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| 1 | Enhanced secondary pollution offset reduction of primary emissions during COVID-19 lockdown in China显示文摘To control the spread of the 2019 novel coronavirus(COVID-19),China imposed nationwide restrictions on the movement of its population(lockdown)after the Chinese New Year of 2020,leading to large reductions in economic activities and associated emissions.Despite such large decreases in primary pollution,there were nonetheless several periods of heavy haze pollution in eastern China,raising questions about the well-established relationship between human activities and air quality.Here,using comprehensive measurements and modeling,we show that the haze during the COVID lockdown was driven by enhancements of secondary pollution.In particular,large decreases in NOx emissions from transportation increased ozone and nighttime NO_(3)radical formation,and these increases in atmospheric oxidizing capacity in turn facilitated the formation of secondary particulate matter.Our results,afforded by the tragic natural experiment of the COVID-19 pandemic,indicate that haze mitigation depends upon a coordinated and balanced strategy for controlling multiple pollutants. | Xin Huang Aijun Ding Jian Gao Bo Zheng Derong Zhou Ximeng Qi Rong Tang Jiaping Wang Chuanhua Ren Wei Nie Xuguang Chi Zheng Xu Liangduo Chen Yuanyuan Li Fei Che Nini Pang Haikun Wang Dan Tong Wei Qin Wei Cheng Weijing Liu Qingyan Fu Baoxian Liu Fahe Chai Steven JDavis Qiang Zhang Kebin He | 2021 | National Science Review2021，8，2： | 47 |
| 2 | An individualized immune signature of pretreatment biopsies predicts pathological complete response to neoadjuvant chemoradiotherapy and outcomes in patients with esophageal squamous cell carcinoma显示文摘No clinically available biomarkers can predict pathological complete response(pCR)for esophageal squamous cell carcinomas(ESCCs)with neoadjuvant chemoradiotherapy(nCRT).Considering that antitumor immunity status is an important determinant for nCRT,we performed an integrative analysis of immune-related gene profiles from pretreatment biopsies and constructed the first individualized immune signature for pCR and outcome prediction of ESCCs through a multicenter analysis.During the discovery phase,14 differentially expressed immune-related genes(DEIGs)with greater than a twofold change between pCRs and less than pCRs( | Chaoqi Zhang Guochao Zhang Nan Sun Zhen Zhang Liyan Xue Zhihui Zhang Haijun Yang Yuejun Luo Xiaoli Zheng Yonglei Zhang Yufen Yuan Ruixue Lei Zhaoyang Yang Bo Zheng Le Wang Yun Che Feng Wang Sihui Wang Shugeng Gao Qi Xue Yi Zhang Jie He | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 7 |
| 3 | Zinc sensitizes prostate cancer cells to sorafenib and regulates the expression of Livin显示文摘在前列腺 carcinogenesis,正常积累锌的上皮的房间被转变成不积累锌的恶意的房间。锌的增加的层次被显示了在前列腺癌症房间与下面调整的 anti-apoptotic 蛋白质通过 caspase 依赖的机制导致 apoptosis。我们的以前的学习显示出那,作为 apoptosis 的禁止者的一个成员蛋白质(国际机场) 家庭, Livin 能在人的前列腺癌症的开始起一个重要作用并且由改变 G1S 房间周期转变支持房间增长。在现在的学习,我们测量了前列腺癌症房间的 apoptosis 敏感到锌和 sorafenib 并且发现那锌敏化前列腺癌症房间到导致 sorafenib 的 apoptosis。令人惊讶地,我们也发现 Livin 不同于它的对应物 Survivin 和 cIAP2,没总是被减少;相反,它赔偿地在前列腺癌症房间在 48 h 在调停锌的 apoptosis 被增加。我们可以扩充 sorafenib 的效果,并且也第一次揭示的结果提议潜力治疗联合,那增加的 Livin 表情可以在对锌的前列腺癌症房间的早房间死亡反应起一个作用。 | Xiaochi Chen Xiangyu Che Jianbo Wang Feng Chen Xuejian Wang Zhiwei Zhang Bo Fan Deyong Yang | 2013 | Acta Biochimica et Biophysica Sinica2013，45，5： | 5 |
| 4 | Distr ibution, risk and bioavailability of metals in sediments of Lake Yamdrok Basin on the Tibetan Plateau, China显示文摘Total contents of metals in soil and sediments on the Tibetan Plateau of China have been widely analyzed,but existing information is insufficient to effectively evaluate metal ecological risk because of a lack of metal bioavailability data.In this study,distribution,potential risk,mobility and bioavailability of metals in sediments of Lake Yamdrok Basin in Tibet of China were explored by combined use of total digestion,sequential extraction and the diffusive gradient in thin-films(DGT).Average concentrations of Cr,Ni,Cu,Zn,As,Cd and Pb in surface sediments were 31.25,30.31,22.00,45.04,31.32,0.13 and 13.39 mg/kg,respectively.Higher levels of metals were found near the inflowing rivers.Residual form was dominant in Cr,Ni,Zn,Cd and Pb,and reducible form was dominant in As and Cd.Metals in surface sediments showed a low enrichment degree overall,but Cd and As had higher ecological risk levels than the other metals.Furthermore,there was a larger average proportion of exchangeable form of As(20.4%)and Cd(9.0%)than the other metals(1.7%-3.3%),implying their higher mobility and release risk.Average DGT-labile concentrations of Cr,Ni,Cu,Zn,As,Cd and Pb were 0.5,4.5,0.7,25.1,60.0,0.22 and 1.0μg/L,respectively.The DGT-labile As was significantly correlated with extractable As forms(p<0.01),suggesting that extractable As in sediments acts as a'mobile pool'for bioavailable As.These results suggest potential risks of As and Cd,especially As,deserve further attention in Lake Yamdrok Basin. | Feifei Che Junyi Chen Bo Zhang Xia Jiang Shuhang Wang | 2020 | Journal of Environmental Sciences2020，32，11： | 4 |
| 5 | Inclusion of purified dietary fiber during gestation improved the reproductive performance of sows显示文摘Background: This study aimed to investigate the impacts of guar gum and cellulose as the source of dietary fiber during gestation on the reproductive performance of sows.Methods: A total of 210 sows(parities 3–6) were randomly allocated into six diets(n = 35) throughout gestation to feed graded levels of dietary fiber(DF), including a corn-soybean meal-based control diet with no wheat bran inclusion(CON, 12.5% DF), a wheat bran-rich diet(DF1, 17.4% DF), and another 4 diets(DF2, 17.7% DF;DF3, 18.1%DF;DF4, 18.4% DF;DF5, 18.8% DF) in which wheat bran were equally substituted by 1%, 2%, 3% and 4% purified FIBER MIX(guar gum and cellulose, 1:4). All sows received similar DE and other nutrients throughout gestation.Results: DF treatment during gestation resulted in normal fecal score(1 to 5 with 1 = dry and 5 = watery) in sows compared with those received the CON diet(P < 0.05). The number of total born piglets had a tendency to be affected by dietary treatment(P = 0.07), and correlation analysis revealed a linear response of total born to dietary fiber levels during gestation(P < 0.01). Sows received the DF2, DF3, and DF5 diets during gestation had a greater ADFI during lactation compared with those in the CON group(P < 0.05) without affecting the daily body weight gain of suckling piglets. Gut microbiota compositions were dramatically changed by the gestation stage and some of those were changed by DF inclusion. Fecal acetate, propionate, and butyrate of sows were markedly increased in late gestation, and butyrate contents in feces of gestating sows were significantly affected by DF levels(P < 0.01).Serum concentrations of pro-inflammatory TNF-α were decreased and anti-inflammatory IL-10 was increased on day30 of gestation by DF levels(P < 0.05).Conclusions: In summary, increasing dietary fiber levels by guar gum and cellulose during gestation improved the reproductive performance of sows, which might be related to changes in immunity and gut microbiota of sows. | Yong Zhuo Bo Feng Yuedong Xuan Lianqiang Che Zhengfeng Fang Yan Lin Shengyu Xu Jian Li Bing Feng De Wu | 2020 | Journal of Animal Science and Biotechnology2020，11，4： | 4 |
| 6 | Long-term oncologic outcomes of laparoscopic versus open partial nephrectomy显示文摘 | ZHENG Jun-hua ZHANG Xiao-long GENG Jiang GUO Chang-cheng ZHANG Xiao-peng CHE Jian-ping YAN Yang PENG Bo WANG Guang-chun XIA sheng-qiang WU Yan | 2013 | Chinese Medical Journal2013，，15： | 4 |
| 7 | Azvudine is a thymus-homing anti-SARS-CoV-2 drug effective in treating COVID-19 patients显示文摘Azvudine(FNC)is a nucleoside analog that inhibits HIV-1 RNA-dependent RNA polymerase(RdRp).Recently,we discovered FNC an agent against SARS-CoV-2,and have taken it into Phase III trial for COVID-19 patients.FNC monophosphate analog inhibited SARS-CoV-2 and HCoV-OC43 coronavirus with an EC_(50) between 1.2 and 4.3 μM,depending on viruses or cells,and selective index(SI)in 15-83 range.Oral administration of FNC in rats revealed a substantial thymus-homing feature,with FNC triphosphate(the active form)concentrated in the thymus and peripheral blood mononuclear cells(PBMC).Treating SARS-CoV-2 infected rhesus macaques with FNC(0.07 mg/kg, qd,orally)reduced viral load,recuperated the thymus,improved lymphocyte profiles,alleviated in flammation and orga n damage,and lessened grou nd・glass opacities in chest X-ray.Sin gle-cell seque ncing suggested the promotion of thymus function by FNC.A randomized,single-arm clinical trial of FNC on compassionate use(n=31)showed that oral FNC(5 mg,qd)cured all COVID-19 patients,with 100%viral ribonucleic acid negative conversion in 3.29±2.22 days(range:1-9 days)and 100%hospital discharge rate in 9.00±4.93 days(range:2-25 days).The side-effect of FNC is minor and transient dizziness and nausea in 16.12%(5/31)patients.Thus,FNC might cure COVID-19 through its anti-SARS-CoV-2 activity concentrated in the thymus,followed by promoted immunity. | Jin-Lan Zhang Yu-Huan Li Lu-Lu Wang Hong-Qi Liu Shuai-Yao Lu Yong Liu Ke Li Bin Liu Su-Yun Li Feng-Min Shao Kun Wang Ning Sheng Rui Li Jin-Jin Cui Pei-Chun Sun Chun-Xia Ma Bo Zhu Zhe Wang Yuan-Hao Wan Shi-Shan Yu Yongsheng Che Chao-Yang Wang Chen Wang Qiangqian Zhang Li-Min Zhao Xiao-Zhong Peng Zhenshun Cheng Jun-Biao Chang Jian-Dong Jiang | 2022 | Signal Transduction and Targeted Therapy2022，7，1： | 3 |
| 8 | A novel derivative of valepotriate inhibits the PI3K/AKT pathway and causes Noxa-dependent apoptosis in human pancreatic cancer cells显示文摘Natural compound valepotriate exhibits inhibitory activity against a number of cancers,but the effect of valepotdriate against pancreatic cancer is unclear,and the structure-activity relationship of valepotriate has not been characterized:In this study,we performed a structure-based similarity search and found 16 hit compounds.Among the 16 hits,(1S,6S,7R)-6-(acetyloxy)-1-[(3-methylbutanoyl)oxy]-4a,5,6,7a-tetrahydro-1H-spiro[cyclopenta[c]pyran-7,2'-oxiran]-4-ylmethyl 3-methylbutanoate(denoted as Amcp)exhibited superior anticancer activity against human pancreatic cancer BxPC-3 and SW1990 cells.The anti-proliferation activity of Amcp was validated in human pancreatic cancer BxPC-3 and SW1990 cells in vitro.Amcp more effectively induced apoptosis in BxPC-3 and SW1990 cells than gemcitabine.At a concentration of 15μM,Amcp Significantly suppressed the PI3K/AKT pathway and disrupted the mitochondrial membrane equilibrium through modulation of Noxa and Mcl-1 balance in both cell lines.Meanwhile,knockdown of Noxa substantially attenuated Amcp-induced reduction of cell viability and anti-apoptotic protein Mcl-1 level in BxPC-3 cells.In addition,Amcp showed synergistic anticancer effects when combined with gemcitabine in BxPC-3 cells.To conclude,this work not only suggests that Amcp possesses a dual-inhibitory activity towards PI3K/AKT pathway and Mcl-1,but also enlightens further development of bioactive valepotriate derivatives. | You-you Yan Ke-yu Shi Fei Teng Jing Chen Jin-xin Che Xiao-wu Dong Neng-ming Lin Bo Zhang | 2020 | Acta Pharmacologica Sinica2020，41，6： | 2 |
| 9 | The Nature-Based Ecological Engineering Paradigm: Symbiosis, Coupling, and Coordination显示文摘1.Introduction We are currently facing three major ecological threats on a global scale:biodiversity loss,climate change,and environmental pollution exacerbation.The degradation of terrestrial and marine ecosystems poses a major risk to human survival and development,brings serious impacts to the wellbeing of 3.2 billion people,and causes the loss of about 10%of the annual global gross domestic product(GDP)[1,2].Meanwhile,the coronavirus disease 2019(COVID-19)epidemic is still spreading rapidly throughout the world,showing that the present relationship between humans and nature is unsustainable.It is necessary to protect nature so as to maintain the self-resilience of ecosystems. | Xiahui Wang Jinnan Wang Bo Wang Benjamin Burkhard Lulu Che Chao Dai Lijie Zheng | 2022 | Engineering2022，，12： | 2 |
| 10 | A New Family of Ce6MoO15 as Fast Oxide Ion Conductor显示文摘A novel solid solution Ce6MoO15 was achieved. Their structure and oxide ionic conductivity were studied.Based on Ce6MoO15, rare earth element substitution on cerium site shows that all resulting oxides enhance the conductivity further, and have high oxide-ion conductivity, which may be a kind of promising material for SOFCs. | Feng Jing Bo Qibing Che Ping Wang Jingping Liu Jianfen Lu Minfeng Zhang Deping Fang Daqing Cao Xueqiang Meng Jian | 2004 | Journal of Rare Earths2004，22，z2： | 2 |
| 11 | Co-Expression of XIAP and Cyclin D1 Complex Correlates with a Poor Prognosis in Patients with Hepatocellular Carcinoma显示文摘 | Yufang Che Fei Ye Ruliang Xu Haitao Qing Xinying Wang Fei Yin Miao Cui David Burstein Bo Jiang David Y. Zhang | 2012 | The American Journal of Pathology2012，，5： | 1 |
| 12 | Syntheses,structures and photoluminescence of a series of metal organic complexes with 1,3,5-benzenetricarboxylate and pyrazino-phenanthroline ligands显示文摘 | Che Guangbo Liu Chunbo Liu bo | 2008 | Cryst Eng Comm2008，10，： | 1 |
| 13 | Preparation of Al-based amorphous coatings and their properties显示文摘Al_(86)Ni_(8)Co_(1)La_(1)Y_(2)Gd_(2) amorphous coatings were prepared using cold gas kinetic spray technology.The results show that Al_(86)Ni_(8)Co_(1)La_(1)Y_(2)Gd_(2) amorphous coatings are achieved with the porosity about 3.2%,thickness about 893 μm,the amount of amorphous phase about 82.5%,the hardness about 300 HV0.2.The corrosion potential and anti-corrosion life of 7075 T6 alloy aluminum are about-0.78 V and 72 h,respectively.The electrochemical analysis and neutral salt spray are about-0.69 V corrosion potential and 274 h anti-corrosion life for amorphous Al-based coatings,respectively.Therefore,the life of the Albased amorphous coatings is about 3.8 times that of 7075 T6 aluminum alloy.Besides,the failure mechanism was analyzed using TEM in this investigation.In a word,Al_(86)Ni_(8)Co_(1)La_(1)Y_(2)Gd_(2) coatings keep dense structure,high amorphous content,favorable amorphous phase stabilizing ability and longer anticorrosion life.That is,Al_(86)Ni_(8)Co_(1)La_(1)Y_(2)Gd_(2) coatings have better comprehensive properties.Therefore,these findings indicate that the present Al_(86)Ni_(8)Co_(1)La_(1)Y_(2)Gd_(2) amorphous coatings prepared using cold gas kinetic spray technique can protect aluminum alloy very well and they can be considered to be used in aviation field. | Lei Jin Le Zhang Kaige Liu Zhigang Che Kai Li Ming Zhang Bo Zhang | 2021 | Journal of Rare Earths2021，39，3： | 1 |
| 14 | Template-mediated strategy to regulate hierarchically nitrogen-sulfur co-doped porous carbon as superior anode material for lithium capacity显示文摘Considering its rapid lithiation/delithiation process and robust capacitive energy storage,hierarchical porous carbon is regarded as a promising candidate for lithium-ion batteries(LIBs).However,it remains a great challenge to construct a porous structure and prevent structure stacking for carbon-based materials.Herein,a templatemediated approach is developed to synthesize hierarchical nitrogen-sulfur co-doped porous carbon(NSPC)using low-cost asphalt precursors.The strategy for synthesis uses g-C_(3)N_(4) and NaHCO_(3) as gaseous templates and NaCl as a solid template,which causes the formation of hierarchical porous carbon with a high specific surface area.The resultant porous structure and nitrogen-doping process can prevent the aggregation of nanosheets,maintain the structural stability upon cycling,and achieve rate-capable lithium storage.Serving as a LIBs anode,reversible specific capacities of the NSPC24 electrode reach 788 and 280 mAh·g^(-1) at 0.1 and 1 A·g^(-1),respectively.Furthermore,its specific capacity remains at 830 mAh·g^(-1) after 115 cycles at 0.1 A·g^(-1).Even after 500 cycles,high specific capacities of 727 mAh·g^(-1) at 0.5 A·g^(-1) and 624 mAh·g^(-1) at 1 A·g^(-1) are achieved,demonstrating excellent cycling performance.The gas-solid bifunctional template-mediated approach can guide the design of porous materials very well,meanwhile realizing the high value-added utilization of asphalt. | Yun LI Wang YANG Hanlin LIU Zhiqiang TU Sai CHE Bo JIANG Chong XU Guang MA Guoyong HUANG Yongfeng LI | 2022 | Frontiers of Materials Science2022，16，1： | 1 |
| 15 | Carbon nanotube/polyaniline core-shell nanowires prepared byin situ inverse microemulsion显示文摘 | Yijun Yu Bo Che | 2005 | Synthetic Metals2005，，150： | 1 |
| 16 | Carbon nanotube/polyaniline core-shell nanowires prepared by in situ inverse microemulsion 显示文摘 | Yu Yijun Che Bo Si Zhihua | 2005 | Synth Met2005，150，： | 1 |
| 17 | Double-antigen sandwich ELISA for detection of antibodies to SARS-associated coronavirus in human serum显示文摘 | S. Chen D. Lu M. Zhang J. Che Z. Yin S. Zhang W. Zhang X. Bo Y. Ding S. Wang | 2005 | European Journal of Clinical Microbiology & Infectious Diseases2005，，8： | 1 |
| 18 | 乳过氧化物酶快速检测试纸的研制(英文)显示文摘目的:开发快速、灵敏和准确的乳过氧化物酶检测方法,用于原料乳验收及相关乳制品加工中对乳过氧化物酶的检测。创新点:首次以试纸检测方法代替传统的试管检测法,借助便携式光电测色仪实现对乳过氧化物酶的定量检测分析。方法:以反光值为检测指标,从缓冲液p H、四甲基联苯胺(TMB)浓度、过氧化氢(H2O2)浓度和表面活性剂四个方面,优化筛选检测试纸的最佳制作条件;通过精密度试验、最低检出浓度和与试管检测法相关性分析,评价试纸检测法的可靠性和准确性。结论:试纸检测体系的优化结果为0.1 mol/L柠檬酸/0.2 mol/L磷酸氢二钠溶液(p H 5.0),22 mmol/L TMB,0.5%Tween-20或0.3%溴化十六烷基三甲铵(CTAB),和0.6 mmol/L H2O2。检测试纸的精密度较好,变异系数在2.47%~6.72%(表1);最低检出浓度为1.000~2.000 mg/L(图7);与试管法检测结果的相关系数为0.9776(图8)。因此,试纸检测法是一种快速、灵敏和准确的乳过氧化物酶检测技术,可满足原料乳验收及相关乳制品加工中对乳过氧化物酶检测的需求。 | Hong-xia CHE Bo TIAN Li-na BAI Li-ming CHENG Li-li LIU Xiao-na ZHANG Zhan-mei JIANG Xiao-xi XU | 2015 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2015，16，8： | 1 |
| 19 | Carbon nanotube/polyaniline core-shell nanowires prepared by in situ inverse microemulsion 显示文摘 | Yu Yijun Che Bo Si Zhihua | 2005 | Synthetic Metals2005，150，： | 1 |
| 20 | Carbon nanotube/polyaniline core-shell nanowires prepared by in situ inverse microemulsion显示文摘 | Yijun Yu Bo Che Zhihua Si Liang Li Wei Chen Gi Xue | 2005 | Synthetic Metals2005，，3： | 1 |
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