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| 1 | An elastin-like recombinamer-based bioactive hydrogel embedded with mesenchymal stromal cells as an injectable scaffold for osteochondral repair显示文摘The aim of this study was to evaluate injectable,in situ cross-linkable elastin-like recombinamers(ELRs)for osteochondral repair.Both the ELR-based hydrogel alone and the ELR-based hydrogel embedded with rabbit mesenchymal stromal cells(rMSCs)were tested for the regeneration of critical subchondral defects in 10 New Zealand rabbits.Thus,cylindrical osteochondral defects were filled with an aqueous solution of ELRs and the animals sacrificed at 4months for histological and gross evaluation of features of biomaterial performance,including integration,cellular infiltration,surrounding matrix quality and the new matrix in the defects.Although both approaches helped cartilage regeneration,the results suggest that the specific composition of the rMSC-containing hydrogel permitted adequate bone regeneration,whereas the ELR-based hydrogel alone led to an excellent regeneration of hyaline cartilage.In conclusion,the ELR cross-linker solution can be easily delivered and forms a stable well-integrated hydrogel that supports infiltration and de novo matrix synthesis. | Filippo Cipriani Blanca Arino Palao Israel Gonzalez de Torre Aurelio Vega Castrillo Hector Jose Aguado Hernandez Matilde Alonso Rodrigo Angel Jose Alvarez Barcia Ana Sanchez Veronica Garcıa Diaz Monica Lopez Pena Jose Carlos Rodriguez-Cabello | 2019 | Regenerative Biomaterials2019，6，6： | 3 |
| 2 | Reciprocal regulation of inflammation and lipid metabolism by liver X receptors显示文摘 | Castrillo A Laffitte BA | 2003 | Nat Med2003，9，2： | 1 |
| 3 | Reciprocal regula- tion of inflammation and lipid metabolism by liver X recep- tors 显示文摘 | Joseph SB Castrillo A Laffitte BA | 2003 | Nat Med2003，9，2： | 1 |
| 4 | Selective activation of liver X receptors by acanthoic acid-related diterpenes显示文摘 | Traves PG Hortelano S Zeini M Chao TH Lam T Neuteboom ST Theodorakis EA Palladino MA Castrillo A Bosca L | | 0，，06： | 1 |
| 5 | Reciprocal regulation of inflammation and lipid metabolism by liver X receptors 显示文摘 | Joseph SB Castrillo A Laffitte BA | 2003 | Nature Medicine2003，9，2： | 1 |
| 6 | Reciprocal regulation of inflammation and lipid metabolism by liver X receptors显示文摘 | Joseph SB Castrillo A Laffitte BA | 2003 | Nature Medicine2003，9，2： | 1 |
| 7 | Nuclear receptors in macrophage biology : at the crossroads of lipid metabolism and inflammation 显示文摘 | CASTRILLO A TONTONOZ P | 2004 | Ann Rev Cell Dev Biol2004，20，： | 1 |
| 8 | Effect of ammonia treat and carbohydrate supplementation on the intake and digestibility of barley straw diets by sheep显示文摘 | Castrillo C Fondevila M Guada J A | 1995 | Anim Feed Sci Technol1995，51，： | 1 |
| 9 | Induction of NR4A orphan nuclear receptor expression in maerophages in response to inflammatory stimuli 显示文摘 | Pei L Castrillo A Chen M | 2005 | J Biol Chem2005，280，29： | 1 |
| 10 | Reciprocal regulation of inflammation and lipid metabolism by liver X receptors显示文摘 | Joseph SB Castrillo A Laffitte BA | 2003 | Nat Med2003，9，2： | 1 |
| 11 | Reciprocal regulation of inflammation and lipid metabolism by liver X receptors显示文摘 | Joseph SB Castrillo A Laffitte BA | 2003 | Nat Med2003，9，2： | 1 |
| 12 | Opalski syndrome:a variant of lateral-medullary syndrome显示文摘 | Gil Polo C Castrillo Sanz A Gutierrez Rios R | 2013 | Neurologia2013，28，： | 1 |
| 13 | Reciprocal regulation of inflammation and lipid metabolism by liver X receptors显示文摘 | Joseph SB Castrillo A Laffitte BA | 2003 | Nat Med2003，9，2： | 1 |
| 14 | Genetic variation in Beauveria bassiana populations associated with the darkling beetle, Alphitobius diaperinus显示文摘 | Louela A Castrillo L Brian M | 1999 | Journal of Invertebrate Pathology1999，73，： | 1 |
| 15 | Strain-specific detection of introduced Beauveris bassiana in agricultural fields by use of sequence-characterized amplified region markers显示文摘 | Castrillo L A Vandenderg J D Wraight S P | 2003 | Journal of Invertebrate Pathology2003，82，1： | 1 |
| 16 | Inhibition of IkappaB kinase phosphorylation by 15-deoxy-Delta( 12, 14)-prostaglandin J(2)in activated routine macrophages 显示文摘 | Castrillo A Diaz-Guerra MJ Hortelano S | 2000 | Mol Cell Biol2000，20，5： | 1 |
| 17 | Reciprocal regulation of inflammation and lipid metabolism by liver X receptors显示文摘 | Joseph SB Castrillo A Laffitte BA et cd | 2003 | Nat Med2003，9，： | 1 |
| 18 | Reciprocal regulation of inflammation and lipid metabolism by liver X receptors显示文摘 | Joseph SB Castrillo A Laffitte BA | 2003 | Nat Med2003，9，： | 1 |
| 19 | Crosstalk between LXR and toll-like receptpor signaling mediates bacterial and viral antagonism of cholesterol metabolism显示文摘 | Joseph SB Vaidya SA | 2003 | Mol Ceil2003，12，4： | 1 |
| 20 | Liver X receptordependent repression of matrix metalloproteinase-9 expression in macrophages显示文摘 | Castrillo A Joseph SB Marathe C | 2003 | J Biol Chem2003，278，10： | 1 |
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