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| 1 | Coexpression of receptor-tyrosine-kinases in gastric adenocarcinoma-a rationale for a molecular targeting strategy?显示文摘AIM: To define the (co-)expression pattern of target receptor-tyrosine-kinases (RTK) in human gastric adenocarcinoma. METHODS: The (co-)expression pattern of VEGFR1-3,PDGFRα/b and EGFR1 was analyzed by RT-PCR in 51 human gastric adenocarcinomas. In addition,IHC staining was applied for confirmation of expression and analysis of RTK localisation. RESULTS: The majority of samples revealed a VEGFR1 (98%),VEGFR2 (80%),VEGFR3 (67%),PDGFRα (82%) and PDGFRβ(82%) expression,whereas only 62% exhibited an EGFR1 expression. 78% of cancers expressed at least four out of six RTKs. While VEGFR1-3 and PDGFRα revealed a predominantly cytoplasmatic staining in tumor cells,accompanied by an additional nuclear staining for VEGFR3 ,EGFR1 was almost exclusively detected on the membrane of tumor cells. PDGFRβ was restricted to stromal pericytes,which also depicted a PDGFRα expression.receptor-tyrosine-kinases coexpression in gastric adenocarcinoma and might therefore encourage an application of multiple-target RTK-inhibitors within a combination therapy. | Daniel Drescher Markus Moehler Ines Gockel Kirsten Frerichs Annett Müller Friedrich Dünschede Thomas Borschitz Stefan Biesterfeld Martin Holtmann Thomas Wehler Andreas Teufel Kerstin Herzer Thomas Fischer Martin R Berger Theodor Junginger Peter R Galle Carl C Schimanski | 2007 | World Journal of Gastroenterology2007，13，26： | 4 |
| 2 | Hematopoietic AMPK [Beta]1 reduces mouse adipose tissue macrophage inflammation and insulin resistance in obesity显示文摘 | Galic Sandra Fullerton Morgan D Schertzer Jonathan D Sikkema Sarah Marcinko Katarina Walkley Carl R Izon David Honeyman Jane Chen Zhi-Ping van Denderen Bryce J Kemp Bruce E Steinberg Gregory R | 2011 | Journal of Clinical Investigation2011，，12： | 2 |
| 3 | Probable involvement of thaxtomins A in pathogenicity of Streptomyces scabies on seedlings显示文摘 | LEINER R H FRY B A CARLING D E | 1996 | Phytopathology1996，86，： | 2 |
| 4 | Correct formulation of theKappa coefficient of agreement显示文摘 | William D H Carl W R | | 0，，04： | 1 |
| 5 | Advances in modeling the effects of selected parameters on the SLS显示文摘 | John D W Carl R D | 1998 | Rapid Prototyping Journal1998，4，2： | 1 |
| 6 | Device-to-device com- munication as an underlay to LTE-advanced networks显示文摘 | KLAUS D MIKA R CARL W | 2009 | IEEE Communications Magazine2009，47，12： | 1 |
| 7 | Advances in modeling the effects of selected parameters on the SLS process 显示文摘 | Williams J D Deckard Carl R | 1998 | Rapid prototyping Journal1998，4，2： | 1 |
| 8 | Evaluation of methods for sampling, recovery and enumeration of bacteria applied to the phylloplane 显示文摘 | Donegan K Carl M Seidler R et d | 1991 | Applied and Environmental Microbiology1991，57，： | 1 |
| 9 | Adsorption and ion exchange:Basic principles and their application in food processing 显示文摘 | Kammerer J Carle R Kammerer D R | 2011 | Journal of Agriculture and Food Chemistry2011，59，1： | 1 |
| 10 | Digital mammography显示文摘 | John M L Carl J D Edward R H | 2004 | Radiol Clin North Am2004，42，6： | 1 |
| 11 | Characterization ofAG-13 , a newly reported anastomosis group of Rhizoctonia solani显示文摘 | Carling D E Baird R E Gitaitis R D e( al | 2002 | Phytopathology2002，92，8： | 1 |
| 12 | Characterization of AG-13, A newly reported anastomosis group of Rhizoctonia solani显示文摘 | Carling D E Baird R E Gitaitis R D | 2002 | Phytopathology2002，92，： | 1 |
| 13 | Correct formulation of the kappa coefficient of agreement显示文摘 | William D H Carl W R | 1987 | Photogram metric Engineering and Remote Sensing1987，53，4： | 1 |
| 14 | In vitro sensitivity of Rhizoctonia solani and other multinucleate and binucleate Rhizoetonia to selected fungicides 显示文摘 | Carling D E Helm D J Leiner R H | 1990 | Plant Disease1990，，74： | 1 |
| 15 | Adenosine 5'-monophosphate- activated protein kinase promotes macrophage polarization to an an- ti-inflammatory functional phenotype 显示文摘 | Sag D Carling D Stout R D | 2008 | J Immunol2008，181，12： | 1 |
| 16 | Vancomycin-resistant Enterococcus domination of intestinal microbiota is enabled by antibiotic treatment in mice and precedes bloodstream invasion in humans显示文摘 | Ubeda Carles Taur Ying Jenq Robert R Equinda Michele J Son Tammy Samstein Miriam Viale Agnes Socci Nicholas D van den Brink Marcel R M Kamboj Mini Pamer Eric G | 2010 | Journal of Clinical Investigation2010，，12： | 1 |
| 17 | Supply Chain Management in Forestry-Case Studies at S(o)dra Cell AB显示文摘 | CARL D R(O)NN M | | 0，，16： | 1 |
| 18 | Characterization of AG-13, a newly reported anastomosis group of Rhizoctonia solani 显示文摘 | Carling D E Baird R E Gitaitis R D | 2002 | Phytopathology2002，92，8： | 1 |
| 19 | Imidazopyrazin-8-ones,imidazotriazin-8-ones and imidazotriazin-8-ones as a2/a3 subtypeselective GABAA agonists for the treatment of anxiety显示文摘 | Goodacre S C Haller D J Carling R W | 2006 | Bioorg Med Chem Lett2006，16，6： | 1 |
| 20 | A plastid phylogeny of the Cosmopolitan fern family Cystopteridaceae (Polypodiopsida) 显示文摘 | CARL J R MICHAEL D W KATHLEEN M P | 2013 | Systematic Botany2013，38，2： | 1 |
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