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您的检索式：作者名="Changhoon Choi"
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| 1 | Optimizing radiotherapy with immune checkpoint blockade in hepatocellular carcinoma显示文摘Hepatocellular carcinoma (HCC) is the fifth most common cancer, and its incidence is rapidly increasing in North America and Western Europe as well as South-East Asia. Patients with advanced stage HCC have very poor outcomes;therefore, the discovery of new innovative approaches is urgently needed. Cancer immunotherapy has become a game-changer and revolutionized cancer treatment. A comprehensive understanding of tumor-immune interactions led to the development of immune checkpoint inhibitors (ICIs) as new therapeutic tools, which have been used with great success. Targeting immune checkpoint molecules such as programmed cell death-1 (PD-1) and cytotoxic T lymphocyteassociated protein-4 (CTLA-4) reinvigorates anti-tumor immunity by restoring exhausted T cells. Despite their effectiveness in several types of cancer, of the many immune suppressive mechanisms limit the efficacy of ICI monotherapy. Radiation therapy (RT) is an essential local treatment modality for a broad range of malignancies, and it is currently gaining extensive attention as a promising combination partner with ICIs because of its ability to trigger immunogenic cell death. The efficacy of combination approaches using RT and ICIs has been well documented in numerous preclinical and clinical studies on various types of cancers but not HCC. The application of ICIs has now expanded to HCC, and RT is recognized as a promising modality in HCC. This review will highlight the current roles of PD-1 and CTLA-4 therapies and their combination with RT in the treatment of cancers, including HCC. In addition, this review will discuss the future perspectives of the combination of ICIs and RT in HCC treatment. | Changhoon Choi Gyu Sang Yoo Won Kyung Cho Hee Chul Park | 2019 | World Journal of Gastroenterology2019，25，20： | 6 |
| 2 | Aqueous dispersion of submicron-sized diamond particles for thermally conductive polyurethane coating显示文摘 | Eunsoo Kang Seongcheol Choi Changhoon Choi Sang Eun Shim | 2012 | Colloids and Surfaces A: Physicochemical and Engineering Aspects2012，，： | 1 |
| 3 | Aqueous dispersion of suhmicron-sized diamond parti- cles for thermally conductive polyurethane coating显示文摘 | Eunsoo Kang Seongcheol Choi Changhoon Choi Sang Eun Shim | 2012 | Colloids and Surfaces A: Physieochemica] and Engineering Aspects2012，415，： | 1 |
| 4 | Photocatalytic properties of nano-structured TiO2 plasma sprayed coating显示文摘 | Lee Changhoon Choi Hanshin Lee Changhee | 2003 | Surface and Coatings Technology2003，173，23： | 1 |
| 5 | Optimally arranged TiO_(2)@MoS_(2) heterostructures with effectively induced built-in electric field for high-performance lithium-sulfur batteries显示文摘To overcome the serious technological issues affecting lithium-sulfur(Li-S) batteries,such as sluggish sulfur redox kinetics and the detrimental shuttle effect,heterostructure engineering has been investigated as a strategy to effectively capture soluble lithium polysulfide intermediates and promote their conversion reaction by integrating highly polar metal oxides with catalytically active metals sulfides.However,to fully exploit the outstanding properties of heterostructure-based composites,their detailed structure and interfacial contacts should be designed rationally.Herein,optimally arranged TiO_(2)and MoS_(2)-based heterostructures(TiO_(2)@MoS_(2)) are fabricated on carbon cloth as a multifunctional interlayer to efficiently trap polysulfide intermediates and accelerate their redox kinetics.Owing to the synergistic effects between TiO_(2)and MoS_(2)and the uniform heterointerface distribution that induces the ideally oriented built-in electric field,Li-S batteries with TiO_(2)@MoS_(2)interlayers exhibit high rate capability(601 mA h g^(-1)at 5 C),good cycling stability(capacity-fade rate of 0.067% per cycle over 500 cycles at2 C),and satisfactory areal capacity(5.2 mA h cm^(-2)) under an increased sulfur loading of 5.2 mg cm^(-2).Moreover,by comparing with a MoS_(2)@TiO_(2)interlayer composed of reversely arranged heterostructures,the effect of the built-in electric field’s direction on the electrocatalytic reactions of polysulfide intermediates is thoroughly investigated for the first time.The superior electrocatalytic activities of the rationally arranged TiO_(2)@MoS_(2)interlayer demonstrate the importance of optimizing the built-in electric field of heterostructures for producing high-performance Li-S batteries. | Jeongyoub Lee Changhoon Choi Jung Been Park Seungho Yu Jinho Ha Hyungsoo Lee Gyumin Jang Young Sun Park Juwon Yun Hayoung Im Subin Moon Soobin Lee Jung-Il Choi Dong-Wan Kim Jooho Moon | 2023 | Journal of Energy Chemistry2023，，8： | 0 |
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