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| 1 | RNA-seq analysis of prostate cancer in the Chinese population identifies recurrent gene fusions, cancer-associated long noncoding RNAs and aberrant alternative splicings显示文摘在有前列腺癌症的不同赛跑的病人之中有显著不同;然而,位于这差别下面的机制仍然保持不清楚。这里,我们在场 transcriptome 的一处全面风景用 RNA-seq,越过关于基因熔化的前列腺癌症 transcriptomes 的揭示巨大的差异,长 noncoding RNA (长 ncRNA ) ,其他的拼接和体的变化从中国人口 14 主要前列腺癌症和他们的配对的正常对应物介绍。14 个肿瘤(21.4%) 中的三个在中国病人怀有 TMPRSS2 尔格熔化,和这熔化的低流行进一步在一个另外的肿瘤集合(10/54=18.5%) 被证实。尤其是,二新奇基因熔化, CTAGE5-KHDRBS3 (20/54=37%) 和 USP9Y-TTTY15 (19/54=35.2%) ,在我们的耐心的队经常发生了。介绍的进一步系统的 transcriptional 识别了是在肿瘤表示的差别的众多的长 ncRNAs。在长 ncRNA 和基因的表示之间的关联的分析建议长 ncRNAs 可以在 transcriptional 规定以外有功能。这研究在中国人口产出新卓见进前列腺癌症的致病。 | Shancheng Ren Zhiyu Peng Jian-Hua Mao Yongwei Yu Changjun Yin Xin Gao Zilian Cui Jibin Zhang Kang Yi Weidong Xu Chao Chen Fubo Wang Xinwu Guo Ji Lu Jun Yang Min Wei Zhijian Tian Yinghui Guan Liang Tang Chuanliang Xu Linhui Wang Xu Gao Wei Tian Jian Wang Huanming Yang Jun Wang Yinghao Sun | 2012 | Cell Research2012，22，5： | 66 |
| 2 | aunalysis of the Genome Sequence of the Medicinal Plant Salvia miltiorrhiza显示文摘 | Haibin Xu Jingyuan Song Hongmei Luo Yujun Zhang Qiushi Li Yingjie Zhu Jiang Xu Ying Li Chi Song Bo Wang Wei Sun Guoan Shen Xin Zhang Jun Qian Aijia Ji Zhichao Xu Xiang Luo Liu He Chuyuan Li Chao Sun Haixia Yah Guanghong Cui Xiwen Li Xian 'en Li Jianhe Wei Juyan Liu Yitao Wang Alice Hayward David Nelson Zemin Ning Reuben J. Peters Xiaoquan Qi Shilin Chen | 2016 | Molecular Plant2016，9，6： | 70 |
| 3 | Genome-wide analysis of heat shock transcription factor families in rice and Arabidopsis显示文摘The heat shock transcription factors (HSFs) are the major heat shock factors regulating the heat stress response. They participate in regulating the expression of heat shock proteins (HSPs), which are critical in the protection against stress damage and many other important biological processes. Study of the HSF gene family is important for understanding the mechanism by which plants respond to stress. The completed genome sequences of rice (Oryza sativa) and Arabidopsis (Arabidopsis thaliana) constitute a valuable resource for comparative genomic analysis, as they are representatives of the two major evolutionary lineages within the angiosperms: the monocotyledons and the dicotyledons. The identification of phylogenetic relationships among HSF proteins in these species is a fundamental step to unravel the functionality of new and yet uncharacterized genes belonging to this family.In this study, the full complement of HSF genes in rice and Arabidopsis has probably been identified through the genome-wide scan. Phylogenetic analyses resulted in the identification of three major clusters of orthologous genes that contain members belonging to both species, which must have been represented in their common ancestor before the taxonomic splitting of the angiosperms. Further analysis of the phylogenetic tree reveals a possible dicot specific gene group. We also identified nine pairs of paralogs, as evidence for studies on the evolution history of rice HSF family and rice genome evolution. Expression data analysis indicates that HSF proteins are widely expressed in plants. These results provide a solid base for future functional genomic studies of the HSF gene family in rice and Arabidopsis. | Jingkang Guo Jian Wu Qian Ji Chao Wang Lei Luo Yi Yuan Yonghua Wang Jian Wang | 2008 | Journal of Genetics and Genomics2008，35，2： | 52 |
| 4 | The prognostic value of preoperative serum levels of CEA,CA19-9 and CA72-4 in patients with colorectal cancer显示文摘INTRODUCTIONCarcinoembryonic antigen ( CEA) , originally described by Gold and Freedman [1] in 1965, is now an acknowledged member of immunoglobulin superfamily[2],with a role as an intracellular adhesion molecule[3].Carbohydrate antigen 19-9(CA19-9), obtained with a monoclonal antibody produced by immunizing a monoclonal antibody produced by immunizing a mouse with a colonic cancer cell line in 1979[4],is a ligand for E-selectin that plays an important role in the addhesion of cancer cells to endothelial cells [5,6]. | Chao Xu Zheng~1 Wen Hua Zhan~1 Ji Zong Zhao~2 Dong Zheng~3 Dong Ping Wang~1 Yu Long He~1 Zhang Qing Zheng~1 ~1Department of General Surgery,~2Laboratory of Surgery,~3Department of Medicine,First Affiliated Hospital,Sun Yat-Sen University of Medical Sciences,Guangzhou 510080,Guangdong Province,ChinaDr.Chao Xu Zheng now working as a surgeon and lecturer in the Department of General Surgery,First Affiliated Hospital,Sun Yat-Sen University of Medical Sciences,who is a Ph.D.student,having 7 papers published. | 2001 | World Journal of Gastroenterology2001，7，3： | 25 |
| 5 | VGLL4 functions as a new tumor suppressor in lung cancer by negatively regulating the YAP-TEAD transcriptional complex显示文摘肺癌症是与高发生和死亡世界范围的大多数破坏疾病之一。河马(Hpo ) 小径是在果蝇和哺乳动物的机关尺寸的一个保存管理者。新兴的证据在癌症开发建议了 Hpo 小径的意义。在这研究,我们通过否定地调整 YAP-TEAD 建筑群的形成在肺 carcinogenesis 作为新奇肿瘤 suppressor 识别 VGLL4, Hpo 的核心部件小径。我们 VGLL4 经常被观察低层的数据表演在老鼠和人的肺癌症标本表示了。VGLL4 的宫外的表示显著地在 vitro 压制肺癌症房间的生长。更重要地, VGLL4 显著地在 de novo 老鼠模型禁止肺癌症前进。我们进一步发现 VGLL4 禁止 YAP-TEAD transcriptional 建筑群的活动。我们 VGLL4 直接在绑定与笨蛋竞争到 TEAD 并且执行的数据表演它通过二 TDU 域的生长禁止的函数。一起,我们的学习证明 VGLL4 是为通过否定地调整 YAP-TEAD 复杂形成并且这样的肺癌症的新奇肿瘤 suppressor Hpo 小径。 | Wenjing Zhang Yijun Gao Peixue Li Zhubing Shi Tong Guo Fei Li Xiangkun Han Yan Feng Chao Zheng Zuoyun Wang Fuming Li Haiquan Chen Zhaocai Zhou Lei Zhang Hongbin Ji | 2014 | Cell Research2014，24，3： | 25 |
| 6 | Hydroformylation of alkenes over rhodium supported on the metal-organic framework ZlF-8显示文摘 | Chao Hou Guofeng Zhao Yongjun Ji Zhiqiang Niu Dingsheng Wang Yadong Li | 2014 | Nano Research2014，7，9： | 18 |
| 7 | Mycoplasma infections and different human carcinomas显示文摘AIM To explore relationships between human carcinomas and mycoplasma infection.METHODS Monoclonal antibody PD4, which specifically recognizes a distinct protein from mycoplasma hyorhinis, was used to detect mycoplasma infection in different paraffinembedded carcinoma tissues with immunohistochemistry. PCR was applied to amplify the mycoplasma DNA from the positive samples for confirming immunohistochemistry.RESULTS Fifty of 90 cases (56%) of gastric carcinoma were positive for mycoplasma hyorhinis. In other gastric diseases, the mycoplasma infection ratio was 28% (18/49) in chronic superficial gastritis, 30% (14/ 46) in gastric ulcer and 37% (18/ 49) in intestinal metaplasia. The difference is significant with gastric cancer (X2=12.06, P<0.05). In colon carcinoma, the mycoplasma infection ratio was 55.1% (32/58), but it was 20.9% (10/49) in adenomarous polyp (X2=13.46, P<0.005).Gastric and colon cancers with high differentiation had a higher mycoplasma infection ratio than those with low differentiation (P< 0.05). Mycoplasma infection in esophageal cancer, lung cancer, breast cancer and glioma was 50.9% (27/53), 52.6% (31/ 59), 39.7%(25/63) and 41% (38/91), respectively. The mycoplasma DNA was successfully amplified with the DNA extracted from the cancer tissues that were positive for mycoplasma infection (detected with antibody PD4).CONCLUSION There was high correlation between mycoplasma infection and different cancers, which suggests the possibility of an association between the two. The mechanism involved in oncogenesis by mycoplasma remains unknown. | Su Huang Ji You Li Jan Wu Lin Meng Cheng Chao Shou Beijing Institute for Cancer Research, Peking University School of Oncology, Beijing 100034. ChinaSu Huang, received B. A from Jiangxi Medical College of China in 1994. Now she is a graduate student pursuing a Ph. D degree at the Peking University School of Oncology. | 2001 | World Journal of Gastroenterology2001，7，2： | 18 |
| 8 | Perioperative transcutaneous electrical acupoint stimulation for improving postoperative gastrointestinal function:A randomized controlled trial显示文摘Background:Postoperative gastrointestinal dysfunction(PGD)is one of the most common complications in patients undergoing major abdominal surgery.Acupuncture has been used widely in gastrointestinal diseases due to its effectiveness and minimally invasive nature.Objective:This study evaluated the efficacy of using transcutaneous electrical acupoint stimulation(TEAS)during the surgery and postoperative recovery in patients with gastric and colorectal surgery for improving postoperative gastrointestinal function.Design,setting,participants and interventions:A total of 280 patients undergoing abdominal surgery were stratified by type of surgery(i.e.,gastric or colorectal surgery)and randomly allocated into the TEAS group(group T)or the sham group(group S).Patients in group T received TEAS at LI4,PC6,ST36 and ST37.Patients in group S received pseudo-TEAS at sham acupoints.The stimulation was given from 30 min before anesthesia until the end of surgery.The same treatment was performed at 9 am on the 1st,2nd and 3rd days after surgery,until the recovery of flatus in patients.Main outcome measures:The primary outcome was the time to the first bowel motion,as detected by auscultation.The secondary outcomes included the first flatus and ambulation time,changes of perioperative substance P(SP),incidence of PGD,postoperative pain,postoperative nausea and vomiting(PONV)and some economic indicators.Results:The time to first bowel motion,first flatus and first ambulation in group T was much shorter than that in group S(P<0.01).In patients undergoing colorectal surgery,the concentration of SP was lower in group T than in group S on the third day after the operation(P<0.05).The average incidence of PGD in all patients was 25%,and the frequency of PGD was significantly lower in group T than in group S(18.6%vs.31.4%,respectively;P<0.05).TEAS treatment(odds ratio=0.498;95%confidence interval:0.232–0.786)and type of surgery were relevant factors for the development of PGD.Postoperative pain score and PONV occurrence were significantly lower in group T(P<0.01).Postoperative hospitalization days and the resulting cost to patients were greatly reduced in the TEAS group(P<0.01).Conclusion:Perioperative TEAS was able to promote the recovery of postoperative gastrointestinal function,reduce the incidence of PGD and PONV.The concentration of SP was decreased by TEAS treatment,which indicates that the brain-gut axis may play a role in how TEAS regulates gastrointestinal function.Trial registration:Chinese Clinical Trial Registry,Chi CTR1900023263. | Wen-jing Li Chao Gao Li-xin An Yu-wei Ji Fu-shan Xue Yi Du | 2021 | Journal of Integrative Medicine2021，19，3： | 16 |
| 9 | Eleven COVID-19 Outbreaks with Local Transmissions Caused by the Imported SARS-CoV-2 Delta VOC-China,July-August,2021显示文摘Starting from December 2019,Wuhan,China,encountered the first outbreak of coronavirus disease 2019(COVID-19)(1-2).The epidemic was successfully suppressed by strict containment so that the number of infected people was reduced to 0 on April 8,2020(3–4).After that,China experienced roughly 3 dozen outbreaks with local transmission caused by imported severe acute respiratory syndrome coronavirus 2(SARS-CoV-2). | Lei Zhou Kai Nie Hongting Zhao Xiang Zhao Bixiong Ye Ji Wang Cao Chen Hong Wang Jiangli Di Jinsong Li Chao Li Zhixiao Chen Ruiqi Ren Peihua Niu Hui Chen Tao Chen Yali Wang Lili Li Bingxue Han Ruhan A Si Chen Dan Li Dan Li Chunxia Jin Xin Zhang Jiangmei Liu Chunyu Xu Yecheng Yao Yenan Feng Zhili Li Bike Zhang Yang Song Peter Hao Yanping Zhang Hao Li Qun Li George F.Gao Guoqing Shi Wenbo Xu | 2021 | China CDC weekly2021，3，41： | 13 |
| 10 | Effect of Essential Oil on Patients with Chronic Prostatitis/Chronic Pelvic Pain Syndrome: A Pilot Randomized Controlled Trial显示文摘Objective: To evaluate the efficacy and safety of essential oil treatment for type Ⅲ chronic prostatitis/chronic pelvic pain syndrome(CP/CPPS). Methods: A randomized controlled trial was conducted from December 2014 to October 2015. Seventy type Ⅲ CP/CPPS patients were assigned to the essential oil group(35 cases) or almond placebo oil control group(35 cases) by a random number table. The oil was smeared by self-massage on the suprapubic and sacral region once a day for 4 weeks. The National Institutes of Health Chronic Prostatitis Syndrome Index(NIH-CPSI) and expressed prostatic secretions(EPS) were examined. The primary outcome was NIH-CPSI pain domain. The secondary outcomes included other NIH-CPSI domains and laboratory examinations of EPS. Adverse events were also observed. Results: Sixty-six subjects completed the full 4-week treatment. There was no significant difference between almond oil control and essential oil groups in terms of the total score of NIH-CPSI, pain, quality of life and urination domain scores of NIH-CPSI and EPS examinations(P>0.05). In the essential oil group, pain between rectum and testicles(perineum) in the domain of pain or discomfort was significantly reduced at week 2 and week 4 compared with almond oil control group(P<0.01). No serious adverse events occurred. Conclusion: The essential oil may reduce the pain or discomfort in the perineum region in patients with CP/CPPS. | YING Jian ZHOU Min-jie CHEN Hai-yong CHEN Lei ZHANG Wei JI Jun YU Chao ZHANG Zhang-jin | 2019 | Chinese Journal of Integrative Medicine2019，25，2： | 13 |
| 11 | Status of hyperhomocysteinemia in China: results from the China Stroke High-risk Population Screening Program, 2018显示文摘A nationwide survey was conducted from October 2018 to September 2019 to assess the prevalence of hyperhomocysteinemia(Hhcy)and its influencing factors in China.A standardized questionnaire was used to collect information.Hhcy was defined as the level of serum homocysteine(HCY)≥15.0µmol/L.The H-type hypertension(HHYP)was defined as hypertension with an elevated serum HCY(≥15.0µmol/L).Finally,110551 residents≥40 years of age from 31 provinces in the mainland of China were included.Overall,the median serum HCY level was 10.9µmol/L(interquartile range 7.9–15.1).A total of 28633 participants(25.9%)were defined as Hhcy.The Hhcy prevalence ranged from 7.9%in Shanghai to 56.8%in Tianjin.The data showed that serum HCY levels were associated with age,male gender,cigarette smoking,hypertension,diabetes,ethnicity,endurance in exercise(inverse),and fruit and vegetable intake(inverse).In addition,15486 participants were defined as HHYP,and the rate was 14.0%.HHYP was an independent predictor of stroke with an adjusted odds ratio of 1.752(95%CI 1.338–2.105).The geographical distribution pattern of the Hhcy epidemic reflects dynamic differences,and national strategies should be carried out to further improve the care of patients with Hhcy across China. | Wenjun Tu Feng Yan Baohua Chao Xunming Ji Longde Wang | 2021 | Frontiers of Medicine2021，15，6： | 12 |
| 12 | Effect of heat treatment on structure and gasification reactivity of petroleum coke显示文摘 | Chao Li Xin Liu Zhijie Zhou Zhenghua Dai Ji Yan Fuchen Wang | 2016 | International Journal of Coal Science & Technology2016，3，1： | 9 |
| 13 | Sequence stratigraphy, paleogeography, and coal accumulation regularity of major coal-accumulating periods in China显示文摘There are 9 major coal-accumulating periods during geological history in China,including the Early Carboniferous,Late Carboniferous-Early Permian,Middle Permian,Late Permian,Late Triassic,Early-Middle Jurassic,Early Cretaceous,Paleogene and Neogene.The coal formed in these periods were developed in different coal-accumulating areas(CAA)including the North China,South China,Northwest China,Northeast China,the Qinghai–Tibet area,and China offshore area.In this paper,we investigated depositional environments,sequence stratigraphy,lithofacies paleogeography and coal accumulation pattern of five major coal-accumulating periods including the Late Carboniferous to Middle Permian of the North China CAA,the Late Permian of the South China CAA,the Late Triassic of the South China CAA,the Early-Middle Jurassic of the North and Northwest China CAA,and the Early Cretaceous in the Northeast China CAA.According to distribution of the coal-bearing strata and the regional tectonic outlines,we have identified distribution range of the coal-forming basins,sedimentary facies types and coal-accumulating models.The sequence stratigraphic frameworks of the major coal-accumulating periods were established based on recognition of a variety of sequence boundaries.The distribution of thick coals and migration patterns of the coal-accumulating centers in the sequence stratigraphic framework were analyzed.The lithofacies paleogeography maps based on third-order sequences were reconstructed and the distribution of coal accumulation centers and coal-rich belts were predicted. | Longyi Shao Xuetian Wang Dongdong Wang Mingpei Li Shuai Wang Yingjiao Li Kai Shao Chao Zhang Caixia Gao Daxiao Dong Aiguo Cheng Jing Lu Congwei Ji Di Gao | 2020 | International Journal of Coal Science & Technology2020，7，2： | 9 |
| 14 | Serum uric acid as an index of impaired renal function in congestive heart failure显示文摘BackgroundHyperuricemia 经常是在有心失败的病人的现在。许多病理学的条件例如织物局部缺血,肾的功能缺陷,心脏的功能缺陷,新陈代谢的症候群,和煽动性的地位,可以影响尿酸(UA ) 新陈代谢。这研究是回顾地在心 failure.MethodsWe 估计他们的潜在的关系到 UA 新陈代谢估计的临床的特征, echocardiological ,肾,与充血的心失败在随机选择的成年人的一个大队在心血管的疾病和 UA 新陈代谢根据他们的参与的以前的证据选择的新陈代谢、煽动性的变量( n = 553 )。由索引聚类,那些变量用因素 analysis.ResultsIn 因素分析被探索,尿酸(SUA ) 形成了的浆液包括了浆液 creatinine (SCr ) 和血脲氮(甜面包) 的肾的功能的变量的主要的簇的部分。在有充血的心失败的病人的变量之间的 Univariate 关联系数证明为 SUA 的最强壮的关联与甜面包(r = 0.48, P <0.001 ) 并且 SCr (r = 0.47, P <0.001 ).ConclusionsThere 是在 SUA 层次和在有充血的心失败的病人的肾的功能的措施之间的一种反的关系。在 SUA 和 SCr 和甜面包层次之间的强壮的关联建议提高的 SUA 集中在心失败反映肾的功能的一个缺陷。 | Yu Tian Ying Chen Bao Deng Gang Liu Zhen-Guo Ji Qing-Zhen Zhao Yu-Zhi Zhen Yan-Qiu Gao Li Tian Le Wang Li-Shuang Ji Guo-Ping Ma Kun-Shen Liu Chao Liu | 2012 | Journal of Geriatric Cardiology2012，9，2： | 9 |
| 15 | Discovery of ~4.0 Ga detrital zircons in the Changdu Block,North Qiangtang,Tibetan Plateau显示文摘在 situ 锆石由 LA-ICP-MS 和 MC-ICP-MS 标明日期使用, 3981 的由岩屑形成的锆石 ??? 鮼铧?? ? 裦蒚铩 ????? 偃 ?? 鮼 ?? 郥趽 ????腘 吗?? | ShiPing He RongShe Li Chao Wang HongFei Zhang WenHua Ji PuSheng Yu PingYang Gu Chao Shi | 2011 | Chinese Science Bulletin2011，56，7： | 9 |
| 16 | Oocyte-expressed yes-associated protein is a key activator of the early zygotic genome in mouse显示文摘 | Chao Yu Shu-Yan Ji Yu-Jiao Dang Qian-Qian Sha Yi-FengYuan Jian-Jie Zhou Li-Ying Yan Jie Qiao Fuchou Tang Heng-Yu Fan | 2016 | Cell Research2016，26，3： | 9 |
| 17 | Lactulose enhances neuroplasticity to improve cognitive function in early hepatic encephalopathy显示文摘Lactulose is known to improve cognitive function in patients with early hepatic encephalopathy; however, the underlying mechanism remains poorly understood. In the present study, we investigated the behavioral and neurochemical effects of lactulose in a rat model of early hepatic encephalopathy induced by carbon tetrachloride. Immunohistochemistry showed that lactulose treatment promoted neurogenesis and increased the number of neurons and astrocytes in the hippocampus. Moreover, lactulose-treated rats showed shorter escape latencies than model rats in the Morris water maze, indicating that lactulose improved the cognitive impairments caused by hepatic encephalopathy. The present findings suggest that lactulose effectively improves cognitive function by enhancing neuroplasticity in a rat model of early hepatic encephalopathy. | Nan Yang He Liu Yao Jiang Ji Zheng Dong-mei Li Chao Ji Yan-yong Liu Ping-ping Zuo | 2015 | Neural Regeneration Research2015，10，9： | 8 |
| 18 | Behavioral Abnormality along with NMDAR-related CREB Suppression in Rat Hippocampus after Shortwave Exposure显示文摘Objective To estimate the detrimental effects of shortwave exposure on rat hippocampal structure and function and explore the underlying mechanisms. Methods One hundred Wistar rats were randomly divided into four groups(25 rats per group) and exposed to 27 MHz continuous shortwave at a power density of 5, 10, or 30 m W/cm^2 for 6 min once only or underwent sham exposure for the control. The spatial learning and memory, electroencephalogram(EEG), hippocampal structure and Nissl bodies were analysed. Furthermore, the expressions of N-methyl-D-aspartate receptor(NMDAR) subunits(NR1, NR2 A, and NR2 B), c AMP responsive element-binding protein(CREB) and phosphorylated CREB(p-CREB) in hippocampal tissue were analysed on 1, 7, and 14 days after exposure. Results The rats in the 10 and 30 m W/cm^2 groups had poor learning and memory, disrupted EEG oscillations, and injured hippocampal structures, including hippocampal neurons degeneration, mitochondria cavitation and blood capillaries swelling. The Nissl body content was also reduced in the exposure groups. Moreover, the hippocampal tissue in the 30 m W/cm^2 group had increased expressions of NR2 A and NR2 B and decreased levels of CREB and p-CREB. Conclusion Shortwave exposure(27 MHz, with an average power density of 10 and 30 m W/cm^2) impaired rats' spatial learning and memory and caused a series of dose-dependent pathophysiological changes. Moreover, NMDAR-related CREB pathway suppression might be involved in shortwave-induced structural and functional impairments in the rat hippocampus. | YU Chao BAI Yan Xin XU Xin Ping GAO Ya Bing HAO Yan Hui WANG Hui TAN Sheng Zhi LI Wen Chao ZHANG Jing YAO Bin Wei DONG Ji ZHAO Li PENG Rui Yun | 2019 | Biomedical and Environmental Sciences2019，32，3： | 7 |
| 19 | Adjuvant Effects of Fermented Red Ginseng Extract on Advanced Non-Small Cell Lung Cancer Patients Treated with Chemotherapy显示文摘Objective: To investigate the adjuvant therapeutic effects of fermented red ginseng(FRG) extract on non-small cell lung cancer(NSCLC) patients treated with chemotherapy. Methods: A total of 60 patients with advanced NSCLC were assigned to two groups using a random number table, i.e., the gemcitabine plus cisplatin(GP) chemotherapy alone group(26 patients) and the FRG + GP chemotherapy group(34 patients), for 60-day treatment. Patients were then assessed according to the Fatigue Symptom Inventory, Chinese medicine symptoms score, Self-Rating Anxiety Scale, Self-Rating Depression Scale, Karnofsky Performance Status Scale, and Functional Assessment of Cancer Therapy-Lung. In addition, chemotherapy toxicity and tumor biomarkers were measured. Results: For NSCLC patients after chemotherapy, FRG extract significantly improved the FSI score, CM symptoms score, psychological status, physical conditions, and quality of life and reduced chemotherapy toxicity(P<0.01), but the expression levels of carcinoembryonic antigen, cytokeratin-19 fragments, and neuron-specific enolase were not significantly different between the chemotherapy alone and the FRG + chemotherapy groups or between pre-and post-treatments(P>0.05). Conclusions: This study demonstrated that FRG extract had an adjuvant effect on advanced NSCLC patients treated with chemotherapy. Further studies with a larger sample size will verify the current findings. | JIANG Shu-long LIU Hong-jie LIU Zhao-chun LIU Ning LIU Rui Young-Reep Kang Joong-Gu Ji ZHANG Chao HUA Bao-jin Shin-Jyung Kang | 2017 | Chinese Journal of Integrative Medicine2017，23，5： | 7 |
| 20 | Heavy-ion and pulsed-laser single event effects in 130-nm CMOS-based thin/thick gate oxide anti-fuse PROMs显示文摘Single event effects of 1-T structure programmable read-only memory(PROM) devices fabricated with a 130-nm complementary metal oxide semiconductorbased thin/thick gate oxide anti-fuse process were investigated using heavy ions and a picosecond pulsed laser. The cross sections of a single event upset(SEU) for radiationhardened PROMs were measured using a linear energy transfer(LET) ranging from 9.2 to 95.6 MeV cm^2mg^(-1).The result indicated that the LET threshold for a dynamic bit upset was ~ 9 MeV cm^2mg^(-1), which was lower than the threshold of ~ 20 MeV cm^2mg^(-1) for an address counter upset owing to the additional triple modular redundancy structure present in the latch. In addition, a slight hard error was observed in the anti-fuse structure when employing209 Bi ions with extremely high LET values(~ 91.6 MeV cm^2mg^(-1)) and large ion fluence(~ 1×10~8 ions cm^(-2)). To identify the detailed sensitive position of a SEU in PROMs, a pulsed laser with a 5-μm beam spot was used to scan the entire surface of the device.This revealed that the upset occurred in the peripheral circuits of the internal power source and I/O pairs rather than in the internal latches and buffers. This was subsequently confirmed by a ^(181)Ta experiment. Based on the experimental data and a rectangular parallelepiped model of the sensitive volume, the space error rates for the used PROMs were calculated using the CRèME-96 prediction tool. The results showed that this type of PROM was suitable for specific space applications, even in the geosynchronous orbit. | Chang Cai Tian-Qi Liu Xiao-Yuan Li Jie Liu Zhan-Gang Zhang Chao Geng Pei-Xiong Zhao Dong-Qing Li Bing Ye Qing-Gang Ji Li-Hua Mo | 2019 | Nuclear Science and Techniques2019，30，5： | 7 |
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