niuxi(RadixAchyran-this Bidentatae), and Chuanxiong(Rhizoma Chuanxiong).Group Ⅳ was administered QGYS (2mL·kg-1·d-1), group Ⅲ was administered benazepril(10 mL·kg-1·d-1), and group Ⅰ, Ⅱ was administered water(2mL·kg-1·d-1)once daily for eight weeks.RESULTS: QGYS reduced the excretion of urinary protein and N-acetyl-β-D-glucosaminidase and alleviated the accumulation of extracellular matrix(ECM) in renal tissue. Additionally, QGYS effectively regulated the levels of transforming growth factor,tissue inhibitor of matrix metalloproteinase, and matrixmetalloprote in asesin the kidney of the rats.CONCLUSION:QGYS may reduce the accumulation of ECM in the kidneys of rats with Adriamycin-induced nephropathy. | Minggang Wei Wei Sun Weiming He Li Ni Xiaofeng Cai Zongqi Cheng Kun Gao Fengling Li Lin Chen Xinping Zhang | 2014 | Journal of Traditional Chinese Medicine2014，34，3： | 4 |
| 19 | Valsartan Inhibited the Accumulation of Dendritic Cells in Rat Fibrotic Renal Tissue显示文摘为了在到 tubulointerstitial 纤维变性的老鼠残余肾和它的贡献观察树枝状的房间(DC ) 的累积,在 DC 上的 valsartan 的影响下面,一个老鼠残余肾模型被小计肾切除术建立。四个试验性的组被包括:正常,假冒,模型(SNx ) 和这个组与 Valsartan (SNxV ) 对待。老鼠分别地在星期 1,4 和 12 点被打死。CD1a+CD80+ DC 是由两倍 immunostaining 方法的 assayed,图象与 Axioplan 2 显微镜学被分析。P-selectin, TGF-1, -SMA, 骨胶原和 fibronectin 的表情被 immunohistochemistry 或 semiquantitative RT-PCR 分析,并且 tubulointerstitial firosis (TIF ) 的水平被获得。CD1a+CD80+ DC 逐渐地在肾的小管, interstitium 和容器之中被增加,特别在在在星期 12 点的模型组的 DC 的 interstitium,和数字在在星期 1 或 4 点的模型组是多于那的大部分。在 tubulointerstitial 区域和 TIF 的度的 P-selectin, TGF-1, -SMA, 骨胶原和 fibronectin 的表情在星期 12 点在模型组实质地被增加。在 interstitium 的 DC 的累积很好与肾的功能和 tubulointerstitial 纤维变性的前进的损失被联系。Valsartan 处理禁止了 DC 的本地累积并且稀释了肾的 tubulointerstitial 损坏。本地 DC 累积与跟随肾的脱离的 tubulointerstitial 纤维变性和肾的机能障碍有关。对血管收缩素的封锁可能是稀释肾的免疫煽动性的损害的一个有势力方法。 | Kaiyin Wu Tong Zhou Guizhi Sun Weiming Wang Yumei Zhang Yanyun Zhang Li Hao Nan Chen | 2006 | Cellular & Molecular Immunology2006，3，3： | 4 |
| 20 | Selective Oxidation of CO in Excess H_2 over Ru/Al_2O_3 Catalysts Modified with Metal Oxide显示文摘与金属氧化物(K2OandLa2O3 ) 修改的 Ru/Al2O3 催化剂从与硝酸盐在 Al2O3 支持上装载混合的 RuCl3 · n H2O 经由早期的湿受精方法被准备。催化剂的活动从改革气体生产的充满氢的煤气的溪流为公司(CO-PROX ) 的优先的氧化在模拟条件下面被评估,并且催化剂的表演被 XRD 和 TPR 调查。结果证明修改催化剂 Ru-K2O/Al2O3 和 Ru-La2O3/Al2O3 的活动温度被降低约 30 ° C 与纯 Ru/Al2O3,和活动温度范围相比被拓宽。Ru-K2O/Al2O3 和 Ru-La2O3/Al2O3 上的公司的变换在 140 160 ° C 超过 99% ,合适在充满氢的气体和 Ru-La2O3/Al2O3 的选择移开公司比在活跃温度范围的 Ru-K2O/Al2O3 的高。细微 methanation 反应在 220 ° C 并且在上面被检测。 | Xirong Chen Hanbo Zou Shengzhou Chen Xinfa Dong Weiming Lin | 2007 | Journal of Natural Gas Chemistry2007，16，4： | 4 |
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