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您的检索式：作者名="Caiguang Yang"
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| 1 | Why are oseltamivir and zanamivir effective against the newly emerged influenza A virus (A/HIN1)?显示文摘 | Kunqian Yu Cheng Luo Guangrong Qin Zhijian Xu Ning Li Hong Liu Xu Shen Jianpeng Ma Qinghua Wang Caiguang Yang Weiliang Zhu Hualiang Jiang | 2009 | Cell Research2009，19，10： | 6 |
| 2 | Dynamic modifications of biomacromolecules: mechanism and chemical interventions显示文摘Biological macromolecules(proteins,nucleic acids,polysaccharides,etc.)are the building blocks of life,which constantly undergo chemical modifications that are often reversible and spatial-temporally regulated.These dynamic properties of chemical modifications play fundamental roles in physiological processes as well as pathological changes of living systems.The Major Research Project(MRP)funded by the National Natural Science Foundation of China(NSFC)—'Dynamic modifications of biomacromolecules:mechanism and chemical interventions'aims to integrate cross-disciplinary approaches at the interface of chemistry,life sciences,medicine,mathematics,material science and information science with the following goals:(i)developing specific labeling techniques and detection methods for dynamic chemical modifications of biomacromolecules,(ii)analyzing the molecular mechanisms and functional relationships of dynamic chemical modifications of biomacromolecules,and(iii)exploring biomacromolecules and small molecule probes as potential drug targets and lead compounds. | Chu Wang Peng Zou Caiguang Yang Lei Liu Liang Cheng Xiaopeng He Liang Zhang Yan Zhang Hualiang Jiang Peng RChen | 2019 | Science China(Life Sciences)2019，62，11： | 2 |
| 3 | The complex structures of ALKBH2 mutants cross-linked to dsDNA reveal the conformational swing of β-hairpin显示文摘Mammalian AlkB homologue 2(ALKBH2)is the primary housekeeping DNA demethylase,effectively repairing endogenously formed methylated lesions in double-stranded DNA.Our previous studies demonstrated that a hydrophobicβ-hairpin motif of ALKBH2 could play crucial roles in base-pair stability interrogation and damaged base flipping.Using chemical cross-linking strategy,we obtained two crystal structures of human ALKBH2 mutant bound to duplex DNA.The structural analysis suggests that theβ-hairpin motif is flexible in conformation and is likely to slide along the DNA duplex in local regions to search for damaged base.This study provides a new mechanistic insight into DNA damage detection by ALKBH2. | CHEN BaoEn GAN JianHua YANG CaiGuang | 2014 | Science China Chemistry2014，57，2： | 0 |
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