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| 1 | An HMG- CoA reductase inhibitor, reduced the expression of matirx metallopor-teinase-9 ( Gelatinase B ) in osteoblastic ceils and HT1080 fibor-sareoma cells 显示文摘 | Thunyakitpisal PD Chaisuparat R Simvastatin | 2004 | J Pbarmacol Sci2004，94，4： | 1 |
| 2 | Simvastatin, anHMG - CoA reductase inhibitor,reduced the expression of matrixmetalloproteinase -9( Gelatinase B ) in osteoblastic cells andHT1080 fibrosarcoma cells显示文摘 | THUNYAKITPISAL P D CHAISUPARAT R | 2004 | J Pharmacol Sci2004，94，4： | 1 |
| 3 | Expression and alterations of the PTEN / AKT / mTOR pathway in ameloblastomas显示文摘 | Scheper MA Chaisuparat R Nikitakis NG | | 0，，06： | 1 |
| 4 | Effect of zoledronie acidon oral broblasts and epithelial cells phonate-associated osteonecrosis显示文摘 | Scheper MA Badros A Chaisuparat R | 2009 | a potential mechanism of bisphos- Br J Haematol2009，144，5： | 1 |
| 5 | Mesenchymal chondrosarcoma of the maxilla: case report and literature review 显示文摘 | Tien N Chaisuparat R Fernandes R | 2007 | J Oral Maxillofac Surg2007，65，6： | 1 |
| 6 | A novel soft-tissue in vitro model for bisphosphonate-associated osteonecrosis显示文摘 | Scheper M Chaisuparat R Cullen K | 2010 | Fibrogenesis Tissue Repair2010，3，： | 1 |
| 7 | A novel soft-tissue in vitro model for bisphosphonate-associated osteonecrosis 显示文摘 | Scheper M Chaisuparat R Cullen K | 2010 | Fibrogenesis Tissue Repair2010，3，： | 1 |
| 8 | A novel so- ft-tissue in vitro model for bisphosphonate-associated os- teonecrosis显示文摘 | Scheper M Chaisuparat R Cullen K | 2010 | Fibrogenesis Tissue Repair2010，3，： | 1 |
| 9 | Dual inhibition of PI3Kalpha and mTOR as an alternative treatment for Kaposi's sarcoma显示文摘 | Chaisuparat R Hu J Jham BC | 2008 | Cancer Res2008，1568，20： | 1 |
| 10 | A novel softtissue in vitro model for bisphosphonate-associated osteone- crosis显示文摘 | Scheper MA Chaisuparat R Cullen KJ | 2010 | Fibrogenesis & Tissue Repair2010，3，1： | 1 |
| 11 | Effect of zoledronic acid on oral fibroblasts and epithelial cells:a potential mechanism of bisphosphonate-associated osteonecrosis显示文摘 | Scheper M A Badros A Chaisuparat R | 2009 | Br J Haematol2009，144，5： | 1 |
| 12 | Magnetic bioassembly platforms towards the generation of extracellular vesicles from human salivary gland functional organoids for epithelial repair显示文摘Salivary glands(SG)are exocrine organs with secretory units commonly injured by radiotherapy.Bio-engineered organoids and extracellular vesicles(EV)are currently under investigation as potential strategies for SG repair.Herein,three-dimensional(3D)cultures of SG functional organoids(SGo)and human dental pulp stem cells(hDPSC)were generated by magnetic 3D bioassembly(M3DB)platforms.Fibroblast growth factor 10(FGF10)was used to enrich the SGo in secretory epithelial units.After 11 culture days via M3DB,SGo displayed SG-specific acinar epithelial units with functional properties upon neurostimulation.To consistently develop 3D hDPSC in vitro,3 culture days were sufficient to maintain hDPSC undifferentiated genotype and phenotype for EV generation.EV isolation was performed via sequential centrifugation of the conditioned media of hDPSC and SGo cultures.EV were characterized by nanoparticle tracking analysis,electron microscopy and immunoblotting.EV were in the exosome range for hDPSC(diameter:88.03±15.60 nm)and for SGo(123.15±63.06 nm).Upon ex vivo administration,exosomes derived from SGo significantly stimulated epithelial growth(up to 60%),mitosis,epithelial progenitors and neuronal growth in injured SG;however,such biological effects were less distinctive with the ones derived from hDPSC.Next,these exosome biological effects were investigated by proteomic arrays.Mass spectrometry profiling of SGo exosomes predicted that cellular growth,development and signaling was due to known and undocumented molecular targets downstream of FGF10.Semaphorins were identified as one of the novel targets requiring further investigations.Thus,M3DB platforms can generate exosomes with potential to ameliorate SG epithelial damage. | Ajjima Chansaenroj Christabella Adine Sawanya Charoenlappanit Sittiruk Roytrakul Ladawan Sariya Thanaphum Osathanon Sasitorn Rungarunlert Ganokon Urkasemsin Risa Chaisuparat Supansa Yodmuang Glauco R.Souza Joao N.Ferreira | 2022 | Bioactive Materials2022，7，12： | 1 |
| 13 | Zoledronic acid directly sup- presses cell proliferation and induces apoptosis in highly tumori- genic prostate and breast eancers显示文摘 | H JonesA Chaisuparat R | 2011 | J Careinog2011，10，： | 1 |
| 14 | Simvastatin, an HMG-CoA reductase inhibitor, reduced the expression of matrix metalloproteinase-9 (Gelatinase B) in osteoblastic cells and HT1080 fibrosarcoma cells 显示文摘 | Thunyakitpisal P D Chaisuparat R | 2004 | J Pharmacol Sci2004，94，4： | 1 |
| 15 | The TSC2/mTOR pathway drives endothelial cell transformation induced by the Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor显示文摘 | Sodhi A Chaisuparat R Hu J | 2006 | Cancer Cell2006，10，2： | 1 |
| 16 | Dual inhibition of PI3Kalpha and p-mTOR as an alternative treatment for Kaposrs sarcoma显示文摘 | Chaisuparat R Hu J Jham BC | 2008 | Cancer Res2008，68，20： | 1 |
| 17 | A novel soft-tissue in vitro model for bisphosphonate-associated osteonecrosis显示文摘 | Scheper MA Chaisuparat R Cullen KJ | 2010 | Fibrogenesis Tissue Repair2010，3，1： | 1 |
| 18 | Sulindac inducesapoptosis and inhibits tumor growth in vivo in head and neck squa-mous cell carcinoma显示文摘 | Scheper MA Nikitakis NG Chaisuparat R | 2007 | Neoplasia2007，9，3： | 1 |
| 19 | Expression and alteration of the PTEN/AKt/mTOR pathway in ameloblastoma显示文摘 | Scheper MA Chaisuparat R Nikitakia NG Sauk JJ | 2008 | Oral Dis2008，14，6： | 1 |
| 20 | Simvastatin, an HMG-CoA reductase inhibitor, reduced the expression of matrix metalloproteinase-9 (Gelatinase B) in osteoblastic cells and HT1080 Fibro- sarcomacells 显示文摘 | THUNYAKITPISAL PD CHAISUPARAT R | 2004 | J Pharmacol Sci2004，94，4： | 1 |
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