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| 1 | Use of a combination strategy to improve neuroprotection and neuroregeneration in a rat model of acute spinal cord injury显示文摘Spinal cord injury is a very common pathological event that has devastating functional consequences in patients. In recent years, several research groups are trying to find an effective therapy that could be applied in clinical practice. In this study, we analyzed the combination of different strategies as a potential therapy for spinal cord injury. Immunization with neural derived peptides(INDP), inhibition of glial scar formation(dipyridyl: DPY), as well as the use of biocompatible matrix(fibrin glue: FG) impregnated with bone marrow mesenchymal stem cells(MSCs) were combined and then its beneficial effects were evaluated in the induction of neuroprotection and neuroregeneration after acute SCI. Sprague-Dawley female rats were subjected to a moderate spinal cord injury and then randomly allocated into five groups: 1) phosphate buffered saline; 2) DPY; 3) INDP + DPY; 4) DPY+ FG; 5) INDP + DPY + FG + MSCs. In all rats, intervention was performed 72 hours after spinal cord injury. Locomotor and sensibility recovery was assessed in all rats. At 60 days after treatment, histological examinations of the spinal cord(hematoxylin-eosin and Bielschowsky staining) were performed. Our results showed that the combination therapy(DPY+ INDP + FG+ MSCs) was the best strategy to promote motor and sensibility recovery. In addition, significant increases in tissue preservation and axonal density were observed in the combination therapy group. Findings from this study suggest that the combination theapy(DPY+ INDP + FG + MSCs) exhibits potential effects on the protection and regeneration of neural tissue after acute spinal cord injury. All procedures were approved by the Animal Bioethics and Welfare Committee(approval No. 178544; CSNBTBIBAJ 090812960)on August 15, 2016. | Elisa García Roxana Rodríguez-Barrera Vinnitsa Buzoianu-Anguiano Adrian Flores-Romero Emanuel Malagón-Axotla Marco Guerrero-Godinez Estefanía De la Cruz-Castillo Laura Castillo-Carvajal Monserrat Rivas-Gonzalez Paola Santiago-Tovar Ivis Morales Cesar Borlongan Antonio Ibarra | 2019 | Neural Regeneration Research2019，14，6： | 6 |
| 2 | Fast-tracking regenerative medicine for traumatic brain injury显示文摘Traumatic brain injury remains a global health crisis that spans all demographics,yet there exist limited treatment options that may effectively curtail its lingering symptoms.Traumatic brain injury pathology entails a progression from primary injury to inflammation-mediated secondary cell death.Sequestering this inflammation as a means of ameliorating the greater symptomology of traumatic brain injury has emerged as an attractive treatment prospect.In this review,we recapitulate and evaluate the important developments relating to regulating traumatic brain injury-induced neuroinflammation,edema,and blood-brain barrier disintegration through pharmacotherapy and stem cell transplants.Although these studies of stand-alone treatments have yielded some positive results,more therapeutic outcomes have been documented from the promising area of combined drug and stem cell therapy.Harnessing the facilitatory properties of certain pharmaceuticals with the anti-inflammatory and regenerative effects of stem cell transplants creates a synergistic effect greater than the sum of its parts.The burgeoning evidence in favor of combined drug and stem cell therapies warrants more elaborate preclinical studies on this topic in order to pave the way for later clinical trials. | Brooke Bonsack Matt Heyck Chase Kingsbury Blaise Cozene Nadia Sadanandan Jea-Young Lee Cesar V. Borlongan | 2020 | Neural Regeneration Research2020，15，7： | 5 |
| 3 | Influence of psychosocial factors on treatment of elderly Chinese patients with hypertension显示文摘Objective The aim of the study is to investigate the effects of psychosocial factors on the treatment of elderly patients with hypertension. Methods Atotalof 260 elderly Chinese patients with hypertension were treated with benazepril alone or benazepril combined with amlodipine for 8 weeks. The target blood pressure (BP) (both <140 mmHg systolic, SBP, and <90 mmHg diastolic, DBP) was achieved in 180 patients, who were then assigned to the well-controlled BP group;the rest were placed in the modestly controlled BP group. The psychosocial factors present in both groups were assessed by the Hamilton depression scale, Hamilton anxiety scale, life event scale and social support evaluation list before and after anti-hypertensive treatment. Results There were no significant differences in gender, mean age, hist ory of hypertension, education and smoking habit, or in SBP and DBP between the groups before treatment. Significant differences were also not found in all psychosocial factors before and after treatment in the patients. However, significant differences were found between the groups with respect to post-treatment SBP and marital status. The patients with modestly controlled BP had significantly higher scores, as well as incidents, on the depressive, anxiety, and stressful life event scales than those with well-controlled BP. The patients with well-controlled BP had significantly higher scores in tangible support, subjective support, and social support compared to the patients with modestly controlled BP. Logistic regression analysis showed the independent contribution of psychosocial factors in reaching the goal of lowering BP at treatment endpoint in these hypertensive patients. Conclusions The results suggest that psychosocial factors stand as a main barrier to achieving the BP-lowering target in the management of elderly Chinese patients with hypertension.(J Geriatr Cardiol 2007;4:202-207.) | Cesar V. Borlongan Christine E. Stahl | 2007 | Journal of Geriatric Cardiology2007，4，4： | 2 |
| 4 | Kallikrein Gene Transfer Protects Against Ischemic Stroke by Promoting Glial Cell Migration and Inhibiting Apoptosis显示文摘 | Chun-Fang Xia Hang Yin Cesar V. Borlongan Lee Chao Julie Chao | 2004 | Hypertension: Journal of the American Heart Association ( Part )2004，，2： | 1 |
| 5 | Severity of controlled cortical impact traumatic brain injury in rats and mice dictates degree of behavioral deficits显示文摘 | Seongjin Yu Yuji Kaneko Eunkyung Bae Christine E. Stahl Yun Wang Harry van Loveren Paul R. Sanberg Cesar V. Borlongan | 2009 | Brain Research2009，，： | 1 |
| 6 | Postischemic Brain Injury Is Exacerbated in Mice Lacking the Kinin B2 Receptor显示文摘 | Chun-Fang Xia Robert S. Smith Bo Shen Zhi-Rong Yang Cesar V. Borlongan Lee Chao Julie Chao | 2006 | Hypertension2006，，4： | 1 |
| 7 | Kallikrein Gene Transfer Protects Against Ischemic Stroke by Promoting Glial Cell Migration and Inhibiting Apoptosis显示文摘 | Chun-Fang Xia Hang Yin Cesar V. Borlongan Lee Chao Julie Chao | 2004 | Hypertension: Journal of the American Heart Association ( Part )2004，，2： | 1 |
| 8 | Kallikrein Gene Transfer Protects Against Ischemic Stroke by Promoting Glial Cell Migration and Inhibiting Apoptosis显示文摘 | Chun-Fang Xia Hang Yin Cesar V. Borlongan Lee Chao Julie Chao | | 2004 (2, P)0，，： | 1 |
| 9 | Peri-hemorrhagic degeneration accompanies stereotaxic collagenase-mediated cortical hemorrhage in mouse显示文摘 | Tadashi Masuda Mina Maki Koichi Hara Takao Yasuhara Noriyuki Matsukawa SeongJin Yu Eunkyung Cate Bae Naoki Tajiri Sonia H. Chheda Marianna Aurora Solomita Nathan Weinbren Yuji Kaneko Sergei A. Kirov David C. Hess Hideki Hida Cesar V. Borlongan | 2010 | Brain Research2010，，： | 1 |
| 10 | Kallikrein Gene Transfer Protects Against Ischemic Stroke by Promoting Glial Cell Migration and Inhibiting Apoptosis显示文摘 | Chun-Fang Xia Hang Yin Cesar V. Borlongan Lee Chao Julie Chao | | Hypertension: Journal of the American Heart Association . 2004 (2, P)0，，： | 1 |
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