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| 1 | Magnesium lithospermate B possesses inhibitory activity on Na^+,K^+-ATPase and neuroprotective effects against ischemic stroke显示文摘瞄准:如果镁 lithospermate B (MLB ) 从 Danshen 提取了,检验,鼠尾草植物 miltiorrhiza 的弄干的根,当为经由一样的分子的机制的这繁体中文植物的 cardiactherapeutic 效果负责的一个活跃部件触发了 bycardiac glycosides,可以行动,例如 ouabain 和异羟基洋地黄毒苷。而且,如果,我们想要测试 MLB 对 ischemic 的 provideneuroprotection 可以是为心脏的 glycosides 观察了摸。方法:在 MLB 和 ouabain 之间的类似 inthe 化学药品结构和分子的配置被分析。Na+ 上的 MLB 和 ouabain 的 Theinhibition 力量,一个商业产品的 K+-ATPase 活动,也, asin 从老鼠大脑和心纸巾净化了膜部分,被检验,对 ischemic 击的 MLB 的 compared.Neuroprotective 效果也用一个外皮的基于 brainslice 的试金模型被评估。结果:商业 Na+ 上的剂量依赖者抑制,为 ouabain 的到那的 K+-ATPaseequivalent 为 MLB 被观察近似由重量的半剂量。ouabain 和 MLB 的 Thisrelative 力量也在 Na+ 上为他们的抑制被观察,从老鼠纸巾净化的 K+-ATPase activityof 血浆膜,尽管这 2 个禁止者有点在这些粗略的摘录展出了 lowercompetence。在 ischemic 沙鼠大脑,与 MLB significantlyreduced 处理以后梗塞尺寸,由 2,3,5-triphenyltetrazolium 氯化物染色设想了, byapproximately 55% 什么时候与控制组相比。结论:这些结果显然 suggestthat Danshen 的心脏的治疗学的效果应该部分至少被归因于 Na+ ,由 MLB 的 K+-ATPase,和那 MLB 的 effectiveinhibition 在 gerbilssubjected 提供 anti-ischemic neuroprotection 给焦点的局部缺血和灌注。 | Jason TC TZEN Tzyy-rong JINN Yi-ching CHEN Feng-yin LI Fu-chou CHENG Li-shian SHI Hank KH SHE Balance CM CHEN Vic HSIEH Mu-lin TU | 2007 | Acta Pharmacologica Sinica2007，28，5： | 25 |
| 2 | CT arterial portography and CT hepatic arteriography in detection of micro liver cancer显示文摘AIM To recognize the characteristic findings of micrQliver cancer (MLC) and to evaluate the effect of CT arterial portography (CTAP) and CT hepatic arteriography (CTHA) in diagnosis of MLC. METHODS Between April 1996 to December 1998, CTAP and CTHA were performed in 12patients with MLC, which were not detect ed byconventional CT examinations. After CTHA, 3 mL-- 5 mL mixture of lipiodol, doxorubic in andmitomycin C were injected into hepatic arterythrough the catheter, and then followed up by CTthree or four weeks later (Lipiodol CT LP-CT).RESULTS A total of 22 micro--tumors (0 .2 cm 0.6 cm in diameter ) were detected in 12patients, which manifested as small perfusiondefects in CTAP and small round enhancement inCTHA. The rate of detectability of CTAP andCTHA was 68.2% (15/ 22) and 77.3% (17/ 22)respectively, and the rate of the simultaneoususe of both procedures reached 86. 4% (19/ 22 ).All micro--tumors were demonstrated as punctatelipiodol deposit fool in LP--CT. After LP--CT, theelevated serum level of Q-fetoprotein (AFP)dropped to the normal level in all patients.CONCLUSION The CTAP and CTHA are the mostsensitive imaging methods for detecting microIiver cancer. Confirmed by the change of theelevated serum AFP level and lipiodol depositfool in LP-CT, small perfusion defects in CTAPand punctate enhancement in CTHA may suggestmicro--liver cancer. | Li L Wu PH Mo YX Lin HG Zheng L Li JQ Lu LX Ruan CM Chen L | 1999 | World Journal of Gastroenterology1999，5，3： | 16 |
| 3 | Apolipoprotein E, angiotensin-converting enzyme and kallikrein gene polymorphisms and the risk of Alzheimer's disease and vascular dementia显示文摘 | Wang HK Fung HC Hsu WC Wu YR Lin JC Ro LS Chang KH Hwu FJ Hsu Y Huang SY Lee-Chen GJ Chen CM | 2006 | 中国生物学文摘2006，20，8： | 8 |
| 4 | Analysis of the PINK1 gene in a cohort of patients with sporadic earlyonset parkinsonism in Taiwan显示文摘 | Fung HC Chen CM Hardy J Singleton AB Lee-Chen GJ Wu YR | 2006 | 中国生物学文摘2006，20，8： | 6 |
| 5 | 糖尿病、糖尿病前期与亚临床心肌损害发生率显示文摘众所周知,处于糖尿病前期者和糖尿病患者存在较高的心血管事件发生风险。然而,糖尿病前期和糖尿病与亚临床心肌损害发生间的关系尚不明确。方法与结果:应用高敏心肌肌钙蛋白T (highly sensitive cardiac troponin T hs-cTnT)分析,测定社区动脉粥样硬化风险研究中9331例受试者两个时间点(间隔6年)的心肌肌钙蛋白T(cardiac troponin T,cTnT)水平,所有受试者为无糖尿病或处于糖尿病前期,或糖尿病不伴心血管疾病(包括心电图检测出来的无临床症状的心肌梗死)。 | Selvin E Lazo M Chen Y Shen L Rubin J McEvoy JW Hoogeveen RC Sharrett AR Ballantyne CM Coresh J 刘莉 | 2014 | 中华高血压杂志2014，22，9： | 2 |
| 6 | Expression of macrophage migration inhibitory factor in acute ischemic myocardial injury显示文摘 | Lai KW Chen YX | 2003 | J Histochem Cytochem2003，51，5： | 1 |
| 7 | Secretory organelles in ECL cells of the rat stomach:an immunohistochemical and electron-microscopic study显示文摘 | Zhao CM Chen D Lintunen M | 1999 | Cell Tissue Res1999，298，： | 1 |
| 8 | Correlation of quantitative assay of hepatitis B surface antigen and HBV DNA levels in asymptomatic hepatitis B virus carriers显示文摘 | Chen CH lee CM Wang JH | 2004 | Eur J Gastroenterol Hepatol2004，16，： | 1 |
| 9 | Overview of obesity in Mainland China显示文摘 | Chen CM | 2008 | Obes Rev2008，9，1： | 1 |
| 10 | Angiotensin-converting enzyme polymorphisms and risk of spontaneous deep intracranialhemorrhage in Taiwan显示文摘 | Chen CM Chen YC Wu YR | 2008 | Eur J Neurol2008，15，11： | 1 |
| 11 | Inhibitory effect of vitamin C in combination with vitamin K3 on tumor growth and metastasis of Lewis lung carcinoma xenografted in C57BL/6 mice显示文摘 | Chen MF Yang CM Su CM | 2011 | Nutr Cancer2011，63，： | 1 |
| 12 | Methylation target array for rapid analysis of Cp G island hypermethylation in multiple tissue genomes显示文摘 | Chen CM Chen HL Hsiau T | 2003 | Am J Pathol2003，163，1： | 1 |
| 13 | Effects of teriparatide on lung function and pain relief in women with multiple osteoporetic vertebral compression fractures显示文摘 | Chen CM L in PY Chen YC | 2014 | Surg Neurol Int2014，5，7： | 1 |
| 14 | Molecular modding of flavonoids thaa inhibits xanthine oxidase显示文摘 | Lin CM Chen CS Chen CT | 2002 | Biochem Bioph Res Co2002，294，1： | 1 |
| 15 | Visualising semantic spaces and author co-cita- tion networks in digital libraries显示文摘 | Chen CM | 1999 | Information Processing & Management1999，35，3： | 1 |
| 16 | Incidence of cancer in nodular goiters显示文摘 | Pang HN Chen CM | 2007 | Ann Acad Med Singapore2007，36，4： | 1 |
| 17 | ANRIL inhibits p15(INK4b)through the TGF-β1 signaling pathway in human esophageal squamous cell carcinoma显示文摘 | Chen D Zhang ZY Mao CM | 2014 | Cell Immunol2014，289，12： | 1 |
| 18 | Predictive factors of gefitinib antitumor in East Asian advanced non-small cell lung cancer patient显示文摘 | CHANG GC TSA I CM CHEN KC | 2006 | J Thorac Oncol2006，1，6： | 1 |
| 19 | Rat stomach ECL cells up-date of biology and physiology显示文摘 | Chen D Zhao CM Lindstrom E | 1999 | General Phamacol1999，32，： | 1 |
| 20 | Two antiplatelet agents from Magnolia officinaUs 显示文摘 | Teng CM Chen CC Ko FN | 1988 | Thromb Res1988，50，6： | 1 |
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