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| 1 | Metabolic inflammation as an instigator of fibrosis during nonalcoholic fatty liver disease显示文摘Non-alcoholic fatty liver disease(NAFLD)is characterized by excessive storage of fatty acids in the form of triglycerides in hepatocytes.It is most prevalent in western countries and includes a wide range of clinical and histopathological findings,namely from simple steatosis to steatohepatitis and fibrosis,which may lead to cirrhosis and hepatocellular cancer.The key event for the transition from steatosis to fibrosis is the activation of quiescent hepatic stellate cells(qHSC)and their differentiation to myofibroblasts.Pattern recognition receptors(PRRs),expressed by a plethora of immune cells,serve as essential components of the innate immune system whose function is to stimulate phagocytosis and mediate inflammation upon binding to them of various molecules released from damaged,apoptotic and necrotic cells.The activation of PRRs on hepatocytes,Kupffer cells,the resident macrophages of the liver,and other immune cells results in the production of proinflammatory cytokines and chemokines,as well as profibrotic factors in the liver microenvironment leading to qHSC activation and subsequent fibrogenesis.Thus,elucidation of the inflammatory pathways associated with the pathogenesis and progression of NAFLD may lead to a better understanding of its pathophysiology and new therapeutic approaches. | Angeliki Katsarou Ioannis I Moustakas Iryna Pyrina Panagiotis Lembessis Michael Koutsilieris Antonios Chatzigeorgiou | 2020 | World Journal of Gastroenterology2020，26，17： | 9 |
| 2 | Extracellular matrix-associated (GAGs, CTGF), angiogenic (VEGF) and inflammatory factors (MCP-1, CD40, IFN-γ) in type 1 diabetes mellitus nephropathy显示文摘 | Olga Ellina Antonios Chatzigeorgiou Sophia Kouyanou Maria Lymberi Christina Mylona-Karagianni Emmanouil Tsouvalas Elli F. Kamper | 2011 | Clinical Chemistry and Laboratory Medicine2011，，1： | 2 |
| 3 | Coupling between progressive damage and permeability of concrete:analysis with a discrete model显示文摘 | CHATZIGEORGIOU G PICANDET V KHELIDJ A | 2005 | Int J Numer Anal Meth Geomech2005，29，10： | 1 |
| 4 | Mathematical Assesmment of Object - Oriented Design Quality显示文摘 | Chatzigeorgiou A | 2003 | IEEE Transactions on Software Engineering2003，29，11： | 1 |
| 5 | Safety of human papillomavirus (HPV) vaccines: a review of the international experience so far 显示文摘 | Agorastos T Chatzigeorgiou K Brotherton J M | 2009 | Vaccine2009，7，52： | 1 |
| 6 | The use of animal models in the study of diabetes mellitus 显示文摘 | CHATZIGEORGIOU A HALAPAS A KALAFATAKIS K | 2009 | In Vivo2009，23，2： | 1 |
| 7 | The pattern of inflammatory/anti-inflammatory cytokines and chemokines in type 1 diabetic patients over time显示文摘 | Antonios Chatzigeorgiou Vaggelis Harokopos Christina Mylona-Karagianni Emmanouil Tsouvalas Vassilis Aidinis Elli Kamper | 2010 | Annals of Medicine2010，，6： | 1 |
| 8 | Safety of hu- man papillomavirus(HPV) vaccines: a review of the international experience so far 显示文摘 | Agorastos T Chatzigeorgiou K Brotherton JM | 2009 | Vaccine2009，27，52： | 1 |
| 9 | Safety of human papillomavirus (HPV) vaccines : A review of the international experience so far 显示文摘 | Agorastos T Chatzigeorgiou K Brotherton JM | 2009 | Vaccine2009，27，52： | 1 |
| 10 | Homogenization of aligned “fuzzy fiber” composites显示文摘 | George Chatzigeorgiou Yalchin Efendiev Dimitris C.Lagoudas | | 0，，19： | 1 |
| 11 | Predicting the probability of change in object-oriented systems 显示文摘 | TSANTALIS N CHATZIGEORGIOU A STEPHANIDES G | 2005 | IEEE Trans on Software Engineering2005，31，7： | 1 |
| 12 | The complement anaphylatoxin C5a receptor contributes to obese adipose tissue inflammation and insulin resistance 显示文摘 | Phieler J Chang KJ Chatzigeorgiou A | 2013 | J Immuno12013，191，8： | 1 |
| 13 | Effeets and interactions of temperature and stress-level re- lated damage on permeability of eonerete显示文摘 | CHOINSKA M KHELIDJ A CHATZIGEORGIOUS G | 2007 | Cement and Con- crete Research2007，37，1： | 1 |
| 14 | The use of animal models in the study of diabetes mellitus显示文摘 | Chatzigeorgiou A Halapas A Kalafatakis K | 2009 | In Vivo2009，23，2： | 1 |
| 15 | Aggressive angiomyxoma of the vulva extending into the pelvis: report of two cases 显示文摘 | Dragoumis K Drevelengas A Chatzigeorgiou K | 2005 | J Obstet Gynecol Res2005，31，4： | 1 |
| 16 | CD40/CD40L signaling and its implication in health and disease显示文摘 | Chatzigeorgiou A Lyberi M Chatzilymperis G | 2009 | Biofactors2009，35，： | 1 |
| 17 | Safety of human papillomavirus (HPV) vaccines: a review of the international experience so far 显示文摘 | Agorastos T Chatzigeorgiou K Brotherton JM | 2009 | Vaccine2009，27，52： | 1 |
| 18 | Endocrine disruptors and polycystic ovary syndrome (PCOS):elevated serum levels of bisphenol A in women with PCOS显示文摘 | Kandaraki E Chatzigeorgiou A Livadas S | 2011 | J Clin Endoerinol Metab2011，96，21： | 1 |
| 19 | Architectural risk analysis of software systems based on security patterns显示文摘 | HALKIDIS S T TSANTALIS N CHATZIGEORGIOU A | 2008 | IEEE Transactions on Dependable and Secure Computing2008，5，3： | 1 |
| 20 | Endocrine disruptors and polycystic ovary syndrome ( PCOS ): elevatedserum levels of bisphenol A in women with PCOS显示文摘 | KANDARAKI E CHATZIGEORGIOU A LIVADAS S | 2011 | J Clin EndocrinolMetab2011，96，3： | 1 |
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