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| 1 | Jianpijiedu Fang improves survival of hepatocarcinoma mice by affecting phosphatase and tensin homolog, phosphoinositide 3-kinase, and focal adhesion kinase显示文摘OBJECTIVE: To investigate the effect of Jianpijiedu Fang (JPJDF) on phosphatase and tensin homolog (PTEN), phosphoinositide 3-kinase (PI3K), and focal adhesion kinase (FAK), and on the survival of hepatocellular carcinoma (HCC) nude mice. METHODS: Forty male nude mice were randomly divided into 4 groups. Human HCC tissue was implanted in the livers of three groups. After 24 h, the three groups were treated respectively with JPJDF (37.5 g/kg), saline (20 mL/kg) and Tegafur (FT-207, 160 mg/kg) once a day for 10 weeks. The control group without implanting the tissue was concurrently treated with saline (20 mL/kg). The survival data and body weight of all mice were recorded, and expression levels of PTEN, PI3K and FAK in normal tissue and cancer tissue of the livers were eval-uated with immunohistochemical method. RESULTS: The cumulative survival rate of the mice in the JPJDF group was higher than those of the other groups. The rate of weight loss was the lowest in JPJDF group. The survivability and weight loss rate in FT-207 group were the poorest in all groups. The expression intensity of PTEN was higher in normal tissues than in cancer tissues, and lower in the normal tissues of HCC models than in that of mice without HCC. The PTEN expression intensity in normal tissue and cancer tissue from mice treated with FT-207 were lower than that from the mice treated with JPJDF or saline.The expression intensity of PI3K was higher in cancer tissue than in normal tissue. The PI3K expression intensity was the lowest in normal tissue and cancer tissue from mice treated with JPJDF, and the intensity from mice treated with FT-207 was the highest. In mice treated with JPJDF, the expression intensity of FAK was higher in the normal tissue and lower in the cancer tissue than those of the other treatment groups. CONCLUSION: The mechanism accounting for the prolonged survival of HCC-bearing mice treated with JPJDF might be related to the reduction in weight loss and the benign regulation of PTEN, PI3K, and FAK. | Baoguo Sun Jun Meng Ting Xiang Zexiong Chen Yulong Li Lisha Lu Shijun Zhang Xiaolin Chen | 2013 | Journal of Traditional Chinese Medicine2013，33，4： | 12 |
| 2 | The timing of graphic, phonological and semantic activation of high and low frequency Chinese characters: An ERP study显示文摘二个事件相关的潜力(ERP ) 实验被执行比较高、低的频率 Chinesecharacters 的图形、语义、音韵学上的激活的时间功课。在实验 1,为高频率材料,当语义 priming 仅仅生产了更小的 N400 时,图形的 priming 生产了更小的 P200 andN400,但是与无关的对相比没有同音的 priming。在实验 2,为低频率材料,图形的 priming 生产了更小的 P200 和 N400,同音的 priming 生产了增加的 P200 和更小的 N400,语义 priming 与无关的对相比生产了中等减少的 N400。结果建议有激活高、低的 frequencyChinesecharacters 的词汇信息的一些差别。图形的激活首先出现,不管频率。为高频率人物,语义激活被发现,但是没有音韵学上的激活。而为低频率人物,,音韵学上的激活出现在语义激活前。 | Chen Baoguo Liu Ying Wang Lixin Peng Danling Charles A. Perfetti | 2007 | Progress in Natural Science:Materials International2007，17，B07： | 9 |
| 3 | Long-term bone and lung consequences associated with hospital-acquired severe acute respiratory syndrome:a 15-year follow-up from a prospective cohort study显示文摘The most severe sequelae after rehabilitation from SARS are femoral head necrosis and pulmonary fibrosis. We performed a 15-year follow-up on the lung and bone conditions of SARS patients. We evaluated the recovery from lung damage and femoral head necrosis in an observational cohort study of SARS patients using pulmonary CT scans, hip joint MRI examinations, pulmonary function tests and hip joint function questionnaires. Eighty medical staff contracted SARS in 2003. Two patients died of SARS, and78 were enrolled in this study from August 2003 to March 2018. Seventy-one patients completed the 15-year follow-up. The percentage of pulmonary lesions on CT scans diminished from 2003(9.40 ± 7.83)% to 2004(3.20 ± 4.78)%(P < 0.001) and remained stable thereafter until 2018(4.60 ± 6.37)%. Between 2006 and 2018, the proportion of patients with interstitial changes who had improved pulmonary function was lower than that of patients without lesions, as demonstrated by the one-second ratio(FEV1/FVC%, t = 2.21, P = 0.04) and mid-flow of maximum expiration(FEF25%–75%, t = 2.76, P = 0.01). The volume of femoral head necrosis decreased significantly from 2003(38.83 ± 21.01)% to 2005(30.38 ± 20.23)%(P = 0.000 2), then declined slowly from 2005 to 2013(28.99 ± 20.59)% and plateaued until 2018(25.52 ± 15.51)%. Pulmonary interstitial damage and functional decline caused by SARS mostly recovered, with a greater extent of recovery within 2 years after rehabilitation. Femoral head necrosis induced by large doses of steroid pulse therapy in SARS patients was not progressive and was partially reversible. | Peixun Zhang Jia Li Huixin Liu Na Han Jiabao Ju Yuhui Kou Lei Chen Mengxi Jiang Feng Pan Yali Zheng Zhancheng Gao Baoguo Jiang | 2020 | Bone Research2020，8，1： | 8 |
| 4 | Expression of IL-1α, IL-6, TGF-β, FasL and ZNF265 During Sertoli Cell Infection by Ureaplasma Urealyticum显示文摘 | Rongping Li Yebin Xi Xiuzhi Liu Guangjie Chen Baoguo Wang Lihua Jiang Weiyi Li | 2009 | Cellular & Molecular Immunology2009，6，3： | 8 |
| 5 | Effect of polypeptide 2B1 on condition of dampness pattern in rats in terms of Traditional Chinese Medicine显示文摘OBJECTIVE: This study investigated how polypeptide 2B1 is involved in regulating and governing dampness in rat models with dampness pattern defined in terms ofTraditional Chinese Medicine.METHODS: We randomly divided 48 SPF10-week-old male Sprague-Dawley(SD) rats into a normal group, normal + Aristolochic acid I(AA-I) for5 min group, normal + AA-I for 60 min group,dampness pattern group(DS-Group), dampness pattern + AA-I for 5 min group, and dampness pattern + AA-I for 60 min group. Groups were then treated accordingly. We took out the lung, stomach, liver, spleen, kidney, large intestine, and small intestine tissues to detect gene and protein expression of organic anion transporter polypeptide 2B1(OATP2B1).RESULTS: Gene expression of OATP2B1 in spleen,kidney, and small intestine of rats with dampness pattern was lower than that in normal rats(P<0.05).The gene expressions of OATP2B1 in liver, stomach,large intestine, and small intestine were lower than that in control rats at different time points after being stimulated by AA-I(P<0.05).CONCLUSION: There is coordination among multiple viscera in handling the condition of dampness,and the mechanism underlying the action may rely on regulating the expression of OATP2B1. | Zhangbin Yang Ting Xiang Shijun Zhang Hongrui Zhan Zexiong Chen Baoguo Sun Xiaoling Chen Jingli Shi Bin Ren | 2014 | Journal of Traditional Chinese Medicine2014，34，2： | 3 |
| 6 | Biomimetic Chiral Pyridoxal and Pyridoxamine Catalysts显示文摘What is the most favorite and original chemistry developed in your research group? Vitamin B6-based biomimetic asymmetric catalysis. How do you get into this specific field? Could you please share some experiences with our readers? Enzymatic transformations are characterized by high efficiency, specific selectivities, and mild conditions, which attracts me to do some chemistry related to biological systems. | Jianfeng Chen Yong Ethan Liu Xing Gong Limin Shi Baoguo zhao | 2019 | Chinese Journal of Chemistry2019，37，2： | 3 |
| 7 | Multi-element analysis of Baijiu(Chinese liquors)by ICP-MS and their classification according to geographical origin显示文摘Objectives:Investigating the element profiles of Be,Al,V,Cr,Mn,Fe,Co,Ni,Cu,Zn,As,Se,Rb,Sr,Ag,Cd,Cs,La,Pr,Nd,Sm,Eu,Gd,Pb,Th,and U of Baijiu(Chinese liquors),and setting up their classification according to geographical origin.Materials and Methods:Twenty-eight Chinese liquors from Shandong,Guizhou,and Sichuan provinces were analyzed by inductively coupled plasma mass spectrometry with the aid of matrix matching,online internal calibration,and direct injection to determine the concentrations of the aforementioned 26 elements.Multivariate statistical analysis,based on the contents of elements in the liquors,was applied to differentiate the liquors from different origins.Results:Both the cluster analysis based on 11 elements and the discriminant analysis based on 5 elements can separate the liquors of Shandong Province from others.A leave-one-out cross test of the discriminant analysis data resulted in 100 per cent accuracy regarding the recognition ability and prediction ability for the liquors from Shandong Province,and an overall 75.0 per cent accuracy of its prediction for all the 28 total liquors.Limitations:The liquors of Guizhou and Sichuan provinces can not be differentiated successfully.Conclusions:The liquors produced in Shandong Province can be differentiated in a great extent from Guizhou and Sichuan provinces based on the multivariate statistical analysis of the concentration of elements in liquors,while those of Guizhou and Sichuan provinces can not be differentiated successfully due to their geographical adjacency. | Xuebo Song Min Hou Zhi Li Lin Zhu Fuping Zheng Mingquan Huang Xiaotao Sun Hehe Li Feng Chen Baoguo Sun | 2018 | Food Quality and Safety2018，2，1： | 3 |
| 8 | Effects of hydrogenation temperature on room-temperature compressive properties of CMHT-treated Ti6Al4V alloy显示文摘Compression tests were performed at room temperature to investigate the effects of hydrogenation temperature on compressive properties of Ti6 Al4 V alloy treated by continuous multistep hydrogenation treatment(CMHT).Pressure-composition isotherms and micro structures were also studied.Results showed that the equilibrium hydrogen pressure increased,and the hydrogen absorption rate decreased with the increase of hydrogenation temperature.The amounts ofβphase andα'martensite increased first and then decreased when Ti6 Al4 V alloy was treated by four times CMHT with the increase of hydrogenation temperature.Hydrogenation temperature played a different role on the compressive properties of CMHT-treated Ti6 Al4 V alloy.The ultimate compression of Ti6 Al4 V alloy treated by 11 times CMHT at850℃increased by 83.3%as compared to the as-received Ti6 Al4 V alloy.The compressive properties of Ti6 Al4 V alloy were dependent on the amounts of different phases and microstructures when Ti6 Al4 V alloy was treated by CMHT at different temperatures. | Baoguo Yuan Xing Liu Jiangfei Du Qiang Chen Yuanyuan Wan Yunliang Xiang Yan Tang Xiaoxue Zhang Zhongyue Huang | 2021 | Journal of Materials Science & Technology2021，，13： | 3 |
| 9 | Grain refinement in an as-cast AZ61 magnesium alloy processed by multi-axial forging under the multitemperature processing procedure显示文摘 | Qiang Chen Dayu Shu Chuankai Hu Zude Zhao Baoguo Yuan | 2012 | Materials Science & Engineering A2012，，： | 2 |
| 10 | Field test on temperature field and thermal stress for prestressed concrete box-girder bridge显示文摘A field test was conducted to investigate the distribution of temperature field and the variation of thermal stress for a prestressed concrete(PC)box-girder bridge.The change of hydration heat temperature consists of four periods:temperature rising period,constant temperature period,rapid temperature fall period and stow temperature fall period.The peak value of hydration heat temperature increases with the increasing casting temperature of concrete;the relation between them is approximately linear.According to field tests,the thermal stress incurred by hydration heat may induce temperature cracks on the PC box-girder.Furthermore,the nonlinear distribution of temperature gradient and the fluctuation of thermal stress induced by exposure to sunlight were also obtained based on continuous in-situ monitoring.Such results show that the prevailing Chinese Code(2004)is insufficient since it does not take into account the temperature gradient of the bottom slab.Finally,some preventive measures against temperature cracks were proposed based on related studies.The conclusions can provide valuable reference for the design and construction of PC box-girder bridges. | Baoguo CHEN Rui DING Junjie ZHENG Shibiao ZHANG | 2009 | Frontiers of Structural and Civil Engineering2009，3，2： | 2 |
| 11 | Correlation between pathogenesis of dampness syndrome and Interleukin-2,Interleukin-8 in rats显示文摘OBJECTIVE: To explore the pathogenesis of dampness syndrome by detecting the changes of interleukin-2 (IL-2) and interleukin-8 (IL-8) levels. METHODS: Female Sprague Dawley rats were divided randomly into five groups according to the random number table: a normal group (GroupⅠ), an external dampness group (GroupⅡ), an internal dampness group (Group Ⅲ), and an external and internal dampness group (GroupⅣ). Twenty days after the model made, IL-2 and IL-8 levels were detected by radioimmunoassay method. RESULTS: The IL-2 and IL-8 levels among groups were significant (F=3.102, P<0.05; F=2.657, P<0.05, respectively). The level of IL-2 in Group Ⅱ and Group Ⅲ were higher than that in GroupⅠ(P<0.05, P<0.01, respectively), especially higher in the Group Ⅲ compared with GroupⅡ (P<0.05). The lev- el of IL-8 in Group Ⅲ were higher than those inGroupⅠ, GroupⅡ and GroupⅣ (P<0.05, P<0.01, P< 0.05, respectively). In the GroupⅢ, the 24-hour wa ter and body weight were higher than that in the GroupⅣ (all P<0.05), and spontaneous movemen frequency was higher than those in GroupⅡ and GroupⅣ (P<0.05). CONCLUSION: Immune activation and inflammato ry reaction might be easily caused by externa danpness other than internal dampness. | Xiaolin Chen Youwu Lin Shijun Zhang Zexiong Chen Carlini Fan Hardi Ting Xiang Baoguo Sun | 2013 | Journal of Traditional Chinese Medicine2013，33，1： | 2 |
| 12 | New spectral indicator assessing the efficiency of crop nitrogen treatment in corn and wheat显示文摘 | Pengfei Chen Driss Haboudane Nicolas Tremblay Jihua Wang Philippe Vigneault Baoguo Li | 2010 | Remote Sensing of Environment2010，，9： | 2 |
| 13 | Structural geology and favorable exploration prospect belts in northwestern Sichuan Basin, SW China显示文摘The northwestern Sichuan region has experienced multi-stage tectonic evolution including marine cratonic basin from the Sinian to the Middle Triassic and intra-continental basin from the Late Triassic to the Cenozoic. Several regional tectonic activities caused complicated stratigraphic distribution and structural deformations in the deep-buried layers. During the key tectonic periods, some characteristic sedimentary and deformation structures were formed, including the step-shaped marginal carbonate platform of Dengying Formation, the western paleo-high at the end of Silurian, and the passive continental margin of the Late Paleozoic–Middle Triassic. The Meso-Cenozoic intra-continental compressional tectonic processes since the Late Triassic controlled the formation of complex thrusting structures surrounding and inside the northwestern basin. The northern Longmenshan fold-thrust belt has a footwall in-situ thrust structure,which is controlled by two sets of detachments in the Lower Triassic and Lower Cambrian and presents as a multi-level deformation structure with the shallow folds, the middle thin-skin thrusts and the deeper basement-involved folds. The thrust belt in front of the Micangshan Mountain shows a double-layer deformation controlled by the Lower Triassic salt detachment, which is composed by the upper monocline and deep-buried imbricate thrust structures. The interior of the basin is characterized by several rows of large-scale basement-involved folds with NEE strike direction. From the perspective of structural geology, the favorable exploration reservoirs and belts in northwestern Sichuan have obvious zoning characteristics. The favorable exploration layers of Dengying Formation of Upper Sinian are mainly distributed in the eastern and northern areas of the northwestern Sichuan Basin, in which the Jiulongshan structural belt, Zitong syncline and Yanting slope are the most favorable. The Lower Paleozoic was transformed by Caledonian paleo-uplift and late Cenozoic folding, and the midwest area such as the Zitong syncline is a potential area for hydrocarbon exploration. The favorable part of the Upper Paleozoic is mainly distributed in the northern Longmenshan belt and its frontal area, where the deep-buried thin-skin thrust structures in the footwall are the key exploration targets. | CHEN Zhuxin LI Wei WANG Lining LEI Yongliang YANG Guang ZHANG Benjian YIN Hong YUAN Baoguo | 2019 | Petroleum Exploration and Development2019，46，2： | 1 |
| 14 | Weighted Least Absolute Deviations Estimation for Periodic ARMA Models显示文摘This paper investigates the weighted least absolute deviations estimator(WLADE) for causal and invertible periodic autoregressive moving average(PARMA) models. Asymptotic normality of the estimator is derived under a fractional moment condition. A simulation study is given to assess the performance of the proposed WLADE. | Baoguo PAN Min CHEN Yan WANG | 2015 | Acta Mathematica Sinica,English Series2015，31，8： | 1 |
| 15 | Field test on temperature field and thermal stress for prestressed concrete box-girder bridge显示文摘 | Baoguo Chen Rui Ding Junjie Zheng Shibiao Zhang | 2009 | Frontiers of Architecture and Civil Engineering in China2009，，2： | 1 |
| 16 | Age of acquisition affects early orthographic processing during Chinese character recognition显示文摘 | Chen Baoguo Dent K You Wenping | 2009 | Acta Psychologica2009，130，： | 1 |
| 17 | Grain refinement in an as-cast AZ61 magnesium alloy processed by multi-axial forging under the multitemperature processing procedure显示文摘 | Qiang Chen Dayu Shu Chuankai Hu Zude Zhao Baoguo Yuan | 2012 | Materials Science & Engineering A2012，，： | 1 |
| 18 | Experimental andnumerical study on culvert in trenchs 显示文摘 | CHEN Baoguo ZHENG Junjie HAN Jie | 2010 | Journal ofPerformance for Constructed Facilities ASCE2010，24，3： | 1 |
| 19 | Sex differences in anogenital distances and digit ratios in wild David's rock squirrels Sciurotamias davidianus显示文摘 | Dapeng ZHAO Zhuoyue CHEN Baoguo LI | 2014 | Current Zoology2014，60，2： | 1 |
| 20 | Spatial variability of shallow groundwater level, electrical conductivity and nitrate concentration, and risk assessment of nitrate contamination in North China Plain显示文摘 | Kelin Hu Yuangfang Huang Hong Li Baoguo Li Deli Chen Robert Edlin White | 2005 | Environment International2005，，6： | 1 |
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