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| 1 | 精子DNA完整性与形态超高倍检测在辅助生殖技术妊娠结局中的临床价值显示文摘近年来,涌现出许多重要的男性不育诊疗新技术。本研究旨在探讨精@DNA完整性与精子空泡率检测对以男性不育因素行IvF或IcsI治疗的不育症的治疗结局。本研究针对152对不育症夫妻行ART技术前进行的精子DNA碎片率与形态学超高倍分析进行队列研究。我们发现对妊娠结局最有预测价值的DNA碎片率切点值为25.5%,阴性预测值为72.7%(P=0.02)。在对空泡率的研究中发现,3、4级的空泡精子的最有预测价值切点值为73.5%,阴性预测值为39.4%(P=0.09),差异无统计学意义。总之,当精子DNA碎片率大于25%时,IVF失败的概率增大,而精子形态学超高倍检测结果对预测患者的妊娠结局无明显获益。 | Gemma López Rafael Lafuente Miguel A Checa Ramón Carreras Mario Brassesco | 2013 | Asian Journal of Andrology2013，15，6： | 12 |
| 2 | Hepatitis B and immunosuppressive therapies for chronic inflammatory diseases: When and how to apply prophylaxis, with a special focus on corticosteroid therapy显示文摘Currently immunosuppressive and biological agentsare used in a more extensive and earlier way in patients with inflammatory bowel disease, rheumatic or dermatologic diseases. Although these drugs have shown a significant clinical benefit, the safety of these treatments is a challenge. Hepatitis B virus(HBV) reactivations have been reported widely, even including liver failure and death, and it represents a deep concern in these patients. Current guidelines recommend to preemptive therapy in patients with immunosuppressants in general, but preventive measures focused in patients with corticosteroids and inflammatory diseases are scarce. Screening for HBV infection should be done at diagnosis. The patients who test positive for hepatitis B surface antigen, but do not meet criteria for antiviral treatment must receive prophylaxis before undergoing immunosuppression, including corticosteroids at higher doses than prednisone 20 mg/d during more than two weeks. Tenofovir and entecavir are preferred than lamivudine because of their better resistance profile in long-term immunosuppressant treatments. There is not a strong evidence, to make a general recommendation on the necessity of prophylaxis therapy in patients with inflammatory diseases that are taking low doses of corticosteroids in short term basis or low systemic bioavailability corticosteroids such as budesonide or beclomethasone dipropionate. In these cases regularly HBV DNA monitoring is recommended, starting early antiviral therapy if DNA levels begin to rise. In patients with occult or resolved hepatitis the risk of reactivation is much lower, and excepting for Rituximab treatment, the prophylaxis is not necessary. | Pilar López-Serrano Elsa de la Fuente Briongos Elisa Carrera Alonso Jose Lázaro Pérez-Calle Conrado Fernández | 2015 | World Journal of Hepatology2015，7，3： | 4 |
| 3 | Effect of femtosecond laser-assisted lens surgery on the optic nerve head and the macula显示文摘AIM: To evaluate the effect of femtosecond laser-assisted lens surgery(FLALS;cataract surgery or refractive lens exchange) on the structure of the optic nerve head and the macula.METHODS: This prospective longitudinal study included healthy eyes undergoing FLALS. Eyes with glaucoma or any other ocular disease that could alter optical coherence tomography results were excluded. Retinal nerve fiber layer(RNFL), Bruch’s membrane opening-minimum rim width(BMO-MRW) and macular thickness(MT) were measured preoperatively, 1 and 6 mo after surgery using spectral-domain optical coherence tomography(SD-OCT). Changes between preoperative and postoperative values were evaluated.RESULTS: A total of 87 eyes of 46 patients were included in this study. Preoperative RNFL, BMO-MRW and MT in microns(μm) were 100.77±10.39, 330.31±49.99 and 276.30±33.39, respectively. Postoperative RNFL, BMO-MRW and MT were 104.74±11.55, 348.32±54.05 and 279.83±22.65 1 mo after surgery and 102.93±11.17, 343.11±53.4 and 278.90±22.19 6 mo after surgery, respectively;which equals an increase of 3.93%, 5.45% and 1.27%,respectively, 1 mo after surgery, and 2.14%, 3.87% and 0.94% 6 mo after surgery. The differences between the preoperative and the postoperative RNFL and BMO-MRW values were statistically significant(P<0.001). Regarding MT values, there were not statistically significant differences(P=0.26).CONCLUSION: Our study suggests that FLALS does not have a negative impact on the structural status of the optic nerve head in healthy eyes, assessed by SD-OCT. There is a slight increase in the values of RNFL, BMO-MRW and MT 1 mo and 6 mo after surgery. | Josefina Renones de Abajo Beatriz Estévez Jorge Jesús María González Martín Humberto Carreras Díaz Juan Francisco Loro Ferrer Alfonso Antón López | 2019 | International Journal of Ophthalmology(English edition)2019，12，6： | 2 |
| 4 | Aqueous and solid complexes of iron( Ⅲ )with hyaluronic acid显示文摘 | Merce A L Marques Carrera L C ASantos Romanholi L K | 2002 | J Inorg Biochem2002，89，34： | 1 |
| 5 | Comparison among air pollutants, meteorological conditions and some chemical pa- rameters in the transplanted lichen Usnea amblyoclada 显示文摘 | CARRERAS H A PIGNATA M L | 2001 | Environmental Pollution2001，111，1： | 1 |
| 6 | Comparative biomonitoring of atmospheric quality in five zones of Co'rdoba city (Argentina) employing the transplanted lichen Usnea sp显示文摘 | CARRERAS H A GUDINO G L PIGNATA M L | 1998 | Environ Pollut1998，103，： | 1 |
| 7 | Vancouver type B2 fractures:best choice of treatment显示文摘 | Guerra-Farfán E Carrera L Mu(n)eton D | 2013 | Eur Orthop Traumatol2013，4，： | 1 |
| 8 | Four radiologieal measures to estimate shoulder balance in seoliosis显示文摘 | Bago J Carrera L March B et at | 1996 | J Pediatr Orthop B1996，5，1： | 1 |
| 9 | Layered Polymer kaolinite Nanocomposites显示文摘 | Gardolinski J E Carrera L C M Cantao M P | 2000 | Journal of Materials Sci- ence2000，，35： | 1 |
| 10 | Long -term effects of cyclosporine A in Alport syndrome 显示文摘 | Callis L Vila A Carrera M | 1999 | Kidney Int1999，55，3： | 1 |
| 11 | Performance of a continuous flow microbial electrolysis cell (MEC) fed with domestic wastewater 显示文摘 | Escapa A Carrera L G Garcia V | 2012 | Bioresource Technology2012，117，： | 1 |
| 12 | Constitutive arginine-dependent nitric oxide synthase activity in different organs of pea seedlings during plant development显示文摘 | CORPAS F J BARROSO J B CARRERAS A VALDERRAMA R PALMA J M LEON A M SANDALIO L M DEL RIO L A | 2006 | Planta2006，224，2： | 1 |
| 13 | Kinetic models for nitrification inhibition by ammonium and nitrite in a suspended and an immobilized biomass systems显示文摘 | Carrera J Jubany I Carvallo L | 2004 | Proc Biochem2004，39，9： | 1 |
| 14 | Disturbances in a power transmission system显示文摘 | Sachtien M L Carreras B A Lynch V E | 2000 | Phys Rev E2000，61，5： | 1 |
| 15 | Four radiological measures to estimate shoulder balance in scoliosis显示文摘 | Bago J Carrera L March B | 1996 | J Pediatr Orthop B1996，5，： | 1 |
| 16 | Significant events of interhemispheric atmospheric mass exchange:Composite structure and evolution显示文摘 | Carrera M L Gyakum J R | 2003 | J Climate2003，16，24： | 1 |
| 17 | A constant flow for concurrently measuring soil water characteristic curve and hydraulic conductivity function显示文摘 | LU N WAYLLANCE A CARRERA L | | 0，，03： | 1 |
| 18 | Engraftment syndrome after auto-SCT:analysis of diagnostic criteria and risk factors in a large series from a single center显示文摘 | CARRERAS E FERNáNDEZ-AVILéS F SILVA L | | 0，，09： | 1 |
| 19 | Size distribution and buoyant density of Burkholderia pseudomallei 显示文摘 | Sagripanti J L Carrera M Robertson J | 2011 | Arch Microbiol2011，193，1： | 1 |
| 20 | Assessment of human heahh risk related to metals by the use of biomonitors in the province of cordoba,argentina显示文摘 | Carreras H A Wannaz E D Pignata M L | 2009 | Environment ofPollution2009，157，： | 1 |
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