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| 1 | Establishment of a new tropospheric delay correction model over China area显示文摘The tropospheric delay is one of the main error sources for radio navigation technologies and other ground-or space-based earth observation systems. In this paper, the spatial and temporal variations of the zenith tropospheric delay (ZTD), especially their dependence on altitude over China region, are analyzed using ECMWF (European Centre for Medium-Range Weather Forecast) pressure-level atmospheric data in 2004 and the ZTD series in 1999-2007 measured at 28 GPS stations from the Crustal Movement Observation Network of China (CMONC). A new tropospheric delay correction model (SHAO) is derived and a regional realization of this model for China region named SHAO-C is established. In SHAO-C model, ZTD is modeled directly by a cosine function together with an initial value and an amplitude at a reference height in each grid, and the variation of ZTD along altitude is fitted with a second-order polynomial. The coefficients of SHAO-C are generated using the meteorology data in China area and given at two degree latitude and longitude interval, featuring regional characteristics in order to facilitate a wide range of navigation and other surveying applications in and around China. Compared with the EGNOS (European Geostationary Navigation Overlay Service) model, which has been used globally and recommended by the European Union Wide Area Augmentation System, the ZTD prediction (in form of spatial and temporal projection) accuracy of the SHAO-C model is significantly improved over China region, especially at stations of higher altitudes. The reasons for the improvement are: (1) the reference altitude of SHAO-C parameters are given at the average height of each grid, and (2) more detailed description of complicated terrain variations in China is incorporated in the model. Therefore, the accumulated error at higher altitude can be reduced considerably. In contrast, the ZTD has to be calculated from the mean sea level with EGNOS and other models. Compared with the direct estimation of ZTD from the 28 GPS stations, the accuracy of the derived ZTD using the SHAO-C model can be improved by 60.5% averagely compared with the EGNOS model. The overall bias and rms are 2.0 and 4.5 cm, respectively, which should be sufficient to satisfy the requirements of most GNSS navigation or positioning applications in terms of the tropospheric delay correction. | SONG ShuLi ZHU WenYao CHEN QinMing LIOU YueiAn | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，12： | 24 |
| 2 | Osteogenic growth peptide enhances the proliferation of bone marrow mesenchymal stem cells from osteoprotegerin-deficient mice by CDK2/cyclin A显示文摘支持骨头形成是在骨质疏松症治疗的基本策略之一,破裂修理。作为骨头形成上的激发器之一, osteogenic 生长肽(OGP ) 在 vitro 并且在 vivo, osteoprotegerin (OPG ) 在被建议了被包含增加造骨细胞的增长和区别。在这研究,我们在骨头髓上评估了 OGP 的效果从在由 3-(4,5-dimethylthiazol-2-yl ) 的 vitro 的 OPG 缺乏的老鼠的间充质的干细胞(MSC )-2,5-diphenyltetrazolium 溴化物试金,碱的磷酸酶(高山) 活动试金,即时聚合酶链反应,和西方的污点分析。结果证明 OGP 刺激了 MSC 增长并且在 mRNA 和蛋白质层次两个都在 MSC 增加了 CDK2 和 cyclin A 的表示。然而, OGP 的 differentiative 效果都没作为高山活动和 Runx2 的表示层次被显示出, Osterix 没被 OGP 显著地增加。我们的学习建议 OGP 可以由刺激 MSC 增长而非区别在 OPG 缺乏的老鼠增加骨头形成,并且可能由触发 CDK2/cyclin 一条小径。 | Qinming Fei Changjun Guo Xiaoya Xu Jianjun Gao Jian Zhang Tongyi Chen Dafu Cui | 2010 | Acta Biochimica et Biophysica Sinica2010，42，11： | 11 |
| 3 | Solvent-free synthesis of zeolite catalysts显示文摘The most used method for preparation of zeolites is hydrothermal synthesis from silicate or aluminosilicate gels at temperatures in the range of 60–200°C.Excess water used in the industrial process results in several issues,including high autogeneous pressure,low efficiency,pollution,etc.To solve these problems,several strategies have been developed.This review describes the solvent-free synthesis of zeolites.The combination of solvent-free synthesis and organotemplate-free synthesis can open the pathway to a highly sustainable zeolite synthesis protocol in industry. | Xiangju Meng Qinming Wu Fang Chen Feng-Shou Xiao | 2015 | Science China Chemistry2015，58，1： | 5 |
| 4 | As sessment of ZTD Derived from ECMWF/NCEP Da ta over China显示文摘 | Chen Qinming Song Shuli Stefan H | 2011 | GPS Solutions2011，15，4： | 1 |
| 5 | Determination of nighttime VTEC average in the Klobuchar ionospheric delay model显示文摘The Klobuchar model has been widely used to correct the ionospheric delay in applications. However, the NVTEC(Nighttime Vertical Total Electron Content) of the Klobuchar model employs an empirical constant of 9 TECU(Total Electron Content Unit) at L1 frequency. In this paper, the rationality and reliability of the nighttime constant setting are investigated using the GIM(Global Ionosphere Map) product of the IGS(International GNSS Service) from 1998 to 2015. Our study indicates that the suitable time span of NVTEC average in nighttime should be between 20:00 and 06:00 LT(local time). The NVTEC is highly correlated with seasons, having positive extremes in spring and autumn and negative extremes in summer through the mean values in all latitudes. In addition to seasonal dependence, solar activity in the solar cycle 23 strongly influences NVTEC as well and leads to its variation within a range between 25 and30 TECU in spring and autumn at solar maximum, which is about 1.5 times greater than that in summer and winter. The NVTEC also has a dependence on the latitude at solar maximum, with the mean value from 30 TECU in low latitudinal regions to 15 TECU in high latitudinal regions. Therefore, these results demonstrate that the nighttime VTEC has much greater deviations from the imperial constant in the Klobuchar model, and the newly estimated constant is expected to bring improvement to the predictability of the Klobuchar ionospheric delay model in nighttime. | Weili Zhou Shuli Song Qinming Chen Na Cheng Hui Xie | 2018 | Geodesy and Geodynamics2018，9，2： | 1 |
| 6 | Assessment of ZTD derived from ECMWF/NCEP data with GPS ZTD over China 显示文摘 | Qinming Chen | 2011 | GPS Solutions2011，15，4： | 1 |
| 7 | vCerberus:A DRTM System Based on Virtualization Technology显示文摘This paper presents vCerberus, a novel hypervisor to provide trusted and isolated code execution within virtual domains vCerberus is considerably tiny, while allowing secure sensitive codes to be executed in an isolated circumstance from the virtual domain, and can be attested by a remote party in an efficient way. These properties will be guaranteed even if the guest operating system is malicious. This protects the secure sensitive codes against the malicious codes in the Guest OS, e.g., the kernel rootkits. We present an approach to dynamically measure and isolate the launch environment on the virtual machines based on the para-virtualization technology and a novel virtualization of trusted platform module (TPM). Our performance experiment result shows that the overhead introduced by vCerberus is minimized; the per-formance of the launch environment in vCerberus is as competitive as the guest OS running on mainstream hypervisors. | CHEN Wenzhi ZHANG Zhipeng YANG Jianhua HE Qinming | 2010 | Wuhan University Journal of Natural Sciences2010，15，3： | 0 |
| 8 | Circulating proteomic biomarkers for diagnosing sporadic amyotrophic lateral sclerosis:a cross-sectional study显示文摘Biomarke rs are required for the early detection,prognosis prediction,and monitoring of amyotrophic lateral sclerosis,a progressive disease.Proteomics is an unbiased and quantitative method that can be used to detect neurochemical signatures to aid in the identification of candidate biomarke rs.In this study,we used a label-free quantitative proteomics approach to screen for substantially differentially regulated proteins in ten patients with sporadic amyotrophic lateral scle rosis compared with five healthy controls.Su bstantial upregulation of serum proteins related to multiple functional clusters was observed in patients with spo radic amyotrophic lateral sclerosis.Potential biomarke rs were selected based on functionality and expression specificity.To validate the proteomics profiles,blood samples from an additional cohort comprising 100 patients with sporadic amyotrophic lateral sclerosis and 100 healthy controls were subjected to enzyme-linked immunosorbent assay.Eight substantially upregulated serum proteins in patients with spora dic amyotrophic lateral sclerosis were selected,of which the cathelicidin-related antimicrobial peptide demonstrated the best discriminative ability between patients with sporadic amyotrophic lateral sclerosis and healthy controls(area under the curve[AUC]=0.713,P<0.0001).To further enhance diagnostic accuracy,a multi-protein combined discriminant algorithm was developed incorporating five proteins(hemoglobin beta,cathelicidin-related antimicrobial peptide,talin-1,zyxin,and translationally-controlled tumor protein).The algo rithm achieved an AUC of 0.811 and a P-value of<0.0001,resulting in 79%sensitivity and 71%specificity for the diagnosis of sporadic amyotrophic lateral scle rosis.Subsequently,the ability of candidate biomarkers to discriminate between early-stage amyotrophic lateral sclerosis patients and controls,as well as patients with different disease severities,was examined.A two-protein panel comprising talin-1 and translationally-controlled tumor protein effectively distinguished early-stage amyotrophic lateral sclerosis patients from controls(AUC=0.766,P<0.0001).Moreove r,the expression of three proteins(FK506 binding protein 1A,cathelicidin-related antimicrobial peptide,and hemoglobin beta-1)was found to increase with disease progression.The proteomic signatures developed in this study may help facilitate early diagnosis and monitor the progression of sporadic amyotrophic lateral sclerosis when used in co mbination with curre nt clinical-based parameters. | Lu He Qinming Zhou Chaoyang Xiu Yaping Shao Dingding Shen Huanyu Meng Weidong Le Sheng Chen | 2024 | Neural Regeneration Research2024，19，8： | 0 |
| 9 | Towards Understanding the Security of Modern Image Captchas and Underground Captcha-Solving Services显示文摘Image captchas have recently become very popular and are widely deployed across the Internet to defend against abusive programs. However, the ever-advancing capabilities of computer vision have gradually diminished the security of image captchas and made them vulnerable to attack. In this paper, we first classify the currently popular image captchas into three categories: selection-based captchas, slide-based captchas, and click-based captchas. Second, we propose simple yet powerful attack frameworks against each of these categories of image captchas. Third, we systematically evaluate our attack frameworks against 10 popular real-world image captchas,including captchas from tencent.com, google.com, and 12306.cn. Fourth, we compare our attacks against nine online image recognition services and against human labors from eight underground captcha-solving services. Our evaluation results show that(1) each of the popular image captchas that we study is vulnerable to our attacks;(2) our attacks yield the highest captcha-breaking success rate compared with state-of-the-art methods in almost all scenarios; and(3) our attacks achieve almost as high a success rate as human labor while being much faster.Based on our evaluation, we identify some design flaws in these popular schemes, along with some best practices and design principles for more secure captchas. We also examine the underground market for captcha-solving services, identifying 152 such services. We then seek to measure this underground market with data from these services. Our findings shed light on understanding the scale, impact, and commercial landscape of the underground market for captcha solving. | Haiqin Weng Binbin Zhao Shouling Ji Jianhai Chen Ting Wang Qinming He Raheem Beyah | 2019 | Big Data Mining and Analytics2019，2，2： | 0 |
| 10 | A perspective on therapies for amyotrophic lateral sclerosis:can disease progression be curbed?显示文摘Amyotrophic lateral sclerosis(ALS)is a progressive neurodegenerative disease involving both upper and lower motor neurons,leading to paralysis and eventually death.Symptomatic treatments such as inhibition of salivation,alleviation of muscle cramps,and relief of spasticity and pain still play an important role in enhancing the quality of life.To date,riluzole and edaravone are the only two drugs approved by the Food and Drug Administration for the treatment of ALS in a few countries.While there is adequate consensus on the modest efficacy of riluzole,there are still open questions concerning the efficacy of edaravone in slowing the disease progression.Therefore,identification of novel therapeutic strategies is urgently needed.Impaired autophagic process plays a critical role in ALS pathogenesis.In this review,we focus on therapies modulating autophagy in the context of ALS.Furthermore,stem cell therapies,gene therapies,and newly-developed biomaterials have great potentials in alleviating neurodegeneration,which might halt the disease progression.In this review,we will summarize the current and prospective therapies for ALS. | Xiaojiao Xu Dingding Shen Yining Gao Qinming Zhou You Ni Huanyu Meng Hongqin Shi Weidong Le Shengdi Chen Sheng Chen | 2021 | Translational Neurodegeneration2021，10，3： | 0 |
| 11 | Increased expression of coronin-1a in amyotrophic lateral sclerosis: a potential diagnostic biomarker and therapeutic target显示文摘Amyotrophic lateral sclerosis(ALS)is the most common motor neuron disease.At present,no definite ALS biomarkers are available.In this study,exosomes from the plasma of patients with ALS and healthy controls were extracted,and differentially expressed exosomal proteins were compared.Among them,the expression of exosomal coronin-1a(CORO1A)was 5.3-fold higher than that in the controls.CORO1A increased with disease progression at a certain proportion in the plasma of patients with ALS and in the spinal cord of ALS mice.CORO1A was also overexpressed in NSC-34 motor neuron-like cells,and apoptosis,oxidative stress,and autophagic protein expression were evaluated.CORO1A overexpression resulted in increased apoptosis and oxidative stress,overactivated autophagy,and hindered the formation of autolysosomes.Moreover,CORO1A activated Ca^(2+)-dependent phosphatase calcineurin,thereby blocking the fusion of autophagosomes and lysosomes.The inhibition of calcineurin activation by cyclosporin A reversed the damaged autolysosomes.In conclusion,the role of CORO1A in ALS pathogenesis was discovered,potentially affecting the disease onset and progression by blocking autophagic flux.Therefore,CORO1A might be a potential biomarker and therapeutic target for ALS. | Qinming Zhou Lu He Jin Hu Yining Gao Dingding Shen You Ni Yuening Qin Huafeng Liang Jun Liu Weidong Le Sheng Chen | 2022 | Frontiers of Medicine2022，16，5： | 0 |
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