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| 1 | Precise nanomedicine for intelligent therapy of cancer显示文摘Precise nanomedicine has been extensively explored for efficient cancer imaging and targeted cancer therapy, as evidenced by a few breakthroughs in their preclinical and clinical explorations. Here, we demonstrate the recent advances of intelligent cancer nanomedicine, and discuss the comprehensive understanding of their structure-function relationship for smart and efficient cancer nanomedicine including various imaging and therapeutic applications, as well as nanotoxicity. In particular, a few emerging strategies that have advanced cancer nanomedicine are also highlighted as the emerging focus such as tumor imprisonment, supramolecular chemotherapy, and DNA nanorobot. The challenge and outlook of some scientific and engineering issues are also discussed in future development. We wish to highlight these new progress of precise nanomedicine with the ultimate goal to inspire more successful explorations of intelligent nanoparticles for future clinical translations. | Huabing Chen Zhanjun Gu Hongwei An Chunying Chen Jie Chen Ran Cui Siqin Chen Weihai Chen Xuesi Chen Xiaoyuan Chen Zhuo Chen Baoquan Ding Qian Dong Qin Fan Ting Fu Dayong Hou Qiao Jiang Hengte Ke Xiqun Jiang Gang Liu Suping Li Tianyu Li Zhuang Liu Guangjun Nie Muhammad Ovais Daiwen Pang Nasha Qiu Youqing Shen Huayu Tian Chao Wang Hao Wang Ziqi Wang Huaping Xu Jiang-Fei Xu Xiangliang Yang Shuang Zhu Xianchuang Zheng Xianzheng Zhang Yanbing Zhao Weihong Tan Xi Zhang Yuliang Zhao | 2018 | Science China Chemistry2018，61，12： | 19 |
| 2 | Infection with novel coronavirus(SARS-CoV-2)causes pneumonia in Rhesus macaques显示文摘The 2019 novel coronavirus(SARS-CoV-2)outbreak is a major challenge for public health.SARS-CoV-2 infection in human has a broad clinical spectrum ranging from mild to severe cases,with a mortality rate of^6.4%worldwide(based on World Health Organization daily situation report).However,the dynamics of viral infection,replication and shedding are poorly understood.Here,we show that Rhesus macaques are susceptible to the infection by SARS-CoV-2.After intratracheal inoculation,the first peak of viral RNA was observed in oropharyngeal swabs one day post infection(1 d.p.i.),mainly from the input of the inoculation,while the second peak occurred at 5 d.p.i.,which reflected on-site replication in the respiratory tract.Histopathological observation shows that SARS-CoV-2 infection can cause interstitial pneumonia in animals,characterized by hyperemia and edema,and infiltration of monocytes and lymphocytes in alveoli.We also identified SARS-CoV-2 RNA in respiratory tract tissues,including trachea,bronchus and lung;and viruses were also re-isolated from oropharyngeal swabs,bronchus and lung,respectively.Furthermore,we demonstrated that neutralizing antibodies generated from the primary infection could protect the Rhesus macaques from a second-round challenge by SARS-CoV-2.The non-human primate model that we established here provides a valuable platform to study SARS-CoV-2 pathogenesis and to evaluate candidate vaccines and therapeutics. | Chao Shan Yan-Feng Yao Xing-Lou Yang Yi-Wu Zhou Ge Gao Yun Peng Lian Yang Xue Hu Jin Xiong Ren-Di Jiang Hua-Jun Zhang Xiao-Xiao Gao Cheng Peng Juan Min Ying Chen Hao-Rui Si Jia Wu Peng Zhou Yan-Yi Wang Hong-Ping Wei Wei Pang Zheng-Fei Hu Long-Bao Lv Yong-Tang Zheng Zheng-Li Shi Zhi-Ming Yuan | 2020 | Cell Research2020，30，8： | 19 |
| 3 | Progress of heat-hazard treatment in deep mines显示文摘在深煤矿把为深热的危险的控制技术基于,我们学习了国内外的深热的损坏和冷却技术的地位,总结了深热的危险的原因,分析并且比较热危险控制的紧急。结果证明深热的损坏的原因能被归因于三个方面,即,气候,地质并且采矿因素,地质的因素被认为为热危险的主要原因。也,我们比较了国内、海外的起源的很多种冷却技术,例如使使技术凉下来的技术,冰冷却技术和水凉下来的中央空调,与一种另外的冷却技术,即,使技术凉下来的 HEMS ,它与它的唯一的纯空气有大、重要的效果使技术凉下来,认识到从地下利用热资源到地面。这种技术使用秘密地获得的热;因此,技术能在煤矿支持低碳的环境经济开发,以便在中国完成低碳的煤生产。 | Yang Xiaojie Han Qiaoyun Pang Jiewen Shi Xiaowei Hou Dinggui Liu Chao | 2011 | Mining Science and Technology2011，21，2： | 15 |
| 4 | A first meningococcal meningitis case caused by serogroup X Neisseria meningitidis strains in China显示文摘 | CHEN Chao ZHANG Tie-gang HE Jing-guo WU Jiang CHEN Li-juan LIU Jun-feng PANG Xing-huo YANG Jie SHAO Zhu-jun HUANG Ying-chun | 2008 | Chinese Medical Journal2008，，7： | 13 |
| 5 | Multicenter Evaluation of the Molecular Line Probe Assay for Multidrug Resistant Mycobacterium Tuberculosis Detection in China显示文摘In order to evaluate the performance of a molecular Hain line probe assay(Hain LPA)for rapid detection of rifampicin and isoniazid resistance of Mycobacterium tuberculosis in China。 | LI Qiang DONG Hai Yan PANG Yu XIA Hui OU Xi Chao ZHANG Zhi Ying LI Jun Chen ZHANG Jian Kang HUAN Shi Tong CHIN Daniel P KAM Kai Man ZHAO Yan Lin | 2015 | Biomedical and Environmental Sciences2015，28，6： | 13 |
| 6 | Single-shot BOTDA based on an optical chirp chain probe wave for distributed ultrafast measurement显示文摘Brillouin optical time-domain analysis(BOTDA)requires frequency mapping of the Brillouin spectrum to obtain environmental information(e.g.,temperature or strain)over the length of the sensing fiber,with the finite frequencysweeping time-limiting applications to only static or slowly varying strain or temperature environments.To solve this problem,we propose the use of an optical chirp chain probe wave to remove the requirement of frequency sweeping for the Brillouin spectrum,which enables distributed ultrafast strain measurement with a single pump pulse.The optical chirp chain is generated using a frequency-agile technique via a fast-frequency-changing microwave,which covers a larger frequency range around the Stokes frequency relative to the pump wave,so that a distributed Brillouin gain spectrum along the fiber is realized.Dynamic strain measurements for periodic mechanical vibration,mechanical shock,and a switch event are demonstrated at sampling rates of 25 kHz,2.5 MHz and 6.25 MHz,respectively.To the best of our knowledge,this is the first demonstration of distributed Brillouin strain sensing with a wide-dynamic range at a sampling rate of up to the MHz level. | Dengwang Zhou Yongkang Dong Benzhang Wang Chao Pang Dexin Ba Hongying Zhang Zhiwei Lu Hui Li Xiaoyi Bao | 2018 | Light(Science & Applications)2018，7，1： | 11 |
| 7 | A bHLH transcription activator regulates defense signaling by nucleo-cytosolic trafficking in rice显示文摘Crosstalk between plant hormone signaling pathways is vital for controlling the immune response during pathogen invasion.Salicylic acid(SA)and jas-monic acid(JA)often play important but antagonistic roles in the immune responses of higher plants.Here,we identify a basic helix-loop-helix transcription acti-vator,OsbHLH6,which confers disease resistance in rice by regulating SA and JA signaling via nucleo-cytosolic trafficking in rice(Oryza sativa).OsbHLH6 expression was upregulated during Magnaporthe oryzae infection.Transgenic rice plants overexpressing OsbHLH6 display increased JA responsive gene expression and enhanced disease susceptibility to the pathogen.Nucleus-localized OsbHLH6 activates JA signaling and suppresses SA signaling;however,the SA regulator OsNPR1(Nonexpressor of PR genes 1)sequesters OsbHLH6 in the cytosol to alleviate its effect.Our data suggest that OsbHLH6 controls disease re-sistance by dynamically regulating SA and JA signaling. | Fanwei Meng Chao Yang Jidong Cao Huan Chen Jinhuan Pang Qiqi Zhao Zongyi Wang Zheng Qing Fu Jun Liu | 2020 | Journal of Integrative Plant Biology2020，62，10： | 10 |
| 8 | Staging systems for predicting survival of patients with hepatocellular carcinoma after surgery显示文摘AIM: To compare the staging systems for stratifying and predicting the prognosis of patients with hepatocel-lular carcinoma (HCC) after partial hepatectomy (PH). METHODS: Clinical data about 438 HCC patients who underwent PH from January 1991 to December 2004 at our hospital were retrospectively analyzed. Tumor stage was evaluated following the Chinese tumor node me-tastasis (TNM) and barcelona clinic liver cancer (BCLC) staging systems, respectively. Survival curves for the HCC patients were plotted using the Kaplan-Meier method and differences were compared by the log-rank test. The accuracy of each system for predicting death of HCC patients was evaluated by calculating the area under the receiver operating characteristic curve. RESULTS: The HCC patients were classified into stag-es Ⅰ-Ⅲ, stages Ⅰ-Ⅳ and stages A-C, according to the 3 staging systems, respectively. Log-rank test showed that the cumulative survival rate was significantly dif-ferent for the HCC patients at 3 Chinese system stag-es, TNM stages Ⅰ and Ⅱ, TNM stages Ⅲ and Ⅳ, and 3 BCLC stages (P < 0.05). However, no significant differ-ence was found in the HCC patients at TNM stages Ⅱ and Ⅲ. The accuracy of the Chinese and BCLC staging systems was higher than that of the TNM staging sys-tem for predicting the survival rate of HCC patients. CONCLUSION: The Chinese and BCLC staging systems are better for stratifying and predicting the prognosis of HCC patients after PH than the TNM staging system. | Lei-Bo Xu Jie Wang Chao Liu Ya-Jin Chen Qing-Jia Ou Ji-Sheng Chen Hao-Wei Pang | 2010 | World Journal of Gastroenterology2010，16，41： | 8 |
| 9 | Mitochondria-targeted antioxidant peptide SS-31 mediates neuroprotection in a rat experimental glaucoma model显示文摘To investigate the neuroprotective effects of the mitochondria-targeted antioxidant Szeto-Schiller peptide 31 (SS-31) in a rat experimental glaucoma model, SS-31 was intraperitoneally (IP) injected into Sprague-Dawley rats, followed by intracameral injection of polystyrene microspheres to induce elevated intraocular pressure (IOP). After 6 weeks, electroretinography (ERG) and flash visual-evoked potentials (F-VEPs) were recorded to assess retinal function. Hematoxylin-eosin staining was performed on retinal cross-sections to measure ganglion cell complex (GCC) thickness. Apoptotic retinal cells were assessed by TUNEL staining. Brn3a-positive retinal ganglion cells (RGCs) were counted in retinal flat mounts via immunofluorescence. The retinal total SOD, SOD2, and MDA expression levels were assessed in retinal tissue homogenates. The cyt c, Baxz and Bcl-2 protein levels in rat retinas were detected by western blot analysis. Bax and Bcl-2 expressions were also evaluated using immunohistochemistry in paraffinized sections. Our results showed that the rats that received microsphere injection developed elevated IOP. SS-31 ameliorated the reductions in the a- and b-wave amplitudes on ERG and the F-VEP amplitude in glaucomatous eyes. GCC thickness was preserved, TUNEL-positive cells were decreased in the retina, and Brn3a-positive RGCs were in creased in the SS-31-treated glaucoma group compared with those in the non-treated glaucoma group. SS-31 significantly reduced MDA levels and increased SOD2 levels after glaucoma induction. Significant suppression of cyt c release, upregulation of Bcl-2, and downregulation of Bax were observed following SS-31 administration. In summary, SS-31 exerts neuroprotective effects in this experimental glaucoma model by inhibiting mitochondrial dysfunction and therefore represents a promising therapeutic agent for glaucoma. | Xiaoqiong Wu Yu Pang Zhilin Zhang Xiabin Li Chao Wang Yingqing Lei Ailing Li Ling Yu Jian Ye | 2019 | Acta Biochimica et Biophysica Sinica2019，51，4： | 7 |
| 10 | Anti-influenza effect and action mechanisms of the chemical constituent gallocatechin-7-gallate from Pithecellobium clypearia Benth显示文摘Host cdc2-like kinase 1 (CLK1) is responsible for the alternative splicing of the influenza virus M2 gene during influenza virus infection and replication that has been recognized as a potential anti-influenza virus target. In this study, we showed that gallocatechin-7-gallate (J10688), a novel CLK1 inhibitor isolated from Pithecellobium clypearia Benth, exerted potent anti-influenza virus activity in vivo and in vitro. ICR mice were intranasally infected with a lethal dose of H1N1. Administration of J10688 (30mg·kg^-1·d^-1, iv, for 5 days) significantly increased the survival rate of the H1N1-infected mice to 91.67% and prolong their mean survival time from 5.83±1.74 days to 13.66±1.15 days. J10688 administration also slowed down body weight loss, significantly alleviated influenza-induced acute lung injury, reduced lung virus titer, elevated the spleen and thymus indexes, and enhanced the immunological function. We further explored its anti-influenza mechanisms in the H1N1-infected A549 cells: as a novel CLK1 inhibitor, J10688 (3, 10, 30μmol/L) dose-dependently impaired synthesis of the viral proteins NP and M2, and significantly downregulated the phosphorylation of splicing factors SF2/ASF and SC35, which regulate virus M2 gene alternative splicing. As a novel CLK1 inhibitor with potent anti-influenza activity in vitro and in vivo, J10688 could be a promising antiviral drug for the therapy of influenza A virus infection. | Chao Li Lv-jie Xu Wen-wen Lian Xiao-cong Pang Hao Jia Ai-lin Liu Guan-hua Du | 2018 | Acta Pharmacologica Sinica2018，39，12： | 6 |
| 11 | Putrescine, spermidine, and spermine play distinct roles in rice salt tolerance显示文摘Polyamines(PAs) play diverse roles in plant growth and development,as well as responses to environmental stimuli.In this study,the effects of PAs on rice salt tolerance were investigated.Salt stress resulted in the alteration of endogenous PAs levels in rice roots and leaves,where spermidine(Spd) and spermine(Spm) contents were increased,and putrescine(Put) content was decreased.RT-qPCR analysis revealed that PAs biosynthesis-related genes ADC1,ODC,and Arginase were significantly downregulated by salt treatment;however,SAMDC transcription was significantly upregulated.Exogenous Spm enhanced rice salt tolerance remarkably;however,exogenous Put and Spd undermined rice salt tolerance.Transgenic rice plants overexpressing SAMDC display a higher ratio of Spm/(Put+Spd) and enhanced salt tolerance.Salt stress also increased polyamine oxidase activities in rice,resulting in elevated reactive oxygen species(ROS) production.Our findings revealed that accumulation of Put and Spd substantially reduced salt tolerance in rice,likely by facilitating ROS production;whereas,conversion of Put and Spd to Spm contributes to rice salt tolerance. | Md Azizul ISlam PANG Jin-huan MENG Fan-wei LI Ya-wen XU Ning YANG Chao LIU Jun | 2020 | Journal of Integrative Agriculture2020，19，3： | 5 |
| 12 | Application of ultrasound contrast in identification and diagnosis of ocular spaceoccupying lesions显示文摘AIM: To analyze the application significance of ultrasound contrast agent in identification and diagnosis of ocular spaceoccupying lesions, and mainly analyze its advantages and problems. METHODS: Thirty-two representative literatures about the application of ultrasound contrast agent in diagnosis of spaceoccupying lesions at home and abroad were collected after focused on sorting the literature reporting the application of ultrasound contrast diagnostic technology in the diagnosis and identification of ocular spaceoccupying lesions in recent years. Its advantages and problems were retrospectively analyzed, and reasonable assessment on existing problems was made and possible solutions to the problems were proposed. RESULTS: As a new imaging diagnostic technique, the contrast-enhanced ultrasound, which can enhance the display of tumor microcirculation vessels and improve the tumor's ultrasound diagnostic capability, was analyzed. Through sorting and comprehensively analyzing the collected literatures, the positive rate of ocular spaceoccupying lesion diagnosis could be significantly improved with ultrasound contrast technology. Thus, the vascular perfusion in normal tissues and lesions was reflected objectively. According to the lesion's perfusion characteristics of the contrast agent plus with the performance features of two-dimensional ultrasound, the ocular spaceoccupying lesions can be accurately diagnosed, and this could provide clinicians with reliable research basis in this field. CONCLUSION: Ultrasound contrast examination is a new testing method, and ultrasound contrast agent can significantly enhance the ultrasonic detection signal, clearly show the blood perfusion in vessels and tissues, increase the image contrast resolution, and improve the lesion's detection capability in the microcirculation perfusion level, especially its important value in the diagnosis of ocular tumor. | Jia-Ying Yuan, Yun-Tao Zhang | 2011 | International Journal of Ophthalmology(English edition)2011，4，4： | 5 |
| 13 | High-performance optical chirp chain BOTDA by using a pattern recognition algorithm and the differential pulse-width pair technique显示文摘Optical chirp chain Brillouin optical time-domain analysis(OCC-BOTDA) has the capabilities of fast measurement, high Brillouin threshold, and freedom from the nonlocal effect;at the same time, however, it also has problems introduced by transient stimulated Brillouin scattering. The influence of the transient interaction is reflected as the broadened asymmetric Brillouin spectrum, the ghost peak, and the frequency shift of the main peak. This introduces difficulty in computing the fiber Brillouin frequency shift with good measurement accuracy. Besides, the OCC modulation causes additional noise due to the uneven amplitude response for different frequency components. In this work, we propose a high-performance OCC-BOTDA using the principal component analysis(PCA) based pattern recognition algorithm and differential pulse-width pair(DPP) technique.After building the Brillouin spectrum database(i.e., all patterns), the fiber intrinsic Brillouin frequency shift can be recognized by the PCA algorithm from a nonstandard Brillouin spectrum profile, resulting in good measurement accuracy. Meanwhile, the DPP technique, subtracting between two Brillouin signals generated by two wide-width pump pulses, is utilized to reduce the OCC modulation noise and avoid the pulse self-phase modulation effect in long-range BOTDA sensing. In the experiment, a temperature measurement with 1.3 MHz measurement precision, 4 m spatial resolution, and 5 s measurement time is achieved over a 100 km single-mode fiber. | BENZHANG WANG BAOHUA FAN DENGWANG ZHOU CHAO PANG YUE LI DEXIN BA YONGKANG DONG | 2019 | Photonics Research2019，7，6： | 5 |
| 14 | A Study of Methods to Identify Industry-University-Research Institution Cooperation Partners based on Innovation Chain Theory显示文摘Purpose: This study aims at identifying potential industry-university-research collaboration(IURC) partners effectively and analyzes the conditions and dynamics in the IURC process based on innovation chain theory.Design/methodology/approach: The method utilizes multisource data, combining bibliometric and econometrics analyses to capture the core network of the existing collaboration networks and institution competitiveness in the innovation chain. Furthermore, a new identification method is constructed that takes into account the law of scientific research cooperation and economic factors.Findings: Empirical analysis of the genetic engineering vaccine field shows that through the distribution characteristics of creative technologies from different institutions, the analysis based on the innovation chain can identify the more complementary capacities among organizations.Research limitations: In this study, the overall approach is shaped by the theoretical concept of an innovation chain, a linear innovation model with specific types or stages of innovation activities in each phase of the chain, and may, thus, overlook important feedback mechanisms in the innovation process.Practical implications: Industry-university-research institution collaborations are extremely important in promoting the dissemination of innovative knowledge, enhancing the quality of innovation products, and facilitating the transformation of scientific achievements.Originality/value: Compared to previous studies, this study emulates the real conditions of IURC. Thus, the rule of technological innovation can be better revealed, the potential partners of IURC can be identified more readily, and the conclusion has more value. | Haiyun Xu Chao Wang Kun Dong Rui Luo Zenghui Yue Hongshen Pang | 2018 | Journal of Data and Information Science2018，3，2： | 5 |
| 15 | Biological characteristics of the cerebral venous system and its hemodynamic response to intracranial hypertension显示文摘 | CHEN Jie WANG Xi-nling LUAN Li-ming CHAO Bao-ting PANG Bo SONG Hui PANG Qi | 2012 | Chinese Medical Journal2012，，7： | 5 |
| 16 | Comparison of Two Molecular Assays For Detecting Smear Negative Pulmonary Tuberculosis显示文摘Objective To compare the performance of MTBDRplus V2 and Xpert MTB/RIF for detecting smear negative pulmonary tuberculosis(PTB). Methods Clinical PTB suspects were enrolled consecutively in Anhui Chest Hospital and Xi'an Chest Hospital from January to December in 2014. The sputum samples of smear negative PTB suspects were collected and decontaminated. The sediment was used to conduct MTBDRplus V2, Xpert MTB/RIF and drug susceptibility test(DST). All the samples with discrepant drug susceptibility result between molecular methods and phenotypic method were confirmed by DNA sequencing. Results A total of 1973 cases were enrolled in this study. The detection rates of Mycobacterium tuberculosis complex(MTBC) by MTBDRplus V2 and Xpert MTB/RIF were 27.67% and 27.98%, respectively. When setting MGIT culture result as a gold standard, the sensitivity and specificity of MTBDRplus V2 were 86.74% and 93.84%, and the sensitivity and specificity of Xpert MTB/RIF were 86.55% and 93.43%, respectively. For the detection of the resistance to rifampin, the sensitivity and specificity of MTBDRplus V2 were 94.34% and 96.62%, and the sensitivity and specificity of Xpert MTB/RIF were 88.68% and 95.96%, respectively. For the detection of the resistance to isoniazid, the sensitivity and specificity of MTBDRplus V2 were 77.38% and 98.02%, respectively. Conclusion MTBDRplus V2 and Xpert MTB/RIF can be used to detect MTBC in smear negative samples with satisfactory performance. | LI Qiang BAO Xun Di LIU Yun OU Xi Chao PANG Yu ZHAO Yan Lin | 2016 | Biomedical and Environmental Sciences2016，29，4： | 5 |
| 17 | Decadal characteristics of the floating Ulva and Sargassum in the Subei Shoal,Yellow Sea显示文摘The data of field surveys during 2009 to 2018 was analyzed to understand the seasonality and inter-annual variability of the floating Ulva and Sargassum in the Subei Shoal,the southwestern Yellow Sea of China on decadal scale.The floating Ulva biomass was consistently originated from the central region of the Subei Shoal in middle to late April,increased rapidly,drifted and extended into the offshore water in May and June.The average floating Ulva biomass in the shoal generally increased over the years with evident inter-annual fluctuations.In contrast,pelagic Sargassum was accumulated in the Subei Shoal and formed the spring bloom only in 2013,2017 and 2018,and the biomass was higher than the co-occurring Ulva during the survey in these three years.Compared to the raft-origin floating Ulva,genesis and development of the pelagic Sargassum was distinct.Based on the current research,the Sargassum biomass was exotic and often initiated in the offshore water in March,and intruded into the shoal in April and May.The analysis on the environmental parameters was inconclusive since multiple anthropogenic and non-indigenous factors could influence the green tides in this region.Further research covering both the East China Sea and the Yellow Sea is needed to trace the origin of the floating Sargassum and to understand the interactions between these two co-occurring seaweeds. | Jie Xiao Shiliang Fan Zongling Wang Mingzhu Fu Hongjun Song Xiao Wang Chao Yuan Min Pang Xiaoxiang Miao Xuelei Zhang | 2020 | Acta Oceanologica Sinica2020，39，10： | 4 |
| 18 | The Ca^(2+)-dependent DNases are Involved in Secondary Xylem Development in Eucommia ulmoides显示文摘Secondary xylem development has long been recognized as a typical case of programmed cell death (PCD) in plants. During PCD, the degradation of genomic DNA is catalyzed by endonucleases. However, to date, no endonuclease has been shown to participate in secondary xylem development. Two novel Ca 2+ -dependent DNase genes, EuCaN1 and EuCaN2, were identified from the differentiating secondary xylem of the tree Eucommia ulmoides Oliv., their functions were studied by DNase activity assay, in situ hybridization, protein immunolocalization and virus-induced gene silencing experiments. Full-length cDNAs of EuCaN1 and EuCaN2 contained an open reading frame of 987 bp, encoding two proteins of 328 amino acids with SNase-like functional domains. The genomic DNA sequence for EuCaN1 had no introns, while EuCaN2 had 8 introns. EuCaN1 and EuCaN2 digested ssDNA and dsDNA with Ca 2+ -dependence at neutral pH. Their expression was confined to differentiating secondary xylem cells and the proteins were localized in the nucleus. Their activity dynamics was closely correlated with secondary xylem development. Secondary xylem cell differentiation is influenced by RNAi of endonuclease genes. The results provide evidence that the Ca 2+ -dependent DNases are involved in secondary xylem development. | Hui-Min Chen Yu Pang Jun Zeng Qi Ding Shen-Yi Yin Chao Liu Meng-Zhu Lu Ke-Ming Cui Xin-Qiang He | 2012 | Journal of Integrative Plant Biology2012，54，7： | 4 |
| 19 | Surface acoustic wave humidity sensors based on uniform and thickness controllable graphene oxide thin films formed by surface tension显示文摘Graphene oxide(GO)is a promising candidate for humidity sensing,and the uniformity and thickness of GO films are important for the reproducibility and test signal strength of humidity sensors.In this paper,uniform and thicknesscontrollable GO films are first formed by the surface tension of different concentrations of GO solution and then transferred to surface acoustic wave(SAW)humidity sensors.This GO film formation and transfer process has very good repeatability and stability,as evidenced by the humidity response of the sensors.With the help of the uniform and highly oxidized GO film,the humidity sensors show a significantly high sensitivity(absolute sensitivity of 25.3 kHz/%RH and relative sensitivity of 111.7 p.p.m./%RH)in a wide test range from 10%RH to 90%RH with very little hysteresis(<1%RH).The sensors achieve good reversibility,excellent short-term repeatability and stability.Moreover,the humidity sensors also show a fast response and recovery time of<10 s. | Xianhao Le Yihan Liu Li Peng Jintao Pang Zhen Xu Chao Gao Jin Xie | 2019 | Microsystems & Nanoengineering2019，5，1： | 4 |
| 20 | Geochemical Characteristics and Geological Significance of Meta-Volcanic Rocks of the Bainaimiao Group, Sonid Right Banner, Inner Mongolia, China显示文摘The Bainaimiao Group, which crops out in the Sonid Right Banner area of Inner Mongolia, China, comprises mainly metamorphosed volcano-sedimentary rocks. This group can be divided into two formations: a lower formation characterized by intermediate-felsic volcanic rocks, and an upper formation of intermediate-mafic volcanic rocks. Zircon dating indicates that biotite leptynite from the lower formation and chlorite-sericite schist from the upper formation crystallized at 499±2 and 478±2 Ma, respectively, corresponding to different volcanic events. Meta-volcanic rocks of the Bainaimiao Group belong to the calcalkaline series, and the SiO2 concentrations suggest that their protoliths were mainly basalts and rhyolites. Greenschist rocks of the group are enriched in light rare earth elements(LREEs) relative to heavy rare earth elements(HREEs), with(La/Yb)N ratios of 3.08–10.9. In addition, they are enriched in large-ion lithophile elements, including Rb, Ba and K, and depleted in the high-field-strength elements Nb, Ta and Ti. The felsic meta-volcanic rocks also exhibit relative enrichments in LREEs compared with HREEs, with high(La/Yb)N ratios of 2.92–9.89, and are enriched in Rb, Ba, Zr and Hf, and depleted in Sr, Nb and Ta. These geochemical characteristics indicate that the meta-basic volcanic rocks were originated from partial melting of sub-arc mantle wedge that had been previously metasomatized by subducted-slab-derived fluids, whereas the meta-felsic volcanic rocks were generated by partial melting of continental crust. These results suggest that the meta-volcanic rocks of the Bainaimiao Group are the products of oceanic plate subduction magmatism along an active continental margin, which can be attributed to Early Paleozoic subduction of the PaleoAsian Ocean plate beneath the northern margin of the North China Craton. | Chao Zhang Jingyu Quan Zhenghong Liu Zhongyuan Xu Xuejiao Pang Yujin Zhang | 2019 | Journal of Earth Science2019，30，2： | 4 |
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