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| 1 | Determinants of percutaneous coronary intervention success in repeat chronic total occlusion procedures following an initial failed attempt显示文摘AIM To investigate the rates and determinants of success of repeat percutaneous coronary intervention(PCI) following an initial failed attempt at recanalising the chronic total occlusions(CTO) percutaneously.METHODS In 445 consecutive first attempt CTO-PCI procedures in our institution,procedural failure occurred in 149(33.5%). Sixty-four re-PCI procedures were performed in 58 patients(39%) all had a single CTO. Procedural and outcome data in the re-PCI population was entered into the institutional database. A retrospective analysis of clinical,angiographic and procedural data was performed. RESULTS Procedural success was achieved in 41(64%) procedures. Univariate analysis of clinical and angiographic characteristics showed that re-PCI success was associated with intravascular ultrasound(IVUS) guidance(19.5% vs 0%,P = 0.042),while failure was associated with severecalcification(30.4% vs 9.7%,P = 0.047) and a JCTO score > 3(56.5% vs 17.1% P = 0.003). Following multiple regression analysis the degree of lesion complexity(J-CTO score > 3),IVUS use,involvement of an experienced CTO operator and LAD CTO location were significant predictors of successful re-PCI. Overall the complication rate was low,with the only MACCE two periprocedural MI's neither of which required intervention. CONCLUSION Re-PCI substantially increases the overall success rate of CTO revascularization. Predictors of re-PCI success included the use of IVUS,the involvement of an experienced CTO operator in the repeat attempt and the location of the CTO. | Cecilia Cuevas Nicola Ryan Alicia Quirós Juan Gustavo Del Angel Nieves Gonzalo Pablo Salinas Pilar Jiménez-Quevedo Luis Nombela-Franco Ivan Nunez-Gil Antonio Fernandez-Ortiz Carlos Macaya Javier Escaned | 2017 | World Journal of Cardiology2017，9，4： | 5 |
| 2 | Coronary angiography findings in cardiac arrest patients with non-diagnostic post-resuscitation electrocardiogram:A comparison of shockable and non-shockable initial rhythms显示文摘AIM To investigate the impact of coronary artery disease in a cohort of patients resuscitated from cardiac arrest with non-diagnostic electrocardiogram.METHODS From March 2004 to February 2016, 203 consecutive patients resuscitated from in or out-of-hospital sudden cardiac arrest and non-diagnostic post-resuscitation electrocardiogram(defined as ST segment elevation or pre-sumably new left bundle branch block) whounderwent invasive coronary angiogram during hospitalization were included. For purpose of analysis and comparison, patients were classified in two groups: Initial shockable rhythm(ventricular tachycardia or ventricular fibrillation; n = 148, 72.9%) and initial non-shockable rhythm(n = 55, 27.1%). Baseline characteristics, coronary angiogram findings including Syntax Score and long-term survival rates were compared. RESULTS Sudden cardiac arrest was witnessed in 95.2% of cases, 66.7% were out-of-hospital patients and 72.4% were male. There were no significant differences in baseline characteristics between groups except for higher mean age(68.1 years vs 61 years, P = 0.001) in the nonshockable rhythm group. Overall 5-year mortality of the resuscitated patients was 37.4%. Patients with non-shockable rhythms had higher mortality(60% vs 29.1%, P < 0.001) and a worst neurological status at hospital discharge based on cerebral performance category score(CPC 1-2: 32.7% vs 53.4%, P = 0.02). Although there were no significant differences in global burden of coronary artery disease defined by Syntax Score(mean Syntax Score: 10.2 vs 10.3, P = 0.96) there was a trend towards a higher incidence of acute coronary lesions in patients with shockable rhythm(29.7% vs 16.4%, P = 0.054). There was also a higher need for ad-hoc percutaneous coronary intervention in this group(21.9% vs 9.1%, P = 0.03). CONCLUSION Initial shockable group of patients had a trend towards higher incidence of acute coronary lesions and higher need of ad-hoc percutaneous intervention vs nonshockable group. | Pedro Martínez-Losas Pablo Salinas Carlos Ferrera María Teresa Nogales-Romo Francisco Noriega María Del Trigo Iván Javier Núnez-Gil Luis Nombela-Franco Nieves Gonzalo Pilar Jiménez-Quevedo Javier Escaned Antonio Fernández-Ortiz Carlos Macaya Ana Viana-Tejedor | 2017 | World Journal of Cardiology2017，9，8： | 3 |
| 3 | Impact of Chronic Kidney Disease on Platelet Function Profiles in Diabetes Mellitus Patients With Coronary Artery Disease Taking Dual Antiplatelet Therapy显示文摘 | Dominick J. Angiolillo Esther Bernardo Davide Capodanno David Vivas Manel Sabaté José Luis Ferreiro Masafumi Ueno Pilar Jimenez-Quevedo Fernando Alfonso Theodore A. Bass Carlos Macaya Antonio Fernandez-Ortiz | 2010 | Journal of the American College of Cardiology2010，，： | 1 |
| 4 | Value of the American College of Cardiology/American Heart Association angiographic classification of coronary lesion morphology in patients with in-stent restenosis显示文摘 | Fernando Alfonso Angel Cequier Juan Angel Vicens Martí Javier Zueco Armando Bethencourt Ramón Mantilla José R. López-Minguez Manuel Gómez-Recio César Morís María J. Perez-Vizcayno Cristina Fernández Carlos Macaya Ricardo Seabra-Gomes | 2006 | American Heart Journal2006，，3： | 1 |
| 5 | Direct Measurement of Proximal Isovelocity Surface Area by Single-Beat Three-Dimensional Color Doppler Echocardiography in Mitral Regurgitation: A Validation Study显示文摘 | Jose Alberto de Agustín Pedro Marcos-Alberca Covadonga Fernandez-Golfin Alexandra Gon?alves Gisela Feltes Ivan Javier Nu?ez-Gil Carlos Almeria Jose Luis Rodrigo Leopoldo Perez de Isla Carlos Macaya Jose Zamorano | 2012 | Journal of the American Society of Echocardiography2012，，8： | 1 |
| 6 | Effect of Early Metoprolol on Infarct Size in ST-Segment–Elevation Myocardial Infarction Patients Undergoing Primary Percutaneous Coronary Intervention显示文摘 | Borja Ibanez Carlos Macaya Vicente Sánchez-Brunete Gonzalo Pizarro Leticia Fernández-Friera Alonso Mateos Antonio Fernández-Ortiz José M. García-Ruiz Ana García-álvarez Andrés I?iguez Jesús Jiménez-Borreguero Pedro López-Romero Rodrigo Fernández-Jiménez J | 2013 | Circulation2013，，14： | 1 |
| 7 | Variability in Individual Responsiveness to Clopidogrel显示文摘 | Dominick J. Angiolillo Antonio Fernandez-Ortiz Esther Bernardo Fernando Alfonso Carlos Macaya Theodore A. Bass Marco A. Costa | 2007 | Journal of the American College of Cardiology2007，，14： | 1 |
| 8 | Insulin Therapy Is Associated With Platelet Dysfunction in Patients With Type 2 Diabetes Mellitus on Dual Oral Antiplatelet Treatment显示文摘 | Dominick J. Angiolillo Esther Bernardo Celia Ramírez Marco A. Costa Manel Sabaté Pilar Jimenez-Quevedo Rosana Hernández Raul Moreno Javier Escaned Fernando Alfonso Camino Ba?uelos Theodore A. Bass Carlos Macaya Antonio Fernandez-Ortiz | 2006 | Journal of the American College of Cardiology2006，，2： | 1 |
| 9 | Risk Stratification of Mortality in Patients With Heart Failure and Left Ventricular Ejection Fraction >35%显示文摘 | Iwona Cygankiewicz Wojciech Zareba Rafael Vazquez Antoni Bayes-Genis Domingo Pascual Carlos Macaya Jesus Almendral Miquel Fiol Alfredo Bardaji Jose R. Gonzalez-Juanatey Vicente Nieto Mariano Valdes Juan Cinca Antoni Bayes de Luna | 2009 | The American Journal of Cardiology2009，，： | 1 |
| 10 | Coronary Artery Disease and Percutaneous Coronary Intervention in a Set of Twins显示文摘 | Luis Segura Raúl Moreno Carlos Macaya | 2007 | 2007，，： | 1 |
| 11 | Morphometric Assessment of Coronary Stenosis Relevance With Optical Coherence Tomography显示文摘 | Nieve Gonzalo Javier Escaned Fernando Alfonso Christian Nolte Vera Rodriguez Pilar Jimenez-Quevedo Camino Ba?uelos Antonia Fernández-Ortiz Eulogio Garcia Rosana Hernandez-Antolin Carlos Macaya | 2012 | Journal of the American College of Cardiology2012，，12： | 1 |
| 12 | Giant and thrombosed left ventricular aneurysm显示文摘Left ventricular aneurysms are a frequent complication of acute extensive myocardial infarction and are most commonly located at the ventricular apex. A timely diagnosis is vital due to the serious complications that can occur,including heart failure,thromboembolism,or tachyarrhythmias. We report the case of a 78-yearold male with history of previous anterior myocardial infarction and currently under evaluation by chronic heart failure. Transthoracic echocardiogram revealed a huge thrombosed and calcified anteroapical left ventricular aneurysm. Coronary angiography demonstrated that the left anterior descending artery was chronically occluded,and revealed a big and spherical mass with calcified borders in the left hemithorax. Left ventriculogram confirmed that this spherical mass was a giant calcified left ventricular aneurysm,causing very severe left ventricular systolic dysfunction. The patient underwent cardioverter-defibrillator implantation for primary prevention. | Jose Alberto de Agustin Jose Juan Gomez de Diego Pedro Marcos-Alberca Jose Luis Rodrigo Carlos Almeria Patricia Mahia Maria Luaces Miguel Angel Garcia-Fernandez Carlos Macaya Leopoldo Perez de Isla | 2015 | World Journal of Cardiology2015，7，7： | 0 |
| 13 | Ergonovine stress echocardiography: Recent experience and safety in our centre显示文摘AIM:To study recent experience and safety of ergonovine stress echocardiography in our centre.METHODS:In this study we collected the clinical variables of patients referred since 2002 for ergonovine stress echocardiography,in addition to indications,the results of this test,complications,blood pressure and heart rate values during the test and the number and results of tests requested before this technique.RESULTS:We performed 40 tests in 38 patients,2 tests were carried out to verify therapy efficacy.The prevalence of classic cardiovascular risk factors was low and the most frequent indication was chest pain (57.5%).Coronary angiography was performed in 32 patients,and showed normal coronary arteries in 27 patients and non-significant stenosis in 5 cases.In 16 patients,coronary angiography was carried out after a positive or inconclusive ischemia test.Another 6 patients had a normal stress test(5 exercise electrocardiography tests and 1 nuclear imaging test).Of the 40 ergonovine stress echocardiography tests,6 were positive(4 in the right coronary artery territory and 2 in the circumflex coronary artery territory),all of them by echocardiographic criteria,and by electrocardiographic criteria in only 3(50%).The presence of non-significant coronary artery stenosis was more frequent in patients with positive ergonovine stress echocardiography(50%vs 6%,P =0.038),and were related to ischemic territory.During the maximum stress stage,there was a higher systolic(130.26±19.17 mmHg vs 136.58±27.27 mmHg,95%CI:-12.77 to 0.14 mmHg,P=0.055)and diastolic blood pressure(77.89±13.49 mmHg vs 83.95± 15.73 mmHg,95%CI:-10.41 to-1.69 mmHg,P=0.008) than at the baseline stage,and the same was registered with heart rate(73±10.96 beats/minvs 79.79± 11.72 beats/min,95%CI:-9.46 to-4.11 beats/min,P <0.01).Nevertheless,there were only 2 hypertensive reactions during the last stage,which did not force a premature end to the test,without sustained tachy or bradyarrhythmias,and the technique was well tolerated in 58%of cases.A unique complication(2.5%)of this test was a prolonged vasospasm with a slight increase in necrosis biomarkers,however,this was without repercussion.CONCLUSION:Ergonovine stress echocardiography can be performed with safety,is well tolerated in the majority of cases,and is useful for determining the ischemia mechanism in selected cases. | Alejandro Cortell Pedro Marcos-Alberca Carlos Almería JoséL Rodrigo Leopoldo Pérez-Isla Carlos Macaya JoséLuis Zamorano | 2010 | World Journal of Cardiology2010，2，12： | 0 |
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