|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 针对患者利益的机器学习和人工智能研究:在透明性、可重复性、伦理和有效性等方面的20个关键问题显示文摘机器学习(ML)、人工智能(AI)和其他现代统计方法正为利用先前尚未开发且极速增长的数据资源提供新的机会,以期让患者获益。尽管目前正在进行许多有前景的研究,特别是在图像方面,但就文献整体而言还缺乏透明度、对可重复性清晰的阐述、对潜在伦理问题的探究,以及对有效性的明确验证。这些问题的存在有许多原因,其中最重要的一点(为此我们提供了初步解决方案)就是当前缺乏针对ML和AI的最佳实践指南。我们认为从事研究的跨学科团队和应用ML/AI影响健康的项目,将因解决有关透明度、可重复性、伦理和有效性(TREE)的一系列问题而受益。这里提出的20个关键问题为研究团队提供了一个研究设计、实施和报告框架;帮助编辑和同行评审专家评估文献的贡献;让患者、临床医生和政策制定者评估新发现可能会给患者带来的获益。 | Sebastian Vollmer Bilal A Mateen Gergo Bohner Franz J Kirdly Rayid Ghani Pall Jonsson Sarah Cumbers Adrian Jonas Katherine S L McAllister Puja Myles David Granger Mark Birse Richard Branson Karel G M Moons Gary S Collins John P A Chris Holmes Harry Hemingwayp 李峰(译) 徐磊(校) 赵邑(校) | 2020 | 英国医学杂志中文版2020，23，9： | 5 |
| 2 | Blood classical monocytes phenotype is not altered in primary non-small cell lung cancer显示文摘AIM: To evaluate the M1 and M2 monocyte phenotype in patients with non-small cell lung cancer(NSCLC) compared to controls. Also, to examine the expression of Th1 and Th2 cytokines in plasma of NSCLC vs controls. METHODS: Freshly prepared peripheral blood mononuclear cells samples were obtained from patients with NSCLC(lung adenocarcinoma and squamous cell lung carcinoma) and from non-cancer controls. Flow cytometry was performed to investigate M1 and M2 phenotypes in peripheral monocytes(classical monocytes CD14+, CD45+ and CD16-) using conventional surface markers. Th1 and Th2 cytokine production was alsoanalysed in the plasma using cytometric bead array technique. RESULTS: There were no significant difference in expression of M1(HLA-DR) and/or M2 markers(CD163 and CD36) markers on classical monocytes in patients with NSCLC compared to non-cancer controls. Expression of CD11 b, CD11 c, CD71 and CD44 was also shown to be similar in patients with NSCLC compared to noncancer controls. Th1 and Th2 cytokines [interleukin(IL)-1β, IL-2, IL-4, IL-5, IL-8, IL-10, IL-12(p70), tumor necrosis factor(TNF)-α, TNF-β, and interferon-γ] analysis revealed no significant difference between patients with NSCLC and non-cancer controls. CONCLUSION: This study shows no alteration in peripheral monocyte phenotype in circulating classical monocytes in patients with NSCLC compared to noncancer controls. No difference in Th1 and Th2 cytokine levels were noted in the plasma of these patients. | Saleh A Almatroodi Christine F Mc Donald Allison L Collins I an A Darby Dodie S Pouniotis | 2014 | World Journal of Clinical Oncology2014，5，5： | 2 |
| 3 | Intra - institutional factors that influence accounting research productivity 显示文摘 | Bucheit S Collins A B Collins D L | 2001 | The Journal of Applied Business Research2001，17，2： | 1 |
| 4 | Groundwater vulnerability assessment using a composite model combining DRASTIC with extensive agricultural land use in Israels Sharon region显示文摘 | Secunda S Collin M L Melloul A J | 1998 | Journal of Environmental Management1998，54，1： | 1 |
| 5 | Species diversity on-hances ecosystem functioning through interspecific facilitation 显示文摘 | Cardinale B J Palmer M A Collins S L | 2002 | Nature2002，415，6870： | 1 |
| 6 | Microenvironmental heterogeneity and Quercus rnichauxii regeneration in experimental gaps显示文摘 | Collins B S Battaglia L L | 2002 | Forest Ecology and Management2002，155，1： | 1 |
| 7 | Corporate governance and strategy:a test of the association between governance structure and diversification on Swedish data显示文摘 | BENGTSSON L | 2000 | Corporate Governance:A International Review2000，，8： | 1 |
| 8 | The Influence of Concept Mapping on Critical Thinking in Baccalaureate Nursing Students显示文摘 | Wheeler L A Collins S K | 2003 | J Prof Nurs2003，19，6： | 1 |
| 9 | Modulation of di- versity by grazing and mowing in native tall-grass prairie显示文摘 | Collins S L Knapp A K Briggs J M | 1998 | Science1998，280，5364： | 1 |
| 10 | Interaction of disturbances in tallgrass prairie: a field experiment显示文摘 | Collins S L | 1987 | Ecology1987，5，： | 1 |
| 11 | Guidelines for infection control indental health-care settings 2003显示文摘 | KOHN W G COLLINS A S CLEVELAND J L | 2003 | Recommendations and Reports2003，53，17： | 1 |
| 12 | Ductal carcinoma in situ with a basal-like phenotype: a possible precursor to invasive basallike breast cancer显示文摘 | Bryan B B Schnitt S J Collins L C | 2006 | Mod Pathol2006，19，： | 1 |
| 13 | Biodiversity under global change显示文摘 | COLLINS S L | 2009 | Science2009，326，5958： | 1 |
| 14 | An evaluation of the Weber classification of ankle fractures显示文摘 | Kennedy J G Johnson S M Collins A L | 1998 | INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED1998，29，8： | 1 |
| 15 | Effect of the reducing power of a beer on dimethyltrisulfide production during aging显示文摘 | Gijs L Collin S | 2002 | Journal of the American Society of Brewing Chemists2002，60，2： | 1 |
| 16 | The natural history of cervical HPV infection: unresolved issues显示文摘 | Woodman C B Collins S I Young L S | 2007 | Nat Rev Cancer2007，7，1： | 1 |
| 17 | Groundwater vulnerability assessment using a composite model combining DRASTIC with extensive agricultural land use in Isreal's Sharon region显示文摘 | Secunda S Collin M L | 1998 | Journal of Environmental Management1998，54，： | 1 |
| 18 | Shrub encroachment in North American grasslands: shifts in growth form dominance rapidly alters control of ecosystem carbon inputs显示文摘 | KNAPP A K BRIGGS J M COLLINS S L | 2008 | Global Change Biology2008，14，3： | 1 |
| 19 | Efficacy of patient-controlled versus conventional analgesia for postoperative pain显示文摘 | BOLLISH S J COLLINS C L KIRKING D M | 1985 | Clinical Pharmacy1985，4，1： | 1 |
| 20 | Preserving and evaluating hearts with ex vivo machine perfusion: an avenue to improve early graft performance and expand the donor pool 显示文摘 | Collins M J Moainie S L Griffith B P et ol | 2008 | Eur J Cardiothorac Surg2008，34，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员