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| 1 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 2 | It is safe to use transdermal glyceryl trinitrate to lower blood pressure in patients with acute ischaemic stroke with carotid stenosis显示文摘Background There is concern that blood pressure(BP)lowering in acute stroke may compromise cerebral perfusion and worsen outcome in the presence of carotid stenosis.We assessed the effect of glyceryl trinitrate(GTN)in patients with carotid stenosis using data from the Efficacy of Nitric Oxide in Stroke(ENOS)Trial.Methods ENOS randomised 4011 patients with acute stroke and raised systolic BP(140-220 mm Hg)to transdermal GTN or no GTN within 48 hours of onset.Those on prestroke antihypertensives were also randomised to stop or continue their medication for 7 days.The primary outcome was the modified Rankin Scale(mRS)at day 90.Ipsilateral carotid stenosis was split:<30%;30-<50%;50-<70%;≥70%.Data are ORs with 95%CIs adjusted for baseline prognostic factors.results 2023(60.5%)ischaemic stroke participants had carotid imaging.As compared with<30%,≥70%ipsilateral stenosis was associated with an unfavourable shift in mRS(worse outcome)at 90 days(OR 1.88,95%CI 1.44 to 2.44,p<0.001).Those with≥70%stenosis who received GTN versus no GTN had a favourable shift in mRS(OR 0.56,95%CI 0.34 to 0.93,p=0.024).In those with 50-<70%stenosis,continuing versus stopping prestroke antihypertensives was associated with worse disability,mood,quality of life and cognition at 90 days.Clinical outcomes did not differ across bilateral stenosis groups.Conclusions Following ischaemic stroke,severe ipsilateral carotid stenosis is associated with worse functional outcome at 90 days.GTN appears safe in ipsilateral or bilateral carotid stenosis,and might improve outcome in severe ipsilateral carotid stenosis. | Jason P Appleton Lisa J Woodhouse Andrew Belcher Daniel Bereczki Eivind Berge Valeria Caso Hui Meng Chang Hanne K Christensen Ronan Collins John Gommans Ann C Laska George Ntaios Serefnur Ozturk Gillian M Sare Szabolcs Szatmari Yongjun Wang Joanna M Wardlaw Nikola Sprigg Philip M Bath for the ENOS investigators | 2019 | Stroke & Vascular Neurology2019，4，1： | 6 |
| 3 | New universal current-mode filter with single input and three output using only five current conveyors显示文摘 | Chang C M | 1993 | Eletronics letters1993，29，： | 3 |
| 4 | Antagonism of miR-33 in mice promotes reverse cholesterol transport and regression of atherosclerosis显示文摘 | Rayner Katey J Sheedy Frederick J Esau Christine C Hussain Farah N Temel Ryan E Parathath Saj van Gils Janine M Rayner Alistair J Chang Aaron N Suarez Yajaira Fernandez-Hernando Carlos Fisher Edward A Moore Kathryn J | 2011 | Journal of Clinical Investigation2011，，7： | 2 |
| 5 | Densities and P-x-y diagrams for carbo dioxide dissolution in methanol,ethano, and acetone mixtures显示文摘 | Chang C J Day C Y Ko C M | 1997 | Fluid Phase Equilib1997，131，： | 2 |
| 6 | Immunomodulation by dietary β-1,3-glucan in the brooders of the black tiger shrimp Penaeus monodon显示文摘 | Chang C F Chen H Y Su M S | 2000 | Fish Shellfish Immun2000，10，： | 2 |
| 7 | Adaptive guaranteed cost control of systems with uncertain parameters显示文摘 | Chang M S L Peng T K C | 1972 | IEEE Transactions on Automatic Control1972，17，4： | 2 |
| 8 | Current-mode lowpass,bandpass and highpass baquads using two CCIIs显示文摘 | Chang C M | 1993 | Electronics letters1993，29，： | 2 |
| 9 | ,universal active current filter with single input and three output using CCIIs显示文摘 | Chang C M | 1993 | Eletronics letters1993，29，22： | 2 |
| 10 | Load forecasting using support vector Machines: a study on EUNITE competition 2001 显示文摘 | Chen B J Chang M W Lin C J | 2004 | IEEE Transactions on Power Systems2004，19，4： | 1 |
| 11 | Faminial risk of hepatocelluarear cinoma among chronic hepatitis B carriers and their relatives显示文摘 | Yu M W Chang H C LiawYF | 2000 | J Natl Cancer Inst2000，92，14： | 1 |
| 12 | Cloning of a creatinase gene from Pseudomonas putida in Escherichia coli by using an indicator plate显示文摘 | Chang M C Chang C C Chang J C | 1992 | Appl Environ Microbiol1992，58，10： | 1 |
| 13 | RNA-binding protein insulin-like growth factor Ⅱ mRNA-binding protein 3 expression promotes tumor invasion and predicts early recurrence and poor prognosis in hepatocellular carcinoma显示文摘 | Jeng Y M Chang C C Hu F C | 2008 | Hepatology2008，48，4： | 1 |
| 14 | A new rat model links two contemporary theories in irritable bowel syndrome显示文摘 | Pimentel M Chatterjee S Chang C | 2008 | Dig Dis Sci2008，53，4： | 1 |
| 15 | Association of polymorphisms of interleukin l beta gene and Helicobacter pylori infection with the risk of gastric ulcer 显示文摘 | CHANG Y T WU M S SHUN C T | 2002 | J Gastrocnterol Hepatol2002，49，47： | 1 |
| 16 | Crystal field analysis of the 3dN ions at low sym- metry sites including the 'imaginary' terms 显示文摘 | CHANG Y M RUDOWICZ C YEUNG Y Y | 1994 | Comput Phys1994，8，5： | 1 |
| 17 | Universal screening for biliary atresia using an infant stool color card in Taiwan显示文摘 | HSIAO C H CHANG M H CHEN H L | 2008 | Hepatology2008，47，4： | 1 |
| 18 | Productivity growth of Taiwan's major domestic airports in the presence of aircraft noise 显示文摘 | Yu M M Hsu S H Chang C C and Lee D H | 2008 | Transportation Research Part E2008，44，3： | 1 |
| 19 | Fractionation of soil phosphorus显示文摘 | Chang S C M L Jackson | 1957 | Soil Sci1957，84，： | 1 |
| 20 | Nonlinear analysis of stress and strain in soils显示文摘 | DUNCAN J M CHANG C Y | 1970 | Journal of the Soil Mechanics and Foundations Division ASCE1970，，5： | 1 |
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