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| 1 | Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer's disease progression显示文摘Recently,increasing evidence has suggested the association between gut dysbiosis and Alzheimer's disease(AD)progression,yet the role of gut microbiota in AD pathogenesis remains obscure.Herein,we provide a potential mechanistic link between gut microbiota dysbiosis and neuroinflammation in AD progression.Using AD mouse models,we discovered that,during AD progression,the alteration of gut microbiota composition leads to the peripheral accumulation of phenylalanine and isoleucine,which stimulates the differentiation and proliferation of pro-inflammatory T helper 1(Thl)cells.The brain-infiltrated peripheral Th1 immune cells are associated with the Ml microglia aaivation,contributing to AD-associated neuroinflammation.Importantly,the elevation of phenylalanine and isoleucine concentrations and the increase of Th1 cell frequency in the blood were also observed in two small independent cohorts of patients with mild cognitive impairment(MCI)due to AD.Furthermore,GV-971,a sodium oligomannate that has demonstrated solid and consistent cognition improvement in a phase 3 clinical trial in China,suppresses gut dysbiosis and the associated phenylalanine/isoleucine accumulation,harnesses neuroinflammation and reverses the cognition impairment.Together,our findings highlight the role of gut dysbiosis-promoted neuroinflammation in AD progression and suggest a novel strategy for AD therapy by remodelling the gut microbiota. | Xinyi Wang Guangqiang Sun Teng Feng Jing Zhang Xun Huang Tao Wang Zuoquan Xie Xingkun Chu Jun Yang Huan Wang Shuaishuai Chang Yanxue Gong Lingfei Ruan Guanqun Zhang Siyuan Yan Wen Lian Chen Du Dabing Yang Qingli Zhang Feifei Lin Jia Liu Haiyan Zhang Changrong Ge Shifu Xiao Jian Ding Meiyu Geng | 2019 | Cell Research2019，29，10： | 192 |
| 2 | Molecular detection of SARS-CoV-2 being challenged by virus variation and asymptomatic infection显示文摘Coronavirus disease 2019(COVID-19)has been a pandemic for more than a year.With the expanding second wave of the pandemic in winter,the continuous evolution of SARS-CoV-2 has brought new issues,including the significance of virus mutations in infection and the detection of asymptomatic infection.In this review,we first introduced several major SARS-CoV-2 mutations since the COVID-19 outbreak and then mentioned the widely used molecular detection techniques to diagnose COVID-19,primarily focusing on their strengths and limitations.We further discussed the effects of viral genetic variation and asymptomatic infection on the molecular detection of SARS-CoV-2 infection.The review finally summarized useful insights into the molecular diagnosis of COVID-19 under the special situation being challenged by virus mutation and asymptomatic infection. | Congshan Jiang Xiaowei Li Changrong Ge Yuanyuan Ding Tao Zhang Shuai Cao Liesu Meng Shemin Lu | 2021 | Journal of Pharmaceutical Analysis2021，11，3： | 2 |
| 3 | Characterization of fermented black soybean natto inoculated with Bacillus natto during fermentation显示文摘 | Yongjin Hu Changrong Ge Wei Yuan | 2010 | Research Article2010，90，： | 1 |
| 4 | Effects of the Monoclonal Antibody against Porcine 40 kDa Adipocyte-specific Plasma Membrane Protein on Adipocytes and Carcass Composition显示文摘老鼠的效果对猪的 adipocytes 和尸体作文上的 40 kDaadipocyte 特定的质膜蛋白质的单音的同种细胞的抗体在 vitro 和 invivo 被调查。结果表明在里面这 monoclonalantibody 的调停补充的 cytotoxicity 能导致的 vitro adipocyte 细胞溶解, adipocyte 类脂化合物累积(P<0.01 ) 的显著减小,和区分得好的胖房间(P<0.01 ) 的重要减少。有在 vitro 独自一个的这抗体的 adipocytes 的处理没导致房间细胞溶解,但是能导致在 pre-adipocyte 的区分 ofwell 的房间和类脂化合物累积(P<0.05 ) 上演的显著减小。在 vivo,与 0.5 mg/kg 或抗体的 1.0 mg/kg 注射的猪显示出更小的 adipocyte 尺寸(P<0.01 ) 并且减少了 adipocytes (P<0.01 ) 的类脂化合物累积。我们的结果也显示了皮下地在 15 kg 或有的 1.0 mg/kg 抗体 at60 kg 与单音的同种细胞的抗体的 0.5 mg/kg 使免疫的那猪 intraperitoneallyor 一个更高瘦的肉百分比( P<0.05 ),更大的腰眼睛区域( P<0.05 ),更低的胖肉百分比( P<0.05 ),更少的背脂肪厚度( P<0.05 )和比控制猪,而是象胎膜脂肪重量,心重量,肝重量,怒气重量,肾重量,肺重量,和调味品那样的另外的尸体特点,百分比不是的更小的叶脂肪重量( P<0.05 )显著地影响了。Theseresults 建议这单音的同种细胞的抗体能被使用在猪的生产制止过多的胖免职。 | Shizheng GAO Changrong GE Xi ZHANG Yonggang LIU | 2007 | Acta Biochimica et Biophysica Sinica2007，39，7： | 1 |
| 5 | Effect of mixed starter cultures fermentation on the characteristic of silver carp sausages 显示文摘 | Hu Yongjin Xia Wenshui Ge Changrong | 2007 | World J Microbiol Biotechnol2007，23，： | 1 |
| 6 | Import Determinants of Organelle-Specific and Dual Targeting Peptides of Mitochondria and Chloroplasts in Arabidopsis thaliana显示文摘大多数 mitochondrial 和 chloroplastic 蛋白质作为带指向明确地指导他们到一个正确细胞器的肽(TP ) 的 N 终端的先锋蛋白质在 cytosol 被综合。然而,有一组蛋白质,双地用模糊 N 终端被指向到线粒体和叶绿体双指向肽(dTP ) 。这里,我们调查了把数学 multivariate 数据分析(MVDA ) 与相结合的细胞器特定的 TP 和 dTPs 的进口决定因素的模式性质在 vitro organellar,进口学习。我们使用了从 Arabidopsis thaliana 象试验性地证实的细胞器特定的 TP 和 dTPs 的手工地选择的数据集合一样在 organellar proteomes 发现的 mitochondrial 和 chloroplastic 蛋白质的大数据集。细胞器特定的 TP 的二个班能被 MVDA 和潜在的模式区分或在贡献分离的氨基酸顺序的频率被揭示。dTPs 被发现有在细胞器特定的 TP 之间的中间的顺序特征。有趣地,把断然控告的残余介绍给 dTPs 出现了在 silico 向 mitochondrial TP 聚类并且导致了叶绿体,然而并非 mitochondrial 进口的抑制在在 vitro organellar,进口学习。这些调查结果建议在 TP 的 N 终端区域的那个正电荷可以为叶绿体进口作为一个回避信号工作。 | Changrong Ge Erika Spanning Elzbieta Glaser Ake Wieslander | 2014 | Molecular Plant2014，7，1： | 1 |
| 7 | Characterization of fermented silver carp sausages inoculated with mixed starter culture 显示文摘 | Hu Yongjin Xia Wenshui Ge Changrong | 2008 | LWT-Food Science and Technology2008，41，： | 1 |
| 8 | Characterization of fermented silver carp sausages inoculated with mixed starter culture 显示文摘 | Yongjin Hu Wenshui Xia Changrong Ge | 2008 | LWT2008，41，： | 1 |
| 9 | BRIEF COMMUNICATION ARISING Geng et al.reply显示文摘The accompanying comment by Dr.Rao,suggests that there is an omission of citation of 12 previous publications in our Wang et al.paper.1 We disagree with the suggestion for the following reasons.We believe that the 12 publications cited by Dr.Rao do not have sufficient relevance to the Wang et al.paper.1 The past decades have witnessed an explosive growth in our understanding of the pathogenesis of Alzheimer's disease(AD),which is a very complicated process.The Wang et al. | Xinyi Wang Guangqiang Sun Teng Feng Jing Zhang Xun Huang Tao Wang Zuoquan Xie Xingkun Chu Jun Yang Huan Wang Shuaishuai Chang Yanxue Gong Lingfei Ruan Guanqun Zhang Siyuan Yan Wen Lian Chen Du Dabing Yang Qingli Zhang Feifei Lin Jia Liu Haiyan Zhang Changrong Ge Shifu Xiao Jian Ding Meiyu Geng | 2020 | Cell Research2020，30，9： | 0 |
| 10 | Combined Optimal Dispatch of Thermal Power Generators and Energy Storage Considering Thermal Power Deep Peak Clipping and Wind Energy Emission Grading Punishment显示文摘Peak load and wind energy emission pressure rise more as wind energy penetration keeps growing,which affects the stabilization of the PS(power system).This paper suggests integrated optimal dispatching of thermal power generators and BESS(battery energy storage system)taking wind energy emission grading punishment and deep peak clipping into consideration.Firstly,in order to minimize wind abandonment,a hierarchical wind abandonment penalty strategy based on fuzzy control is designed and introduced,and the optimal grid-connected power of wind energy is determined as a result of minimizing the peak cutting cost of the system.Secondly,considering BESS and thermal power,the management approach of BESS-assisted virtual peak clipping of thermal power generators is aimed at reducing the degree of deep peak clipping of thermal power generators and optimizing the output of thermal power generators and the charging and discharging power of BESS.Finally,Give an example of how this strategy has been effective in reducing abandonment rates by 0.66% and 7.46% individually for different wind penetration programs,and the daily average can reduce the peak clipping power output of thermal power generators by 42.97 and 72.31 MWh and enhances the effect and economy of system peak clipping. | Junhui Li Xuanzhong Luo Changxing Ge Cuiping Li Changrong Wang | 2024 | Energy Engineering2024，121，4： | 0 |
| 11 | Fatty Acid Composition and Amino Acid Content in Beef of Dehong Buffalo and Its Cross Combinations显示文摘The Dehong buffalo( D),F1 hybrids of Dehong buffalo × Murrah buffalo( MD) and F1 hybrids of Dehong × Nili buffalo( ND) as the experimental animals to investigate their fatty acid composition and amino acid content. Five of each buffalos were bred by freely grazing and slaughtered at 35. 8-month old age to investigate the fatty acid composition and amino acid content in beef of Dehong buffalo,MD buffalo and ND buffalo. The results showed that,saturated fatty acid content of Dehong buffalo( 44. 33%) was significantly higher than that of ND buffalo( 41. 39%) and MD buffalo( 41. 48%)( P < 0. 05),and the latter two were not significantly different( P > 0. 05). The content of PUFA in Dehong buffalo( 53. 90%) was significantly lower than ND( 56. 83%) and MD( 56. 83%)( P <0. 05),however,the n- 6∶ n- 3( 4. 25) of Dehong buffalo was significantly higher than ND( 3. 14) and MD( 3. 52)( P < 0. 05). The content of amino acids in muscle was not significantly different between Dehong buffalo,MD buffalo and ND buffalo( P > 0. 05),while the acidic amino acid content of Dehong buffalo was higher than that of MD buffalo and ND buffalo. | Yin Hong Wang Guiying Yang Yue Liao Guozhou Cheng Zhibin Gu Dahai Xu Zhiqiang Ge Changrong Jia Junjing | 2014 | Animal Husbandry and Feed Science2014，6，5： | 0 |
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