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您的检索式：作者名="Camilla Pramfalk"
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| 1 | Thyroid hormones and thyroid hormone receptors: Effects of thyromimetics on reverse cholesterol transport显示文摘Reverse cholesterol transport (RCT) is a complex process which transfers cholesterol from peripheral cells to the liver for subsequent elimination from the body via feces. Thyroid hormones (THs) affect growth, develop- ment, and metabolism in almost all tissues. THs exert their actions by binding to thyroid hormone receptors (TRs). There are two major subtypes of TRs, TRα and TRβ, and several isoforms (e.g. TRα1, TRα2, TRβ1, and TRβ2). Activation of TRα1 affects heart rate, whereas activation of TRβ1 has positive effects on lipid and lipoprotein metabolism. Consequently, particular interest has been focused on the development of thyromimetic compounds targeting TRβ1, not only because of their ability to lower plasma cholesterol but also due their ability to stimulate RCT, at least in pre-clinical models. In this review we focus on THs, TRs, and on the effects of TRβ1-modulating thyromimetics on RCT in various animal models and in humans. | Matteo Pedrelli Camilla Pramfalk Paolo Parini | 2010 | World Journal of Gastroenterology2010，16，47： | 4 |
| 2 | Role of thyroid receptor β in lipid metabolism显示文摘 | Camilla Pramfalk Matteo Pedrelli Paolo Parini | 2011 | BBA - Molecular Basis of Disease2011，，8： | 1 |
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